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Wyszukujesz frazę "Sawicka, Hanna" wg kryterium: Autor


Wyświetlanie 1-2 z 2
Tytuł:
Combined optimisation and MCDA based solution of the tram depot location problem
Autorzy:
Sawicki, Piotr
Sawicka, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/2067408.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
tram depot location
MCDA
multiple criteria decision aid
combinatorial optimisation
AHP method
AHORNsimple application
zajezdnia tramwajowa
lokalizacja zajezdni
kryteria w podejmowaniu decyzji
optymalizacja
metoda AHP
Opis:
This paper deals with an issue of technical facilities location in a public transport system. The decision problem is formulated as a selection of the most advantageous alternative, i.e. the location of a new tram depot among the already existing facilities of this type. The selection is preceded by the evaluation of the alternatives. The assessment is not a trivial task, because there are many groups of interest with usually contradictory points of view. Therefore, the evaluation of the new tram depot locations should represent different aspects, e.g., economical, technical, environmental, and organizational. To handle such a complex decision problem the authors propose a methodology, which is a composition of the optimisation and multiple criteria evaluation techniques. The developed methodology is experimentally applied to the selection of one out of five tram depot locations in the public transport system of the city of Poznan, Poland. All the computational experiments are performed by means of optimization and multiple criteria decision aiding (MCDA) methods and tools, i.e. a linear optimization engine Solver Premium Platform and AHP method with its application AHORNsimple. The calculations are the basis for recommending the location of a new depot in the central part of the transport system network, which is a reasonable solution taking into account, e.g. the proximity of the main railway line, the possibility of triple distribution of the transport means from depot. The proposed methodology of the decision problem solution gives also an opportunity to create the hierarchy of considered tram depot locations as well as to compare the position in the ranking of the best solution with the existing one. Since the proposed methodology assumes the selection of the most suitable MCDA method to the problem under consideration and the decision maker’s preferences, it guarantees that the result of analysis becomes reliable and the decision aiding process is credible.
Źródło:
Archives of Transport; 2021, 60, 4; 88--103
0866-9546
2300-8830
Pojawia się w:
Archives of Transport
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
Autorzy:
Horwacik, Irena
Durbas, Małgorzata
Boratyn, Elżbieta
Sawicka, Anna
Węgrzyn, Paulina
Krzanik, Sylwia
Górka, Anna
Drożniak, Joanna
Augustyniak, Ewa
Kowalczyk, Aleksandra
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1038977.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
GD2 ganglioside
microarray
14G2a
neuroblastoma
mimitin
Opis:
Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 423-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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