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    Wyświetlanie 1-7 z 7
    Tytuł:
    A concept and general characteristics of the library of statistical subroutines A-STAT
    Autorzy:
    Bartkowiak, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/747363.pdf
    Data publikacji:
    1983
    Wydawca:
    Polskie Towarzystwo Matematyczne
    Tematy:
    library of statistical subroutines
    A-STAT
    Opis:
    Artykuł nie zawiera streszczenia
    The article contains no abstract
    Źródło:
    Mathematica Applicanda; 1983, 11, 22
    1730-2668
    2299-4009
    Pojawia się w:
    Mathematica Applicanda
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Price volatility spillovers among major wheat markets in the world
    Autorzy:
    Sadiq, Mohammed Sanusi
    Powiązania:
    https://bibliotekanauki.pl/articles/2141407.pdf
    Data publikacji:
    2022-10-10
    Wydawca:
    Uniwersytet Przyrodniczy w Poznaniu. Wydawnictwo Uczelniane
    Tematy:
    resource use
    efficiency
    okra
    production
    Osun Stat
    Opis:
    Okra (Abelmoschus esculentus L. Moench) yield is characterized by low productivity but may be increased through the adoption of new technology or the efficient allocation of existing resources. In addition, improving the level of resource allocation is important for improving productivity. This study investigated resource use efficiency in small-scale okra production. A multi-stage sampling procedure was used to select 100 respondents. The primary data generated through the survey of 100 okra farmers were analyzed using descriptive statistics, the ordinary least squares regression model, and marginal value analysis. The average age of the respondents was 45 years, with 7 members in the household, and 2.8ha being farmed. The ordinary least squares regression estimate indicated age, labor, farm size, and herbicide and insecticide use that influenced okra production. Returns to scale was 2.09; resource use efficiency indicated the following values: farm size 0.343, herbicide application 0.857, insecticide application 0.75, and labor 4.80. The high cost of inputs (1.93), low numbers of extension contact with farmers (1.82), high incidence of pests and disease (1.49), non-access to credit (1.39), difficulty in obtaining labor (1.23), drought (1.15), and marketing problems (1.09) are constraints negatively affecting okra production. Although the positive and statistically significant effect of pesticides, farm size, and labor indicate these inputs can effectively improve okra production, small-scale okra production is inefficient because farmers use too many pesticides and farmland and less labor than is needed. The marginal product of inputs is not enough to offset the corresponding marginal cost. Therefore, small-scale farmers should operate on smaller farms than they currently do, apply pesticides at recommended rates, and spend more on labor. So, training should be organized through extension workers and agricultural research stations to improve scientific knowledge of farmers for efficient use of productive resources.
    Źródło:
    Journal of Agribusiness and Rural Development; 2022, 65, 3; 251-262
    1899-5241
    Pojawia się w:
    Journal of Agribusiness and Rural Development
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Head of State’s Constitutional Liability
    Autorzy:
    Grabowska, Sabina
    Powiązania:
    https://bibliotekanauki.pl/articles/594608.pdf
    Data publikacji:
    2017
    Wydawca:
    Wydawnictwo Adam Marszałek
    Tematy:
    head of stat
    constitutional liability
    parliament
    constitutional court
    referendum
    Opis:
    The paper aims to introduce the concept of constitutional liability of the President, and the institutions of the President’s constitutional liability. The author presents the liability and its relations with other types of head of state’s liabilities. The presented analysis includes all European countries.
    Źródło:
    Polish Political Science Yearbook; 2017, 1 (46); 153-167
    0208-7375
    Pojawia się w:
    Polish Political Science Yearbook
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    STAT activation and differential complex formation dictate selectivity of interferon responses
    Autorzy:
    Wesoly, Joanna
    Szweykowska-Kulinska, Zofia
    Bluyssen, Hans
    Powiązania:
    https://bibliotekanauki.pl/articles/1041103.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    transcription factor complexes
    gene regulation
    IRFs
    JAK/STAT pathway
    IFNs
    Opis:
    Interferons (IFNs) induce gene expression by phosphorylating latent transcription factors belonging to the signal transducer and activator of transcription (STAT) family, mediated by janus kinases (Jaks). STAT dimers directly activate genes containing the IFNγ activation site (GAS) DNA element, with different STAT proteins displaying slightly different intrinsic DNA binding specificities. The combinatorial association of STATs with the additional DNA binding adaptor protein interferon regulatory factor (IRF)9 expands the range of enhancer elements that can be targeted by the JAK-STAT pathway to interferon-stimulated response element (ISRE) and IRF response element (IRE). Based on the amino-acid sequence similarity within the IRF family and functional overlap with the STAT family, in this paper we hypothesize that other IRF members could serve as adapter proteins for the STATs during IFN responses to redirect them to subsets of ISRE, GAS and/or IRE-containing IFN-stimulated genes (ISGs). In addition, the fact that STAT2 homodimers are not capable of binding consensus GAS sites leaves the possibility for a novel type of DNA-binding site bound by STAT2 homodimers and potentially other STAT complexes.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 27-38
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation.
    Autorzy:
    May, Petra
    Schniertshauer, Ute
    Gerhartz, Claudia
    Horn, Friedemann
    Heinrich, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/1043431.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immediate early genes
    STAT transcription factors
    acute phase proteins
    gp130
    Opis:
    Interleukin-6 is a potent inducer of acute-phase response gene transcription. The intracellular signal transduction mechanisms by which this and other biological effects of the cytokine are achieved include activation of the JAK-STAT signaling pathway. More specifically, activation of the signal transducers and activators of transcription STAT1, 3, and 5 in response to IL-6 has been described. We examined the relative potency of these three STAT factors for the activation of acute-phase gene promoters in HepG2 cells in a reporter gene-based assay, where specific STAT factors could be activated via recombinant receptor constructs bearing different STAT-recruiting modules. These experiments indicate that amongst the STAT factors known to be activated by IL-6 STAT3 is the most potent activator of acute-phase gene transcription.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 595-601
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nuclear localization and binding affinity of STAT5b for the α2-macroglobulin gene promoter during rat liver development and the acute-phase response
    Autorzy:
    Mihailović, Mirjana
    Dinić, Svetlana
    Bogojević, Desanka
    Ivanović-Matić, Svetlana
    Uskoković, Aleksandra
    Arambašić, Jelena
    Grigorov, Ilijana
    Grdović, Nevena
    Vidaković, Melita
    Martinović, Vesna
    Petrović, Miodrag
    Poznanović, Goran
    Powiązania:
    https://bibliotekanauki.pl/articles/1041082.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    rat liver development
    phosphorylation
    nuclear extract
    nuclear matrix
    STAT5b
    α2-macroglobulin
    Opis:
    Expression of the rat α2-macroglobulin (MG) gene undergoes dynamic changes throughout an individual's life and during the acute-phase (AP) response. Details of the participation of the STAT family of transcription factors in its control remain incompletely understood. Here we examined the involvement of STAT5b in MG gene expression during development and the AP response. Immuno-blot analysis revealed the highest nuclear level of STAT5b in the fetus and during postnatal development, whereas in the adult it decreased. Stimulation of MG expression during the AP response was accompanied by a decrease in STAT5b. Examination of STAT5b localization revealed that the relative concentrations of STAT5b were higher in the nuclear matrix than in the nuclear extract. Affinity chromatography with the extended promoter region of the MG gene (-825/+12), followed by immuno-blot analysis, revealed dynamic changes in STAT5b binding. The highest concentration of the promoter-binding form of STAT5b was observed in the fetus. As postnatal development progressed, the level of promoter-bound STAT5b decreased and in the adult liver it was the lowest. Stimulation of MG gene expression during the AP response in both the fetus and adult was accompanied by significantly decreased STAT5b binding to the MG promoter. The AP response was accompanied by lower levels of STAT5b serine and tyrosine phosphorylation in both fetus and adult. In the nuclear matrix derived from adult tissues, tyrosine phosphorylated species were completely absent. We conclude that developmental-stage differences in the mechanisms that determine STAT5b nuclear localization contribute to its activity in vivo.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 331-340
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MGF360-12L of ASFV-SY18 is an immune-evasion protein that inhibits host type I IFN, NF-κB, and JAK/STAT pathways
    Autorzy:
    Chen, Q.
    Wang, X.X.
    Jiang, S.W.
    Gao, X.T.
    Huang, S.Y.
    Liang, Y.
    Jia, H.
    Zhu, H.F.
    Powiązania:
    https://bibliotekanauki.pl/articles/16647496.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    African swine fever virus
    MGF360-12L
    type I IFN
    NF-κB
    JAK/STAT
    Opis:
    African swine fever virus (ASFV) causes feverous and hemorrhagic disease of domestic pigs and European wild boars with high mortality, yet no commercial vaccine is currently available. Several ASFV strains with natural deletion or gene-targeted knockout of multiple MGF360 and MGF505 genes are attenuated in vitro and in vivo, and can offer full protection against homologous challenge. However, the mechanisms underlying the protection are not fully understood. This study aims to investigate the effects of MGF360-12L of ASFV-SY18 on the cGAS-STING signaling pathway and explore the potential mechanisms. We identified that ASFV-SY18 MGF360-12L could inhibit cGAS-STING, TBK1, or IRF3-5D-stimulated IFN-β expression and ISRE activation. Specifically, MGF360-12L inhibits both the activation of PRD(III-I) in a dose-dependent manner, and suppresses the exogenous expression of TBK1 and IRF3-5D. MGF360-12L could block NF-κB activation induced by overexpression of cGAS-STING, TBK1, IKKβ. Downstream of the IFN-β signaling, MGF360-12L blocks the ISRE promoter activation by reducing total protein level of IRF9. Moreover, MGF360-12L protein can inhibit IFN-β-mediated antiviral effects. In conclusion, our findings suggest that MGF360-12L is a multifunctional immune-evasion protein that inhibits both the expression and effect of IFN-β, which could partially explain the attenuation of relevant gene-deleted ASFV strains, and shed light on the development of efficient ASFV live attenuated vaccines in the future.
    Źródło:
    Polish Journal of Veterinary Sciences; 2023, 26, 1; 119-130
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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