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Tytuł:
The prognostic influence of pre-surgery bone conduction values on the improvement of hearing in patients treated surgically as a result of middle-ear conditions
Autorzy:
Job, Katarzyna
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1397269.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
bone conduction thresholds
hearing improvement
myringoplasty
stapedotomy
Opis:
Introduction: The influence of the mechanics of the middle ear on the function of the inner ear has been studied for many years. Among surgeries performed in the middle-ear area, those restoring full functionality of the system transmitting sound inside the middle ear may be pointed out as those fully restoring the mechanical influence of the middle ear on the function of the inner ear. Aim: The aim of the performed analysis is to find the prognostic importance of measured pre-surgery values of bone conduction on the improvement of hearing in patients operated as a result of middle-ear disorders. Material and methods: The analysis included 271 patients hospitalised and operated on due to otosclerosis or perforation of the tympanic membrane between 2016 and 2019. Only patients who had not had a surgical operation within the middle ear prior to the study were included. An audiological assessment was performed with the use of pure tone thresholds audiometry. Results: A beneficial influence of the performed surgery on the improvement of bone conduction was observed in patients, in which the average threshold value of bone conduction measured before the surgery did not exceed 40 dB. In cases of the perceptive component of hearing impairment being higher than 40 dB, no statistically significant, beneficial influence of a performed stapedotomy or myringoplasty on the change of bone conduction thresholds was observed. Conclusions: The perception component of hearing impairment up to 40 dB indicates bone conduction improvement after surgical restoration of the influence of middle-ear mechanics on the inner ear in patients treated as a result of otosclerosis, as well as of eardrum perforation.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 3; 8-13
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The suitability of scanning electron microscopy in the evaluation of bone structure surfaces and selection of alloplastic materials for facial skeletal reconstruction
Autorzy:
Job, Katarzyna
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1397288.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
hydroxyapatite
scanning electron microscope
secondary electron detection
Opis:
Introduction: Functional and aesthetic problems can arise even from small losses created in the facial skeleton. Injuries and oncological surgeries are the most frequent causes of these losses within the facial skeleton. Advances in surgical interventions have allowed for ever-increasing degrees of resections, increasing oncological radicality as well as treatment effectiveness, providing the patient with the chance for a longer life. However, this subsequently requires the use of even more advanced reconstruction techniques in order to restore quality of life and comfort to the patient, as well as enable their return to professional and social activities. The necessity of reconstructive surgery applies not only to patients with cancer, but also to patients with impaired or failing sensory and organ function as a result of inflammatory conditions, injuries, or non-oncological surgeries. There are many available reconstruction procedures, which depend on the location of the loss, the type of tissue lost, the degree of loss and patient-dependent factors. Materials used in reconstruction surgeries may include the patients’ tissues when available, and artificial reconstruction materials otherwise. Material and methods: The analysis involved fragments of bone tissue removed during surgery. Due to the nature of the medical procedure and the inability to replant the tissue, it was regarded as medical waste. The preparations used were observed under an optical microscope and an electron scanning microscope, and a chemical analysis was performed. The chemical composition of samples was analysed using a low vacuum detector (LVD) at an accelerating voltage of 15 kV and 10 kV and at a spot size of 4 and 3.5. The observations were performed in a secondary electron (SE) detection system. Results: Observation of parameters under an optical microscope and of images obtained using an electron scanning microscope showed the presence of typical, compact bone tissue with varied surface shapes in each case (various degrees of unevenness and porosity). Chemical composition analysis confirmed the presence of compounds from the CaO-P2O5-H20 system. The Ca/P (calcium/phosphorus) ratio obtained from the chemical analysis varied from 1.33 to 2.1, and indicated a varied morphology of calcium phosphates forming the bone structures of the facial skeleton. Conclusions: 1. Calcium phosphates are characterised by excellent biocompatibility because of their chemical affinity to bone, and are ideal for the reconstruction of bone losses within the facial skeleton. 2. Biodegradable polymers have the highest functional potential among several groups of biomaterials used in tissue engineering because of their ability to be tailored individually, in addition to their high biocompatibility.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 4; 14-19
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Long-term results of a hearing test in patients operated for chronic otitis media
Autorzy:
Boroń, Aleksandra
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1397351.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
chronic otitis media
long-term postoperative hearing improvement
tympanoplasty
Opis:
Introduction: Chronic otitis media is characterized by tympanic membrane perforation and conductive hearing loss. In the active form of this disease, there will also be periodic or permanent otorrhea. With a number of surgical techniques available depending on intraoperative findings, otosurgery is the treatment of choice in such cases, the extent of which depends on the type and extent of the pathological changes. Material and Method: We carried out an analysis of 79 patients with chronic otitis media undergoing surgery at the Department of Otolaryngology, Jagiellonian University Medical College in Kraków between 2005 and 2014. Total audiometry was used as a part of hearing assessment, before the surgery, 6 months after the surgery and in the distant 10-year observation period. In addition, each patient completed the questionnaire and was examined by an otolaryngologist. Results: The analysis included 79 patients operated on due to chronic otitis media. The mean bone conduction (for frequencies 500,1000 and 2000 Hz) before surgery was 31.8 dB, it did not differ significantly (p = 0.355) after 6 months after surgery (32.8 dB), while it significantly increased (p < 0.001) in a distant 10-year control of 43.4 dB. The mean air conduction (for frequencies 500, 1000 and 2000 Hz) before the procedure was 57.6 dB, it significantly improved in the early control by 50.5 dB, at p < 0.001. In long-term follow-up it increased again to 61.3 dB and was significantly different from the early postoperative period (p < 0.001). The mean air-bone gap for frequencies 500, 1000 and 2000 Hz before surgery was on average 26.4 dB, it was significantly (p < 0.001) reduced in the postoperative period by 17.6 dB. The level of air-bone gap remained at a similar level in distant control. Conclusions: (1) A completely preserved ossicular chain in the absence of active chronic otitis media is the best prognosis for stable hearing improvement over the years with normal inner ear function; (2) Reoperation worsens the long-term results of a hearing test compared to the first operation.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 6; 9-15
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Challenges of modern medicine - geriatric otolaryngology or the advantages of cooperation between an otolaryngologist and a geriatrician
Autorzy:
Skalska, Anna
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1397785.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
ageing
ENT problems
hearing impairment
frailty
geriatric preoperative assessment
Opis:
Advanced age is often burdened with many deficits that are a consequence of the aging process, unfavorable lifestyle and multi-morbidity. They contribute to increased morbidity and disability of the older people. Laryngological problems often concern seniors, particularly progressing with age hearing impairment, dizziness, balance disorders, epistaxis, nasopharyngeal diseases, larynx, sinuses, and salivary glands disorders. They are not only a health threat, such as head and neck cancer, but they contribute to the deterioration of mobility, falls and injuries, depression, cognitive functions impairment and, consequently, functional disability, loss of independence and a sense of isolation. In this context, taking as an example the most common ailment, which is hearing impairment, laryngological procedures in the form of the use of hearing aids or cochlear implant improves cognitive functions, mood, self-esteem, opportunities for social interaction and everyday functioning, and the quality of life of older people. In turn, in view of the typical for older age polypathology and of significant reduction of the reserves of the organism, effective treatment aimed at improving health, preventing complications of diagnostics and therapy as well as disability with the desire to maintain independence and good quality of life requires the cooperation of different specialists. The knowledge and experience of geriatricians and the comprehensive geriatric assessment used as the diagnostic tool, aimed at identifying deficits typical of seniors’ age may significantly contribute to a more adequate risk and benefit assessment, selection of optimal treatment for a given health situation and identification of high-risk individuals requiring during the treatment period special supervision to reduce the risk of complications and the risk of development of geriatric syndromes such as delirium, cognitive disorders, malnutrition, falls and injuries, functional disability.
Źródło:
Polish Journal of Otolaryngology; 2019, 73, 1; 1-6
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Auditory ossicles in Scanning Electron Microscopy
Autorzy:
Wiatr, Agnieszka
Składzień, Jacek
Wiatr, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1397399.pdf
Data publikacji:
2020-05-12
Wydawca:
Index Copernicus International
Tematy:
middle ear surgery
ossicular chain
Scanning Electron Microscope
Opis:
Introduction: Knowledge about the physiology of a healthy middle ear is essential for understanding the activity and mechanics of the ear as well as the basics of ossiculoplasty. Trauma of the epithelial lining of the tympanic cavity as well as the ossicular chain may be the result of chronic inflammation and surgery. Depending on the observed changes of the middle ear lining, there are several types of distinguished chronic inflammatory changes: simple, with cholesteatoma, with the formation of inflammatory granulation tissue, in course of specific diseases. Purpose: The aim of the article is presentation of the microstructure and vasculature of the ossicular chain in the Scanning Electron Microscope. Particular attention is drawn to the anatomical aspects of the structure and connections of auditory ossicles as vital elements for reconstruction of the conduction system of the middle ear. Material and method: The analysis covered auditory ossicles standardly removed in accordance with the methodology of the investigated surgical procedures. The preparations were evaluated in a scanning electron microscope. Results: The exposure of bone surface promotes deep erosion. The advanced process of destruction of bone surface in the case of chronic otitis media correlates with a significant degree of damage to both the lining covering the auditory ossicles and that surrounding articular surfaces. Conclusions: (1) The ossicles in the image of the Scanning Electron Microscope are covered with lining. It passes from the surface of the ossicles to the vascular bundles, forming vascular sheaths; (2) Damage to lining continuity on the surface of the auditory ossicles promotes the rapid destruction of bone tissue in the inflammatory process; (3) The dimensions of the individual ossicles are respectively: malleus – 8.36 +/- 0.01, incus – 8.14 +/- 0.0, stapes – 3.23 +/- 0.01 mm. Behavior of the anatomical length of ossicular chain during tympanoplasty appears to be essential to maintaining adequate vibration amplitude of the conductive system of the middle ear.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 4; 1-7
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation investigated by scanning electron microscope based on an analysis of 140 patients
Autorzy:
Wiatr, Agnieszka
Job, Katarzyna
Składzień, Jacek
Wiatr, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1397266.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
bone defects
chronic otitis media
inflammatory granulation
scanning electron microscope
structure of cholesteatoma
Opis:
Introduction: Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. The above process is controlled by the OPG/RANKL/RANK system. Aim: The aim of the study is a comparative analysis of surgical material obtained from patients with diagnosed chronić cholesteatoma and chronic otitis media with inflammatory granulation in the assessment of the Scanning Electron Microscope (SEM). Material and methods: An analysis of 140 patients operated on due to chronic otitis media was performed. Forty patients who had been diagnosed with chronic cholesteatoma of the middle ear and chronic granulomatous otitis media were selected for a detailed analysis in the SEM. The final study under SEM included 20 patients. Results: The regular structure of cholesteatoma depicted in the SEM concerned 5 patients. In the remaining 7 patients, the system was irregular and even chaotic. The lack of regularity can also be observed in the case of granulation tissue, which in the SEM image presented itself as an irregular tissue mass without detectable regularities. Conclusions: (1) The regular pattern of the cholesteatoma matrix cells observed in some patients with chronic cholesteatoma of the middle ear reduces the molecular permeability of inflammatory cytokines, concurrently limiting the destructive activity on bone structures; (2) the presence of inflammatory granulation tissue in the middle ear is accompanied by an influx of leukocytes: neutrophils and lymphocytes, which are the source of pro-inflammatory cytokines, the growth of which activates the processes leading to the damage of bone tissue and the development of inflammation; (3) no specimen of acquired cholesteatoma revealed the presence of commensal organisms from Demodex species on the surface of the exfoliated human epithelium.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 3; 21-27
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of surgery in otosclerosis on the non-operated ear
Autorzy:
Wiatr, Agnieszka
Job, Katarzyna
Składzień, Jacek
Wiatr, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1397275.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
otosclerosis
Carhart's notch
stapedotomy
non-operated ear
Opis:
Backgrounds Otosclerosis is an underlying disease of the bony labyrinth. The hearing loss is most often of conductive nature, in some cases the involvement of the bony part of the cochlea results in mixed hearing loss. Aims: The aim of the analysis was to answer the question whether a surgery on one of the ears affects the state of the other ear in the course of otosclerosis. Methods The analysis included 140 patients hospitalized and operated on between 2010 - 2016. Only patients who had not had a surgical operation within the middle ear due to otosclerosis prior to the study were included in it. An audiological assessment was performed with the use of pure tone threshold audiometry taking into account. Results In the group of patients with no Carhart's notch, the mean threshold of bone conduction was statistically lower than before the procedure for the frequencies of 500, 1000 Hz and statistically equal for the frequency of 2000 Hz. The same analysis in the group of patients with Carhart's notch present in the pre-surgical tonal audiogram of the non-operated ear showed a statistically significant lower value of the post-surgical threshold bone conduction value. Conclusion It was confirmed the possibility of improving the hearing of the non-operated ear after the stapedotomy of the opposite ear, in the author's own studies by an average of 5 dB in the low-frequency range.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 2; 15-20
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors that have an influence on bone conduction thresholds changes after otosurgery in the patients operated on due to the perforation of the tympanic membrane with the preserved ossicular chain
Autorzy:
Wiatr, Maciej
Wiatr, Agnieszka
Kocoń, Sebastian
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1398515.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
bone conduction
miryngoplasty
chronic otitis media
Opis:
Introduction: The aim of the middle ear surgery is to eliminate abnormalities from the mucous, ensure the due airing of the postoperative cavity and reconstruct the sound-conducting system in the middle ear. Numerous reports can be found in literature on the changes to bone conduction as a consequence of middle ear surgery. Study objective: The aim of the work is to define the factors that affect bone conduction in the patients operated on due to the perforation of the tympanic membrane with the preserved and normal mobile ossicular chain. Material and method: A prospective analysis of patients operated on due to diseases of the middle ear in 2009–2012 was carried out. The cases of patients operated on for the first time due to chronic otitis media were taken into consideration. The analysis encompassed the patients who had undergone myringoplasty. The patients were divided into several groups taking into account the abnormalities of the mucous observed during otosurgery. Results: A significant improvement of bone conduction was observed in the patients with dry perforation, without other lesions in the middle ear. The appropriate pharmacological treatment before otosurgery in patients with permanent discharge from the ear resulted in significant bone conduction improvement. The elimination of granulation lesions turned out to be a positive factor for the future improvement of the function of the inner ear. Conclusions: The lack of abnormalities on the mucous of the middle ear (e.g. granulation,) and discharge has a positive impact on improvement of bone conduction after myringoplasty. Adhesions in the tympanic cavity, especially in the niche of the round window, have a negative impact on improvement of bone conduction in patients after myringoplasty.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 4; 26-33
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Launching of a cochlear implant program at the Cracow Otolaryngology Clinic
Autorzy:
Wiatr, Maciej
Niemczyk, Kazimierz
Składzień, Jacek
Wiatr, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1399610.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
Cochlear implant
sensorineural deafness
hearing loss treatment
Opis:
Introduction: It is estimated that hearing impediment affects approximately 12% of the population. Some forms of hearing disorders can be successfully treated conservatively, while in others surgery plays a key role. Often, therapeutic methods are exhausted and the patient faces the decision about the need for acoustic organ prosthesis. Depending on the causes of anomalies, apparatus for air conduction, bone conduction or cochlear implants are used. A cochlear implant replaces the damaged sensory cells of the inner ear. It constitutes an electronic prosthesis of the acoustic organ, composed of two parts. The internal part (implanted in the inner ear) consists of an implant and electrodes, which conduct electrical signals to the cochlea. The external part consists of a microphone, a speech processor, and a transmitter. Care report: A 70-year-old patient with deep hearing loss in the right ear and deafness of the left ear. During the interview, the patient denied mechanical injuries of the head and neck, acoustic trauma, inflammation or otorrhea. Based on the conducted tests, qualification otolaryngology, audiology, and otoneurology, radiology, surdologopedy and psychology were performed for cochlear implant insertion. The patient was qualified for cochlear implantation in the left ear under general anesthesia. The surgical team was composed of dr hab. Maciej Wiatr, prof. dr hab. Kazimierz Niemczyk, prof. dr hab. Jacek Składzień, MD Agnieszka Wiatr with anesthetic monitoring under the supervision of MD Renata Witkowska. The patient was discharged home on day 7 after surgery in good general and local condition. Simultaneous rehabilitation was started at the Center for Daily Rehabilitation of Hearing and Speech at the Specialist Center of Diagnosis and Rehabilitation for Children and Adolescents with Hearing Disabilities of the Polish Association of the Deaf in Cracow.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2019, 8, 1; 1-6
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of preserved stapedial superstructure on hearing improvement
Autorzy:
Boroń, Aleksandra
Wiatr, Agnieszka
Składzień, Jacek
Wiatr, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1397296.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
chronic otitis media
stapedial superstructure
tympanoplasty
Opis:
Introduction: Ossiculoplasty can be carried out in a number of ways, depending on the anatomical and functional conditions encountered during otosurgery and the experience of a given centre. The extent of damage to the ossicular chain determines the reconstruction method. Aim: The objective of the study was to analyse treatment effects in terms of postoperative hearing improvement in patients with chronic otitis media, with a particular emphasis on stapedial superstructure preservation. Material and method: The records of 294 consecutive patients undergoing their first ENT surgery due to chronic otitis media at the Department of Otolaryngology of Collegium Medicum, Jagiellonian University of Kraków in 2009–2013 were analysed. In order to assess the role of preserved stapedial superstructure, 96 patients were eligible for further analysis. Results: The analysis points to a significant hearing improvement after ossiculoplasty with the preserved stapedial superstructure as compared with the patients after footplate mobilisation. On the other hand, the research results point to significantly smaller hearing improvement in those patients, in whom only stapes was preserved, as compared with those, in whom a more extensive reconstruction of the ossicular chain was possible. Conclusions: The air-bone gap measured before otosurgery often fails to reflect the extent of abnormalities and cannot, therefore, be considered as the only prognostic factor for postoperative hearing improvement. Stapes preservation is crucial for hearing improvement after middle ear surgery.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 1; 17-22
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Otolaryngological symptoms in patients treated for tick-borne diseases
Autorzy:
Sowula, Klaudia
Składzień, Jacek
Szaleniec, Joanna
Tomik, Jerzy
Gawlik, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1398185.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
borreliosis
Lyme disease
co-infections
bartonellosis
laryngology
Opis:
Introduction: In recent years tick-borne diseases have become a very serious problem. The most common of these infections are borreliosis (Lyme disease) and tick-borne encephalitis (TBE). Lately there is growing incidence of Bartonella, Babesia, Anaplasma and Brucella co-infections. The similarity between the symptoms of tick-borne diseases and other pathologies causes serious diagnostic issues. Material and methods: 216 patients aged 18–55, who presented to the outpatient clinic for tick-borne diseases in the years 2014–2016, were enrolled in the study. The patients had been diagnosed with Lyme disease and co-infections. The principal diagnostic tests to confirm the infections included ELISA, Western-Blot and circulating immune complexes (CIC).Results: In the group of 216 patients, 162 presented with otolaryngological symptoms. The most common complaint was tinnitus (76,5%) accompanied by vertigo and dizziness (53,7%), headache (39%), unilateral sensorineural hearing loss (16,7%). The patients also had tick-borne coinfections, among them the most common was Bartonella henselae (33,4%) and Bartonella quintana (13%).Conclusions: Otolaryngological symptoms are a  common manifestation of tick-borne diseases. They are most frequently observed in Lyme disease and Bartonella spp. infections. The symptoms in the head and neck region are usually occur in chronic Lyme disease with predominant IgG antibodies nad VlsE antigen.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 1; 30-34
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of RCAS1 level in neoplasms and placenta.
Autorzy:
Wicherek, Lukasz
Dutsch, Magdalena
Mak, Pawel
Klimek, Marek
Skladzien, Jacek
Dubin, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1043411.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
EBAG9
RCAS1
immune escape
apoptotic cell death
fetal rejection
Opis:
The tumor associated antigen RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) expressed with high frequency in various cancer and trophoblast cells, inhibits growth of estrogen receptor-expressing cells and induces apoptosis. Because previous reports demonstrated RCAS1 presence only by non-quantitative immunocytochemistry methods, we decided to use a Western blotting with anti-RCAS1 monoclonal antibodies for estimation of the relative content of the tumor-associated antigen. One hundred tissue samples were assayed (neoplasms, chronic inflammatory diseases, healthy tissues, trophoblasts and placentas at term). RCAS1 was present in all neoplastic, placental and trophoblast tissue samples and its level in malignant samples was statistically significantly higher than in benign neoplasms. The amount of RCAS1 in chronic inflammations was also significantly increased in immune mediated diseases, like allergic nasal polyps and sarcoidosis. The RCAS1 protein was not revealed in healthy mucous membrane and in muscle tissues. The presented results suggest that RCAS1 might play an important role in tumor escape from host immunological surveillance and carry weight in the down regulation of the maternal immune response, thereby maintaining pregnancy.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1187-1194
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of treatment under subterraneotherapy conditions at the “Wieliczka” Salt Mine Health Resort on the symptoms of diseases of the nose and paranasal sinuses
Autorzy:
Woźniak, Aleksandra
Nowak, Karol
Pełkowska, Anna
Rys, Katarzyna
Gawlik, Jolanta
Składzień, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1398963.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
chronic non-allergic rhinitis
respiratory rehabilitation
subterraneotherapy
Opis:
Introduction: Chronic rhinosinusitis is an important disease of the upper respiratory system which substantially reduces patient quality of life and the methods of symptomatic treatment are tremendously limited. Aim: The aim of this study was to evaluate the next therapeutic option which is a combination of respiratory rehabilitation and subterraneotherapy. Material and methods: The study covered 57 patients of whom 15 were men and 42 women. The average age of patients was 60 +/- 10.87 (standard deviation). 44 patients finished 15 days of therapy which covers full-time treatment. The average age of these patients was 59.7 +/- 11.6 (standard deviation). Results: In the study group, there was a statistically significant reduction among all analyzed symptoms of chronic rhinosinusitis. The general severity of symptoms decreased from 5.66 cm to 2.57 cm (p < 0.001), blockade/congestion of the nose from 5.49 to 2.23 cm (p < 0.001), anterior nasal discharge from 5.33 cm to 2.5 cm (p < 0.001), posterior nasal discharge from 6.04 cm to 2.71 cm (p < 0.001), facial pain/pressure from 3.43 cm to 1.45 cm (p < 0.001), headache from 3.73 cm to 1.19 cm (p < 0.001) and reduction or loss of smell from 4.17 cm to 1.94 cm (p < 0.001). Conclusions: Such a notable improvement in all analyzed symptoms led us to conclude that respiratory rehabilitation, especially such conducted in adequate climatic conditions, should be a valuable therapeutic option in the symptomatic treatment of patients with chronic rhinosinusitis.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2021, 10, 1; 22-27
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stability of ABR Wave V Threshold in Early Hearing Diagnostics in Children from Selected Groups at Risk of Congenital Hearing Loss
Autorzy:
Kocoń, Sebastian
Skórkiewicz, Konrad
Stręk, Paweł
Ziarno, Remigiusz
Składzień, Jacek
Hartwich, Patryk
Tomik, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1397251.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
ABR
hearing screening
hearing threshold
newborn
Opis:
Introduction: Upon hearing that the “little” patient has trouble with hearing, we are mostly interested in the level of his hearing threshold. When the child is in the first year of life, results can only be achieved by means of ABR test. Subsequent control tests, especially in children from the hearing loss risk groups selected in this study, show that the obtained outcomes are subject to fluctuations. Their fluctuating nature is manifested by the instability of wave V threshold in subsequent diagnostic periods. Such variability often delays the implementation of the appropriate proceeding. Knowledge of the dissimilarity of behavior of the wave V threshold occurring in individual groups at risk of hearing loss allows for the correct interpretation of the obtained results, and thus, effective therapeutic measures. Aim: The aim of the paper is to analyze the stability of wave V threshold during the first year of life in children from selected risk groups for congenital hearing disorders. Material and methods: From the patient population of 2,114 individuals examined in 2015–2016 at a reference center participating in the Universal Neonatal Hearing Screening Program in 2015–2016, the results of 250 children were subjected to retrospective analysis. Furthermore, 4 groups of little patients were formed (children with Down syndrome; children with other diseases or damage to the nervous system; children with cleft palate or cleft lip and cleft palate; children with congenital cytomegaly) in whom diagnostic practice revealed variable results of the wave V threshold. We analyzed the results of tests obtained during the first year of the child’s life divided into 4 diagnostic periods. Results: The highest percentage of instability in the established threshold of wave V between individual diagnostic periods occurred in the group of children with cleft palate or cleft lip and cleft palate. In the group of children with Down syndrome, it was observed that the instability of the ABR test results decreased over time. In the group of children with other diseases or damage of the nervous system, the highest percentage of the lack of stable ABR wave V thresholds was observed between the 1st and 2nd as well the 1st and 4th diagnostic periods. On the other hand, in the group of children with congenital CMV, there was a relatively low percentage of instability of results. Conclusions: (1) Although the ABR test is a diagnostic standard, in particular groups of patients the study is burdened with high variability of measurement results in subsequent diagnostic periods. Such a group of patients are children with cleft palate or cleft lip and cleft palate; therefore, it must receive particular attention in treatment planning; (2) in selected groups at risk of hearing loss, due to the high percentage of children with hearing impairment (70%), the validity of performing newborn hearing screening tests was confirmed.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 1; 7-15
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recommendations of the Main Board of the Polish Society of Otorhinolaryngologists, Head and Neck Surgeons for providing services during the COVID-19 pandemic for outpatient and hospital practices
Autorzy:
Wierzbicka, Małgorzata
Niemczyk, Kazimierz
Jaworowska, Ewa
Burduk, Paweł
Składzień, Jacek
Szyfter, Witold
Markowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1397312.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
COVID-19
epidemy
head & neck
outpatient
surgery
Opis:
Recommendations of the Main Board of the Polish Society of Otorhinolaryngologists, Head and Neck Surgeons for providing services during the COVID-19 pandemic constitute the guidance to outpatient and hospital practices in all cases where contact with a patient whose status of COVID-19 is unknown. They have been created based on world publications and recommendations due to the current state of the COVID-19 pandemic. Justification for suspension of planned provision of services in the first phase of a pandemic was presented. The indication of the best medical practices for the time of stabilization, but with the persistence of the risk of COVID-19 infection in the population are discussed. The possibility of providing services in the following months of the pandemic is important. We provide the rationale for launching medical activities and indicate optimal practices until the consolidation of SARS COV-2 prevention and treatment methods.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 3; 1-5
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
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