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    Wyświetlanie 1-6 z 6
    Tytuł:
    The effect of quercetin on oxidative DNA damage and myelosuppression induced by etoposide in bone marrow cells of rats
    Autorzy:
    Papież, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1039316.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    quercetin
    etoposide
    myelosuppression
    oxidative DNA damage
    comet assay
    Opis:
    There is increasing evidence for the existence of an association between the presence of etoposide phenoxyl radicals and the development of treatment-related acute myeloid leukemia (t-AML), which occurs in a few percent of patients treated with this chemotherapeutic agent. The most common side effect caused by etoposide is myelosuppression, which limits the use of this effective drug. The goal of the study was to investigate the influence of antioxidant querectin on myelosuppression and oxidative DNA damage caused by etoposide. The influence of quercetin and/or etoposide on oxidative DNA damage was investigated in LT-12 cell line and bone marrow cells of rats via comet assay. The effect of quercetin on myelosuppression induced by etoposide was invetsigated by cytological analysis of bone marrow smears stained with May-Grünwald-Giemsa stain. Etoposide caused a significant increase in oxidative DNA damage in bone marrow cells and LT-12 cell line in comparison to the appropriate controls. Quercetin significantly reduced the oxidative DNA damage caused by etoposide both in vitro and in vivo. Quercetin also significantly protected against a decrease in the percentage of myeloid precursors and erythroid nucleated cells caused by etoposide administration in comparison to the group treated with etoposide alone. The results of the study indicate that quercetin could be considered a protectively acting compound in bone marrow cells during etoposide therapy.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 1; 7-11
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The antioxidant quercetin protects HL-60 cells with high myeloperoxidase activity against pro-oxidative and apoptotic effects of etoposide
    Autorzy:
    Papież, Monika
    Krzyściak, Wirginia
    Powiązania:
    https://bibliotekanauki.pl/articles/1039217.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    apoptosis
    etoposide
    quercetin
    myeloperoxidase
    reactive oxygen species
    4-aminobenzoic acid hydrazide
    Opis:
    The protective action of quercetin against the pro-oxidant and apoptotic effect of etoposide was investigated in HL-60 cells with a high level of myeloperoxidase (MPO) activity and in cells treated with MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH). Quercetin significantly protected MPO-rich cells against the pro-oxidative (p<0.05) and apoptotic (p<0.05) effects of etoposide. Pre-treatment with ABAH abolished this protective influence of quercetin on apoptosis induced by etoposide but actually enhanced the action effect of quercetin against etoposide-generated reactive oxygen species (ROS) level by this cytostatic drug. Thus quercetin can protect HL-60 cells against the pro-oxidative activity of etoposide regardless of MPO activity.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 795-799
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Analysis of Mortality Changes in Selected European Countries in The Period 1960-2006
    Autorzy:
    Denkowska, Sabina
    Papież, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/465830.pdf
    Data publikacji:
    2010
    Wydawca:
    Główny Urząd Statystyczny
    Tematy:
    mortality
    graduated initial rate of mortality cluster analysis
    Opis:
    Demographic changes which took place in the 20th century clearly reveal progressive ageing of whole societies. This phenomenon influences the risk connected with calculating the products of insurance companies and pension funds, where calculated mortality is one of the most important factors. The paper presents the analysis of mortality changes in male and female populations in selected countries from Central Europe (the Czech Republic, Hungary, Poland and Slovakia) and from Western Europe (France, Italy, Spain and Sweden) in the period 1960-2006. The analysis of the mortality changes has been carried out with the use of variables proposed in 2007 by J. P. Morgan in his work Life Metrics - A toolkit for measuring and managing longevity and mortality risks. The data used for the analysis have been obtained from www.mortality.org. The van Broekhoven algorithm has been applied for smoothing crude mortality rates across different ages. The analysis of mortality changes in selected European countries in the period 1960-2006 has shown considerable differences in the changes of initial mortality rate. Apart from obvious differences in male and female mortality, significant differences in the dynamics of mortality between Western and Central European countries were revealed. The most significant differences in the change of graduated initial mortality rate have been observed for people above 40-45 from Central and Western European countries. The period of most striking disproportions in the change of graduated initial mortality rate were the years 1970-1990, which seems to be the result of the socioeconomic policy in Central European countries.
    Źródło:
    Statistics in Transition new series; 2010, 11, 3; 136-157
    1234-7655
    Pojawia się w:
    Statistics in Transition new series
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In Search of Hedges and Safe Havens in Global Financial Markets
    Autorzy:
    Wanat, Stanisław
    Śmiech, Sławomir
    Papież, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/465669.pdf
    Data publikacji:
    2016
    Wydawca:
    Główny Urząd Statystyczny
    Tematy:
    market regimes
    clustering methods
    copula
    DCC-GARCH
    Opis:
    The aim of the paper is to search for hedges and safe havens within three instrument classes: assets (represented by the S&P500 index), gold and oil prices, and dollar exchange rates. Weekly series of returns of all the instruments from the period January 1995 – June 2015 are analysed. The study is based on conditional correlations between the instruments in different market regimes obtained with the use of copula-DCC GARCH models. It is assumed that different market regimes will be identified by statistical clustering techniques; however, only conditional variances (without conditional covariances) will be taken into account. The reason for this assumption is connected with the fact that variances can be understood as market risk, and, as such, are a good indicator of market conditions. A considerable advantage of such an approach is the lack of need to determine the number of market regimes, as it is established by clustering quality measures. What is more, the methodology used in the paper makes it possible to treat the relations between instruments symmetrically. The results obtained in the study reveal that only dollar exchange rates can be treated as a (strong) hedge and a (strong) safe haven for other instruments, while gold and oil are a hedge for assets.
    Źródło:
    Statistics in Transition new series; 2016, 17, 3; 557-574
    1234-7655
    Pojawia się w:
    Statistics in Transition new series
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Potentiation of adipogenesis and insulinomimetic effects of a novel vanadium complex (N′-[(E)-(5-bromo-2oxophenyl)methylidene]-4methoxybenzohydrazide)oxido(1,10phenanthroline)vanadium(IV) in 3T3-L1 cells
    Autorzy:
    Kazek, Grzegorz
    Głuch-Lutwin, Monika
    Mordyl, Barbara
    Menaszek, Elżbieta
    Szklarzewicz, Janusz
    Gryboś, Ryszard
    Papież, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/93178.pdf
    Data publikacji:
    2019
    Wydawca:
    Państwowa Wyższa Szkoła Zawodowa w Tarnowie
    Tematy:
    vanadium complex
    phosphatases inhibition
    adipocytes
    adipogenesis
    glucose utilization
    kompleks wanadu
    inhibicja fosfataz
    adipocyt
    adipogeneza
    wykorzystanie glukozy
    Opis:
    Recent research on the action of vanadium compounds shows its important effect on adipogenesis processes and adipocyte function. On the basis of previous screening tests in cellular models, the novel vanadium complex (N′-[(E)-(5-bromo-2-oxophenyl)methylidene]4-methoxybenzohydrazide)oxido(1,10-phenanthroline)vanadium(IV) was selected for this study. This complex exhibits potent inhibition of tyrosine phosphatases, and differences in the degree of inhibition were observed particularly for phosphatases. A significant increase in intracellular lipid accumulation and proliferative effect on 3T3-L1 preadipocytes confirmed the ability of this complex to enhance adipogenesis. The insulinomimetic activity of the tested complex was also demonstrated in fully differentiated 3T3-L1 adipocytes, in which glucose utilization was potentiated. The obtained results support the hypothesis that vanadium complexes show promising possibilities for use as new therapeutic strategies for the treatment of type 2 diabetes.
    Źródło:
    Science, Technology and Innovation; 2019, 4, 1; 55-62
    2544-9125
    Pojawia się w:
    Science, Technology and Innovation
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cell-based screening for identification of novel vanadium complexes with multidirectional activity relative to cells associated with metabolic disorders
    Autorzy:
    Kazek, Grzegorz
    Głuch-Lutwin, Monika
    Modryl, Barbara
    Menaszek, Elżbieta
    Szklarzewicz, Janusz
    Gryboś, Ryszard
    Papież, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/93098.pdf
    Data publikacji:
    2019
    Wydawca:
    Państwowa Wyższa Szkoła Zawodowa w Tarnowie
    Tematy:
    vanadium complex
    cell-based screening
    anti-diabetic activity
    kompleks wanadu
    badanie przesiewowe oparte na komórkach
    aktywność przeciwcukrzycowa
    Opis:
    In this study, 110 newly synthesized vanadium complexes from different structural groups were screened in three cell-based models representing the main target tissues for anti-diabetic drugs. In glucose utilization in C2C12 myocyte experiments, 93% of vanadium complexes were shown to have equal or greater activity than bis(maltolato)oxovanadium(IV) (BMOV), the methyl analog of bis(ethylmaltolato)oxovanadium(IV) (BEOV) which has been tested in clinical trials. Moreover, 49% and 50% of these complexes were shown to have equal or greater activity than BMOV in lipid accumulation in 3T3-L1 adipocytes and insulin secretion in RINm5F beta cell experiments, respectively. These results were the basis for the selection of compounds for the subsequent steps in the characterization of anti-diabetic properties. This study provides strong support for the application of screening cell-based assays with a phenotypic approach for the discovery of novel anti-diabetic drugs from the vanadium complex class. This is especially desirable due to the multiple and not fully defined mechanisms of action vanadium compounds.
    Źródło:
    Science, Technology and Innovation; 2019, 4, 1; 47-54
    2544-9125
    Pojawia się w:
    Science, Technology and Innovation
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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