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    Wyświetlanie 1-5 z 5
    Tytuł:
    Nitric oxide and platelet energy metabolism.
    Autorzy:
    Tomasiak, Marian
    Stelmach, Halina
    Rusak, Tomasz
    Wysocka, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1041559.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    mitochondrial energy production
    porcine platelets
    nitric oxide
    glycolysis
    Opis:
    This study was undertaken to determine whether nitric oxide (NO) can affect platelet responses through the inhibition of energy production. It was found that NO donors: S-nitroso-N-acetylpenicyllamine, SNAP, (5-50 μM) and sodium nitroprusside, SNP, (5-100 μM) inhibited collagen- and ADP-induced aggregation of porcine platelets. The corresponding IC50 values for SNAP and SNP varied from 5 to 30 μM and from 9 to 75 μM, respectively. Collagen- and thrombin-induced platelet secretion was inhibited by SNAP (IC50 = 50 μM) and by SNP (IC50 = 100 μM). SNAP (20-100 μM), SNP (10-200 μM) and collagen (20 μg/ml) stimulated glycolysis in intact platelets. The degree of glycolysis stimulation exerted by NO donors was similar to that produced by respiratory chain inhibitors (cyanide and antimycin A) or uncouplers (2,4-dinitrophenol). Neither the NO donors nor the respiratory chain blockers affected glycolysis in platelet homogenate. SNAP (20-100 μM) and SNP (50-200 μM) inhibited oxygen consumption by platelets. The effect of SNP and SNAP on glycolysis and respiration was not reduced by 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one, a selective inhibitor of NO-stimulated guanylate cyclase. SNAP (5-100 μM) and SNP (10-300 μM) inhibited the activity of platelet cytochrome oxidase and had no effect on NADH:ubiquinone oxidoreductase and succinate dehydrogenase. Blocking of the mitochondrial energy production by antimycin A slightly affected collagen-evoked aggregation and strongly inhibited platelet secretion. The results indicate that: 1) in porcine platelets NO is able to diminish mitochondrial energy production through the inhibition of cytochrome oxidase, 2) the inhibitory effect of NO on platelet secretion (but not aggregation) can be attributed to the reduction of mitochondrial energy production.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 3; 789-803
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigating the content of microplastics and other extraneous particles in Polish bottled water
    Autorzy:
    Aleksander-Kwaterczak, Urszula
    Gaj, Dominika
    Stelmach, Alex
    Wróbel, Tomasz P.
    Powiązania:
    https://bibliotekanauki.pl/articles/27310134.pdf
    Data publikacji:
    2023
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    plastic bottles
    drinking water
    solid particles
    polymers
    microplastics
    FT-IR spectroscopy
    Opis:
    Bottled water has enjoyed a global increase in popularity since it is generally perceived to be superior in quality to tap water and necessary when tap water is non-potable. As a result, ensuring that it meets the requisite quality standards is of vital importance. This work aims to examine the content of solid particles, including microplastics, in bottled water available in Polish stores. The second aspect is the preliminary determination of the influence of the water gassing process, together with thermal and light factors, on the content of particles in the water. The number of particles was counted by colour and shape, with the number ranging from 87 to 188 per litre of water; on average, there were 136 ±32 particles per litre of water, demonstrating that water from disposable plastic bottles is contaminated with various substances. The difference in the number of particles may be due to the origin of the waters, the processes they were subjected to prior to bottling, the properties of the bottles as packaging, and the conditions and length of storage and transport. Additional Fourier-transform infrared spectroscopy (FT-IR) analysis confirmed that about 75% of the particles were polymers, and 50% of them were plastics. Particularly alarming is the fact that the bottled waters mostly contained microplastic particles (MP) of smaller sizes, the kind which is recognized as being the most dangerous to human health. In the study, most particles were in the form of irregular shapes, which may indicate that they come from the destruction of waste or plastic products. This is also indicated by the domination of colourless particles. More particles were found in waters exposed to high and low temperatures than in waters stored at room temperature, potentially indicating that storage conditions for drinking water are important. Taking into account the results obtained, increasing attention should be paid to the health risks posed by such microplastics and there is a clear need to introduce legal regulations on the matter. The lack of any legal guidelines or unified standards in the field of MP research means that the results are not always representative, and it also makes it difficult to compare the results from different studies.
    Źródło:
    Geology, Geophysics and Environment; 2023, 49, 4; 335--353
    2299-8004
    2353-0790
    Pojawia się w:
    Geology, Geophysics and Environment
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The involvement of Na+/K+-ATPase in the development of platelet procoagulant response
    Autorzy:
    Tomasiak, Marian
    Stelmach, Halina
    Rusak, Tomasz
    Ciborowski, Michał
    Radziwon, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1041052.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cardiac glycosides
    ouabain
    Na+/K+-ATPase
    atrial fibrillation
    platelets
    procoagulant activity
    Opis:
    In circulation, platelets may come into contact with both exogenous (cardiac glycoside treatment) and endogenously produced inhibitors of Na+/K+-ATPase. We examined whether blocking of platelet Na+/K+-ATPase by ouabain results in generation of procoagulant activity. It was shown that an in vitro treatment of platelets with ouabain (20-200 µM for 20 to 60 min) is associated with an intracellular accumulation of sodium ([Na+]i), generation of a weak calcium signal, and expression of procoagulant activity. The ouabain-induced procoagulant response was dose- and time-related, less pronounced than that evoked by collagen and similar to that produced by gramicidin, not affected by EDTA or aspirin, and strongly reduced in the absence of extracellular Na+ or by hyperosmolality. Flow cytometry studies revealed that ouabain treatment results in a unimodal left shift in the forward and side scatter of the entire platelet population indicating morphological changes of the plasma membrane. The shift was dose related, weaker than that evoked by collagen and similar to that produced by gramicidin. Ouabain-treated platelets express phosphatidylserine (PS). The ouabain-evoked PS expression was dose- and time-dependent, weaker than that produced by collagen and similar to that evoked by gramicidin. Electronic cell sizing measurements showed a dose-dependent increase in mean platelet volume upon treatment with ouabain. Hypoosmotically-evoked platelet swelling resulted in the appearance of procoagulant activity. Thromboelastography measurements indicate that, in whole blood, nanomolar (50-1000 nM, 15 min) concentrations of ouabain significantly accelerate the rate of clot formation initiated by contact and high extracellular concentration of calcium. We conclude that inefficiently operating platelet Na+/K+-ATPase results in a rise in [Na+]i. An increase in [Na+]i and the swelling associated with it may produce PS exposure and a rise in membrane curvature leading to the generation of a procoagulant activity.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 3; 625-639
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE INFLUENCE OF SELECTED FACTORS ON OXYGEN EFFICIENCY
    Autorzy:
    Pasiak, Wojciech
    Stelmach, Anna
    Pasiak, Przemysław
    Weber, Dorota
    Bańbuła, Marek
    Zubliewicz, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/449156.pdf
    Data publikacji:
    2018-10-11
    Wydawca:
    Politechnika Opolska. Wydział Wychowania Fizycznego i Fizjoterapii
    Tematy:
    oxygen efficiency, physiotherapy, Harvard step test, physical activity, lifestyle
    Opis:
    Oxygen (aerobic) efficiency is one of the most important determinants of our physical ability, which in turn is the most significant aspect of the human body. Physical activity is very often connected with health and life long health care. The purpose of this article is to show how aerobic efficiency is affected by different lifestyles and predilections among groups selected by the researcher. This will enable the determination of those factors that influence oxygen efficiency. Purpose. The purpose of this research is to establish how aerobic efficiency, being the most important determinant of physical activity, presents in the chosen groups of respondents and how it is affected by various factors. Materials and methods. 30 respondents between the ages of 18 and 24 who study or work took part in the research. All of them claimed to pursue regular physical activity. Based on the interview with the respondents several subgroups were indicated: males, females, smokers, non-smokers, consumers of alcohol and non-drinkers.Results. Research conducted for the purpose of this manuscript enabled the evaluation of how oxygen efficiency presented in the different groups selected for the purpose of this study. Respondents who took part in the research varied based on gender and use of stimulants: Cigarettes reduce the Fitness Index (FI) rate. Males have a better FI rate than females. Alcohol does not reduce the FI rate. Those who smoke cigarettes have a lower oxygen efficiency rate then those drinking alcohol.
    Źródło:
    Journal of Physical Education & Health - Social Perspective; 2018, 7, 11; 51-60
    2084-7971
    Pojawia się w:
    Journal of Physical Education & Health - Social Perspective
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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