Temat: 2-quinoline - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Synthesis and anticancer activity evaluation of some new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline.
Autorzy:: Kubica, Krzysztof P.
Taciak, Przemyslaw P.
Czajkowska, Agnieszka
Sztokfisz-Ignasiak, Alicja
Wyrebiak, Rafal
Podsadni, Piotr
Mlynarczuk-Bialy, Izabela
Malejczyk, Jacek
Mazurek, Aleksander P.
Powiązania:: https://bibliotekanauki.pl/articles/895388.pdf
Data publikacji:: 2018-08-31
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: anticancer activity
cytotoxicity assay
2-quinoline
cell migration assay
Opis:: In this study we designed and synthesized twenty new derivatives of 2-(4-benzoyl-1-piperazinyl)-quinoline and 2-(4-cinnamoyl-1-piperazinyl)-quinoline with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR spectroscopy and MS spectrometry. The activity of novel compounds was evaluated in the cell viability assay as well as in the wound healing assay. Presented data show that examined substances have anticancer activity in cell culture. Seven compounds which showed a high rate of cell growth inhibition were selected for further studies. Three of them strongly reduced growth of B16F10 cells. The novel compounds constitute a good base for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 891-901
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Synthesis, Characterization and Biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position
Autorzy:: Vaghasiya, R. G.
Ghodasara, H. B.
Vachharajani, P. R.
Shah, V. H.
Powiązania:: https://bibliotekanauki.pl/articles/412211.pdf
Data publikacji:: 2014
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Quinoline, 4-amino-1,2,4-triazole-3-thiol
therapeutic agents
antimicrobial assai
Opis:: Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give final compounds. All of these compounds were screened for their in vitro antimicrobial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
Źródło:: International Letters of Chemistry, Physics and Astronomy; 2014, 8; 30-37
2299-3843
Pojawia się w:: International Letters of Chemistry, Physics and Astronomy
Dostawca treści:: Biblioteka Nauki

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