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    Wyświetlanie 1-8 z 8
    Tytuł:
    Biological Action in and out of the Water Window
    Autorzy:
    Vyšín, L.
    Davídková, M.
    Wachulak, P.
    Fiedorowicz, H.
    Bartnik, A.
    Krůs, M.
    Kozlová, M.
    Skála, J.
    Dostál, J.
    Dudžák, R.
    Juha, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/1029783.pdf
    Data publikacji:
    2018-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.14.G-
    52.38.-r
    Opis:
    This study is dealing with the difference of radiation chemical yields of single and double strand breaks induced in plasmid DNA by photons inside and outside of the soft X-ray water window, i.e., in the wavelength range from 2.28 nm to 4.88 nm. Photons were generated by various plasma sources providing nanosecond and sub-nanosecond pulses of extreme ultraviolet, soft X-ray and X-ray radiation. DNA strand breaks were determined by agarose gel electrophoresis. Higher radiation chemical yields of both single and double strand breaks were found using picosecond and nanosecond sources of extreme ultraviolet and X-ray radiation.
    Źródło:
    Acta Physica Polonica A; 2018, 133, 2; 236-238
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Market reactions to dividends announcements: evidence from the Warsaw Stock Exchange
    Autorzy:
    Gnap, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/2120157.pdf
    Data publikacji:
    2022-06-30
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    signalling hypothesis
    Warsaw Stock Exchange
    dividend policy
    JEL Codes: D82, G14, G35
    teoria sygnalizacji
    Giełda Papierów Wartościowych w Warszawie
    polityka dywidend
    Opis:
    The main goal of article is to investigate the Warsaw Stock Exchange market reaction to announcements in connection with planned dividend payouts. The research sample comprises 45 entities listed on the Warsaw Stock Exchange between 2017 and 2021. The analysis uses the simple rate of return and the buy-and-hold excess return. Regression analysis shows that change in DPR does not fully explain the share price changes. Nonetheless, the weak market reaction to dividend payment announcements may lead to the conclusion that Polish stocks already take into account information about dividend payouts.
    Głównym celem artykułu jest zbadanie reakcji rynku na ogłoszenia w związku z planowanymi wypłatami dywidendy. Próba badawcza obejmuje 45 podmiotów notowanych na Giełdzie Papierów Wartościowych w Warszawie w latach 2017–2021. W analizie wykorzystano prostą stopę zwrotu oraz nadwyżkową stopę zwrotu typu buy-and-hold. Analiza regresji wskazuje, że zmiana wskaźnika DPR nie wyjaśnia w pełni zmiany cen akcji podmiotów objętych analizą. Niemniej jednak słaba reakcja rynku na komunikat o wypłacie dywidendy może prowadzić do wniosku, że polskie akcje już uwzględniają informacje o jej wypłacie.
    Źródło:
    Ruch Prawniczy, Ekonomiczny i Socjologiczny; 2022, 84, 2; 193-207
    0035-9629
    2543-9170
    Pojawia się w:
    Ruch Prawniczy, Ekonomiczny i Socjologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
    Autorzy:
    Horwacik, Irena
    Durbas, Małgorzata
    Boratyn, Elżbieta
    Sawicka, Anna
    Węgrzyn, Paulina
    Krzanik, Sylwia
    Górka, Anna
    Drożniak, Joanna
    Augustyniak, Ewa
    Kowalczyk, Aleksandra
    Rokita, Hanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038977.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    doxorubicin
    GD2 ganglioside
    microarray
    14G2a
    neuroblastoma
    mimitin
    Opis:
    Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 423-433
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessing the Indoor Pollutants Effect on Ornamental Plants Leaves by FT-IR Spectroscopy
    Autorzy:
    Husti, A.
    Cantor, M.
    Stefan, R.
    Miclean, M.
    Roman, M.
    Neacsu, I.
    Contiu, I.
    Magyari, K.
    Baia, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1398690.pdf
    Data publikacji:
    2016-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.14.-g
    87.15.B-
    87.64.km
    92.60.Sz
    Opis:
    Air pollution has become a mass phenomenon, a major and global problem of modern society, affecting billions of people and environment. People are exposed to various levels of pollutants not just in the outdoor environment, but also in indoors. The quality of life and well-being of employees can be increased by incorporating ornamental plants in the work environment. Among the great variety of plants species able to remove/reduce indoor air pollutants Dracaena deremensis, Sansevieria trifasciata and Ficus elastica were hereby investigated. Their ability to remove chemical pollutants was evaluated in real-life conditions and the changes induced by the environmental stress on the structure and biochemical composition of the plants leaves were evidenced by the Fourier transform infrared spectroscopy. The most pronounced concentration decrease was noticed for the CO₂ (58.33% removed concentration), whereas the mean value of the removed concentration of other chemical pollutants was of ≈ 25%. The Fourier transform infrared spectra analysis revealed that, although the plants are subjected to the chemical pollutants action, they maintain the structure by adjusting their metabolism. A decrease in the overall protein contribution in the amide bands and an increase of the bands assigned to polysaccharide vibrations, illustrate the consequences of the pollution action. Moreover, the chlorophyll presence is evidenced in the IR spectra of all samples by the bands around 1040, 1445, 1620, and 1735 cm^{-1}. The results show that the Fourier transform infrared spectra are an important source of information for the rapid characterization of the chemical structure of the biological systems under environmental stress.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 1; 142-149
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative Analysis of KP-HSA Complex by Spectroscopic Methods
    Autorzy:
    Mąciażek-Jurczyk, M.
    Równicka-Zubik, J.
    Dyja, R.
    Sułkowska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1400125.pdf
    Data publikacji:
    2013-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.50.-j
    33.50.Dq
    82.56.-b
    87.14.-g
    87.14.E-
    Opis:
    The main objective of the presented study was to characterize the high (HAS) and low affinity (LAS) binding sites of ketoprofen (KP) in human serum albumin (HSA) structure with the use of spectrofluorescence and proton nuclear magnetic resonance spectroscopy. In vitro fluorescence analysis was used to estimate the effect of KP on the HSA fluorescence. The association constants $K_{a} [M^{-1}]$ of KP-HSA complex in the HAS were determined with the use of Scatchard, Klotz, and Hill analysis. The quenching $K_{Q} [M^{-1}]$ constants were determined on the basis of the Stern-Volmer equation. Binding of ketoprofen to plasma protein was also studied with the use of 8-anilinonapthalene-1-sulfonic acid (ANS) and 5-dimethylaminonaphthalene-1-sulfonic acid (DNSA) as the fluorescence probes in IIIA and IIA subdomains of HSA, respectively. To estimate the cooperativeness in proteins Hill's coefficient $n_{H}$ was used. The analysis of proton nuclear magnetic resonance spectra of KP in the presence of HSA allows us to observe the interactions between aromatic rings of the drug and the rings of amino acids located in the hydrophobic subdomains of the protein on the basis of the changes of chemical shifts Δ σ [ppm] of drug protons resonances. Moreover the $K_{a}$ constants $[M^{-1}]$ of KP-HSA complex in the LAS were determined.
    Źródło:
    Acta Physica Polonica A; 2013, 123, 4; 673-680
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A gene mutation in Mexican colorectal cancer patients
    Autorzy:
    Gallegos-Arreola, Martha
    Zúñiga-González, Guillermo
    Sánchez-López, Josefina
    Cruz, Alondra
    Peralta-Leal, Valeria
    Figuera, Luis
    Puebla-Pérez, Ana
    Ronquillo-Carreón, Carlos
    Puebla-Mora, Ana
    Powiązania:
    https://bibliotekanauki.pl/articles/1038394.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    TYMS 2R/3R
    colorectal cancer
    polymorphism
    DPYD [IVS]14+1G>A
    Mexican population
    Opis:
    Objective: To examine the association between TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A mutation by comparing healthy subjects with colorectal cancer (CRC) patients in the Mexican population. Method: Genotyping of the 2R/3R was performed by polymerase chain reaction (PCR) and [IVS]14+1G>A mutation by real-time PCR analysis. Results: The observed frequencies of the TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation in DPYD did not indicate an increased risk for CRC (p>0.05). However we observed an association of the 2R/2R (OR 3.08, 95% CI 1.66-6.08, p=0.0017) and heterozygous (OR 1.98, 95% CI 1.32-2.97, p=0.0012) genotypes as risk factors when comparing controls and CRC patients that were also tobacco consumers. An association between the genotype and the disease was evident. The distribution of the 2R/2R genotype and hematological toxicity (adjusted OR 2.26, 95% CI 1.54-4.45, p=0.0259), heterozygous (2R/3R) with tumor stage III-IV (OR 1.81, 95% CI 1.11-2.94, p=0.020) and 2R/2R-2R/3R in non-chemotherapy response CRC patients with hematological (OR 2.3, 95% CI 1.21-4.4, p=0.014) and gastric toxicities (OR 3.11, 95% CI 1.18-8.2, p=0.035) confirmed that this factor may significantly contribute to the CRC susceptibility. Conclusion: TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation in DPYD was not associated with susceptibility to CRC. However, the 2R/2R and 2R/3R genotypes of TYMS polymorphism could significantly contribute to hematological and gastric toxicity in CRC patients in this sample population.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 2; 227-234
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Strain Relaxation of ZnTe/CdTe and CdTe/ZnTe heterostructures: In Situ Study
    Autorzy:
    Riesz, F.
    Kret, S.
    Karczewski, G.
    Wojtowicz, T.
    Kossut, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1952073.pdf
    Data publikacji:
    1996-11
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    61.14.Hg
    68.55.Bd
    68.65.+g
    Opis:
    The strain relaxation kinetics of ZnTe/CdTe and CdTe/ZnTe heterostructures grown on GaAs substrates by molecular beam epitaxy are studied by in situ reflection high-energy electron diffraction. The observed critical layer thickness is 5 monolayers for ZnTe/CdTe and less than 1 monolayer for CdTe/ZnTe. The relaxation is anisotropic. Dislocation core parameters and relaxation rate constants were determined using a kinetic model and assuming strain-dependent activation energy of dislocation movement.
    Źródło:
    Acta Physica Polonica A; 1996, 90, 5; 911-914
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In the Search of Electron Correlation Effects in DNA
    Autorzy:
    Wróbel, A.
    Wróbel, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1537235.pdf
    Data publikacji:
    2010-08
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.14.gk
    75.20.-g
    71.10.Fd
    Opis:
    We discuss the energy scale separation induced in DNA by gaps between molecular orbital states of individual bases and by electron correlations. We also demonstrate how this separation gives rise to effective low energy models of electron transport in DNA.
    Źródło:
    Acta Physica Polonica A; 2010, 118, 2; 409-412
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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