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Tytuł:
Comparative phytochemistry, antioxidant, antidiabetic, and anti-inflammatory activities of traditionally used Ocimum basilicum L. Ocimum gratissimum L., and Ocimum tenuiflorum L.
Autorzy:
Sharma, Arun Dev
Kaur, Inderjeet
Angish, Sooraj
Thakur, Alisha
Sania, Sania
Singh, Amritpal
Powiązania:
https://bibliotekanauki.pl/articles/16648104.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
antioxidants
anti-inflammatory
antidiabetic
Ocimum
Opis:
Ocimum spp. are the widely studied herbal plants because of their diverse biological activities. The present study aimed at comparative extraction of secondary metabolites and evaluation of their biological activities in different solvents such as acetone, ethanol, methanol, and water. Three Ocimum species, namely Ocimum basilicum L. (Green tulsi), Ocimum gratissimum L. (Jungli tulsi), and Ocimum tenuiflorum (Black tulsi), were selected for this study. Leaf extracts from dried powder of these species were prepared in different solvents. The contents of total phenolics, flavonoids, and total condensed tannins were estimated using standard assays. Fingerprint analysis using UV, Fourier transform infrared (FT-IR), and fluorescent spectroscopy was also conducted. Total antioxidant, antidiabetic, and anti-inflammatory activities of the extracts were evaluated. Fingerprint analysis indicated the presence of a sufficient level of polyphenolics in all the solvent extracts. Among all the solvents, acetone provided a higher yield of phenolics, flavonoids, and tannins in all Ocimum species. Black Ocimum showed the maximum level of antioxidants. All Ocimum extracts exhibited a sufficient level of antidiabetic and anti-inflammatory activities. The results indicated that by using appropriate solvents, bioactive compounds from Ocimum species can be extracted and used as therapeutic agents with potential biological activities.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 2; 131-142
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and Biological Evaluation of Some New Hydrazone Derivatives Bearing Pyrimidine Ring as Analgesic and Anti-Inflammatory Agents
Autorzy:
Akdağ, Kadriye
Ünal, Gökhan
Tok, Fatih
Arıcıoğlu, Feyza
Temel, Halide E.
Kaymakcıoğlu-Koçyiğit, Bedia
Powiązania:
https://bibliotekanauki.pl/articles/895455.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
anti-inflammatory activity
hydrazones
analgesic activity
Opis:
New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio)pyrimidine-5-carbohydrazide. Synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis. All compounds were investigated for analgesic and anti-inflammatory activity with hot plate test and biochemical assay, respectively. The results of anti-inflammatory activity showed that compound 2t had maximal Lipoxygenase (LOX) inhibition (66.30%) whereas inhibitions of 2a, 2c, 2i, 2k, 2l, 2m, 2p, 2s and 2u were observed between approximately 45-15 %. Our results also indicated that 15 compounds of 21 had analgesic effect in hot plate test. Analgesic effect of 2l, 2s, 2t began earlier than others while effect of 2i began at latest time. According to the activity results, compound 2t have significant analgesic and anti-inflammatory effects.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1147-1159
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New thiopyridine complexes: design, electrochemical preparation and biological assessment
Autorzy:
El-Sabbagh, Osama I.
Yamany B., Yamany
Eldeab, Hany A.
Powiązania:
https://bibliotekanauki.pl/articles/778283.pdf
Data publikacji:
2019
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Thiopyridine
complexes
electrochemical
antimicrobial
anti-inflammatory
Opis:
Novel complexes of Ru (III), Cu (II) and Au (III) (2–4) were prepared using 6-phenyl-2-thioxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (HL, 1) adopting either electrochemical or traditional chemical methods. The electrochemical method is preferred in the synthesis of the complexes than the chemical one because it affords pure products with higher yields in shorter reaction time. The novel thiopyridine complexes were characterized by elemental analyses, IR, 1H, 19F-NMR, TGA and DTA measurements. The antimicrobial activity evaluation revealed that the complex bearing copper metal 3 has nearly the same activity as the reference drug ciprofloxacin. Anti-inflammatory activity evaluation showed that complex 4 containing gold displayed anti-inflammatory activity higher than the reference drug celecoxib upon using carrageenan rat hind paw edema method.
Źródło:
Polish Journal of Chemical Technology; 2019, 21, 4; 20-25
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF DIOSGENIN ON LIPOPOLYSACCHARIDES INDUCED RAW 264.7 CELLS
Autorzy:
ning, jing
chang, yu
wang, ruxia
lan, zhiwei
ru, qing
liu, mingchun
tian, chunlian
Powiązania:
https://bibliotekanauki.pl/articles/895615.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Diosgenin
Anti-inflammatory
lipopolysaccharides
cytotoxicity
phagocytosis ability  
Opis:
Diosgenin is a steroidal sapogenin compound, and possesses multiple biological activities including anti-inflammatory, anticancer, immunological regulation, and anti-aging. The current study focused on its anti-inflammatory activities and cytotoxicity by analysis of NO production, phagocytosis activity, secretion of TNF-α and IL-6 and cell viability in LPS-induced RAW 264.7 cells. An IC50 value of diosgenin of 2.8 μM was calculated for diosgenin by regression of cell viability from concentrations ranging from 0.01 to 25 μM; this indicated that 0.01, 0.02, 0.04 μM diosgenin could reduce phagocytic activity very significantly (p<0.01) in a dose-dependent manner with no cytotoxic effect on the LPS-induced RAW 264.7 cells. However, there was no significant effect on NO content and secretion of TNF-α and IL-6 after diosgenin treatment. The research revealed that low concentrations diosgenin can directly inhibit cells phagocytosis, with no effect on the release of inflammatory mediators and cytokines. This lays a foundation for screening for a safe dose in research and developent of derivatives and new formulation of diosgenin for its anti-inflammatory effect.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 313-317
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of ginger and curcumin on diabetic nephropathy induced by streptozotocin in rats
Autorzy:
Taha, Alaa
Ashour, Hanaa K.
Reffat, Manar
Elkhawaga, Omali Y.
Powiązania:
https://bibliotekanauki.pl/articles/24987713.pdf
Data publikacji:
2023-11-28
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
Oxidative stress
Anti-inflammatory
diabetic nephropathy
Ginger
Cunrcumin
Opis:
Background: Diabetes mellitus is a global health concern affecting 173 million adults annually that requires effective treatment. Medicinal plants such as ginger and curcumin are rich in bioactive compounds that have therapeutic potential. The aim of this study was to evaluate the therapeutic potential of ginger and curcumin extracts in diabetic nephropathy in the rat model. Material and methods: High-performance liquid chromatography was used to examine ginger and curcumin extracts. Fifty male Sprague Dawley rats were divided into five groups: control, untreated diabetic, ginger-treated diabetic, curcumin-treated diabetic and a ginger + curcumin combination group. Diabetes was induced with a single intraperitoneal dose of streptozotocin. Rats received daily oral doses of ginger, curcumin or the combination of both. After sixteen weeks, rats were anesthetized and various tests were conducted to evaluate treatment outcomes. Results: The rats treated with combined ginger and curcumin extracts had superior outcome in terms of more antioxidant activity, better glycemia management and less DN-related kidney damage (reduced albuminuria and less histological changes). Conclusions: Our findings indicate that ginger and curcumin extracts have therapeutic potential in mitigating functional and structural alterations in the kidneys of diabetic rats, possibly due to their anti-diabetic and anti-inflammatory properties.
Źródło:
European Journal of Translational and Clinical Medicine; 2023, 6, 2; 51-65
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile as a novel anti-Inflammatory scaffold: synthesis, biological evaluation and docking studies
Autorzy:
Bharathi, R.
Santhi, N.
Powiązania:
https://bibliotekanauki.pl/articles/1075445.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
anti-inflammatory
benzonitrile
pyrazoles
spectral IR
spectral NMR
Opis:
A new series, 4-(3-(2-amino-3,5-dibromophenyl)-1-(4-substitutedbenzoyl)-4,5-dihydro-1H-pyrazol-5-yl)benzonitrile (4a-h), were synthesized and evaluated for in vitro anti-inflammatory activities. The spectral (IR, NMR) and elemental analyses data of the product indicated the formation of new pyrazoles 4a-h. Compound 4e exhibited potent anti-inflammatory property about 85.45 % inhibitions. This value was compared with standard diclofenac sodium. Additionally, molecular docking increased our understanding of their receptor-ligand binding. These results demonstrated that pyrazole derivatives are potential inhibitors. Overall, the results suggest that the pyrazoles 4a-h is important lead compounds for the continuing battle against inflammation.
Źródło:
World Scientific News; 2019, 126; 148-162
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dose-effect relationship on anti-inflammatory activity on LPS induced RAW 264.7 cells and antioxidant activity of rutin in vitro
Autorzy:
tian, chunlian
guo, yuru
chang, yu
zhao, jihang
cui, cancan
liu, mingchun
Powiązania:
https://bibliotekanauki.pl/articles/895707.pdf
Data publikacji:
2019-06-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
antioxidant
Anti-inflammatory
lipopolysaccharide
rutin
dose-effect relationship
Opis:
Rutin, as a common flavonol glycoside, exists abundantly in many plants and exhibits various nutritional and pharmacological function. Current study focused on the dose-effect relationship of rutin on the anti-inflammatory and antioxidant activities in vitro against LPS-stimulated RAW 264.7 cells and free radicals or ferric-ion. This study evaluated the anti-inflammatory activity by observation cell morphological and determination of the content of NO, TNF-α, IL-1β and IL-6, and the phagocytic activity in LPS induced RAW 264.7 cells; and revealed the antioxidant activities via assay of DPPH radical scavenging capacity, ABTS radical scavenging capacity, and reducing power. The study indicated that 5, 10, 20, 50 and 100 μM of rutin all exhibited a better anti-inflammatory activity, in especial 50 and 100 μM. Meanwhile, it exerted a stronger antioxidant activities than BHT, and equivalent to VC at the same concentration. Combined, the results suggested that rutin will be a potential and important adjuvant in treatment of inflammatory diseases and oxidative stress.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 511-522
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inula viscosa phenolic extract suppresses colon cancer cell proliferation and ulcerative colitis by modulating oxidative stress biomarkers
Autorzy:
Kheyar, Naoual
Bellik, Yuva
Serra, Ana Teresa
Kheyar, Farida
Bedjou, Fatiha
Powiązania:
https://bibliotekanauki.pl/articles/16648114.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
Inula viscosa
ulcerative colitis
colorectal cancer
anti-inflammatory
antiproliferative
Opis:
Inula viscosa is a perennial herbaceous plant native to the Mediterranean Basin, which is used topically for the treatment of various diseases in folk medicine. This study aimed to evaluate the in vivo intestinal anti-inflammatory activity of the ethanolic extract of I. viscosa (EEIV) and to test its effect on a colorectal cancer cell line. EEIV was administered to rats orally and daily at 100 and 200 mg/kg body weight for 7 days, and then colitis was induced by intrarectal instillation of 2 ml of 4% (v/v) acetic acid (AA) solution. At the end of the experiment, clinical examinations of the rats were conducted by evaluating macroscopic and histological signs of colonic tissues and measuring erythrocyte sedimentation rate (ESR) and the levels of C-reactive protein, fibrinogen, myeloperoxidase (MPO), malondialdehyde (MDA) and nitric oxide (NO). Using MTS assay, the antiproliferative effect of EEIV against human colon carcinoma HT29 cells and cytotoxicity on nondifferentiated Caco-2 cell line was evaluated. EEIV significantly decreased the ESR and fibrinogen levels as compared to control colitic rats (P < 0.001). It also significantly decreased the NO, MDA, and MPO levels in the colon tissue compared with the untreated colitic group (P < 0.001). These results were confirmed by macroscopic and histological examination, which showed significant protection against AA-induced ulcerative colitis. Furthermore, EEIV at a concentration of 369.88 μg/ml did not show cytotoxicity on confluent Caco-2 cells, with significant inhibition of colorectal cancer cell (HT29) growth (EC50 = 62.39 μg/ml). These results demonstrate that EEIV plays a potential role as pharmacological tool in the management of inflammatory bowel disease and prevention of colorectal cancer.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 3; 269-284
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analgesic and anti-inflammatory activities of some transition metal schiff base complexes
Autorzy:
Jesmin, M.
Islam, M. K.
Ali, S. M. M.
Powiązania:
https://bibliotekanauki.pl/articles/411762.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Analgesic activity
Anti-inflammatory activity
Schiff bases complexes
Writhing test
Opis:
Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylideneglycinato diaqua cobalt(II) dimer] (SGCo)2, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylideneglycinato diaqua zinc(II) dimer] (SGZ)2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 8; 64-72
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-inflammatory activity of Turkey source pumpkin seed oil in rat oedema model
Autorzy:
Arslanbaş, Emre
KARA, Haki
KARAYİĞİT, Mehmet Ö.
DOĞAN, Halef O.
YILDIZ, Şeyma N.
Powiązania:
https://bibliotekanauki.pl/articles/895458.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
rat
Anti-inflammatory
carrageenan
indomethacin
pumpkin seed oil
oedema model
Opis:
This study aimed to determine the effects of Turkey-sourced pumpkin seed oil (PSO), administered orally to rats in different dosages, to research its anti-inflammatory effect in rat oedema model, induced by carrageenan, based on different dosages, and to evaluate its effects comparatively with indomethacin. The study was conducted on 42 rats in total, divided into 7 groups (control, carr, PSO40, PSO100, PSO40+carr, PSO100+carr and indo+carr). In the study, doses of 40 and 100 mg/kg of PSO were found to significantly suppress rat paw oedema in time, and it was observed that this effect was more pronounced in the fourth hour. It was found that MDA and cytokine (TNF-α, IL-6, IL-1β) levels were inhibited, and GPX and SOD activities were enhanced in groups that received PSO and indo+carr groups. Histopathological examinations also support these findings. As a result of the study, the significant anti-inflammatory effect of Turkey-sourced PSO was attributed to the existence of unsaturated fatty acids and enriched phytochemical compounds.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 305-312
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibacterial, antifungal, anti-oxidant, anti-inflammatory and anti-hypertensive activities of N-chloropyrazinamide
Autorzy:
Vaijayanthi, S. P.
Mathiyalagan, N.
Powiązania:
https://bibliotekanauki.pl/articles/412474.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antibacterial activity
antifungal activity
antioxidant activity
anti-inflammatory
anti-hypertensive activity
N-chloropyrazinamide
Opis:
N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 7; 1-8
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health-promoting effects of Manuka honey
Prozdrowotne działanie miodu Manuka
Autorzy:
Grzebisz, N.
Grzebisz, E.
Powiązania:
https://bibliotekanauki.pl/articles/2052609.pdf
Data publikacji:
2016
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
methylglyoxal
honey
manuka
anti-inflammatory substances
metyloglioksal
miód
Manuka
substancje przeciwzapalne
Opis:
Honey properties are determined by the level of methylglyoxal (antimicrobial substance) from 30 to 550 in the case of MGO method or from 5 to 20 by UMF method. Previous studies have shown that high levels of methylglyoxal in Manuka honey support the body’s defense mechanisms, mainly by stimulating the growth of probiotic intestinal bacteria. The antibacterial properties of honey make it possible to use it to treat wounds and bedsores and prevent inflammation in the body, which is important in a sports training. The most significant study results showed that honey has a positive effect on increasing the body’s immune response as it is highly antioxidant and anti-inflammatory. It means it can be used in healing wounds by stopping the growth of harmful bacteria, for example : Staphylococcus aureus. Its intake prevents the atherosclerosis. Moreover, acetylcholine present in Manuka honey lowers blood pressure and improves blood circulation, choline has a protective effect on the liver and increases the secretion of bile. Metal ions stimulate the production of red blood cells and hemoglobin. The high content of methylglyoxal, and thus, the specific health benefits of Manuka honey can be used in the diet and supplementation of athletes. Changes occurring in the body due to physical exercise, like the oxidative stress, increase the level of free radicals ,and in result,cause a fall in the exercise potential of the body as well as reduce the immunological barrier. This problem can be particularly observed in winter athletes. Current research results on pro-health properties of Manuka honey have indicated that it can counteract those negative effects. Namely, negative factors of physical exercise are blocked in an athlete’s body by honey [1], and Manuka honey may, in particular, have a positive impact on the health of physically active people.
Miód pszczeli znany jest od wieków jako produkt spożywczy korzystnie oddziaływujący na organizm człowieka. W zależności od stężenia metyloglioksalu (substancji przeciwbakteryjnej) miody oznaczane są wartościami od 30 do 550 w przypadku metody MGO lub od 5 do 20 przy metodzie UMF. Dotychczasowe badania wykazały, że wysokie stężenie metyloglioksalu w miodach Manuka wspiera mechanizmy obronne organizmu m.in. poprzez pobudzanie wzrostu liczby probiotycznych bakterii jelitowych. Właściwości antybakteryjne miodu pozwalają na wykorzystanie go w leczeniu ran i odleżyn oraz przeciwdziałają stanom zapalnym w organizmie, co jest istotne w treningu sportowym. Najważniejsze wyniki badań wykazały, że miód pozytywnie wpływa na zwiększenie odpowiedzi immunologicznej organizmu, działanie antyoksydacyjne i przeciwzapalne, leczenie ran i zatrzymanie rozwoju szkodliwych bakterii, jak np. gronkowiec złocisty. Jego spożywanie zapobiega zmianom miażdżycowym. Obecna w miodzie acetylocholina obniża ciśnienie i poprawia krążenie krwi, cholina działa ochronnie na wątrobę oraz zwiększa wydzielanie żółci. Jony metali stymulują produkcję czerwonych ciałek krwi i hemoglobiny. Wysoka zawartość metyloglioksalu i co za tym idzie, szczególne właściwości prozdrowotne miodu Manuka, mogą być wykorzystywane w diecie i suplementacji u sportowców. Zmiany zachodzące w organizmie pod wpływem wysiłku fizycznego, min. zjawisko stresu oksydacyjnego, zwiększenie ilości wolnych rodników powodują obniżenie możliwości wysiłkowych organizmu i zmniejszenie bariery immunologicznej, na która szczególnie narażeni są sportowcy zimowi. Negatywnym skutkom może przeciwdziałać suplementacja miodem Manuka, na co wskazywać mogłyby dotychczasowe wyniki badań nad właściwościami prozdrowotnymi tej substancji. Negatywne czynniki są blokowane w organizmie sportowca przez miody (Davis, Perez 2009), ale miód Manuka może w szczególności pozytywnie oddziaływać na stan zdrowia osób aktywnych fizycznie. Poniższa praca ma na celu przedstawienie prozdrowotnych właściwości miodu Manuka.
Źródło:
Health Problems of Civilization; 2016, 10, 2; 43-50
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aronia melanocarpa Leaves as a Source of Chlorogenic Acids, Anthocyanins, and Sorbitol, and Their Anti-Inflammatory Activity
Autorzy:
Zielińska, Agnieszka
Bryk, Dorota
Paradowska, Katarzyna
Wawer, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1363310.pdf
Data publikacji:
2020
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
Aronia melanocarpa leaves
sorbitol
chlorogenic acids
anti-inflammatory activity
NMR
HPLC
Opis:
Aronia melanocarpa E. berries are a valuable component of the healthy diet. They are extremely high in phenolics exhibiting strong antioxidant properties. However, not much information is available on the chemical composition and bioactive potential of chokeberry leaves. Therefore, the analyses of sugars and phenolics of extracts from chokeberry leaves collected from June to October were performed using spectroscopic (NMR) and chromatographic (HPLC-DAD/RI, GC-MS) methods. The leaf extracts contained a significant amount of sorbitol, especially those made of leaves collected since June to July (avg. 145.2 mg/g d.w.). The average contents of Cya-3-Gal and chlorogenic acids in the extracts were at 0.52 mg g d.w. and up to 13.1 mg/g d.w., respectively. Chokeberry leaf extracts from green and red leaves were subjected to the in vitro study on human umbilical vein endothelial cells (HUVCs). Both extracts suppressed TNF-α-induced surface expression of ICAM-1 and VCAM-1 molecules, and exhibited anti-adhesive and anti-inflammatory properties. Green and red leaves may foster a therapeutic potential in the prevention of atherosclerosis and other pathological events involving leucocyte adhesion. That is why chokeberry leaves can be considered as a promising component of functional foods owing to the high content of chlorogenic acids and sorbitol.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2020, 70, 4; 409-418
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of poloxamer 407 on the properties of hydrophilic gels containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035517.pdf
Data publikacji:
2010
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs.
chitosan
complex
lactic acid
poloxamer 407
vaginal infections
Opis:
Anatomical and physiological conditions in the vagina do not facilitate easy application of the drug neither its maintenance on the site of application. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. Gels containing lactic acid complexed with chitosan at a stechiometric ration 1:1 and 2:1 and 5 - 25% content of PEG-200 are able to move from 25 to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 20 to 24 cm. The addition of 20 – 25% poloxamer 407 increases the pH to 4.55 to 5.30 for 1:1 gels and 4.00 to 4.85 for 2:1 gels. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 in comparison to the reference gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 143-148
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination
Autorzy:
Mitura, K.
Wilczek, P.
Niemiec-Cyganek, A.
Morenc, M.
Dudek, M.
Sobczyk-Guzenda, A.
Fraczyk, J.
Kolesińska, B.
Powiązania:
https://bibliotekanauki.pl/articles/284974.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
detonation nanodiamond particles
chemical modification
anti-inflammatory drugs
FTIR spectroscopy
mouse fibroblasts
Opis:
Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.
Źródło:
Engineering of Biomaterials; 2017, 20, 140; 12-20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 53

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