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    Wyświetlanie 1-12 z 12
    Tytuł:
    Data retention as a counter-terrorism instrument. The analysis in the context of civil rights protection
    Autorzy:
    Trela-Zielińska, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/2031478.pdf
    Data publikacji:
    2017-12-31
    Wydawca:
    Wydawnictwo Adam Marszałek
    Tematy:
    telecommunications data retention
    terrorism
    civil rights
    privacy
    Opis:
    The article analyses the legitimacy of citizens telecommunications data retention usage in the fight against terrorism. Data retention, that is the preventive storage of information on the source, data, hour and duration of a connection, type of the connection, communication tool and location of a recipient, is a powerful source of knowledge about citizens and their use should be soundly justified. However, both the European Union and Polish practices show that behind this interference in privacy there is neither a guarantee that the data stored would be used exclusively to fight terrorism and severe crimes, nor a sufficient access control mechanism. The efficiency of data use in the fight against organized crimes, including terrorism, is also dubious. In her work the author analyses Polish studies concerning information disclosure issues, Internet publications of the European Union and American reports on retention programmes, as well as Polish and foreign positions of non-governmental organizations engaged in the civil rights protection in this respect.
    Źródło:
    Reality of Politics; 2017, 8; 141-153
    2082-3959
    Pojawia się w:
    Reality of Politics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sampling, metadata and DNA extraction - important steps in metagenomic studies
    Autorzy:
    Felczykowska, Agnieszka
    Krajewska, Anna
    Zielińska, Sylwia
    Łoś, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039153.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    sampling
    DNA extraction
    DNA purification
    soil
    water
    wastewater
    metadata
    Opis:
    Metagenomic studies have become increasingly popular. They allow for the estimation of biodiversity in complex populations. This diversity presents an enormous but largely unexpected genetic and biological pool and can be exploited for the recovery of novel genes, entire metabolic pathways and their products. Generally metagenomic study is a genomic analysis of organisms by direct extraction and cloning of DNA from their natural environment. The most common problems of modern metagenomics are as follows: majority of the microorganisms present in the environment cannot be cultivated by standard techniques, DNA extraction methods are not very effective, isolated DNA is contaminated with various compounds, a choice for a screening method is not obvious.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 151-160
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of acetylsalicylic acid on hematotoxicity of benzene
    Autorzy:
    Kowalówka-Zawieja, Joanna
    Zielińska-Psuja, Barbara
    Przystanowicz, Jędrzej
    Sommerfeld, Karina
    Powiązania:
    https://bibliotekanauki.pl/articles/2179057.pdf
    Data publikacji:
    2013-10-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    benzene
    acetylsalicylic acid
    interactions
    hematotoxicity
    blood
    bone marrow
    Opis:
    Objectives: The aim of the study was to evaluate the influence of acetylsalicylic acid (ASA) on benzene hematotoxicity in rats. Materials and Methods: The study was carried out on rats exposed for 2, 4 and 8 weeks to benzene vapour at a conentration of 1.5 or 4.5 mmol/m³ of air (5 days per week, 6 hours per day) alone or together with ASA at the doses of 5, 150 or 300 mg/kg body weight (per os). Results: Benzene at a concentration of 4.5 mmol/m³ caused a slight lymphopenia, granulocytosis and reticulocytosis in blood. In bone marrow traits of megaloblastic renewal, presence of undifferentiated cells and giant forms of granulocytes as well as an increase in myeloperoxidase and decrease in chloroacetate esterase activity and lipids content were noted. ASA (150 and 300 mg/kg b.w.) influenced some of hematological parameters, altered by benzene intoxication. ASA limited the solvent-induced alteration in blood reticulocyte count and in the case of bone marrow in the erythroblasts count. Traits of megaloblastic renewal in bone marrow were less pronounced. Besides, higher activity of myeloperoxidase and the decrease in the level of lipids in granulocytes were noted. Conclusion: Our results suggest that ASA limited the benzene-induced hematotoxicity.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2013, 26, 5; 802-812
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    HOW PURE IS PURE ALEXIA? A NEUROPSYCHOLOGICAL ANALYSIS OF A CASE SERIES OF PATIENTS WITH ALEXIA DUE TO LEFT HEMISPHERIC STROKES
    Autorzy:
    Leśniak, Marcin M
    Zielińska, Aleksandra J
    Czepiel, Wojciech
    Seniów, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/2137953.pdf
    Data publikacji:
    2020-11-19
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    stroke
    reading
    agnostic alexia
    cognitive disorder
    Opis:
    The aim of this study was to analyze a case series with acquired alexia after stroke within the posterior areas of the left hemisphere, in the context of the current criteria for pure alexia and their relevance to the set of symptoms observable in clinical practice. Seven patients with ischemic strokes and an initial diagnosis of pure alexia were enrolled for detailed analysis. The evaluation consisted of neuropsychological assessment in the form of standardized tests and non-standardized reading tasks, while oculomotor activity during reading was measured. Language functions, visual object and space perception, verbal and nonverbal memory, and visuospatial constructional ability were among the domains assessed. In five of the participants, pure alexia was recognized based on sig- nificant and specific discrepancies between test scores, indicating primary abnormalities in the visual processing of letter strings as a basic mechanism of the disorder. In most of the patients, coexisting cognitive deficits were revealed; however, these were dispropor- tionately milder and less functionally significant than reading disturbances. Pure alexia is a relatively rare disorder after a stroke, but it considerably affects the quality of everyday independent functioning. Its clinical characteristics in practice rarely meet all the criteria proposed in the subject literature. The differential diagnosis of this form of alexia and other reading disorders requires detailed clinical analysis.
    Źródło:
    Acta Neuropsychologica; 2020, 18(4); 493-506
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of single application of paracetamol and/or N-acetylcysteine on rats in subchronic exposition to trichloroethylene vapours. II. Effect on hepatic glutathione level
    Wpływ pojedynczej dawki paracetamolu i/lub N-acetylocysteiny na szczury przewlekle eksponowane na trichloroetylen. II. Wpływ na wątrobowy poziom glutationu
    Autorzy:
    Plewka, Danuta
    Plewka, Andrzej
    Kowalówka-Zawieja, Joanna
    Zielińska-Psuja, Barbara
    Przystanowicz, Jędrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1178789.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    N-acetylcysteine
    glutathione
    liver
    paracetamol
    trichloroethylene
    Opis:
    Background: Feature of modern existing hazards both environmental and occupational is cumulative exposure often leading to unexpected response of the organism resulting, among other things, in interactions with cytochrome P450 system involved in biotransformation of trichloroethylene and paracetamol. Hepatotoxity of paracetamol is closely connected with hepatic glutathione level. „In therapy of acute paracetamol poisoning application of N-acetylcysteine as a factor, which protects GSH level in cells, is recommended.” Materials and method: Tests were performed on rats which were treated with trichloroethylene, paracetamol and/or N-acetylcysteine. In rat liver total level of glutathione was determined i.e. reduced and oxidized form. Results: Paracetamol just after completion of the exposure affected the glutathione level. Trichloroethylene throughout the period of observation stimulated growth of glutathione level in liver. N-acetylcysteine didn’t have any influence on the level of investigated tripeptyde. Conclusions: N-acetylcysteine removes negative effect of paracetamol especially when it’s applied with 2-hour delay. After exposure for trichloethylene immediate application of N-acetylcysteine caused noticeable lowering of glutathione level. Cumulative exposure for three xenobiotics had positive influence for glutathione level in rat liver.
    Wstęp: Cechą współcześnie występujących zagrożeń, zarówno środowiskowych jak i zawodowych jest narażenie łączne, wielokrotnie prowadzące do nieprzewidzianej odpowiedzi biologicznej organizmu, wynikającej między innymi z oddziaływań na układ cytochromu P450 biorący udział w biotransformacji trichloroetylenu i paracetamolu. Hepatotoksyczność paracetamolu jest między innymi ściśle związana z wątrobowym poziomem glutationu. W terapii zatruć ostrych paracetamolem zalecane jest podawanie N-acetylocysteiny jako czynnika ochraniającego poziom GSH w komórkach. Materiał i metody: Badania wykonano na szczurach, które traktowano trichloroetylenem, paracetamolem i/lub N-acetylocysteiną. W wątrobie szczura oznaczano poziom całkowity glutationu, tj. formę zredukowaną i utlenioną. Wyniki: Paracetamol tuż po zakończeniu ekspozycji negatywnie wpływał na poziom glutationu. Trichloroetylen przez cały czas obserwacji stymulował wzrost poziomu glutationu w wątrobie. N-acetylocysteina nie miała żadnego wpływu na poziom badanego tripeptydu. Wnioski: N-acetylocysteina usuwała negatywny wpływ paracetamolu, szczególnie wtedy, kiedy podano ją z 2-godzinnym opóźnieniem. Po narażeniu na trichloroetylen natychmiastowe podanie N-acetylocysteiny niosło za sobą wyraźnie obniżenie poziomu glutationu. Narażenie łączne na trzy oceniane ksenobiotyki.
    Źródło:
    Medycyna Środowiskowa - Environmental Medicine; 2012, 15, 3; 91-95
    1505-7054
    2084-6312
    Pojawia się w:
    Medycyna Środowiskowa - Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of single application of paracetamol and/or N-acetylcysteine on rats subchronic exposed to trichloroethylene vapours. I. Effect on hepatic moonooxygenase system dependent of cytochrome P450
    Wpływ pojedynczej dawki paracetamolu i/lub N-acetylocysteiny na szczury przewlekle eksponowane na trichloroetylen. I. Wpływ na wątrobowy układ monooksygenaz zależnych od cytochromu P450
    Autorzy:
    Plewka, Andrzej
    Plewka, Danuta
    Przystanowicz, Jędrzej
    Kowalówka-Zawieja, Joanna
    Zielińska-Psuja, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1178949.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    N-acetylcysteine
    cytochrome P450
    liver
    paracetamol
    trichloroethylene
    Opis:
    Background: There is a number of factors which potentially affect occurrence of toxic change in liver after overdosing of paracetamol. Hepatic metabolism of trichloroethylene has primary impact on hepatotoxic effect of this solvent. This means that the combined exposure to these xenobiotics can be particularly harmful for human. The influence of N-acetylcysteine (NAC) as a protective factor after paracetamol intoxication was studies. Materials and method: Tests were carried out on rats which were treated with trichloroethylene, paracetamol and/or N-acetylcysteine. In the hepatic microsomal fraction activity of the components of cytochrome P450- dependent monooxygenases was determined Results: Paracetamol slightly stimulated cytochrome P450 having no effect on reductase activity cooperating with it. Cytochrome b5 and its reductase were inhibited by this compound. Trichloroethylene was the inhibitor of compounds of II microsomal electron transport chain. N-acetylcysteine inhibited activity of reductase of NADH-cytochrome b5. Conclusions: Tested doses of the xenobiotics influenced on II microsomal electron transport chain. Protective influence of N-acetylcysteine was better if this compound was applied 2 hours after exposure on xenobiotics.
    Wstęp: Istnieje szereg czynników, które potencjalnie wpływają na ryzyko wystąpienia zmian toksycznych w wątrobie po przedawkowaniu paracetamolu. Wątrobowy metabolizm trichloroetylenu ma pierwszorzędny wpływ na hepatotoksyczny efekt tego rozpuszczalnika. Oznacza to, że narażenie łączne na te ksenobiotyki może być szczególnie szkodliwe dla człowieka. Oceniono wpływ N-acetylocysteiny (NAC) jako czynnika osłaniającego po zatruciu paracetamolem. Materiał i metody: Badania wykonano na szczurach, które traktowano trichloroetylenem, paracetamolem i/lub N-acetylocysteiną. We frakcji mikrosomalnej wątroby oznaczano aktywność składników monooksygenaz zależnych od cytochromu P450. Wyniki: Paracetamol lekko stymulował cytochrom P450 nie mając wpływu na aktywność reduktazy współpracującej z nim. Cytochrom b5 i jego reduktaza były hamowane przez ten związek. Trichloroetylen był inhibitorem składników II mikrosomalnego łańcucha transportu elektronów. N-acetylocysteina hamowała aktywność reduktazy NADH-cytochrom b5. Wnioski: Badane dawki ocenianych ksenobiotyków swój wpływ ujawniały raczej na składniki II mikrosomalnego łańcucha transportu elektronów. Ochronny wpływ N-acetylocysteiny był wyraźniejszy, jeśli podano ten związek 2 godziny po zakończeniu ekspozycji na badane ksenobiotyki.
    Źródło:
    Medycyna Środowiskowa - Environmental Medicine; 2012, 15, 2; 64-71
    1505-7054
    2084-6312
    Pojawia się w:
    Medycyna Środowiskowa - Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of single application of paracetamol and/or N-acetylcysteine on rats in subchronic exposition to trichloroethylene vapours. III. Effect on some isoforms of cytochrome P450 in liver
    Wpływ pojedynczej dawki paracetamolu i/lub N-acetylocysteiny na szczury przewlekle eksponowane na trichloroetylen. III. Wpływ na wybrane izoformy cytochromu P450 w wątrobie
    Autorzy:
    Plewka, Andrzej
    Plewka, Danuta
    Kowalówka-Zawieja, Joanna
    Przystanowicz, Jędrzej
    Zielińska-Psuja, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1178723.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    N-acetylcysteine
    isoforms of cytochrome P450
    liver
    paracetamol
    trichloroethylene
    Opis:
    Background: In case of overdose of paracetamol the ability of hepatic biotransformation is saturated and accumulation of toxic metabolite – NAPQI takes place. Main CYP isoforms considered to be responsible for bioactivation of APAP and promoting the same liver intoxication are CYP2E1, CYP1A2, CYP3A4 and in animals 2B1/2 isoforms additionally. Purpose of this work was examination of paracetamol influence and/or trichloroethylene on the composition of hepatic cytochrome P450 isoforms. Materials and method: Tests were carried out on rats which were treated with trichloroethylene, paracetamol and/or N-acetylcysteine. In the microsomal fraction content of three isoforms of cytochrome P450 i.e. CYP2E1, CYP2B1/2 and CYP1A2 were determined. Results: Paracetamol slightly stimulated CYP2B1/2 lowering simultaneously level of CYP1A2. Trichloroethylene stimulated CYP2B1/2. N-acetylcysteine stimulated all tested P450 isoforms. N-acetylcysteine given together with examinated xenobiotics induced studied P450 isoforms. Conclusions: N-acetylcysteine demonstrated a protective effect on studied CYP isoforms especially when was given upon termination of xenobiotics exposure.
    Wstęp: W przypadku przedawkowania paracetamolu, zdolność wątroby do detoksykacji zostaje wysycona i następuje akumulacja toksycznego metabolitu, jaki jest NAPQI. Główne izoformy CYP, uważane za odpowiedzialne za bioaktywację APAP-u i sprzyjające w ten sposób zatruciom wątrobowym, to CYP2E1, CYP1A2 oraz CYP3A4 a u zwierząt dodatkowo izoformy 2B1/2. Celem pracy było zbadanie wpływu paracetamolu i/lub trichloroetylenu na skład wątrobowych izoform cytochromu P450. Materiał i metody: Badania wykonano na szczurach, które traktowano trichloroetylenem, paracetamolem i/lub N-acetylocysteiną. We frakcji mikrosomalnej wątroby oznaczano zawartość trzech izoform cytochromu P450, tj., CYP2E1, CYP2B1/2 oraz CYP1A2. Wyniki: Paracetamol lekko stymulował CYP2E1 obniżając równocześnie poziom CYP1A2. Trichloroetylen stymulował CYP2B1/2. N-acetylocysteina miała stymulujący wpływ na wszystkie badane izoformy P450. N-acetylocysteina podawana łącznie z badanymi ksenobiotykami prowadziła do wyraźnych wzrostów CYP. Wnioski: N-acetylocysteina wykazywała ochronny wpływ na poziomy badanych izoform cytochromu P450, szczególnie, jeśli została podana zaraz po zaprzestaniu ekspozycji na ksenobiotyki.
    Źródło:
    Medycyna Środowiskowa - Environmental Medicine; 2012, 15, 4; 24-30
    1505-7054
    2084-6312
    Pojawia się w:
    Medycyna Środowiskowa - Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    China’s economic growth – selected financial aspects
    Autorzy:
    Rosińska-Bukowska, Magdalena
    Zielińska-Lont, Klaudia
    Bogołębska, Joanna
    Anielak, Karolina
    Bukowski, Sławomir
    Powiązania:
    https://bibliotekanauki.pl/books/47243188.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Opis:
    China’s economic miracle is widely admired, studied and analysed ever since the country started experiencing unprecedented development pace. This monograph focuses on selected financial aspects of China’s economic growth that seldom are at the centre of attention of the researchers. The authors stress that the maturing financial system contributes greatly to the country’s transition to a modern, developed economy. Research conducted for this monograph is part of a wider analysis of Asia’s competitive position – Asia’s global expansion: business and financial aspects (2020), http://dx.doi.org/10.18778/8142-990-0. Different areas of the Chinese financial system are analysed in detail in order to show that the country has largely passed the stage of catching up with the most developed economies of the world and in certain cases has already taken the lead. China’s bond market is growing in liquidity, its financial institutions are among the largest in the world and at the same time are able to meet the strictest prudential requirements. Innovativeness of China’s FinTech sector has surpassed many established financial institutions of the world. China’s financial institutions are ready to compete on the global market and the Chinese economy will no longer build its competitive position exclusively on cheap labour. The findings of these book will help understanding what type of challenges are waiting ahead of the Middle Kingdom. The authors of the monograph are researchers from the University of Lodz, the Department of International Business and Trade, http://www.instytutgm.uni.lodz.pl/about/the-department-of-international-business-and-trade/
    Dostawca treści:
    Biblioteka Nauki
    Książka
    Tytuł:
    First insight into microbial community composition in a phosphogypsum waste heap soil
    Autorzy:
    Zielińska, Sylwia
    Radkowski, Piotr
    Ossowski, Tadeusz
    Ludwig-Gałęzowska, Agnieszka
    Łoś, Joanna
    Łoś, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1038561.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    microbial community
    16S rRNA gene
    soil sample
    postproduction waste
    phosphogypsum
    reclamation
    Opis:
    The aim of this study was to investigate the soil microbial communities of a phosphogypsum waste heap. The soil microbial community structures can differ over time, as they are affected by the changing environmental conditions caused by a long-term exposure to different kinds of pollutions, like is the case of soil in the post-production waste area in Wiślinka (in the northern part of Poland) currently undergoing restoration. Our analyses indicated that the most abundant phyla were Proteobacteria, Acidobacteria, and Actinobacteria, and generally such an abundance is common for most of the studied soils. The most dominant class were Alphaproteobacteria, with their participation in 33.46% of the total reads. Among this class, the most numbered order was Sphingomonadales, whereas among this order the Sphingomonadaceae family was the most abundant one. The Sphingomonadaceae family is currently in the center of interest of many researchers, due to the ability of some of its members to utilize a wide range of naturally occurring organic compounds and many types of environmental contaminants. This kind of knowledge about microbial populations can support efforts in bioremediation and can improve monitoring changes in the contaminated environments.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 4; 693-698
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The most widespread problems in the function-based microbial metagenomics
    Autorzy:
    Felczykowska, Agnieszka
    Krajewska, Anna
    Zielińska, Sylwia
    Łoś, Joanna
    Bloch, Sylwia
    Nejman-Faleńczyk, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1039154.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    function-based metagenomics
    metagenomic library screening
    gene expression
    microbials
    databases
    codon usage bias
    cell accumulation
    Opis:
    Metagenomics is a powerful tool to better understand the microbial niches, especially these from extreme habitats like oceans and seas, hot springs or deserts. However, one who is going to face the metagenomic studies should realize the challenges which might occur in the course of experiments. This manuscript indicates common problems in function-driven metagenomics, especially factors that influence gene expression are taken into account. Codon usage bias, internal cell accumulation, correct protein folding or presence of proper initiation factors are discussed and possible ways to overcome these problems are proposed. Finally, the annotation process is described, including possible limitations that one should take under consideration. What is more, the most popular databases for metagenomic data are mentioned and discussed.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 161-166
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system.
    Autorzy:
    Plewka, Andrzej
    Zielińska-Psuja, Barbara
    Kowalówka-Zawieja, Joanna
    Nowaczyk-Dura, Grażyna
    Plewka, Danuta
    Wiaderkiewicz, Anna
    Kamiński, Marcin
    Orłowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1044264.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    trichloroethylene
    liver
    rat
    acetaminophen
    cytochrome P450,glutathione
    Opis:
    The aim of the study was to evaluate the effect of acetaminophen (APAP) and/or trichloroethylene (TRI) on the liver cytochrome P450-dependent monooxygenase system, CYP2E1 and CYP1A2 (two important P450 isoforms), and liver glutathione (GSH) content in rats. Rats were given three different doses of APAP (250, 500 and 1000 mg/kg b...) and then the above-mentioned parameters were measured for 48 h. The lowest APAP dose produced small changes in the cytochrome P450 content of liver. At 500 mg/kg APAP increased the cytochrome P450 content to 230% of the control. The inductive effect was seen at 1000 mg/kg dose but at 24 h and later. NADPH-cytochrome P450 reductase activity was the highest after the lowest dose of APAP, while after the highest dose it was equal to the control value. TRI increased both the cytochrome P450 content and the NADPH-cytochrome P450 reductase activity. When TRI was combined with APAP, both these parameters increased in the first hours of observation, but they returned to the control values at 24 h. When APAP was given at 250 mg/kg, GSH levels decreased to 55% of the control at 8 h and returned to the control values at 24 h. The higher doses of APAP decreased GSH levels more than the lowest dose, but after 24 h GSH levels did not differ from those of the control. When TRI was given at 250 mg/kg, the GSH levels decreased to 68% of the control at 2 h and then they increased gradually and tended to exceed the control values at 48 h. The effect of TRI combined with APAP on the level of GSH was virtually the same as that of APAP alone given at 500 mg/kg.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 1129-1136
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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