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    Tytuł:
    Dont we overestimate drug allergies in children?
    Autorzy:
    Podlecka, Daniela
    Jerzyńska, Joanna
    Brzozowska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/21375381.pdf
    Data publikacji:
    2023-11-27
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    hypersensitivity
    drug allergy
    children
    local anesthetics
    nonsteroidal anti-inflammatory drugs
    β-lactam antibiotics
    Opis:
    Objectives On average about 10% of parents report hypersensitivity to at least 1 drug in their children. After diagnosis process a few of these reactions are being confirmed as drug hypersensitivity reactions. The aim of the study was to assess the real-life prevalence of drug hypersensitivity in children based on drug provocation tests. Material and Methods The authors included 113 children, aged 4–18 years, referred to Pediatrics and Allergy Clinic in Łódź, Poland, due to incidence of adverse reaction during treatment. Medical history regarding allergies to drugs was taken in accordance to the form developed by the United States Food and Drug Administration Adverse Event Reporting System. Skin prick tests, intradermal test and drug provocation test were performed in all patients. Results In all 113 patients suspected of drug allergy, after all diagnostic procedures, the authors proved IgE-mediated allergy to β-lactams, nonsteroid anti-inflammatory drugs, local anesthetics in 19 patients (16.8%). Previous history of allergy was a risk factor for drug allergy in studied patients (p = 0.001). The most frequent symptoms of allergy were urticaria and erythematous papular rash. Conclusions Drug allergy is a difficult problem in the practice of a doctor and is difficult to diagnose, especially in the pediatric population. It seems that too often isolated symptoms reported during infection or disease are taken as a symptom of drug allergy, and not as a symptom resulting from the course of the disease.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 5; 632-642
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    When toothache results in asthma diagnosis
    Autorzy:
    Rahimo, Maryam
    Jerzyńska, Joanna
    Brzozowska, Agnieszka
    Podlecka, Daniela
    Powiązania:
    https://bibliotekanauki.pl/articles/2085656.pdf
    Data publikacji:
    2022-02-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    children
    asthma
    anaphylaxis
    drug allergy
    local anesthetic agents
    dyspnea
    Opis:
    Local anesthetics (LA) have been used for a wide variety of procedures over the years due to their analgesic effect. These drugs have been seen to cause adverse events in the pediatric population, but an actual allergy must be in question. A case of an apparent hypersensitivity reaction to LA used in the setting of dental procedures in a 14.5-year-old girl with a forgotten history of asthma was reported and medical documentation review was performed. After treatment with LA during several dental procedures, the patient presented the shortness of breath, malaise and fainting, which then resolved spontaneously. After proper history taking, and skin and provocation tests, the patient was diagnosed with bronchial asthma and emotional sensitivity. The patient’s recommendation included using an antihistamine and controlling her asthma before the use of LA, and administering the drug in a supine position. It is essential to consider all possible etiologies of an adverse event after using drugs in the pediatric population and to perform proper testing before making the diagnosis of a drug allergy.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 107-110
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prenatal polyunsaturated fatty acids and atopic dermatitis and food allergy in children from Polish Mother and Child Cohort study
    Autorzy:
    Jerzyńska, Alexandra
    Polańska, Alicja
    Trafalska, Elżbieta
    Jankowska, Agnieszka
    Podlecka, Daniela
    Brzozowska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/21375686.pdf
    Data publikacji:
    2023-09-07
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    polyunsaturated fatty acids
    omega-6
    omega-3
    food allergy
    atopic dermatitis
    prospective cohort
    Opis:
    Objectives Polyunsaturated fatty acids (PUFAs) are involved both in immune system regulation and inflammation. The aim of this prospective study was to evaluate the association between maternal dietary intake of PUFAs during pregnancy and atopic dermatitis (AD) and food allergy (FA) in their children up to 7–9 years of age. Material and Methods The study population consists of 557 mother–child pairs from the Polish Mother and Child Cohort (REPRO_PL). Based on the Food Frequency Questionnaire completed between the 20–24th weeks of pregnancy, n-3 and n-6 PUFAs as well as n-6:n-3 fatty acid ratio were estimated using food composition tables. Children’s health examinations at the age of 1, 2, and 7–9 years were performed by an allergist. Generalized estimating equations were performed in order to assess the prevalence of AD and FA at 3 time points. Independent variables in the equation were n-3, n-6 PUFAs and n-6:n-3 PUFAs ratio. In addition multivariate models were performed to assess the association of PUFAs with AD and FA. Results The prevalence of AD was 37%, 26% and 21% and FA 26%, 22% and 22% at age of 1, 2 and 7–9 years, respectively. Higher n-6:n-3 fatty acid ratio correlated with higher prevalence of AD at age of 7–9 years (p < 0.07). In multivariate model n-6 PUFAs were significantly associated with increased risk of persistent FA (OR = 1.5, 95% CI: 1.1–2.1). Conclusions These results may contribute to the existing knowledge on the impact of maternal diet during pregnancy on children’s optimal health, however further studies are needed before drawing conclusions and creating clinical practice guidelines.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2023, 36, 3; 428-436
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Exhaled volatile organic compounds (VOCs) for prediction of asthma exacerbation in children
    Autorzy:
    Gmachowska, Katarzyna
    Podlecka, Daniela
    Bonikowski, Radosław
    Majak, Paweł
    Kapka, Karolina
    Jerzyńska, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/45905286.pdf
    Data publikacji:
    2024-09-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    children
    asthma
    atopy
    lung function tests
    asthma monitoring
    VOCs
    Opis:
    Objectives To find possible relationship between asthma exacerbation and metabolomic profile of airways, assessed by non-invasive method – free volatile organic compounds (VOCs) in exhaled air in children. Material and Methods The study included 80 children aged 4–18 years with asthma: 42 children with a min. 3 asthma exacerbations in the past 12 months, and 38 children without a history of exacerbations in the past year. During the study visit, each patient was examined, medical history (including information regarding atopy and eosinophil blood count) was taken, spirometry and fractional exhaled nitric oxide (FeNO) were tested, an exhaled air sample was taken to test for the presence of VOCs, and the patient also completed standardized form – Asthma Control Questionnaire. Volatile organic compounds were measured by combined gas chromatography coupled to mass spectrometry. Results The obtained results of VOCs were correlated with the history of the disease. The 2 gas profiles were defined and they formed 2 clinically distinct clusters (p = 0.085). Cluster 2 was characterized for children with a higher number of bronchial asthma exacerbations and worse lung function parameters (predicted percentage forced expiratory volume in 1 s [FEV1] [p = 0.023], FEV1/ forced vital capacity ratio [FVC] [p = 0.0219]). The results were independent of the age, sex, BMI, atopy (house dust mite allergy) and eosinophil blood count. Conclusions The study findings suggest that a relative group of gases may be a useful predictor of having asthma exacerbations in children. Additionally, a single FeNO value was unlikely to be clinically useful in predicting asthma exacerbations in children. The VOCs profile reflecting the metabolism of the airway epithelium and local microbiota was associated with the course of asthma, which strongly justifies further prospective validation studies.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2024, 37, 3; 351-359
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Duration of breastfeeding and psychomotor development in 1-year-old children – Polish Mother and Child Cohort Study
    Autorzy:
    Stelmach, Iwona
    Kwarta, Paulina
    Jerzyńska, Joanna
    Stelmach, Włodzimierz
    Krakowiak, Jan
    Karbownik, Michał
    Podlecka, Daniela
    Hanke, Wojciech
    Polańska, Kinga
    Powiązania:
    https://bibliotekanauki.pl/articles/2161996.pdf
    Data publikacji:
    2019-04-03
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    children
    neurodevelopment
    duration of breastfeeding
    child psychomotor development
    Bayley Scales of Infant and Toddler Development
    1-year-old children
    Opis:
    Objectives The objective of this study was to evaluate the association between breastfeeding duration and child neurodevelopment based on the Polish Mother and Child Cohort Study. Material and Methods The current analysis included 501 mother–child pairs. The analysis evaluating the association between the length of breastfeeding and child neurodevelopment considered the following variables: maternal age and body mass index, weight gain during pregnancy, parental level of education, marital status, socioeconomic status, child gender, birthweight, type of delivery, preterm delivery, pre- and postnatal exposure to tobacco constituents and child day care attendance. Psychomotor development was assessed in 1-year-olds on the Bayley Scales of Infant and Toddler Development. Results The length of breastfeeding correlated positively with maternal age at delivery (ρ = 0.13), maternal and paternal level of education (ρ = 0.2 and ρ = 0.14 respectively), birthweight (ρ = 0.1) and marital status (ρ = 0.16) (p < 0.05). A negative correlation between the length of breastfeeding and maternal smoking status during the first year after delivery (ρ = –0.19) and weight gain during pregnancy (r = –0.1) was observed (p < 0.05). The association between the duration of breastfeeding and child development was not statistically significant in the model with the inclusion of confounding variables. A significant association between language development and maternal level of education (p = 0.004), gender of the child (p = 0.0007) and maternal weight gain during pregnancy (p = 0.01) was found. A negative association between cognitive development and maternal salivary cotinine during pregnancy (p = 0.03) and a negative association between motor development and maternal smoking status during the first year after delivery (p = 0.007) were also found. Conclusions This study found no significant association between the duration of breastfeeding and child development after adjustment for confounders. Int J Occup Med Environ Health. 2019;32(2):175–84
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2019, 32, 2; 175-184
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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