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    Wyświetlanie 1-15 z 15
    Tytuł:
    Culture and media systems: Interview with Peter Gross
    Autorzy:
    Głowacki, Michał
    Gross, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/471248.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Komunikacji Społecznej
    Opis:
    Interview with Peter Gross
    Źródło:
    Central European Journal of Communication; 2014, 7, 2(13); 291-294
    1899-5101
    Pojawia się w:
    Central European Journal of Communication
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Media Culture Kaleidoscopes: The Core of a Media System - Interview with Professor Peter Gross
    Autorzy:
    Głowacki, Michał
    Gross, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/16648095.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Komunikacji Społecznej
    Tematy:
    media culture
    interview
    Źródło:
    Central European Journal of Communication; 2023, 16, 1(33); 133-136
    1899-5101
    Pojawia się w:
    Central European Journal of Communication
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of the manufacturing possibility of thin-walled robotic portals for conveyance workplaces
    Autorzy:
    Michalik, Peter
    Dobranský, Jozef
    Hrabovský, Leopold
    Petruš, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/102021.pdf
    Data publikacji:
    2018
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    robotic
    thin-walled
    CNC machine center
    CAM application
    cienkie ściany
    centrum maszyn CNC
    aplikacja CAM
    Opis:
    The paper discusses evaluation of machining solutions for oversized thin-walled robotic portal component for conveyance workplaces. The following portal CNC machining centers have been selected. Firstly, a FSGC 300 “portal type” portal was proposed, with a 50000 mm “X” axis and Heidenhain control system, the second portal was a DMU 340 portal with the maximum axis “X” of 6000 mm and Siemens Sinumerik control system and the last portal was the VF-10 / 40 one, with the maximum axis “X” of 3048 mm and Fanuc control system. Further, the method of fixing a thin-walled robotic portal is designed and individual options are evaluated for their economy. The CAM software application used for programming the production was SolidWorks.
    Źródło:
    Advances in Science and Technology. Research Journal; 2018, 12, 1; 338-345
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The impact of the COVID-19 outbreak on aviation
    Autorzy:
    Kešeľová, Michaela
    Šváb, Patrik
    Korba, Peter
    Hovanec, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/1925930.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    aviation
    COVID-19
    outbreak
    impact
    lotnictwo
    epidemia
    skutki
    Opis:
    Purpose: The purpose of this article is the need to document the impact of this global pandemic on global air transport. The aim is to present the impact of the pandemic, not only on air transport in general, but also on individual airports and airlines. Design/methodology/approach: The article was prepared after a thorough analysis of the available resources dealing with this global pandemic. It required a thorough examination of the reports, conclusions and individual statements of the leading representatives of the airline community, as well as statements of the European Commission. Findings: The result of the article is a worrying assumption that this pandemic will have a devastating impact on air transport. Many airlines will not be able to continue operating without the financial support of third parties. However, this will have a more significant impact on air transport in the future, as this impact will depend mainly on the duration of the restrictive measures. Research limitations/implications: The limits of this article are mainly the changing statistics of people infected with the coronavirus. The graphs and links in the text correspond to coronavirus and infection statistics as of April 2020. Practical implications: In practice, this global pandemic will have particularly negative consequences on air transport. Several airlines have already declared bankruptcy or, in the best cases, asked the government for help in the form of funds. The real consequences of the pandemic will be known in the future, following the lifting of restrictive measures. However, according to the authors’ assumption, air transport will have to make a significant effort to get back to the position it was in before this pandemic. Originality/value: The article presents a comprehensive summary and analysis of the current state of air traffic in the time of the global coronavirus pandemic. The value of the article will be especially appreciated by the aviation community.
    Źródło:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska; 2020, 148; 253-262
    1641-3466
    Pojawia się w:
    Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    GAEC 5 Direct Payment System Implementation Challenges in Slovakia
    Autorzy:
    Pipíšková, Petra
    Muchová, Zlatica
    Dežerický, Dávid
    Michal, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/24201744.pdf
    Data publikacji:
    2023
    Wydawca:
    Polskie Towarzystwo Inżynierii Ekologicznej
    Tematy:
    water erosion
    conditionality
    GAEC5
    GSAA
    CAP EU
    DMR 3.5
    DMR 5.0
    soil loss
    Opis:
    The Agricultural Payments Agency (supervisory and registry authority) of the Slovak Republic has announced an erosion hazard layer to meet the requirements of GAEC5 (Minimising soil erosion. Limit soil erosion by putting in place suitable practical measures). If a farmer fails to observe the layer data, they will be fined and might lose access to direct subsidies (also known as direct payments). The layer that has been announced raises a number of questions and concerns amongst beneficiaries of direct subsidies and users of land parcels. For instance, with the Pastuchov land parcel, the uncertainties associated with the application of GAEC5 were raised. A comparison of the water erosion layer commitment for 2023 with the erosion calculated by the Universal Soil Loss Equation (USLE) method based on the Digital Relief Model (DRM) generated from airborne laser scanning has confirmed the uniformity in all classified categories of water erosion over a 65% land parcel area. The situation of the land user has been diminished (i.e. they have to comply with GAEC5 even when there is no reason to) over 11% of the area. The situation of the land user has improved over 24% of the area (i.e. they do not have to comply with the conditions even when there is reason to). This paper describes the problems and outlines the possibilities for the necessary adjustment of compliance with the GAEC5 conditions in Slovakia.
    Źródło:
    Journal of Ecological Engineering; 2023, 24, 6; 109--118
    2299-8993
    Pojawia się w:
    Journal of Ecological Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Possibilities of Tetrahedrite Separation from Polymetallic Ore
    Możliwość separacji tetraedrytu z rud polimetalicznych
    Autorzy:
    Marcin, Michal
    Sisol, Martin
    Varga, Peter
    Brezani, Ivan
    Matasovsky, Michal
    Oravcova, Andrea
    Powiązania:
    https://bibliotekanauki.pl/articles/318153.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Przeróbki Kopalin
    Tematy:
    flotation
    shaking table
    recovery
    tetrahedrite
    flotacja
    stół koncentracyjny
    odzysk
    tetraedryt
    Opis:
    Using the separation methods, the tetrahedrite concentrate, which contains multiple elements, was obtained from the tetrahedrite ore. We focused mainly on copper, but also on iron and antimony. Ore also contains undesirable elements such as arsenic or mercury. The aim of this paper is an efficient separation of the utility components. Gravity separation and flotation was used. The first processing step was gravity separation on shaking table the second step was froth flotation in flotation column.
    Stosując metody separacji otrzymano z tetraedrytu koncentrat który zawiera wiele pierwiastków, Autorzy skupili się głównie na miedzi, żelazie i antymonie. Ruda zawiera również niepożądane pierwiastki, takie jak arsen lub rtęć. Celem przedstawionej pracy jest efektywne oddzielenie składników użytecznych. Zastosowano separację grawitacyjną i flotację. Pierwszym etapem przetwarzania było oddzielenie grawitacyjne na stole wytrząsającym, drugim etapem była flotacja pianowa w kolumnie flotacyjnej.
    Źródło:
    Inżynieria Mineralna; 2020, 2, 1; 105-108
    1640-4920
    Pojawia się w:
    Inżynieria Mineralna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Beneficiation of Talc-Magnesite Ore with Cu-Co Mineralization
    Wzbogacenie rudy talku-magnezu z mineralizacją Cu-Co
    Autorzy:
    Brezani, Ivan
    Sisol, Martin
    Marcin, Michal
    Sykora, Maros
    Matasovsky, Michal
    Varga, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/318024.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Przeróbki Kopalin
    Tematy:
    przeróbka minerałów
    kobalt
    kobaltyt
    talk
    wzbogacanie
    mineral processing
    cobalt
    cobaltite
    talc
    beneficiation
    Opis:
    Magnesite ore with a low chalcopyrite – cobaltite mineralization was subjected to a series of separations designed to evaluate the possible concentration of the two accessory minerals. Although the Cu-Co grade in the ore (> 0.01% Co, > 0.1% Cu) is significantly lower than the typical economic grades, content of the main valuable mineral for which the ore is mined and processed in combination with a listing of cobalt as a critical raw material, coupled with their higher price might compensate for the additional beneficiation stages. The ore was first crushed and subsequently classified to -100 μm and +100 -400 μm size fractions. The fine fraction was upgraded by froth flotation processing in laboratory froth flotation cell. The coarser fraction was processed in several separation stages including gravity separation on shaking table, magnetic separation and corona electrostatic separation. The same procedure was also repeated with a higher-grade sample as a verification of the procedures. Preliminary results suggest that the accessory minerals can be separated from the talc-magnesite ore and individual mineral concentrates with about 19% Co and 28% Cu were prepared. However, further work must be done to achieve desirable recoveries for the processing to be economically viable.
    Ruda magnezu o niskiej mineralizacji chalkopirytu – kobaltytu została poddana serii separacji mających na celu ocenę możliwego uzysku dwóch minerałów towarzyszących. Chociaż zawartość Cu-Co w rudzie (> 0,01% Co,> 0,1% Cu) jest znacznie niższy niż wartości opłacalne ekonomicznie, zawartość głównego cennego minerału (magnezytu) , dla którego ruda jest wydobywana i przetwarzana w połączeniu z zawartością kobaltu jako surowca krytycznego może zrekompensować koszt dodatkowych etapów wzbogacania. W pierwszym etapie rudę kruszono, a następnie klasyfikowano do frakcji o wielkości -100 μm i +100 -400 μm. Drobną frakcję poddawano flotacji pianowej w laboratoryjnej maszynce flotacyjnej. Grubsza frakcja była przetwarzana w kilku etapach, w tym separacja grawitacyjna na stole wstrząsanym, separacja magnetyczna i separacja elektrostatyczna. Ta sama procedura została powtórzona z próbką o wyższych zawartościach. Wstępne wyniki sugerują, że minerały towarzyszące można oddzielić od rudy talku i magnezytu i zyskano koncentraty mineralne z zawartością około 19% Co i 28% Cu. Jednakże konieczne są dalsze prace w celu osiągnięcia pożądanych uzysków, aby przetwarzanie było opłacalne ekonomicznie.
    Źródło:
    Inżynieria Mineralna; 2019, 21, 1; 141-144
    1640-4920
    Pojawia się w:
    Inżynieria Mineralna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modelling and Simulation the Value Stream Mapping – Case Study
    Autorzy:
    Pekarcíková, Miriam
    Trebuňa, Peter
    Kliment, Marek
    Král, Štefan
    Dic, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/1841410.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    value stream mapping
    Kanban
    model
    simulation
    Opis:
    Digitization in the production area represents the integrated planning and management of production and logistics systems and networks based on digital models, methods, and tools, which are built on a common flexible information and communication platform. Currently known and used Lean tools need to be dynamized and oriented to the creation of digital business, where digital models can be heterogeneous, respectively usable in several projects. One of these possibilities is the use of the Lean production method – Value Stream Mapping, the potential of which in the context of the above mentioned is great. The aim of the presented article is based on Gemba analysis of the production process to process the value stream in the environment of the software tool TX Plant Simulation for the needs of flexible reflection on changes in various parameters within the value stream. The case study carried out under this article aims, among other things, to highlight the importance of combining simple Lean Production tools with software in finding, testing, and designing alternative solutions. The potential of using the processed model was also processed for the needs of digitization of business processes in the future.
    Źródło:
    Management and Production Engineering Review; 2021, 12, 2; 107-114
    2080-8208
    2082-1344
    Pojawia się w:
    Management and Production Engineering Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Creation of More Efficient Work Environment through the New Design of the Automatic Robotic Assembly Station
    Autorzy:
    Daneshjo, Naqib
    Sabadka, Dušan
    Malega, Peter
    Dzuro, Matúš
    Jankovič, Michal
    Powiązania:
    https://bibliotekanauki.pl/articles/2201791.pdf
    Data publikacji:
    2022
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    automotive industry
    innovation
    automatic assembly line
    efficiency
    flexible production
    Opis:
    This paper deals with the design of an automatic robotic assembly station with the aim of creating a new and more efficient working environment in the production process on the assembly line and thus contributing to meeting customer requirements. The paper presents theoretical knowledge on innovations and on the innovation process. The introduction of an automated workplace will lead to a higher production line than it follows from evaluation of data collected over time. The result of the work is a proposal to create a new and more efficient work environment
    Źródło:
    Advances in Science and Technology. Research Journal; 2022, 16, 4; 74--84
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanochemical Reduction of Synthetic Sulphidic Copper-Bearing Minerals in an Industrial Scale
    Redukcja mechanochemiczna syntetycznych minerałów siarczkowo-miedziowych w skali przemysłowej
    Autorzy:
    Tesinsky, Matej
    Balaz, Matej
    Rajnak, Michal
    Kanuchova, Maria
    Balaz, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/319061.pdf
    Data publikacji:
    2019
    Wydawca:
    Polskie Towarzystwo Przeróbki Kopalin
    Tematy:
    mechanochemia
    redukcja mechaniczno-chemiczna
    mielenie wysokoenergetyczne
    siarczki
    mechanochemistry
    mechanochemical reduction
    high-energy milling
    sulphides
    Opis:
    In this paper the mechanochemical reduction of binary sulphides chalcocite (Cu2S) and covellite (CuS) by elemental iron were investigated. The composition and properties of nano-powders prepared by high-energy milling were analyzed by X-ray diffraction, X-ray photoelectron spectroscopy and magnetic measurements. The XRD results showed that in case of chalcocite Cu2S the reaction takes place until 360 minutes, as no elemental iron, could be identified afterwards. In case of covellite CuS, after 480 minutes of mechanochemical reduction, a significant amount of non-reacted elemental iron could still be observed. The investigation of magnetic properties reveals significant decrease of saturation magnetization as a result of milling. XPS results showed a significant surface oxidation in both systems. Unlike the conventional high-temperature reduction of chalcocite and covellite, the mechanochemical reduction is fast and ambient temperature and atmospheric pressure are sufficient for its propagation.
    W artykule przedstawiono wyniki badań nad mechaniczno-chemiczną redukcję dwusiarczkowych chalkozynów (Cu2S) i kowelinu (CuS) przez żelazo pierwiastkowe. Skład i właściwości nanoproszków wytworzonych przez mielenie wysokoenergetyczne analizowano metodą dyfrakcji rentgenowskiej, rentgenowskiej spektroskopii fotoelektronowej i pomiarów magnetycznych. Wyniki XRD wykazały, że w przypadku chalkozynu Cu2S reakcja zachodzi do 360 minut, ponieważ później nie można zidentyfikować żelaza pierwiastkowego. W przypadku kowelinu CuS, po 480 minutach redukcji mechaniczno-chemicznej, można było zaobserwować znaczną ilość nieprzereagowanego żelaza pierwiastkowego. Badanie właściwości magnetycznych ujawnia znaczne zmniejszenie podatności magnetycznej w wyniku rozdrabniania. Wyniki XPS wykazały znaczne utlenienie powierzchni w obu przypadkach. W przeciwieństwie do konwencjonalnej wysokotemperaturowej redukcji chalkozynu i kowelinu, redukcja mechano-chemiczna jest szybka, a temperatura otoczenia i ciśnienie atmosferyczne są wystarczające do jej propagacji.
    Źródło:
    Inżynieria Mineralna; 2019, 21, 1; 135-140
    1640-4920
    Pojawia się w:
    Inżynieria Mineralna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Influence of Material Configuration of Fibre-Metal Laminates with Alumina Core on Flexural Strength
    Autorzy:
    Frankiewicz, Mariusz
    Karoluk, Michał
    Dziedzic, Robert
    Timmel, Tristan
    Scholz, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/24201172.pdf
    Data publikacji:
    2022
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Lotnictwa
    Tematy:
    fibre-metal laminates
    flexural strength
    fatigue
    composite materials
    Opis:
    Fibre metal laminates (FMLs) consisting of layers made of PA6 polyamide prepregs reinforced with glass and carbon fibres and an aluminium alloy core are the new variant of the other types used by aerospace FML materials such as GLARE or CARALL. By using a thermoplastic matrix, they can be shaped by stamping processes, which allows for a more efficient production process than classical laminating methods such as vacuum bagging. In addition to the improved impact energy absorption efficiency, the metallic core can be utilised to effectively bond the composite part to adjacent metallic structures. This article presents the influence of the material configuration of fibre-metal laminates consisting of continuous fibre-reinforced thermoplastic outer layers integrated with a layer of metallic aluminium alloy inserts - a number of layers, type and direction of reinforcing fibres - on the static and fatigue flexural properties. In this study, eight laminate configurations were prepared using a one-step variothermal consolidation process. The results showed that in the three-point flexural fatigue test, the samples exceeded 106 cycles at stresses <30% of the static bending strength. Laminates with predominantly longitudinally reinforced layers showed the highest fatigue strength among the FML samples analysed. The type of reinforcing fibres and the number of layers were less affected on the analysed mechanical properties.
    Źródło:
    Fatigue of Aircraft Structures; 2022, 14; 18--28
    2081-7738
    2300-7591
    Pojawia się w:
    Fatigue of Aircraft Structures
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Case Study: Testing the Overall Efficiency of Equipment in the Production Process in TX Plant Simulation Software
    Autorzy:
    Pekarčíková, Miriam
    Trebuna, Peter
    Kliment, Marek
    Trojan, Jozef
    Kopec, Ján
    Dic, Michal
    Kronová, Jana
    Powiązania:
    https://bibliotekanauki.pl/articles/2201181.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    process
    simulation
    efficiency
    TX plant simulation
    OEE
    energy consumption
    Opis:
    The article deals with a widely used method of measuring the overall efficiency of equipment (OEE), which in combination with technologies and software tools is gaining in importance. The overall efficiency of OEE equipment is a key performance metric for machines and equipment to identify hidden capacities and increase production productivity. The intensification of Industry 4.0 in traditional manufacturing companies supports and creates the conditions for their transformation into a smart factory. The integration of intelligent machines and devices with complex human-machine communication network systems requires a new direction in measuring and increasing OEE. Mass customization, resp. personalization of production raises a high need to monitor, improve and further maintain productivity. The aim of the article is to create a simulation model of the production process and test the energy consumption of selected equipment using TX Plant Simulation software with a proposal of measures to increase the OEE of the company.
    Źródło:
    Management and Production Engineering Review; 2023, 14, 1; 34--42
    2080-8208
    2082-1344
    Pojawia się w:
    Management and Production Engineering Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impact of pilots’ tiredness on the outcome of psychological testing
    Autorzy:
    Socha, Vladimir
    Hanakova, Lenka
    Freigang, Michal
    Kraus, Jakub
    Stojic, Slobodan
    Socha, Lubos
    Hanak, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/375429.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
    Tematy:
    human factors
    fatigue
    psychological testing
    performance
    pilot
    flight symulator
    wskaźniki ludzkie
    zmęczenie
    test psychologiczny
    wydajność
    symulator lotu
    Opis:
    Presented work is primarily oriented on the experimental verification of the influence of fatigue on the psychological condition of the flying personnel, using psychological and performance tests. For the evaluation of a pilot performance, the 24 hours experiment was conducted. In total, eight subjects participated in the experimental measurements. Eight participants went through several tests, including simulator flights, to investigate the effects of the fatigue on the results of psychological measurements. Measurements included workload evaluation, using NASA task load evaluation concept and performance testing, using the so-called OR-test. Significant statistical differences between measurements performed during 24 hours were not found in the case of NASA task load Scores. In the case of OR-test, Friedman ANOVA and subsequent post-hoc analysis show that the greatest decrease in performance was observed in approximately 22 hours of wakefulness, i.e. approximately in half of the measuring process. The concept of 24-hour measurements for the quantification of fatigue is not commonly used yet as well as objectivization using performance testing. As the apparent effect of fatigue is mainly on performance testing results, it can be argued that this work could serve as a basis for further studies on fatigue. Also, it could serve as a support for introducing new pilots' psychological testing procedures in the future, which could contribute to current efforts to improve aviation safety.
    Źródło:
    Transport Problems; 2019, 14, 2; 55-67
    1896-0596
    2300-861X
    Pojawia się w:
    Transport Problems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acoustic emission of corroded weldments during tensile test
    Autorzy:
    Sustr, Michal
    Zacal, Jaroslav
    Dostal, Peter
    Cerny, Oldrich
    Pristavka, Miroslav
    Dobrocky, David
    Gaspar, Stefan
    Pasko, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/409757.pdf
    Data publikacji:
    2019
    Wydawca:
    STE GROUP
    Tematy:
    weld joint
    hot-dip galvanising
    corrosion
    acoustic emission
    protection
    Opis:
    The article deals with the use of acoustic emission to identify the formation of cracks during the mechanical loading in the corrosive attacked weldment S235JR+N. The experiment includes the methodology for continual record of emissive signals, data analysis and monitoring of material response to monitor mechanical stress effect in real time. There is possibility to observe response of corrosive degraded samples in real time during mechanical stress through the suitably designed methodology of detection, process and analysing of acoustic emission signals. It is possible to gain new information about processes rising inside the material by this way of data measurement. The signals of acoustic emission can be used as the way of identification for the micro cracks rising in the inner and also external structure of effortful materials.
    Źródło:
    Management Systems in Production Engineering; 2019, 4 (27); 211-216
    2299-0461
    Pojawia się w:
    Management Systems in Production Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
    Autorzy:
    Król, Magdalena
    Galicki, Michał
    Grešner, Peter
    Wieczorek, Edyta
    Jabłońska, Ewa
    Reszka, Edyta
    Morawiec, Zbigniew
    Wąsowicz, Wojciech
    Gromadzińska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038523.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    estrogen receptor
    antioxidant enzymes
    gene expression
    breast cancer tissue
    Opis:
    Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 51-57
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-15 z 15

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