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    Wyświetlanie 1-2 z 2
    Tytuł:
    Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequences
    Autorzy:
    Nauman, Alicja
    Turowska, Olga
    Poplawski, Piotr
    Master, Adam
    Tanski, Zbigniew
    Puzianowska-Kuznicka, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1041047.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    human clear cell renal cell carcinoma (ccRCC)
    low molecular weight forms of cyclin E (LMW)
    cyclin E
    E2F1 transcription factor
    gene for cyclin E (CCNE)
    Opis:
    The expression of cyclin E gene (CCNE) in relation to the expression of its major regulatory protein, E2F1, was examined in clear cell renal cell carcinomas (ccRCC). We show that the overexpression of E2F1 is accompanied by the significant increase of the mean amounts of cyclin E mRNA, as well as of total cyclin E protein and its low molecular weight forms in cancer tissues as compared to peritumoral controls. A significant increase of the mean amount of total cyclin E was found in peritumoral tissues compared to cancer-free kidneys, suggesting that cancer cells might secrete factors having a profound influence on the metabolism of neighbouring tissues. A significant, positive correlations between E2F1 protein and total cyclin E mRNA, as well as between E2F1 protein and full length cyclin E protein were found in cancer-free kidneys and in peritumoral tissues, but not in ccRCCs. The overexpression of cyclin E positively correlated with the decreasing degree of tumor differentiation, implicating a role for cyclin E in the promotion of tumorigenesis.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 3; 595-602
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Single-Layer Sutures in Abdominal Cavity Surgery
    Autorzy:
    Tański, Zbigniew
    Jarząbek, Zbigniew
    Konowalski, Bartosz
    Truszkowski, Maciej
    Biedrzycki, Jakub
    Kuzaka, Bolesław
    Kuzaka, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1392078.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    complications
    complications treatment
    fluid therapy
    one-layer suture
    ways of performing
    Opis:
    The aim of our study was to evaluate of short-term outcomes of 4210 patients who underwent open abdominal surgery with used either single-layer, absorbable, or continuous sutures. Seromuscular anastomosis were presented (without mucosa). Fluid therapy: GDT and zero-balance GDT were also discussed. Anastomosis leakage developed in 6 patients. They were treated by creating a stoma. Simultaneously, septic shock was treated. Re-anastomoses were performed after some time and after sepsis was suppressed. Results of treatment with use of double-layer sutures, which was is use before 1978, were presented. Analysis of 536 patients treated at the same time was conducted and 53 patients with anastomosis leakage was identified. Out of this group, 2 patients survived. Based on the literature review, the methods for performing anastomosis. Attention was paid to the advantages of single layer over multi-layer sutures: effectiveness, simplicity and lower cost of treatment. The occurrence of mechanical ileus was less frequently observed since ceasing to employ peritoneoplasty, and preoperational preparation of gastrointestinal tract in patients had a beneficial influence on their postoperative course. Postoperative complications were discussed mainly based on additional examinations such as TC and MRI. The attention was focused on the importance of medical observation and clinical examination by an experienced surgeon in order to identify postoperative complications. Antibiotic treatment in cases of postoperative complications was presented, as well as fluid therapy: GDT, zero-balance GDT and the procedures employed in cases of complications such as: anastomosis leakage, mechanical ileus, inter-peritoneal abscess. Anastomotic stenosis was not observed in this group of patients.
    Źródło:
    Polish Journal of Surgery; 2019, 91, 5; 12-20
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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