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Tytuł:
The delusional type of schizophasia: An analysis of schizophatic texts
Urojeniowy typ schizofazji. Na przykładzie analizy tekstów schizofatycznych
Autorzy:
Woźniak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/28408967.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
schizofazja
schizofrenia
urojenia
diagnoza zaburzeń mowy
kohezja
koherencja
schizophasia
schizophrenia
delusions
diagnosis of speech-language disorders
cohesion
coherence
Opis:
Schizofazję zwykle kojarzy się z niespójnością wypowiedzi w jej wymiarach semantycznym i formalno‑gramatycznym. Artykuł podnosi kwestię niespójności pragmatycznej tekstu i zawiera propozycje włączenia do spektrum schizofazji także wypowiedzi odnoszących się do urojeń. Zawarte w artykule przykłady analiz wypowiedzi osób cierpiących na schizofrenię, dokonane za pomocą skal do oceny schizofazji (TLC, KSOS) potwierdzają tę tezę.
Schizophasia is usually associated with the incoherence of an utterance in its semantic and formal-grammatical dimensions. The article raises the issue of pragmatic incoherence in text and proposes to include in the spectrum of schizophasia also statements relating to delusions. The article’s examples of analyses of statements of schizophrenic patients made with the help of scales for assessing schizophasia (TLC, SSRS – in Polish: KSOS) support this thesis. This thesis is confirmed by the examples included in the article of analyses of statements made by people with schizophrenia using scales for assessing schizophasia (TLC, KSOS).
Źródło:
Logopaedica Lodziensia; 2023, 7; 229-242
2544-7238
2657-4381
Pojawia się w:
Logopaedica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Personalization of structural PDB files
Autorzy:
Woźniak, Tomasz
Adamiak, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/1039449.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
structural bioinformatics
PDB file
format
conversion
Opis:
PDB format is most commonly applied by various programs to define three-dimensional structure of biomolecules. However, the programs often use different versions of the format. Thus far, no comprehensive solution for unifying the PDB formats has been developed. Here we present an open-source, Python-based tool called PDBinout for processing and conversion of various versions of PDB file format for biostructural applications. Moreover, PDBinout allows to create one's own PDB versions. PDBinout is freely available under the LGPL licence at http://pdbinout.ibch.poznan.pl
Źródło:
Acta Biochimica Polonica; 2013, 60, 4; 591-593
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Subsurface imaging of fluvial deposits of the Wisła River valley in Kraków (southern Poland) by 2D ERT survey
Autorzy:
Bania, Grzegorz
Woźniak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/2201218.pdf
Data publikacji:
2022
Wydawca:
Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
Tematy:
electrical resistivity tomography
ERT
gradients of interpreted resistivity
2D ERT modeling
fluvial deposits
Wisła River valley
southern Poland
Opis:
We describe the application of 2D ERT (electrical resistivity tomography) surveys to investigate the spatial complexity of fluvial deposits of the Wisła River valley in the eastern part of Kraków (southern Poland). All ERT survey lines were completed within the industrially influenced floodplain of the Wisła River at two research sites. Due to the transformation of the natural state of the environment through many years of industrial activity of the ArcelorMittal Kraków plant, some of the geomorphological elements analysed have been irretrievably transformed and hidden by anthropogenic accumulations such as waste landfills and engineering structures. Hence, many years of soil contamination have changed the primary resistivity characteristics of the subsurface. For this purpose, the measurement array applied combines standard arrays, i.e., Wenner-Schlumberger and Dipole-Dipole, which gave improved results (higher resolution) in comparison to the standard single array. The data interpretation method was supported by the calculation and visualization of the vertical and horizontal gradients of the interpreted resistivity within the resistivity sections. This approach allowed accurate determination of resistivity boundaries on the ERT resistivity sections and thus helped lithological interpretation of the fluvial deposits in the research area. The resistivity of water in a channel located within one of the analysed areas has impacted some of the research results. Furthermore, 2D ERT forward modeling was implemented to generate synthetic datasets. The synthetic data allowed investigation of the influence of groundwater contamination on the resistivity distribution within superficial layers, and also tested the ability of the 2D ERT model to recognize the detailed spatial distribution of palaeomeander (meander scar) infills. All methods have provided new information on the industrially influenced floodplain of the Wisła River in Kraków.
Źródło:
Geological Quarterly; 2022, 66, 3; art. no. 23
1641-7291
Pojawia się w:
Geological Quarterly
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dokładność serwisu EGNOS w kontekście obsługi operacji lotniskowych
Autorzy:
Felski, Andrzej (1952- ).
Banaszek, Krzysztof.
Woźniak, Tomasz.
Zakrzewski, Piotr (1958- ).
Powiązania:
Zeszyty Naukowe / Akademia Marynarki Wojennej im. Bohaterów Westerplatte 2011, nr 1(184), s. 31-44
Data publikacji:
2011
Tematy:
System nawigacji satelitarnej stosowanie
EGNOS (system) obsługa i eksploatacja
GPS
Opis:
Rys., tab.
Bibliogr.
Dostawca treści:
Bibliografia CBW
Artykuł
Tytuł:
Friends and Neighbours Voting in Local Elections in Open List System: Evidence from Poland
Głosowanie przyjacielsko-sąsiedzkie w wyborach lokalnych w systemie list otwartych: dane z Polski
Autorzy:
Czapiewski, Tomasz
Woźniak, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1858023.pdf
Data publikacji:
2021-12-31
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
local elections
friends and neighbours voting (FNV)
personal votes
Szczecin
wybory samorządowe
głosowanie przyjacielsko-sąsiedzkie
głosy personalne
Opis:
This paper seeks to extend previous analyses of localism of candidates. To our knowledge, this is the first study of the ‘friends and neighbours’ voting (FNV) effect in Central and Eastern Europe employing the data of the candidate’s exact place of residence and using dispersion of votes between electoral precincts, as in Poland votes in each precinct are counted and published separately. The basic hypothesis of the paper was that the place of residence is a factor that significantly affects the spatial distribution of votes. Using spatial autocorrelation, we identify spatial clusters of votes for specific candidates. The conducted research indicates that the intensity of the FNV effect differs between candidates. This local bonus, which in fact is the FNV effect, is an attribute of selected candidates. It can be seen that a candidate’s locality is a more important attribute influencing voting results in certain city districts, while in others it is of limited importance. This mechanism may be explained to some extent by referring to the notion of motivation to win personal votes and party strategies of the selectors. Moreover, it was proved that the spatial distribution of votes of candidates who have their place of residence in the area from which they stand for election is significantly different from the distribution of votes among non-resident candidates.
Niniejszy artykuł ma na celu poszerzenie dotychczasowych badań dotyczących lokalizmu kandydatów. Według naszej wiedzy jest to pierwsze w Europie Środkowo-Wschodniej badanie efektu głosowania przyjacielsko-sąsiedzkiego (FNV) z wykorzystaniem danych o dokładnym miejscu zamieszkania kandydata oraz zróżnicowaniu liczby głosów pomiędzy obwodami wyborczymi, gdyż w Polsce głosy w każdym obwodzie są liczone i publikowane osobno. Podstawową hipotezą pracy jest stwierdzenie, że miejsce zamieszkania to czynnik istotnie wpływający na przestrzenny rozkład głosów. Wykorzystując autokorelację przestrzenną, identyfikowane są przestrzenne skupiska głosów oddanych na konkretnych kandydatów. Przeprowadzone badania wskazują, że natężenie efektu FNV jest różne dla poszczególnych kandydatów. Ta lokalna premia, jaką jest efekt FNV, jest atrybutem wybranych kandydatów. Można zauważyć, że lokalność kandydata jest ważnym elementem wpływającym na wyniki głosowania w niektórych okręgach miejskich, a w innych ma ograniczone znaczenie. Mechanizm ten można do pewnego stopnia wyjaśnić, odwołując się do pojęcia motywacji do zdobywania głosów personalnych oraz strategii partyjnych selekcjonerów. Ponadto wykazano, że rozkład przestrzenny głosów kandydatów, którzy mają miejsce zamieszkania na obszarze, z którego kandydują, różni się istotnie od rozkładu głosów kandydatów niezamieszkałych w okręgu.
Źródło:
Athenaeum. Polskie Studia Politologiczne; 2021, 72; 168-187
1505-2192
Pojawia się w:
Athenaeum. Polskie Studia Politologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The current state of bioeconomy in Poland
Autorzy:
Woźniak, Ewa
Twardowski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1038731.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bioeconomy
biotechnology
bioregion
GMO
Opis:
Conversion of scientific achievements to market a product is a key issue and the best description of significance of science for society. In the case of experts in the natural sciences in Poland, we observe a high intellectual potential of researchers and several scientific discoveries. However, Polish inventions are very rarely available on the market and the number of national and international patent applications done by Polish scientists is very limited. For the development of bioeconomy, the progress in biotechnology is critical.
Źródło:
Acta Biochimica Polonica; 2016, 63, 4; 731-735
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Test of rolling stock compatibility with axle counters
Badania kompatybilności taboru kolejowego z licznikami osi
Autorzy:
Olejniczak, Tomasz
Woźniak, Krystian
Kowalski, Michał
Powiązania:
https://bibliotekanauki.pl/articles/33572116.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Poznański Instytut Technologiczny
Tematy:
rolling stock
axle counter
compatibility
tests
sensor
noise
tabor kolejowy
licznik osi
kompatybilność
badania
czujnik
zakłócenia
Opis:
The article presents the problems linked to the compatibility of the rolling stock with axle counters, specifying acceptable levels of interference for selected types of sensors, and conducting research. Taking measurements on railway infrastructure requires proper preparation of both the substantive test object and measuring station. Measurements are made in accordance with a plan that takes into account all the situations in which the vehicle being tested can generate interference that may cause unstable operation of sensors, such as start-up or braking.
W artykule przedstawiono problematykę związaną z kompatybilnością taboru z licznikami osi, określającą dopuszczalne poziomy zakłóceń dla wybranych typów czujników oraz przeprowadzaniem badań. Wykonywanie pomiarów na infrastrukturze kolejowej wymaga odpowiedniego przygotowania zarówno merytorycznego, badanego obiektu jak i stanowiska pomiarowego. Pomiary wykonuje się zgodnie z przygotowanym planem, który uwzględnia wszystkie sytuacje, w których badany pojazd może generować zakłócenia powodujące niestabilną pracę czujników, takie jak rozruch czy hamowanie.
Źródło:
Rail Vehicles/Pojazdy Szynowe; 2017, Nr 3; 61-65
0138-0370
2719-9630
Pojawia się w:
Rail Vehicles/Pojazdy Szynowe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Public opinion on biotechnology and genetic engineering in the European Union: Polish consumer study
Autorzy:
Woźniak-Gientka, Ewa
Tyczewska, Agata
Twardowski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/16648093.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
biotechnology
genetic engineering
agribiotechnology
social attitude
public perception
Opis:
The aim of the article is to show the current state of public opinion of Poles on biotechnology and genetic engineering in the context of European Union countries. The authors refer to the results of their own study based on a survey conducted in 2019 in Poland. To introduce the matter of public opinion on biotechnology and genetic engineering in the European Union a short review of research related to the topic is presented, showing discrepancies in perception of biotechnology and genetic engineering. The results of the survey showed that more than half of Poles noticed that products obtained by genetic engineering techniques are available on the market. Despite the fear of the research in the field of biotechnology and genetic engineering, 39 to 69% (depending on the subject of research) of Poles supported them. Moreover, 62% of Poles were opponents of genetically modified feeds as they believed that they can be harmful to human life and health. The findings regarding the current consumer perception, knowledge, and attitude towards genetically modified foods and feeds will help in building strategic approaches to educating society about genetically modified organisms and genetically modified products.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 2; 185-201
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of electrical resistivity imaging and land surveying in the analysis of underground construction impact on the Warsaw scarp
Autorzy:
Kaczmarek, Łukasz
Woźniak, Marek
Mieszkowski, Radosław
Dybciak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/2025311.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
electrical resistivity imaging
position measurements
underground
Warsaw Scarp
displacements
Opis:
The pa per pres ents the anal y sis of the II Un der ground Line con struc tion’s im pact on the War saw Scarp with the use of the elec tri cal re sis tiv ity im ag ing (ERI, also known as the elec tri cal re sis tiv ity to mog ra phy) and fur ther to tal sta tion posi tion mea sure ments. The un der ground passes un der the scarp per pen dic u lar in the area of Dynasy Street 6, in Downtown dis trict. The elec tri cal re sis tiv ity im ag ing was per formed for rec og ni tion of the geo log i cal struc ture and a potential land slide sur face or zone. The gra di ent sys tem was used dur ing the prospection. In these anal y ses, the lon gi tu di nal sec tion was 40 m long, and the depth of sur vey amounted to 6 m. In the case of the 200 m long trans verse sec tion, there sulted depth of sur vey was 30 m. The geo phys i cal im age of the lon gi tu di nal sec tion, does not con tain loos en ing soil zones, which could in di cate slip sur face. Next, to tal sta tion mea sure ments, which were tied to the ar chi val geo detic obser va tions’ re sults, were car ried out. The aim of the mea sure ments was to ver ify the ac tiv ity of the hor i zon tal and verti cal dis place ments. The TBM ex ca va tion pro cess led to sum mary ver ti cal dis place ments up to approx. 24 mm and hor i zon tal dis place ments amount ing to approx. 13 mm. To sum up, the cur rent land sur veys re veals mi nor un der ground line’s con struc tion im pact on the scarp dis place ment. Nev er the less, the sen si tive ur ban en vi ron ment re quires fur ther mon i tor ing, es pe cially that the op er a tion loads can re sult in dis place ment rate change.
Źródło:
Studia Quaternaria; 2016, 33; 83-90
1641-5558
2300-0384
Pojawia się w:
Studia Quaternaria
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on selected parameters of engine with the active combustion chamber
Autorzy:
Głogowski, Michał
Woźniak, Marek
Szydłowski, Tomasz
Siczek, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/24202476.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Naukowe Silników Spalinowych
Tematy:
combustion engine
active combustion chamber
variable compression ratio
silnik spalinowy
aktywna komora spalania
zmienny stopień sprężania
Opis:
The present study was focused on the combustion engine with a variable compression ratio (VCR), namely the four-stroke air-cooled engine with the active combustion chamber (ACC). An indicated pressure, torque, power, and specific fuel consumption of that engine were investigated experimentally as a goal of the present study. Experiments were conducted using two versions of an engine. Two parameters particularly influencing the ACC engine performance including the maximum compression ratio CRmax and the indicator γfm determining the correct operation of the ACC system, were described. It was found that the ACC engine allowed avoiding detonation combustion without changing the amount and composition of the combustible mixture, and even without delaying the ignition advance angle. In addition, the possible range of control of the combustion process allowed the ACC engine to operate with different types of hydrocarbon fuels, for example, in the form of petrol with various alcohol admixtures. The very intense flow of the combustible mixture inside the cylinder of the ACC engine allowed describing the combustion in the ACC engine with zero-dimensional mathematical models with the dual Vibe function providing the proper characterization of the heat release process. The use of very high maximum compression ratios allows the ACC engine to operate to a certain extent as a Homogeneous Charge Compression Ignition (HCCI) engine with high lambda coefficients.
Źródło:
Combustion Engines; 2023, 62, 3; 3--12
2300-9896
2658-1442
Pojawia się w:
Combustion Engines
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmental modeling in small catchments in the context of climate change: Reda case study
Autorzy:
Walczykiewicz, Tomasz
Jakusik, Ewa
Skonieczna, Magdalena
Woźniak, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/108615.pdf
Data publikacji:
2020
Wydawca:
Instytut Meteorologii i Gospodarki Wodnej - Państwowy Instytut Badawczy
Tematy:
eutrophication
modeling climate change
nutrient mitigation
Opis:
The BONUS MIRACLE project focuses on understanding the of the impact of climate change on water environments, including it’s affects on hydrological regimes and nutrient concentrations. The overall objective of MIRACLE is to initiate a social learning process in collaboration with stakeholders, that can identify new configurations for governance (conceptual, institutional, and practice based) in order to reduce nutrient enrichment and flood risk in the Baltic Sea region. These configurations should be understood as new solutions to protect water resources, ecosystem services and provide win-win solutions. To achieve this environmental modelling of the Reda catchment, Poland, is used as a pilot study for the project. Mathematical models which specified the detailed processes associated with water cycles, including determining interconnections and quantifying variables characteristic to the assessment of the water resource quantity and quality, were found to be useful. Due to the complexity of some models, launching, entering the appropriate data in the correct formats and calibrating the models proved to be challenging. Future developments in the water management sector should concentrate on specific local catchment areas where the application of integrated water resource management principles and the adaptation to climate change are more easily merged with local spatial planning. However, a larger number and higher frequency of measurements would be required.
Źródło:
Meteorology Hydrology and Water Management. Research and Operational Applications; 2020, 8, 1; 98-106
2299-3835
2353-5652
Pojawia się w:
Meteorology Hydrology and Water Management. Research and Operational Applications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the frequency of the transforming growth factor beta-1 sequence polymorphisms in patients with alcohol dependence syndrome
Autorzy:
Augustyńska, Beata
Araszkiewicz, Aleksander
Woźniak, Marcin
Grzybowski, Tomasz
Skonieczna, Katarzyna
Woźniak, Alina
Żyła, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1039134.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
transforming growth factor TGFβ-1
alcohol dependence syndrome
TGF-β1 gene
Opis:
Alcohol abuse is one of the most significant factors in the development of liver fibrosis. The pathomechanism of liver fibrosis is the same regardless of its etiology. Fibrosis is a sign of an imbalance between the synthesis of the extracellular matrix components and their degradation. Among the many cytokines that affect hepatic stellate cell activation it seems that transforming growth factor beta (TGF-β) is the most significant, either as the direct factor stimulating polymerase chain reaction (HSC) proliferation and transformation into myofibroblasts, or as the direct factor causing an increase in the activity of genes responsible for the synthesis of extracellular matrix components. The aim of the study was to reveal possible dependencies and differences between the presence of certain alleles of the TGF-β1 gene and its blood level in the study and control group. Blood samples were obtained from 39 patients, the control group consisted of 21 patients. The results obtained in the course of this study showed no statistically significant differences between the frequencies of particular polymorphisms. In the case of haplotype frequencies, insignificant differences were found for the algorithm Excoffier-Laval-Balding predicted haplotypes while one significant difference between the study and control groups was detected in case of the TC haplotype frequency predicted using the Expectation-Maximization algorithm. However, the difference in frequency of TC haplotype predicted by both algorithms was not significant. Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-β1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study.
Źródło:
Acta Biochimica Polonica; 2015, 62, 1; 63-67
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Studies on the Mechanical Properties of C45 Steel with Martensitic Structure after a High Tempering Process
Autorzy:
Woźniak, Waldemar
Sąsiadek, Michał
Jachowicz, Tomasz
Edl, Milan
Zając, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/2201724.pdf
Data publikacji:
2022
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
steel
heat treatment
quenching
tempering
steel structure
martensite structure
martensitic structure
Opis:
This article describes the studies of the mechanical properties of the martensitic structure of C45 steel, obtained as a result of heat treatment. This steel was subjected to high tempering, within the temperature range of 500 ÷ 700°C (every 50°C) and for various exposure times, from 15 minutes to 23 hours. Moreover, martensitic steel was subjected to tests by quenching at a temperature of 850°C for 20 minutes and then tempering it for 1 hour, within the temperature range of 50 ÷ 800°C (every 50°C). The resulting steel samples were subjected to strength tests, that is, to tensile and hardness tests and also to tests on the micro-structure. The results of these studies are presented and discussed, in detail, in terms of their practical application.
Źródło:
Advances in Science and Technology. Research Journal; 2022, 16, 3; 306--315
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of the reactance of rail vehicles wheelsets
Autorzy:
Garczarek, Adam
Woźniak, Krystian
Olejniczak, Tomasz
Waśkowicz, Radosław
Stachowiak, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/33343772.pdf
Data publikacji:
2023-11-30
Wydawca:
Sieć Badawcza Łukasiewicz - Poznański Instytut Technologiczny
Tematy:
resistance
impedance
reactance
traction vehicles
measurement methodology
wheelset
Opis:
The article presents issues related to the determination of resistance, impedance, and reactance of rail vehicles wheelsets in relation to applicable standards and regulations. The methodology of conducting this type of test is discussed, and a configured test stand is presented to measure the resistance and impedance of the wheelsets. The uncertainty budget for this type of testing is discussed. Exemplary measurement results are presented and analyzed.
Źródło:
Rail Vehicles/Pojazdy Szynowe; 2023, 1-2; 32-37
0138-0370
2719-9630
Pojawia się w:
Rail Vehicles/Pojazdy Szynowe
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in expression of serine proteases HtrA1 and HtrA2 during estrogen-induced oxidative stress and nephrocarcinogenesis in male Syrian hamster
Autorzy:
Zurawa-Janicka, Dorota
Kobiela, Jaroslaw
Stefaniak, Tomasz
Wozniak, Agnieszka
Narkiewicz, Joanna
Wozniak, Michał
Limon, Janusz
Lipinska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1040768.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
17-β-estradiol
HtrA proteases
estrogen-induced carcinogenesis
oxidative stress
Opis:
Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian hamster. We used semi-quantitative RT-PCR to estimate the HtrA1 and HtrA2 mRNA levels in kidney tissues, and Western blotting to monitor the amount of the HtrA proteins. Within the first five hours following estrogen administration both HtrA1 mRNA and the protein levels were increased significantly. No changes in the expression of HtrA2 were observed. This indicates that HtrA1 may be involved in the response against oxidative stress induced by estrogen treatment in hamster kidney. During prolonged estrogenization, a significant reduction of the HtrA1 mRNA and protein levels was observed after 6 months of estradiol treatment, while the expression of HtrA2 was significantly elevated starting from the third month. This suggests an involvement of the HtrA proteins in estrogen-induced nephrocarcinogenesis in hamster. Using fluorescence in situ hybridization we localized the HtrA1 gene at the qb3-4 region of Syrian hamster chromosome 2, the region known to undergo a nonrandom deletion upon prolonged estrogenization. It is possible that the reduced level of HtrA1 expression is due to this chromosomal aberration. A full-length cDNA sequence of the hamster HtrA1 gene was obtained. It codes for a 50 kDa protein which has 98 and 96% identity with mouse and human counterparts, respectively.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 9-20
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 22

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