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Wyświetlanie 1-4 z 4
Tytuł:
The Inconsistent, Everyday Legal Consciousness of Contemporary Poles
Autorzy:
Skąpska, Grażyna
Radomska, Ewa
Wróbel, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/22858335.pdf
Data publikacji:
2023-09-27
Wydawca:
Polskie Towarzystwo Socjologiczne
Tematy:
agency
legal competency
legal alienation
everyday legal consciousnes
legal nihilism from above
Opis:
On the basis of a nationwide survey conducted in 2020, this article strives to answer questions concerning the legal consciousness of contemporary Poles. Above all, it aims to establish whether the law is of value in Polish society—used as a tool for the resolution of conflicts, protection of rights, and the management of social relationships. The analysis is anchored in the Polish tradition of research on legal consciousness, but goes beyond that tradition to emphasize a sense of agency and competency as key components of legal consciousness. Moreover, the analysis links legal consciousness to other areas of life controlled by legal regulations. Supported by such theoretical considerations, this article presents an empirical model of legal consciousness in order to ponder a question about the empirical roots of the rule of law and legal alienation in the consciousness of Poles today.
Źródło:
Polish Sociological Review; 2023, 223, 3; 289-318
1231-1413
2657-4276
Pojawia się w:
Polish Sociological Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combination of IL-12 gene therapy and CTX chemotherapy inhibits growth of primary B16(F10) melanoma tumors in mice
Autorzy:
Mitrus, Iwona
Delić, Klaudia
Wróbel, Natalia
Missol-Kolka, Ewa
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1041249.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antiangiogenic therapy
interleukin-12 gene
combined therapy
Opis:
We investigated suppression of murine B16(F10) melanoma tumor growth following a therapy which involved concomitant administration of cyclophosphamide and plasmid DNA bearing interleukin-12 gene. Since both therapeutic factors display antiangiogenic capabilities, we assumed that their use in blocking the formation of new blood vessels would result in augmented inhibition of tumor growth. This combined therapy regimen indeed resulted in a considerable suppression of tumor growth. We observed a statistically significant extension of treated animals' lifespan. Interestingly, the therapeutic effect was also obtained using a plasmid without an interleukin gene insert. This observation suggests that plasmid DNA, which has been widely applied for treating neoplastic tumors, contains element(s) that elicit immune response in mice.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 357-360
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Peroxidative oxidation of halides catalysed by myelopcroxidase. Effect of fluoride on halide oxidation
Autorzy:
Zgliczyński, Jan
Stelmaszyńska, Teresa
Olszowska, Ewa
Krawczyk, Andrzej
Kwasnowska, Elżbieta
Wróbel, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1046075.pdf
Data publikacji:
1983
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1983, 30, 2; 213-222
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of lipegfilgrastim on hematopoietic reconstitution and supportive treatment after megachemotherapy with autologous peripheral blood stem cell transplantation in patients with lymphoproliferative malignancies
Autorzy:
Frączak, Ewa
Dybko, Jarosław
Rybka, Justyna
Biedroń, Monika
Dereń-Wagemann, Izabela
Urbaniak-Kujda, Donata
Kuliczkowski, Kazimierz
Wróbel, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1064904.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
G-CSF
auto-PBSCT
lymphoproliferative malignancies
Opis:
Megachemotherapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) is a standard treatment option in patients below 70 years of age with multiple myeloma (MM) as well as with relapsed and refractory lymphomas. Recombinant granulocyte colony-stimulating factors (G-CSF) are commonly used to accelerate bone marrow recovery after chemotherapy and reduce the duration of severe neutropenia. Lipegfilgrastim is a glicopegylated G-CSF with prolonged action registered for adult patients with malignant neoplasms in order to reduce the duration of neutropenia and the incidence of febrile neutropenia (FN). So far, there is not enough data to confirm the effectiveness and safety of this drug in patients with hematological malignancies including those undergoing auto-PBSCT. The aim of this study was to determine the effect of lipegfilgrastim on hematopoietic regeneration and supportive care after auto-PBSCT in patients with lymphoproliferative malignancies. The study population consisted of 30 patients (12 female and 18 male; median age: 50 years ± 13), including 13 patients with MM, 5 with Hodgkin’s lymphoma (HL) and 12 with non-Hodgkin’s lymphoma (nHL). The median number of transplanted CD34+ cells was 3.96 ± 1.56 × 10^6/kg of body mass. On day +1 after auto-PBSCT, the patients received lipegfilgrastim in a single 6 mg subcutaneous injection. The control group consisted of 32 patients (13 female and 19 male; median age: 50 years ± 6.4), including 13 with MM, 8 with HL and 11 with nHL, who received subcutaneous filgrastim in a dose of 5 μg/kg/day from day +1 after transplantation and continued to an absolute neutrophil count (ANC) > 1.5 × 10^9/L. There was no significant difference in the time of regeneration ANC > 0.5 × 10^9/L which was 10.65 ± 1.00 vs. 11.51 ± 2.29 days respectively in the study and control group. Similar observations were noted regarding the duration of febrile neutropenia (2.16 ± 2.22 vs. 1.70 ± 4.17 days; p = 0.998), regeneration of platelets (PLT) > 20 × 10^9/L (12.41 ± 2.41 vs. 13.82 ± 4.48 days; p = 0.233) and demand for transfusion of red blood cells (0.76 ± 1.07 vs. 1.33 ± 2.33 units; p = 0.414) and platelets (11.5 ± 6.9 vs. 19.2 ± 17.7 units; p = 0.08). Different results were observed for the length of hospitalization, which was significantly shorter in the lipegfilgrastim group (16.14 ± 14 vs. 24.46 ± 6.79 days; p = 0.000). Lipegfilgrastim is as effective as filgrastim with regards to the regeneration of the hematopoietic system, duration of febrile neutropenia, demand for transfusion of blood products and significantly reduces hospitalization in patients with lymphoproliferative malignancies after auto-PBSCT.
Źródło:
OncoReview; 2016, 6, 2; A66-71
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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