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Wyświetlanie 1-9 z 9
Tytuł:
Moral hazard and its implications on health insurance sector – overview of impact of COVID-19 pandemic
Autorzy:
Sikora-Alicka, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/2123399.pdf
Data publikacji:
2022
Wydawca:
Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
Tematy:
moral hazard
health insurance
COVID-19
Opis:
Kenneth J. Arrow’s disruptive work, 'Medical Uncertainty and Welfare Economics’, published in 1963, was one of the first studies investigating the effects of moral hazard on the healthcare sector. Since then, countless works exploring that subject have been published. The history of research on moral hazard in medical insurance shows that this concept is defined differently in other areas of the economy than healthcare. Purpose – The proposed work is an attempt to understand and conceptualize the moral hazard in health insurance. As uncommon circumstances marked 2020, we now consider health insurance through the impact of the SARS-CoV-2 pandemic. This work discusses the results of an investigation of the impact of moral hazard and its implications on the health insurance sector during COVID-19. Research method – The author designed and conducted a study that presented several metrics involving the distribution of medical expenditures, the effect of price on medical care consumption, the PLS (profit and loss sharing) concept, and their mediating and moderating effect on moral hazard in the insurance sector. Results – There is a statistically significant and very strong relationship with a positive sign (β = 0.79; p <0.001) between the price effect and the moral hazard. The analyses show also that the price effect coexists statistically with the PLS, and the relationship between these variables is moderately strong and positive (β = 0.79; p <0.001). Originality – Insignificant relationship between the PLS and the moral hazard can be seen while the price is entered into the model (β = 0.03; p = 0.450). The lack of mediation could confirm that the price effect plays a major role in a moral hazard.
Źródło:
Optimum. Economic Studies; 2022, 1(107); 113-126
1506-7637
Pojawia się w:
Optimum. Economic Studies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
STUDIES TOWARDS HEMOCOMPATIBILITY OF POLYAMINE CONJUGATES WITH BICYCLIC SYSTEMS
Autorzy:
Szumilak, Marta
Markowicz-Piasecka, Magdalena
Mikiciuk-Olasik, Elzbieta
Stanczak, Andrzej
Sikora, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/895466.pdf
Data publikacji:
2018-08-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
coagulation
biocompatibility
fibrinolysis
erythrotoxicity
polyamine conjugates
Opis:
Assessing hemocompatibility of anticancer drug candidate is very important task due to the fact that coagulation disorders are often correlated with malignancy or induced by chemotherapy. The aim of this study was to examine the influence of some polyamine conjugates with bicyclic systems on the process of coagulation and fibrinolysis. In addition their effect on the healthy human erythrocytes (RBCs) was assessed. Prothrombin Time (PT), Activated Partial Tromboplastin Time (APTT), clot formation and lysis test (CL-test) were performed to evaluate the influence of some polyamine conjugates on plasma hemostasis. The effects of tested compounds on RBCs were assessed using hemolysis assays and microscopy studies. APTT and PT examination revealed that all tested compounds apart from the highest concentrations of compounds 3 and 5 did not exert significant effects on intrinsic and extrinsic coagulation pathways. Despite their substantial influence on the kinetic parameters of the process of clot formation and fibrinolysis, the examined compounds, over the entire concentration range, did not alter the overall potential of clot formation and lysis (CLAUC) suggesting that they might be regarded as biocompatible concerning plasma hemostasis. At potential therapeutic concentrations (constituting IC50 value for MCF-7 cells) tested polyamine conjugates showed no adverse effects on the membranes of RBCs. Promising antiproliferative activity of representative polyamine conjugates together with their hemocompatibility make them good anticancer drug candidates for further preclinical evaluation.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 861-874
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SOCIAL CONTEXTS OF FOOD EXCLUSION
Autorzy:
Krukowska, Joanna
Rancew-Sikora, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/646751.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie
Tematy:
food practice, food studies, qualitative research, Poland
Opis:
This article deals with social problems experienced by people who exclude certain groups of products from their everyday diet. These exclusions stem from various reasons and involve a range of everyday material and social practices. They evoke particular kinds of social interactions within the household, among hosts and guests, and also induce different reflexive interpretations of the participants.The aim of this paper is to explore the problem of how elimination diets are practised and explained on an everyday basis, and to describe particular strategies and techniques undertaken by food excluders in shops, in their kitchens, and at the table. The empirical basis for the qualitative investigation is a set of eight participant observations combined with in-depth interviews conducted with urban residents with higher education living in northern Poland.
Źródło:
Studia Humanistyczne AGH; 2018, 17, 2
2084-3364
Pojawia się w:
Studia Humanistyczne AGH
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Support of internal transport optimization in farms with the use of spatial information systems
Wspomaganie optymalizacji transportu wewnętrznego w gospodarstwach rolnych z wykorzystaniem systemów informacji przestrzennej
Autorzy:
Sikora, Jakub
Szeląg-Sikora, Anna
Gródek-Szostak, Zofia
Niemiec, Marcin
Stuglik, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1427012.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Inżynierii Rolniczej
Tematy:
vegetable agricultural production
internal transport
data base
agrarian structure
warzywnicza produkcja rolnicza
transport wewnętrzny
baza danych
struktura agrarna
Opis:
Excessive distribution of holdings is one of the most important barriers which causes that in a great part of Poland rational use of farms in impossible. This problem particularly concerns the south and east region of the country. Correct spatial distribution of lands belonging to holdings is one of the most crucial factors that enable an economically profitable activity of these farms. The aim of the paper was verification of the applicability of the prepared spatial data base, farm-land configuration of agricultural plots of the selected agricultural farms to indicate the areas of optimization of the internal transport. As a result, based on the developed spatial data base, an impact of the land configuration of agricultural plots in the investigated group of agricultural producers on organization of the field transport between the holding and agricultural plots was determined. The scope of the paper covered a vegetable producer group, which associates 5 farms that have in total 620 ha of agricultural land.
Nadmierne rozdrobnienie gospodarstw jest jedną z najważniejszych barier, która uniemożliwia racjonalne użytkowanie gruntów w dużej części obszaru Polski. Problem ten szczególnie mocno dotyczy południowo-wschodnich regionów kraju. Prawidłowe przestrzenne rozmieszczenie gruntów gospodarstw jest jednym z najważniejszych czynników umożliwiających prowadzenie przez te gospodarstwa opłacalnej ekonomicznie działalności. Celem pracy było zweryfikowanie aplikacyjności wykonanej przestrzennej bazy danych, rozłogu działek rolnych wybranej grupy producentów rolnych, w celu wskazania obszarów optymalizacji transportu wewnętrznego. W efekcie na podstawie wykonanej przestrzennej bazy danych określono wpływ rozłogu działek rolnych w badanej grupie producentów rolnych na organizację transportu polowego pomiędzy siedzibą gospodarstwa a działkami rolnymi. Zakresem pracy objęto grupę producentów warzyw, która zrzesza 5 gospodarstw rolnych, posiadających łącznie 620 ha użytków rolnych.
Źródło:
Agricultural Engineering; 2020, 24, 4; 87-94
2083-1587
Pojawia się w:
Agricultural Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Support of internal transport optimization in farms with the use of spatial information systems
Wspomaganie optymalizacji transportu wewnętrznego w gospodarstwach rolnych z wykorzystaniem systemów informacji przestrzennej
Autorzy:
Sikora, Jakub
Szeląg-Sikora, Anna
Gródek-Szostak, Zofia
Niemiec, Marcin
Stuglik, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1427130.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Inżynierii Rolniczej
Tematy:
vegetable agricultural production
internal transport
data base
agrarian structure
warzywnicza produkcja rolnicza
transport wewnętrzny
baza danych
struktura agrarna
Opis:
Excessive distribution of holdings is one of the most important barriers which causes that in a great part of Poland rational use of farms in impossible. This problem particularly concerns the south and east region of the country. Correct spatial distribution of lands belonging to holdings is one of the most crucial factors that enable an economically profitable activity of these farms. The aim of the paper was verification of the applicability of the prepared spatial data base, farm-land configuration of agricultural plots of the selected agricultural farms to indicate the areas of optimization of the internal transport. As a result, based on the developed spatial data base, an impact of the land configuration of agricultural plots in the investigated group of agricultural producers on organization of the field transport between the holding and agricultural plots was determined. The scope of the paper covered a vegetable producer group, which associates 5 farms that have in total 620 ha of agricultural land.
Nadmierne rozdrobnienie gospodarstw jest jedną z najważniejszych barier, która uniemożliwia racjonalne użytkowanie gruntów w dużej części obszaru Polski. Problem ten szczególnie mocno dotyczy południowo-wschodnich regionów kraju. Prawidłowe przestrzenne rozmieszczenie gruntów gospodarstw jest jednym z najważniejszych czynników umożliwiających prowadzenie przez te gospodarstwa opłacalnej ekonomicznie działalności. Celem pracy było zweryfikowanie aplikacyjności wykonanej przestrzennej bazy danych, rozłogu działek rolnych wybranej grupy producentów rolnych, w celu wskazania obszarów optymalizacji transportu wewnętrznego. W efekcie na podstawie wykonanej przestrzennej bazy danych określono wpływ rozłogu działek rolnych w badanej grupie producentów rolnych na organizację transportu polowego pomiędzy siedzibą gospodarstwa a działkami rolnymi. Zakresem pracy objęto grupę producentów warzyw, która zrzesza 5 gospodarstw rolnych, posiadających łącznie 620 ha użytków rolnych.
Źródło:
Agricultural Engineering; 2020, 24, 4; 87-94
2083-1587
Pojawia się w:
Agricultural Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Altered mouse leukemia L1210 thymidylate synthase, associated with cell resistance to 5-fluoro-dUrd, is not mutated but rather reflects posttranslational modification
Autorzy:
Cieśla, Joanna
Frączyk, Tomasz
Zieliński, Zbigniew
Sikora, Jacek
Rode, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1041288.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
protein phosphorylation
L1210
thymidylate synthase
posttranslational modification
FdUrd resistance
Opis:
Thymidylate synthase purified from 5-fluoro-dUrd-resistant mouse leukemia L1210 cells (TSr) was less sensitive to slow-binding inhibition by 5-fluoro-dUMP than the enzyme from the parental cells (TSp), both enzyme forms differing also in sensitivity to several other dump analogues, apparent molecular weights of monomer and dimer, and temperature dependence of the catalyzed reaction. Direct sequencing of products obtained from RT-PCR, performed on total RNA isolated from the parental and 5-fluoro-dUrd-resistant cells, proved both nucleotide sequences to be identical to the mouse thymidylate synthase coding sequence published earlier (NCBI protein database access no. NP_067263). This suggests that the altered properties of TSr are caused by a factor different than protein mutation, presumably posttranslational modification. As a possibility of rat thymidylate synthase phosphorylation has been recently demonstrated (Samsonoff et al. (1997) J Biol Chem 272: 13281), the mouse enzyme amino-acid sequence was analysed, revealing several potential phosphorylation sites. In order to test possible influence of the protein phosphorylation state on enzymatic properties, endogenous TSp and TSr were purified in the presence of inhibitors of phosphatases. Although both enzyme forms were phosphorylated, as shown by electrophoretical separation followed by phosphoprotein detection, the extent of phosphorylation was apparently similar. However, the same two purified enzyme preparations, compared to the corresponding preparations purified in the absence of phosphatase inhibitors, showed certain properties, including sensitivity to the slow-binding inhibition by FdUMP, altered. Thus properties dependence on phosphorylation was indicated.
Źródło:
Acta Biochimica Polonica; 2006, 53, 1; 189-198
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enhancement of COVID-19 symptom-based screening with quality-based classifier optimisation
Autorzy:
Kozielski, Michał
Henzel, Joanna
Tobiasz, Joanna
Gruca, Aleksandra
Foszner, Paweł
Zyla, Joanna
Bach, Małgorzata
Werner, Aleksandra
Jaroszewicz, Jerzy
Polańska, Joanna
Sikora, Marek
Powiązania:
https://bibliotekanauki.pl/articles/2086854.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
classification
classification quality
screening
COVID-19
klasyfikacja
jakość klasyfikacji
badania przesiewowe
Opis:
Efforts of the scientific community led to the development of multiple screening approaches for COVID-19 that rely on machine learning methods. However, there is a lack of works showing how to tune the classification models used for such a task and what the tuning effect is in terms of various classification quality measures. Understanding the impact of classifier tuning on the results obtained will allow the users to apply the provided tools consciously. Therefore, using a given screening test they will be able to choose the threshold value characterising the classifier that gives, for example, an acceptable balance between sensitivity and specificity. The presented work introduces the optimisation approach and the resulting classifiers obtained for various quality threshold assumptions. As a result of the research, an online service was created that makes the obtained models available and enables the verification of various solutions for different threshold values on new data.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2021, 69, 4; e137349, 1--8
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A micelle mediated extraction as a new method of obtaining the infusion of Bidens tripartita
Autorzy:
Śliwa, Karolina
Sikora, Elżbieta
Ogonowski, Jan
Oszmiański, Jan
Kolniak-Ostek, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1038779.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ultrasonic assisted micelle-mediated extraction
three-part beggarticks
whey protein concentrate
Opis:
In this paper, the extracts of three-part beggarticks (Bidens tripartita) were prepared using ultrasonic assisted micelle-mediated extraction method (UAMME). Different kind of surfactants and WPC (whey protein concentrate) were applied. In the B. tripartita extracts twenty polyphenols were identified by UPLC-DAD-MS. Both aqueous and UAMME extracts mainly contained chlorogenic acid, caftaric acid and its derivatives as well as luteolin 7-O-glucoside. The luteolin was extracted with Rokanol B2 and Triton X-100. Furthermore, antioxidative properties of the extracts were analyzed with two methods: reactions with di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium (DPPH) reagent and Follin's method. The DPPH radical scavenging by micellar extracts was in general comparable with the antioxidant activity of conventional extracts. The most active was sample with Tego Care CG90, reducing about 73% of the radical. Obtained results confirmed that the UAMME might be an alternative method, to the liquid-liquid or solid-liquid extraction, of obtaining specified extracts rich in active compounds. Selecting a suitable surfactant may thus provide the expected composition of the extract.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 543-548
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biological response of CH/Ag coatings deposited on niti shape memory alloy
Autorzy:
Goryczka, Tomasz
Salwa, Piotr
Mazurek, Urszula
Gola, Joanna
Sikora, Bartosz
Skubis, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/285577.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Źródło:
Engineering of Biomaterials; 2019, 22, no.153; 27
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-9 z 9

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