- Tytuł:
- The comparisons of blood plasma and cerebrospinal fluid S100B protein concentrations in patients with Alzheimer`s disease, amyotrophic lateral sclerosis, and multiple sclerosis
- Autorzy:
-
Tarasiuk, J.
Kapica-Topczewska, K.
Chorąży, M.
Borowik-Zaręba, A.
Mroczko, B.
Kochanowicz, J.
Kułakowska, A. - Powiązania:
- https://bibliotekanauki.pl/articles/1918848.pdf
- Data publikacji:
- 2019-08-26
- Wydawca:
- Uniwersytet Medyczny w Białymstoku
- Tematy:
-
S100
blood
cerebrospinal fluid
Alzheimer's disease
Amyotrophic lateral sclerosis
Multiple sclerosis - Opis:
- Introduction:S100 calcium-binding protein B (S100B) is a biochemical marker of astroglial damage. Purpose: To assess the pathophysiological implications of S100B concentrations in blood plasma and cerebrospinal fluid of patients with neurodegenerative central nervous system disorders. Materials and Methods: In this study, we determined and compare S100B concentrations in blood plasma and cerebrospinal fluid obtained from subjects diagnosed with Alzheimer's disease (n=20), amyotrophic lateral sclerosis (n=12), multiple sclerosis (n=40) and the reference group (n=20), using enzyme-linked immunosorbent assay. Results: Concentrations of S100B in plasma collected from patients diagnosed with Alzheimer's disease (252,38±183,50 pg/mL) and multiple sclerosis (164,92±250,14 pg/mL) were above laboratory standards, but in patients with amyotrophic lateral sclerosis (53,96±56,92 pg/mL) and the reference group (2,12 pg/mL) were below laboratory norms (N>75 pg/mL). Concentrations of S100B in plasma collected from patients with Alzheimer's disease (252,38±183,50 pg/mL) were significantly higher than in patients with amyotrophic lateral sclerosis (53,96±56,92 pg/mL) (p<0,029). Concentrations of S100B in CSF collected from the reference group (546,96±236,62 pg/mL) and from patients with Alzheimer's disease (587,53±189,57 pg/mL), amyotrophic lateral sclerosis (404,41±179,56 pg/mL), multiple sclerosis (462,03±146,01 pg/mL) were very similar, and none of pairwise comparisons reached statistical significance. Conclusions: Results of our studies indicate the importance of S100B protein concentration assessment in blood in central nervous system disorders differential diagnostics.
- Źródło:
-
Progress in Health Sciences; 2019, 1; 22-27
2083-1617 - Pojawia się w:
- Progress in Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł