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Wyświetlanie 1-2 z 2
Tytuł:
The continuous bioconversion of glycerol to 1,3-PD by using encapsulated C. freundii cells
Autorzy:
Kowalska, Urszula
Mizielińska, Małgorzata
Soból, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/1178073.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
PDADMAC beads
alginate capsules
bioimmobilization
encapsulation
Opis:
The aim of the work was to decrease the costs of bioconversion process by using chip and simple chromatographic columns containing immobilized C. freundii cells during fermentation. The goal was also modification of medium to control of pH of process in these columns. The purpose of the study was also to ascertain the new systems of biopolymers used for encapsulation of bacterial cells. The stability of obtained membranes in different mediums has been examined. The waste glycerol conversion to 1,3-PD over continuous process has been analyzed as well. The results of the study showed that the double crosslinked alginate beads are better carriers than alginate capsules coated by chitosan during conversion of waste glycerol to 1,3-PD. Unfortunatrly these two kinds of capsules should not be used for continuous process and repeated bioconversions because of low mechanical properties of the beads. PDADMAC beads and modified (e.g. by additions) PDADMAC capsules should not be used for continuous and repeated bioconversions as well.
Źródło:
World Scientific News; 2018, 95; 193-214
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE
Autorzy:
Gadziński, Piotr
Froelich, Anna
Kowalska, Urszula
Soból, Marcin
Szybowicz, Mirosław
Osmałek, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/895611.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
drug release
gellan gum
roxithromycin
ionotropic gelation
natural polymers
Opis:
The aim of the work was to investigate the properties of polysaccharide matrices loaded with roxithromycin (ROX), made on the basis of low-acyl gellan and its blends with sodium alginate, pectin, karaya gum, methycellulose and κ-carageenan. The obtained formulations were investigated as potential oral dosage forms with the ability to protect it from the acidic conditions of the stomach. Another desired feature of the obtained systems was the sustained release of the active ingredient allowing for potential shifting the therapeutic effect to the colon. The morphology of the matrices was evaluated with optical and scanning electron microscopy. Moreover, Raman spectroscopy and thermal analysis were performed for ROX, polymers, ROX/polymers physical mixtures and the matrices. Next, the swelling behavior was examined. The matrices were evaluated for ROX content and encapsulation efficiency. The last stage concerned the drug release studies. All matrices after production revealed more or less oval shape with visible deformation most probably occurring during drying. Raman analysis and DSC confirmed the crystalline form of ROX and showed no evidence of interactions between the drug and the excipients. It was shown that the matrices containing gellan combined with methylcellulose or κ-carageenan at pH=7.4 released ROX slower than the other matrices which might be promising in terms of colonic drug delivery. Moreover, the polymer matrices remained physically stable at acidic pH similar to the environment of the stomach. However, in these conditions drug degradation was observed which indicates the necessity to further modify the applied technology.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 319-330
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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