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    Wyświetlanie 1-3 z 3
    Tytuł:
    Pancreatic cysts or pancreatic cystic neoplasms? An analysis of 145 cases
    Autorzy:
    Wlaźlak, Michał
    Oleśna, Aleksandra
    Danilewicz, Marian
    Strzelczyk, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1392895.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    pancreas
    cyst
    neoplasm
    surgery
    cancer
    Opis:
    Introduction: Detection of the frequency of pancreatic cystic lesions has increased in the recent years. The majority are pseudocysts, the remaining cysts are mainly neoplasms. Proven risk of malignancy affects intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). The aim of this study was to analyze clinical data of patients with pancreatic cysts or pancreatic cystic neoplasms on operate at Department of General and Transplant Surgery in the Barlicki Hospital in Lodz. Material and methods: In 2007-2016, there were 145 patients operated on at the Department of General and Transplant Surgery in Barlicki Hospital in Lodz, due to pancreatic cystic lesion. The type of operation, histopathological diagnosis and basic demographic data were analyzed. Results: Non-neoplastic cyst (mainly pseudocysts) was found in 66.9% of patients, neoplasms were detected in 33.1%. The mean age was significantly higher in patients with neoplasm than without neoplasm (57.06 years vs. 50.88 years, p=0.009). Neoplastic cyst occurred more frequently in women (68.75% of women, 31.25% of men, p=0.001). Malignant tumor was found in 14.58% of neoplasms cases and in 4.83% of all pancreatic cystic lesions. Conclusions: According to the analyzed material, there is a significant risk of malignancy in patients with pancreatic cyst. Neoplastic cysts are more common in women. Discussion: Pancreatic cystic tumors are treated mainly by resections of pancreas. In case of benign lesions with low risk of malignancy, there are less extensive operations performed, such as enucleations of lesions. There are no guidelines that could be used satisfactorily in follow up of patients with pancreatic cysts.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 5; 22-26
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Submandibular salivary gland tumors: a clinicopathologic review of 58 cases
    Autorzy:
    Oleśna, Aleksandra
    Kubiak, Marcin Jarosław
    Kaczmarczyk, Dariusz
    Morawiec-Sztandera, Alina
    Powiązania:
    https://bibliotekanauki.pl/articles/1399736.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    Fine-needle aspiration cytology
    Salivary gland neoplasm
    Salivary gland cancer
    Opis:
    Objectives: Salivary gland tumors account for only 3% of head and neck tumors. Their character is mostly benign, although tumors of the submandibular gland are more often malignant. The purpose of this article was to evaluate the structure of patients operated due to submandibular gland tumor and to study the correlation between fine-needle aspiration cytology and postoperative histopathological examination. Methodology: We retrospectively analyzed the medical records of all patients with submandibular gland tumors. The collected data included the demographic structure, results of preoperative fine-needle aspiration cytology and postoperative histopathologic examination. Results: We analyzed 58 patients – 35 women and 23 men with a mean age of 56.6 years. The character of the lesion was benign in 45 cases and malignant in 13. The most frequent benign tumors were pleomorphic adenoma, inflammatory tumor and Warthin’s tumor, whereas most common malignancies were carcinoma planoepitheliale and lymphoma . There were four recurrences. Moreover, we compared results of preoperative fine-needle aspiration cytology and histopathological findings. The accuracy of this examination was almost 83%; 56% of incorrect results involved nondetection of malignancies. The sensitivity and specificity in the diagnosis of those tumors were 58.3% and 97.5%, respectively. Conclusions: The most common types of submandibular gland tumors are pleomorphic adenoma and carcinoma planoepitheliale and lymphoma amongst malignancies. Fine-needle aspiration cytology is accurate in the preoperative diagnosis, mistakes are mostly caused by underdiagnosis of malignant tumors.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2018, 7, 1; 31-35
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Elevated preoperative levels of CA 19-9 and CA 125 predicts overall survival time in the pancreatic adenocarcinoma. Single institution series.
    Autorzy:
    Hogendorf, Piotr
    Skulimowski, Aleksander
    Durczyński, Adam
    Kumor, Anna
    Poznańska, Grażyna
    Poznańska, Agnieszka
    Oleśna, Aleksandra
    Rut, Joanna
    Øvereng Juliebø, Siri
    Szmiel, Aneta
    Pirowski, Wojciech
    Strzelczyk, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1391695.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    general surgery
    pancreatic neoplasms
    biomarkers
    prognostic factors
    Opis:
    Introduction: Pancreatic cancer is a devastating disease, being the seventh cause of cancer-related deaths worldwide. Its aggressiveness is due to its specific biology and the late diagnosis of cancer. Therefore, the prognosis for patients suffering from this cancer is dismal, with 5-year overall survival rate of around 6–10%. Up to date, only a complete surgical resection of the cancerous entity warrants a significant improvement in patients’ survival. Nevertheless, the pancreatic cancer’s biology is still not fully elucidated, so that the accuracy of prognosis for certain patients is highly uncertain. Consequently, the importance of both clinical and basic research aiming to reveal the crucial molecular factors affecting long-term prognosis should be highlighted. There is a growing number of evidence that biomarkers of PC not only reflect the presence of tumor itself but also present a “hint” regarding its physiology. Thus the aim of this study was to assess the levels of commonly measured biomarkers and their influence on patients’ overall survival. Materials and methods: The retrospective analysis of data on 129 patients admitted to our Department due to the diagnosis of pancreatic cancer was carried out. On the day of admission all the patients had their levels of CA19-9, CA125, CEA and CA15-3 measured. The overall survival (OS) was defined as time elapsing from the day of admission to the day of death. The Kaplan- Meier curves were built for all potential factors, Cox regression model was applied to carry out a multivariate analysis. Results: We retrospectively analyzed 129 patients with a mean age of 62 years. As many as 95 of them had an unresectable lesion and 34 underwent curative operation. In total, the analyzed patient group was characterized by a median survival of 7 months and 12 days. Cumulative 1-year, 2-year and 4-year survival rates were 35%, 16% and 15%, respectively. In univariate analysis, factors such as age >= 60, inoperable lesion, CA19-9 >= 200, CA125 >= 20 and Neutrophile to Lymphocyte Ratio (NLR) >= 5 were associated with a lower median OS. In multivariate analysis, three factors, CA19-9 >= 200, CA125 >= 20 and age >= 60, were found to be statistically significant. Indeed, patients possessing all of them noted much poorer outcomes regarding OS factors: 89 days versus 235 days for the other patients (log rank test P = 0.02). Conclusions: Our study fortifies the evidence that preoperative levels of CA19-9 and CA125 have a direct influence on the longterm OS. Interestingly, in our patient group, the correlation of biomarkers with OS was higher than that of resectability. However, our study has some limitations regarding, for instance, the lack of data on chemotherapy, comorbidities etc. In the view of recent molecular studies on mucin involvement in PC development, it provides a strong clinical evidence to prove their importance.
    Źródło:
    Polish Journal of Surgery; 2020, 92, 3; 32-38
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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