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Tytuł:
Nasal allergen challenge – an important diagnostic tool in rhinology
Autorzy:
Arcimowicz, Magdalena
Krzych-Fałta, Edyta
Powiązania:
https://bibliotekanauki.pl/articles/1399272.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
local allergic rhinitis
nasal allergen challenge
rhinitis
Opis:
The nasal allergen challenge (NAC) is used in the diagnosis of rhinitis. The primary use of NAC is to confirm allergy to a specific inhaled allergen. NAC reproduces the allergic reaction of the nasal mucosa under standardized and controlled conditions that occurs after direct intranasal administration of allergens. As the only used method for assessing the degree of allergy, it mimics the body’s natural response to the sensitizing factor in the early and late stages of an allergic reaction. NAC is used in the diagnosis of chronic, occupational and local rhinitis, as well as in the differential diagnosis of rhinitis and ophthalmic symptoms. Under conditions similar to natural exposure, it determines the relationship between the allergen and symptoms of allergic rhinitis, especially in the case of difficulties in interpreting the results of skin tests and the serum concentration of specific IgE. It is a truly valuable tool in determining the indications for immunotherapy and the selection of allergens for desensitization therapy. It also serves as a method of monitoring the effectiveness of immunotherapy and pharmacotherapy. For scientific purposes, NAC is used to study the mechanisms of an allergic reaction and the influence of various factors on its course. It is considered safe, but requires appropriate instruments and qualified personnel.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 4; 33-38
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatment strategy of allergic rhinitis in the face of modern world threats
Autorzy:
Rapiejko, Piotr
Jurkiewicz, Dariusz
Pietruszewska, Wioletta
Zielnik-Jurkiewicz, Beata
Woroń, Jarosław
Lipiec, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1398252.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
air pollution
treatment
uncontrolled allergic rhinitis
antihistamines
dose escalation
fexofenadine
Opis:
Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater the risk of developing bronchial asthma. One of the factors affecting the severity of symptoms and the degree of their control is air pollution. In some patients, despite proper treatment, persistence or only partial remission of symptoms (uncontrolled allergic rhinitis) is observed. This can lead to an increase in comorbidities - inflammation of the paranasal sinuses, otitis media and asthma - both in children and in adults. The treatment of allergic rhinitis, in accordance with the standards, consists in: education of the patient, elimination of the allergen from the environment and factors intensifying the course of the disease, selection of proper pharmacotherapy and specific allergen immunotherapy. Many factors influence the selection of the antihistamine used, e.g., the opportunity of safe increase of the dosage.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 2; 1-12
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A new therapeutic option in the management of allergic rhinitis
Autorzy:
Lipiec, Agnieszka
Jurkiewicz, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/23203220.pdf
Data publikacji:
2021-10-29
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
mometasone
olopatadine
treatment
Opis:
Allergic rhinitis (AR) affects both the quality of life and daily functioning of a patient. Carefully selected personalized therapy determines good management of disease symptoms. In the latest update of the ARIA (Allergic Rhinitis and its Impact on Asthma) guidelines, the algorithm for therapeutic management is based on the assessment of a patient’s condition with the use of a Visual Analogue Scale (VAS), therefore adopting an approach which involves either escalation (step up) or reduction (step down) of treatment. First-line drugs include: second-generation antihistamines, intranasal corticosteroids (INCS) and a combination of INCS with azelastine. Since the combination of INCS with intranasal H1 antihistamine drugs allows patients to benefit from therapeutic advantages of both drug categories, it is considered to be a universal treatment strategy. The combination of mometasone furoate with olopatadine hydrochloride is the latest therapeutic option in this drug category. These drugs prove highly effective and demonstrate a favorable safety profile.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 5; 44-51
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of allergic rhinitis in children and adolescents with recurrent headache
Autorzy:
Passali, Francesco Maria
Spinosi, Maria Carla
Mignacco, Giulia
Cingi, Cemal
Rodriguez, Hugo Anibal
Passali, Desiderio
Powiązania:
https://bibliotekanauki.pl/articles/1398248.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
migraine
allergic rhinitis
cephalgy
allergy
headache
Opis:
Introduction: Migraine and allergies are common occurrences. The aim of this study was to investigate the relationship between respiratory allergy and cephalalgic migraine in childhood. Materials and Methods: We screened 800 children for headache and its characteristics. After that we investigated the presence of allergy performing prick tests, rhinoscopy, endoscopy, rhinomanometry, nasal cytology and mucociliary clearance tests. Results: Out of 800 children screened, 96 suffered from headache. Among these, 67 resulted to suffered from both headache and allergy. We found a significant correlation between allergy and headache onset in the morning and headache onset in the evening in non-allergic subjects. The average duration of the a headache attack was independent from the presence of allergy, as well as the frequency of the cephalalgy attacks, and the localization of the pain. Prodromal symptoms connected with headache were reported to be: dizziness, aurea, sparkling scotoma, nausea and vomiting, and they were associated with absence of allergy. We also found a relationship between female gender and headache onset, but in teen-agers only. Paracetamol or FANS were used in the majority of cases, but antihistaminic therapy and/or nasal topical sprays were also reported. Discussion: For an effective diagnostic and therapeutic approach to migraine, the pediatrician should take into account atopy and its related allergic manifestations requiring a consultation with an otolaryngologist or allergist, if necessary. Our findings also stress the potential role of medicines that are not usually utilized for migraine attacks, such as antihistamines or decongestionant nasal sprays.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 2; 50-59
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The dynamics of pollen seasons of the most allergenic plants - 15-year observations in Warsaw
Autorzy:
Lipiec, Agnieszka
Rapiejko, Piotr
Furmańczyk, Konrad
Jurkiewicz, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1398282.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
pollen monitoring
pollen count
Opis:
Introduction: Allergic rhinitis concerns nearly 25% of the Polish population. Among pollen allergens, the most common reasons for allergic rhinitis are: grass, birch and mugwort. Knowledge of the characteristics of pollen seasons is necessary in diagnostics, monitoring of therapy and prevention of allergic rhinitis. Purpose: This work aims to analyze pollen seasons of the most allergenic plants in the Polish population; grass, birch and mugwort in the years 2003–2017 in Warsaw. Material and methods: Measurements of pollen concentration were carried out using Burkard volumetric spore trap operating in continuous mode. Analysis of pollen seasons was conducted based on the following characteristics: beginning, end, and length of season, the seasonal pollen index (SPI), defined as the sum of average daily pollen concentrations over the year, maximum daily concentration, number of days with maximum and threshold concentration. Linear regression together with the Pearson correlation coefficient were used in statistical analysis to study the relationship between variables; furthermore, descriptive characteristics of distributions studied were determined. Results: The average beginning of the birch pollen season in the analyzed period is April 10th, and it belongs to seasons of medium length (47 days on average). Birch pollen count above 75 grains/m3, when most allergic people develop symptoms, was recorded for an average of 18 days. The highest daily birch pollen count reaching 6321 grains/m3 (2012) exceeded the lowest value of the maximum concentration by almost 20 times (2015). Among the taxa analyzed, the highest values of daily counts and annual sums were recorded for birch pollen. The average date for the beginning of grass pollination season is on May 13th. It is the longest pollen season (on average 134 days), and the period when concentration exceeded 50 grains/m3 covered an average of 26 days. The highest daily grass pollen counts reaching
496 grains/m3 (2007) exceeded the lowest value of maximum concentration by 3.5 times (2016). The average date of the beginning of mugwort pollen season is July 16th. The season lasts 65 days on average, when concentration exceeding 30 grains /m3 was registered for an average of 12 days. The highest daily mugwort pollen count reaching 154 grains/m3 (2007) exceeded the lowest value of maximum concentration by 4 times (2013). For all analyzed taxa, the strongest correlated variables are the sum of average daily pollen concentrations over the year (SPI ) and daily maximum concentration (correlation for birch pollen = 0.92, for grass pollen = 0.88, and for mugwort pollen = 0.91). Conclusions: Periods of pollen in the air show certain variation in the analyzed 15-year period. The maximum concentration in the pollen season for the analyzed taxa and the the sum of average daily pollen concentrations over the year show the highest variability, particularly strongly expressed in the case of birch pollen. There is a linear relationship between the sum of average daily pollen concentrations over the year and the maximum concentration value as well as the number of days with the threshold concentration for all analyzed taxa. Variability of parameters describing the dynamics of pollen seasons indicates the need to monitor, both by patients with hay fever and physicians, the current information on the concentration of pollen in the air during the pollen season.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 6; 44-53
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of treatment under subterraneotherapy conditions at the “Wieliczka” Salt Mine Health Resort on the symptoms of diseases of the nose and paranasal sinuses
Autorzy:
Woźniak, Aleksandra
Nowak, Karol
Pełkowska, Anna
Rys, Katarzyna
Gawlik, Jolanta
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1398963.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
chronic non-allergic rhinitis
respiratory rehabilitation
subterraneotherapy
Opis:
Introduction: Chronic rhinosinusitis is an important disease of the upper respiratory system which substantially reduces patient quality of life and the methods of symptomatic treatment are tremendously limited. Aim: The aim of this study was to evaluate the next therapeutic option which is a combination of respiratory rehabilitation and subterraneotherapy. Material and methods: The study covered 57 patients of whom 15 were men and 42 women. The average age of patients was 60 +/- 10.87 (standard deviation). 44 patients finished 15 days of therapy which covers full-time treatment. The average age of these patients was 59.7 +/- 11.6 (standard deviation). Results: In the study group, there was a statistically significant reduction among all analyzed symptoms of chronic rhinosinusitis. The general severity of symptoms decreased from 5.66 cm to 2.57 cm (p < 0.001), blockade/congestion of the nose from 5.49 to 2.23 cm (p < 0.001), anterior nasal discharge from 5.33 cm to 2.5 cm (p < 0.001), posterior nasal discharge from 6.04 cm to 2.71 cm (p < 0.001), facial pain/pressure from 3.43 cm to 1.45 cm (p < 0.001), headache from 3.73 cm to 1.19 cm (p < 0.001) and reduction or loss of smell from 4.17 cm to 1.94 cm (p < 0.001). Conclusions: Such a notable improvement in all analyzed symptoms led us to conclude that respiratory rehabilitation, especially such conducted in adequate climatic conditions, should be a valuable therapeutic option in the symptomatic treatment of patients with chronic rhinosinusitis.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2021, 10, 1; 22-27
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of chlorinated water on the development of allergic diseases - an overview
Autorzy:
Kanikowska, A.
Napiórkowska-Baran, K.
Graczyk, M.
Kucharski, M.A.
Powiązania:
https://bibliotekanauki.pl/articles/2081977.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
asthma
allergic rhinitis
allergic diseases
swimming pool
chlorinated water
Opis:
Indoor swimming pools can be used all year round and serve for one of the most popular sport pursued for recreation The positive effect of swimming arises in particular from the involvement of all the muscles of the body, decreasing the burden on the joints, as well as functional improvement of both the lungs and heart. Chlorine is typically used to disinfect swimming pool water and as a result the changes that take place lead to the formation of by-products, such as monochloramines (NH2Cl), dichloramines (NH2Cl2) i trichloramines (NH2Cl3), trihalogenometans (THM) or haloacetic acid (HAA). The highest concentration of these substances is just above the water surface and they may cause irritation of skin, eyes and mucosa of the respiratory tract. The toxic effect of high chlorine concentration and its side-products on the respiratory system is known, but the effect of low concentrations of these compounds is still not fully determined. Recent studies suggest that development of allergic diseases among swimmers may be increased by epithelial disorders driven by airway barrier dysfunction caused by chlorine irritation. Swimming in chlorinated water may be linked to symptoms of bronchial hyperreactivity, asthma and rhinitis especially in children, elite swimmers and employees of indoor swimming pools. Hypersensivity pneumonitis related to the use of swimming pools may manifest as a swimming pool or sauna user lung, most commonly caused by water polluting pathogens. The article summarizes recent data concerning the influence of chlorinated water on the development of allergic diseases.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 4; 651-655
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radon-enriched hot spring water therapy for upper and lower respiratory tract inflammation
Autorzy:
Passali, Desiderio
Gabelli, Giacomo
Passali, Giulio Cesare
Mösges, Ralph
Bellussi, Luisa Maria
Powiązania:
https://bibliotekanauki.pl/articles/1398521.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
Balneology
Allergic Rhinitis
Chronic Rhino sinusitis
Asthma
Radon
Opis:
Background Radon-222-enriched hot spring therapy, which is characterized by a safe level of radioactivity, is used for the treatment of rheumatic disorders, and its efficacy has already been studied in several clinical trials. Radon-water inhalation therapy for the treatment of upper and lower airway inflammatory diseases is used in many hot springs centers. However, its application has not been reviewed to date. Methods We systematically searched the PubMed and Scopus databases for clinical trials published in the last 20 years in which objective parameters of upper and lower airway function had been tested before and after radon-enriched inhalation treatment. Results Four prospective studies were found: 1 asthma trial, 1 placebo-controlled chronic rhinosinusitis trial, 1 upper respiratory tract inflammation with nasal obstruction trial, and 1 case-control allergic rhinitis trial. Patients were treated with nasal inhalations of radon-enriched water for 12 to 28 days and were assessed at baseline and after therapy. After 2 weeks of treatment, nasal resistance decreased, flow increased, mucociliary clearance was enhanced, ciliated-to-muciparous cell ratio increased, and %FEV1 increased in asthmatic patients. Conclusion Radon-enriched inhalation therapy improves objective indicators of nasal function in allergic rhinitis and chronic rhinosinusitis, and causes relief of pulmonary obstruction in asthma.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 4; 8-13
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dust exposure and health of workers in duck hatcheries
Autorzy:
Guillam, Marie-Thérèse
Martin, Sylvie
Le Guelennec, Marine
Puterflam, Julie
Le Bouquin, Sophie
Huneau-Salaün, Adeline
Powiązania:
https://bibliotekanauki.pl/articles/989539.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
occupational exposure
hatchery
organic dust
asthma
allergic rhinitis
Opis:
Objectives. The objectives of this cross-sectional study were to investigate dust exposure and respiratory health of workers in duck hatcheries in western France. Method. Ninety volunteer workers, who work in sorting rooms and/or incubation rooms, participated in exposure assessments and medical examinations. Medical examinations were performed by occupational health practitioners. They filled-in a questionnaire with the workers, followed by a lung function test on each worker. General characteristics and prevalence of chronic respiratory symptoms were described in each type of working rooms. Associations between symptoms and exposure (working room or dust level) were studied in GEE multivariate models. Results. Overall prevalence of chronic respiratory symptoms (cough, phlegm) and chronic bronchitis were similar or lower than in the reference population. However, prevalence of these symptoms was higher for those working in sorting rooms, that were associated with an increased risk of respiratory symptoms and decreased lung function. Respirable dust was also significantly associated with an increased risk of respiratory symptoms. The prevalence of asthma and rhinitis were well above those in the reference population, but did not vary among working rooms. Descriptive data suggested an occupational origin for some cases. Conclusion. Hatchery workers were at increased risk of compromised respiratory health due to dust exposure, particularly those who work in sorting rooms. Asthma and rhinitis were in excess in this population of workers. Thorough clinical examination of these workers should be performed and all exposures assessed.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure to pollen allergens in allergic rhinitis expressed by diurnal variation of airborne tree pollen in urban and rural area
Autorzy:
Lipiec, Agnieszka
Puc, Małgorzata
Kruczek, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/23203214.pdf
Data publikacji:
2019-04-05
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
diurnal pollen counts
rural
tree pollen
urban
Opis:
Exposure to airborne pollen allergens results in allergic symptoms in subjects who are sensitized. The paper presents diurnal variation in the counts of airborne allergenic pollen of selected trees (Betula L., Alnus Mill., Corylus L., Fagus L. and Ulmus L.) in two localities differing in the degree of urbanization: the city of Szczecin (urban) and the village of Gudowo, West Pomerania in northwest Poland (rural) in the years 2012–2014. The measurements were made by the volumetric method using a Burkardtype sampler operating in a continuous mode. The greatest similarities in the beginning of the main pollen season between the two sites studied were observed for birch and elm trees, while in the length of the main pollen season, for birch and alder trees. Pollen counts of alder and hazel reached higher levels in the rural area, while the levels of ash tree pollen counts were higher in the urban area. The level of birch tree pollen counts was similar in the two sites studied. For the majority of taxons observed in the urban and rural areas the dynamics of hourly changes in tree pollen counts were similar. The pollination peak was noted in the daytime, usually in the afternoon. For ash and elm trees increased pollen counts were observed at nighttime, while the birch tree pollen counts were at a high level for most of the 24 h cycle. The knowledge of seasonal and diurnal variations in tree pollen counts is crucial for prevention in patients with allergic rhinitis, sensitized to tree pollen allergens.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 5; 24-30
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The indirect costs of allergic diseases
Autorzy:
Stróżek, Joanna
Samoliński, Bolesław
Kłak, Anna
Gawińska-Drużba, Emilia
Izdebski, Radosław
Krzych-Fałta, Edyta
Raciborski, Filip
Powiązania:
https://bibliotekanauki.pl/articles/2161972.pdf
Data publikacji:
2019-06-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Atopic Dermatitis
asthma
allergy
allergic rhinitis
indirect costs
Europe
Opis:
It is estimated that every third person living in Europe suffers from allergic diseases. Allergies are a growing health problem in Poland where 40% of the population have allergy symptoms, including 12% afflicted with asthma. The actual cost of allergic diseases is difficult to estimate due to the lack or incompleteness of the relevant data. The aim of this review is to present estimates of the indirect costs of allergic diseases in Poland and globally, using asthma, allergic rhinitis and atopic dermatitis as examples. The analysis also includes the impact of allergic diseases on the costs to the social welfare system and employers. The literature review of the indirect costs of allergic diseases shows that the indirect costs of a disease, which substantially exceed the direct costs, increase with the disease activity and severity. Interestingly, some studies have found that the indirect costs of lost productivity due to hours missed from work to take care of a sick child could be threefold higher than those of absence due to a worker’s own illness. The indirect costs of a disease can be significantly reduced by early diagnosis and appropriate treatment. Int J Occup Med Environ Health. 2019;32(3):281–90
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 3; 281-290
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of residential proximity to traffic on respiratory disorders in school children in upper Silesian Industrial Zone, Poland
Autorzy:
Skrzypek, Michał
Zejda, Jan E.
Kowalska, Małgorzata
Czech, Elżbieta M.
Powiązania:
https://bibliotekanauki.pl/articles/2179793.pdf
Data publikacji:
2013-03-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
air pollution
road traffic
children
respiratory health
asthma
allergic rhinitis
Opis:
Objective: A number of studies show an association between traffi c-related air pollution and adverse respiratory health effects in children. However, most evidence relates to the regions with low or moderate levels of ambient air pollution. The study was undertaken to assess the impact of traffi c-related air pollution on respiratory health status in children living in the area of high levels of industrial and municipal ambient air pollution. Materials and Methods: Analyses involved data obtained from cross-sectional study on respiratory health in children (N = 5733), conducted between 2003–2004 in Bytom, one of the largest cities of Silesian Metropolis (Poland). Exposure to traffic-related air pollution was assessed by means of geographic information system and expressed as several measures of potential exposure to traffic-related air pollution, involving residential distance to major road and traffic density in the residential area. Logistic regression was used to examin association between reported respiratory health and traffic measures. Results: Statistically signifi cant association was found between doctor-diagnosed asthma and residential proximity to traffic. Results of multivariate logistic regression (logOR; 95%CI) confi rmed the effect of living in an area of a city with high-traffic-density on childhood asthma: 1.60 (1.07–2.39). Similar effects were found in case of allergic rhinitis and rhinitis symptoms, but the observed associations were not statistically signifi cant. Conclusion: The study fi ndings suggest that even in an area with poor regional ambient air quality, adverse respiratory health outcomes are more frequent in children living in a proximity to the high vehicle traffic flow
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 83-91
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of 11 beta hydroxysteroid dehydrogenase in severe allergic rhinitis
Autorzy:
Ohta, Nobuo
Noguchi, Naoya
Takahashi, Tomoko
Suzuki, Tatsutoshi
Kakuta, Risako
Suzuki, Yusuke
Awataguchi, Toshiichi
Suzuki, Takahiro
Takahashi, Yukiko
Shoji, Fumi
Wada, Kota
Kawano, Tasuku
Ono, Isao
Kusano, Yusuke
Miyasaka, Tomomitsu
Osafune, Hiroshi
Matsutani, Sachiko
Yaginuma, Yuji
Ishida, Yusuke
Saito, Yutaro
Yamazaki, Muneharu
Ikeda, Ryoukichi
Powiązania:
https://bibliotekanauki.pl/articles/1397797.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
11 beta-hydroxysetroid dehydrogenase
glucocorticoid resistance
glucocorticoid therapy
glucocorticoid response
Opis:
Objective: To clarify the roles of 11 beta-HSD in resistance to glucocorticoid therapy for allergic rhinitis, a case series study was conducted. Methods: The patient group consisted of 20 subjects with allergic rhinitis, aged from 21 to 46 years (mean age 26.5), who showed persistent GC resistance necessitating surgical removal of the inferior turbinate after 6 months’ GC treatment. The patients with poor response to GC treatment for 6 months’ were defined as GC resistance. The control group consisted of 10 subjects aged from 16 to 39 years (mean age 24.5) who underwent maxillofacial surgery, from whom nasal tissues were taken and who did not receive GC treatment. Nasal mucosal tissues from patients and cntorol subjects were examined immunohistochemically. The sections were washed with 0.01 M phosphate-buffered saline (PBS; pH 7.2) containing 0.15 M NaCl and 0.01% Triton X-100, and incubated for 2 h with rabbit polyclonal anti-11 beta HSD1 and 11 beta-HSD2 antibody (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA), each diluted 1:200 in PBS containing 0.1% bovine serum albumin. Immunostained sections were assessed under an Olympus microscope with an eyepiece reticule at 200 X magnification. Cell counts are expressed as means per high-power field (0.202 mm2). Control group means (arithmetic mean ± SD) were compared with patient group means by Mann–Whitney U-test at P = 0.05. Results: Although 11 beta-HSD1 was expressed to a similar extent in patients and controls, 11 beta-HSD2 was expressed significantly more in patients with severe allergic rhinitis, resulting in a increased HSD-1/HSD-2 ratio. The significantly increased expression of 11 beta-HSD2 in the nasal epithelium and submucosal inflammatory cells of patients with severe nasal allergy were observed in the present study. Conclusion: Our findings suggest that 11 beta-HSD2 plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.
Źródło:
Polish Journal of Otolaryngology; 2019, 73, 2; 18-22
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Local allergic rhinitis: nasal allergen provocation testing as a good tool in the differential diagnosis
Autorzy:
Wojas, Oksana
Samoliński, Bolesław
Krzych-Fałta, Edyta
Powiązania:
https://bibliotekanauki.pl/articles/2116657.pdf
Data publikacji:
2020-03-13
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
dermatophagoides farinae
nasal mucosa
nasal provocation test
dermatophagoides pteronyssinus
entopy
local allergic rhinitis
Opis:
Local allergic rhinitis (LAR) is a specific phenotype of allergic rhinitis. One characteristic feature of LAR is a medical history indicative of an allergic disease, negative skin-prick test results, undetectable levels of specific IgE, and a positive allergen-specific nasal provocation test. This paper presents a case of a patient with LAR and underlying house dust mite allergy, who was ultimately diagnosed >10 years after the onset of his first symptoms. Currently, there are only pharmacological treatments available for LAR. However, some studies show encouraging results with the use of allergen-specific immunotherapy in LAR, which offer hope for a future use of this causative treatment in LAR patients.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 2; 241-246
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rhinitis in children
Nieżyt nosa u dzieci
Autorzy:
Ziuzia, Laura
Dobrzyński, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1399351.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
allergic rhinitis
classification
diagnosis
nonallergic rhinitis
rhinitis
treatment
alergiczny nieżyt nosa
diagnostyka
klasyfikacja
leczenie
niealergiczny nieżyt nosa
nieżyt nosa
Opis:
Rhinitis (RN) is inflammation of the nasal mucous membrane, manifested by impaired patency, pruritus, sneezing and the presence of secretions. Depending on the mechanism of creation of an inflammatory reaction, RN is divided into: (1) allergic rhinitis (AR) and (2) nonallergic rhinitis (NAR), and in case of their overlap, it is said to be (3) mixed (MR). The basis for the diagnosis of NN are: physical examination and interview (including ENT) and properly selected auxiliary research. The fundamental approach in RN in children is: education of patients and their parents, avoiding exposure to irritants (including allergens), nasal irrigation, air humidification and proper hydration of the child, and pharmacotherapy, and in selected cases of ARN, also allergen specific immunotherapy. The basis of pharmacotherapy in RN are intranasal glucocorticoids (dnGKS) and second-generation antihistamines, although their efficacy in NAR is lower than in AR. Due to the high incidence and adverse consequences, such as: decreased quality of life, sleep and mood disorders, deterioration in school education and relationship with other diseases, including: asthma, adenoid hypertrophy, conjunctivitis, chronic inflammation of paranasal sinuses and otitis media, RN is an important clinical problem. It is necessary to further investigate the issue to better understand this problem and to avoid its negative consequences, especially in the paediatric population.
Nieżyt nosa (NN) to stan zapalny błony śluzowej nosa, objawiający się upośledzeniem jego drożności, świądem, kichaniem i obecnością w nim wydzieliny. W zależności od mechanizmu powstawania reakcji zapalnej NN dzieli się na: (1) alergiczny nieżyt nosa (ANN) i (2) niealergiczny nieżyt nosa (NANN), a w przypadku ich nakładania się mówi się o (3) NN mieszanym. Podstawą rozpoznania NN są: badanie podmiotowe i fizykalne (w tym laryngologiczne) oraz właściwie dobrane badania pomocnicze. Zasadniczym postępowaniem w NN u dzieci jest: edukacja chorych i ich rodziców, unikanie ekspozycji na czynniki drażniące (w tym alergeny), płukanie jam nosa, nawilżanie powietrza i właściwe pojenie dziecka oraz farmakoterapia, a w wybranych przypadkach ANN, również swoista immunoterapia alergenowa. Podstawą farmakoterapii w NN są glikokortykosteroidy donosowe (dnGKS) i leki antyhistaminowe drugiej generacji, choć ich skuteczność w NANN jest mniejsza niż w ANN. Z uwagi na dużą częstość występowania oraz niekorzystne następstwa, takie jak: obniżenie jakości życia, zaburzenia snu i nastroju, pogorszenie wyników w nauce i związek z innymi chorobami, w tym: astmą, przerostem migdałka gardłowego, zapaleniem spojówek, przewlekłym zapaleniem zatok przynosowych i zapaleniem ucha środkowego, NN stanowi istotny problem kliniczny. Konieczne jest prowadzenie dalszych badań, celem większego zrozumienia tego problemu oraz uniknięcia wystąpienia jego negatywnych następstw, zwłaszcza w populacji dziecięcej.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 72-84
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
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