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Wyświetlanie 1-8 z 8
Tytuł:
THE RADIOSTABILITY OF BETAMIPRON IN THE SOLID STATE
Autorzy:
Zalewski, Przemysław
Kilińska, Karolina
Cielecka-Piontek, Judyta
Skibiński, Robert
Miklaszewski, Andrzej
Bednarski, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/895691.pdf
Data publikacji:
2019-08-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
EPR
radiation sterilization
radiostability
Q-TOF
betamipron
Opis:
The influence of ionising radiation on physicochemical properties of betamipron in solid state was studied. No changes for betamipron irradiated with a dose of 25 kGy, required to attain sterility, was observed by spectroscopic and chromatographic methods. Solid betamipron has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 629-634
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of the UHPLC-DAD method for simultaneous determination of four active pharmacological ingredients in cannabinoid plant material
Autorzy:
Zalewski, Przemysław
Krause, Anna
Milewski, Marek
Wielgus, Karolina
Szalata, Milena
Słomski, Ryszard
Piontek, Judyta C.
Powiązania:
https://bibliotekanauki.pl/articles/895446.pdf
Data publikacji:
2018-08-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
validation
UHPLC-DAD
cannabinoid extract
Opis:
A stability-indicating ultra-high-performance liquid chromatography (UHPLC) with DAD detector was developed and validated for the simultaneously determination of Δ9-tetahydrocannabitol (THC), cannabidiol (CBD), Δ9-tetahydrocannabinolic acid (THC-COOH) and cannabidiolic acid (CBD-COOH) in extracts of Cannabis sativa L.. The separation was achieved on a Kinetex, C18, 100 x 2.1 mm, 2.6 µm. The gradient separation was started with mixture of methanol and 12mM ammonium acetate in ratio 75:25 (%/%). The methanol was increased to 100% from 0.0 min to 10.0 min, then maintained 100% for the next 1.0 min, then decreased to 75% from 11.0 min to 15.0 min and held at 75% from 15.0 min to 20.0 min. The injection volume was 5.0 µL and the wavelength of detection was controlled at 228 nm.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 885-890
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE RADIOLYTIC STUDIES OF DORIPENEM MONOHYDRATE IN THE SOLID STATE
Autorzy:
Zalewski, Przemysław
Kilińska, Karolina
Piontek, Judyta C.
Skibiński, Robert
Szymanowska, Daria
Miklaszewski, Andrzej
Bednarski, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/895484.pdf
Data publikacji:
2018-10-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
doripenem
radiation sterilization
microbiological activity
radiostability
Q-TOF
Opis:
The influence of ionising radiation on physicochemical properties of doripenem in solid state was studied. No changes for doripenem irradiated with a dose of 25 kGy, required to attain sterility, was observed by FT-IR and chromatographic methods, although the presence of free radicals (7.7*1017 radicals/g) was detected by EPR. The antibacterial activity of doripenem irradiated with a dose of 25 kGy was unchanged. Solid doripenem has proven to be very stable on irradiation, and irradiation has been found to be a suitable method for its sterilization.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1127-1133
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
THE RADIATION STERILIZATION OF IMIPENEM AND CILASTATIN IN THE SOLID STATE
Autorzy:
Zalewski, Przemysław
Kilińska, Karolina
Piontek, Judyta C.
Miklaszewski, Andrzej
Szymanowska, Daria
Skibiński, Robert
Bednarski, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/895601.pdf
Data publikacji:
2019-06-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
imipenem
radiation sterilization
microbiological activity
radiostability
Q-TOF
Opis:
One of the best sterilization methods for chemically unstable drugs, such as carbapenems, is irradiation. The chemical and physical properties of radiosterilized imipenem and cilastatin were analyzed using spectrophotometric and chromatographic methods. Unstable free radicals were presented in samples after irradiation; their mean lifetime was 142±64 h. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy changed for Klebsiella pneumoniae and Escherichia coli. Imipenem and cilastatin in the solid state are not resistant to radiation sterilization; therefore, this method cannot be used for sterilization of this compound.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 431-438
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The radiolytic studies of panipenem in the solid state
Autorzy:
Zalewski, Przemysław
Rosiak, Natalia
Kilińska, Karolina
Skibiński, Robert
Szymanowska, Daria
Tykarska, Ewa
Piekara-Sady, Lidia
Lewandowska, Kornelia
Miklaszewski, Andrzej
Piontek, Judyta C.
Powiązania:
https://bibliotekanauki.pl/articles/895501.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
HPLC
FT-IR
EPR
radiation sterilization
Q-TOF
panipenem
Opis:
The influence of ionizing radiation on the physicochemical properties of panipenem in solid state was studied. In the first part of our studies, we evaluated the possibility of applying radiosterilization to obtain sterile panipenem. Spectroscopic (FT-IR, Raman), chromatography (HPLC and HPLC-MS) and X-ray powder diffraction (XRPD) studies have shown that irradiation of ertapenem with the 25 kGy, the dose required to achieve sterility, does not change the physicochemical properties of the studied compound. The antimicrobial activity of panipenem irradiated with the dose of 25 kGy was reduced for three species. It was confirmed that the decrease in antimicrobial activity might be related to isomerization of panipenem.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 241-250
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the laser welding process on changes in the magnetic induction of the Religa Heart ROT pump
Wpływ procesu spawania laserowego na zmiany indukcji magnetycznej wirnika pompy wspomagania serca Religa Heart ROT
Autorzy:
Stano, Sebastian
Kustosz, Roman
Kapis, Artur
Kurtyka, Przemysław
Zalewski, Jerzy
Zarwańska, Magda
Powiązania:
https://bibliotekanauki.pl/articles/115085.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
spawanie laserowe impulsowe
stop tytanu
rozkład indukcji magnetycznej
wirnik pompy
wspomaganie serca
pompa Religa Heart ROT
pulse laser welding
titanium alloy
magnetic induction distribution
pump rotor
heart assistance
Religa Heart ROT pump
Opis:
The study addresses the results concerning the laser welding technology of the titanium circulatory support blood pump Religa Heart ROT. Pulse laser welding parameters were determined and selected. The influence of the pulse welding parameters and other conditions of welding process on the magnetic induction distribution of the mechanical circulatory support blood pump was investigated.
W artykule przedstawiono wyniki badań procesu spawania laserowego tytanowego wirnika pompy wspomagania serca Religa Heart ROT. Określono parametry spawania laserowego w trybie impulsowym zapewniające uzyskanie odpowiedniego wtopienia oraz ich wpływ na zmiany indukcyjności magnesów neodymowych znajdujących się wewnątrz wirnika pompy. Opracowano parametry technologiczne spawania laserowego zapewniające brak zmian indukcyjności wirnika pompy po spawaniu.
Źródło:
Welding Technology Review; 2019, 91, 4; 39-47
0033-2364
2449-7959
Pojawia się w:
Welding Technology Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of textured surface topography parameters on cells proliferation and tissue growth in the mechanical circulatory support application
Autorzy:
Kurtyka, Przemysław
Major, Roman
Kustosz, Roman
Zalewski, Jerzy
Wiecek, Justyna
Bartkowiak, Amanda
Kaczmarek, Marcin
Joszko, Kamil
Grajoszek, Aniela
Powiązania:
https://bibliotekanauki.pl/articles/1844854.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2021, 24, 163; 47
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of factors associated with the nutritional mixture leading to liver complications in patients treated by means of parenteral nutrition at home
Autorzy:
Matras, Przemysław
Żuchowska, Katarzyna
Banakiewicz, Katarzyna
Bobak, Adam
Jajko, Krzysztof
Szypowski, Roman
Zalewski, Grzegorz
Zieliński, Paweł
Rudzki, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1396531.pdf
Data publikacji:
2013-12-01
Wydawca:
Index Copernicus International
Tematy:
hepato-billiary complications
long-term parenteral nutrition
Opis:
The major problem of total parenteral treatment consists in the balancing of the source and dose of the nutritional mixture, so as to not deepen malnutrition with a positive impact on the patients’ organism. The aim of the study was to evaluate selected factors that induce hepato-billiary complications in patients treated by means of parenteral nutrition at home. Material and methods. The retrospective study comprised 70 patients with biochemistry performed every three months. Considering statistical analysis patients were allocated to four groups, depending on the period of treatment. Group A analysis results were based on the activity of aminotransferases, group B on the activity of bilirubin. Both groups A and B were additionally divided into group I where we assigned normal values of control lab results, and group II with improper results after treatment. Results. Differences between groups Ia vs IIa were presented on the basis of the daily supply of glucose: mean- 2.52 vs 3.49 g/kg (p=0.000003), glucose/lipids ratio: mean- 3.76 vs 4.90 g/kg (p=0.0001), daily non-protein energy: mean- 16.73 vs 21.06 kcal/kg (p=0.0001). Differences between groups Ib vs IIb were presented on the basis of the daily supply of glucose: mean- 2.76 vs 3.46 g/kg (p=0.0007), glucose/lipids ratio: mean- 3.98 vs 5.13 g/kg (p=0.01), daily non-protein energy: mean-17.96 vs 20.36 kcal/kg (p=0.04). Based on the above-mentioned analysis the main goal in the prevention of hepatic complications should lead to the reduction of the dose of glucose. Increased glucose supply leads to increased number of hepato-billiary complications. Conclusions. Based on obtained results we were able to conclude that in case of liver complications associated with parenteral nutrition, proper management consists in the modification of nutritional mixtures (reduction in the daily glucose supply and change in the proportions of extra-protein energy). Such management has the greatest clinical effect. When determining the composition of the nutritional mixture one should adjust the glucose supply, so as to offset both sources of extra-protein energy
Źródło:
Polish Journal of Surgery; 2013, 85, 12; 681-686
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-8 z 8

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