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Wyświetlanie 1-15 z 17
Tytuł:
Corrections to "L2 -characteristic classes of Maslov–Trofimov of hamiltonian systems on the Lie algebra of the upper triangular matrices" (Fund. Math. 156 (1998), 99–110)
Autorzy:
Nowak, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1205248.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Źródło:
Fundamenta Mathematicae; 1999, 160, 2; 197-198
0016-2736
Pojawia się w:
Fundamenta Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
$L_2$-characteristic classes of Maslov–Trofimov of hamiltonian systems on the Lie algebra of the upper-triangular matrices
Autorzy:
Nowak, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1205361.pdf
Data publikacji:
1998
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Opis:
We generalize the construction of Maslov-Trofimov characteristic classes to the case of some G-manifolds and use it to study certain hamiltonian systems.
Źródło:
Fundamenta Mathematicae; 1998, 156, 2; 99-110
0016-2736
Pojawia się w:
Fundamenta Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamics of estrogen-induced oxidative stress
Autorzy:
Kobiela, Jarek
Stefaniak, Tomasz
Krajewski, Jacek
Kalinska-Blach, Beata
Zurawa-Janicka, Dorota
Lachinski, Andrzej
Gackowski, Daniel
Olinski, Ryszard
Nowak, Jerzy
Knap, narcyz
Lipinska, Barbara
Sledzinski, Zbigniew
Wozniak, Michal
Powiązania:
https://bibliotekanauki.pl/articles/1041076.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
8-oxodGuo
estradiol
protein oxidation
carcinogenesis
DNA damage
lipid peroxidation
Opis:
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 289-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interactive Decision Aiding Technique for a New Product Selection Problem
Autorzy:
Michnik, Jerzy
Nowak, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/592928.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Ekonomiczny w Katowicach
Tematy:
Analiza wielokryterialna
Podejmowanie decyzji
Produkt
Decision making
Multicriteria analysis
Product
Opis:
An important part of the innovation management is to select the best new product project from the preliminary large set of potential alternatives. This problem is broadly discussed in the extant literature. Although the qualitative approaches dominate in literature, there are few examples of more formal decision procedures based on multiple criteria analysis. This article brings an example of interactive procedure that can help decision making in the new product development. As to the authors knowledge, such approach has not been proposed so far to the problem of selecting new product. The interactive procedure gives to the DM an opportunity to actively participate in the whole process and observe its development. During the procedure, the DM can disclose his preferences and values of trade-offs. This kind of assessment of differences in importance of criteria is assumed as more reliable then the direct assessment of weights.
Źródło:
Studia Ekonomiczne; 2013, 137; 53-68
2083-8611
Pojawia się w:
Studia Ekonomiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Likelihood Ratio in Evidential Evaluation of Polygraph Examination
Autorzy:
Konieczny, Jerzy
Wolańska-Nowak, Paulina
Powiązania:
https://bibliotekanauki.pl/articles/1374979.pdf
Data publikacji:
2019
Wydawca:
Wyższa Szkoła Policji w Szczytnie
Tematy:
argumentation
comparison question techniques
evidential reasoning
generalisations
evidential weight
Opis:
The starting point of the paper is the observation that the likelihood ratio (LR) is not used in the evaluation practice of — so important in the field of internal security — polygraph examinations. Meanwhile, LR is the only scientifically justifiable parameter that shows the evidential weight of particular evidence. The authors present theoretical attempts to use LR for evidential assessment of the polygraph examinations value and subject them to criticism. The main objective of the paper is to present the LR calculation procedure in the context of interpretation of a polygraph examination result treated as evaluative expertise. The following assumptions are made: the analysis includes only comparison question techniques; examination results enable to include a relevant subject only in one of the three categories: deception indicated, no deception indicated, inconclusive; there are various ways to assign LR; in the course of LR assignment, the arbitrary adoption of the values of some variables is admissible. Several examples of LR calculations are presented in different tactical configurations of polygraph examinations. The significance of including the inconclusive results in the examination technique characteristics is analysed. The possibility of applying the cumulative LR is indicated, however, leaving this question open. Consequences of the LR application in the interpretation of polygraph examinations are also presented as an argument in the criminal analysis. Conclusions show that treating polygraph examinations as evaluative expertise opens a new perspective on this method of forensic identification and deserves to be continued; however, the issue of the evidential use of polygraph examination results, in the light of the evaluation made with the use of the Bayesian approach, requires a number of further discussions among lawyers and scientists.
Źródło:
Internal Security; 2019, 11(1); 95-112
2080-5268
Pojawia się w:
Internal Security
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protection of Air Transport Against Acts of Unlawful Interference: Whats Next?
Autorzy:
Nowak, Jacek
Achimowicz, Jerzy
Ogonowski, Krzysztof
Biernacki, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/2010725.pdf
Data publikacji:
2020
Wydawca:
Centrum Rzeczoznawstwa Budowlanego Sp. z o.o.
Tematy:
air transport
security
airport
security systems
technical security measures
transport lotniczy
bezpieczeństwo
lotnisko
systemy ochrony
techniczne środki bezpieczeństwa
Opis:
Air transport consists in moving people or goods by air. Aircrafts, known as the main means of air transport, can be divided into two categories: airplanes and helicopters. Such transport is the most modern and the most dynamically developing branch of transport. It is also considered to be the safest mode of transport, even though, for various reasons, aviation accidents still occur. Security in aviation has various connotations. According to the International Civil Aviation Organization (ICAO), it is a state in which the possibility of damage to persons or property is minimized and is maintained as part of a continuous process of hazard identification and safety risk management at an acceptable level or below this acceptable level. Aviation security includes flight safety and aviation security against acts of unlawful interference. There is a significant difference between the meaning of "safety" and "security". The first of these concepts means preventing unintentional damage, while the second refers to the procedures undertaken in order to prevent deliberate damage resulting from an intentional act. As it appears from the abovementioned information, the immovable part of aviation safety is aircraft protection, including the protection of civilian airports.The aim of the article is to draw attention to the problems of air transport security, including the security of airports, related to the evolution of threats and the functioning of the airport security system. The problem that the authors address is expressed in a question: in what directions should the current solutions in the field of air transport security be improved in order to effectively prevent acts of unlawful interference in the future? Theoretical research methods, such as the analysis and synthesis of information contained in literature and source materials, inference, comparison, were used to develop the article.
Źródło:
Safety & Defense; 2020, 2; 75-88
2450-551X
Pojawia się w:
Safety & Defense
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cardiovascular effects of histamine H3 receptor antagonist JNJ 5207852 in haemorrhagic shock in rats
Efekty sercowo-naczyniowe działania antagonisty receptorów histaminowych H3 JNJ 5207852 we wstrząsie krwotocznym u szczurów
Autorzy:
Jochem, Jerzy
Mitera, Agata
Izydorczyk, Marta
Nowak, Damian
Waliczek, Martyna
Powiązania:
https://bibliotekanauki.pl/articles/1036526.pdf
Data publikacji:
2016
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
histamine
h3 receptor
haemorrhagic shock
rat
histamina
receptor h3
wstrząs krwotoczny
szczur
Opis:
INTRODUCTION: Histamine H3 receptors are widely distributed in the central and peripheral nervous system, including postganglionic adrenergic endings. They act mainly as presynaptic auto- and heteroceptors and are responsible for regulating the synthesis and release of histamine and other neurotransmitters/neuromodulators. The aim of the study was to examine the cardiovascular effects of the histamine H3 receptor blockade in the sympathoinhibitory phase of haemorrhagic shock. MATERIAL AND METHODS: Studies were carried out on male Wistar rats anaesthetized with ketamine/xylazine (100 mg/kg + 10 mg/kg, intraperitoneally), subjected to irreversible haemorrhagic shock (0% survival at 2 h) with a mean arterial pressure (MAP) of 20–25 mmHg. At 5 min of critical hypotension, the rats were injected intravenously with H3 receptor antagonist JNJ 5207852 or saline. RESULTS: Haemorrhage led to a decrease in pulse pressure (PP) and heart rate (HR). JNJ 5207852 (1 and 5 mg/kg) evoked long-lasting rises in MAP, PP and HR, with an improvement in survival at 2 h (5 mg/kg). Chemical sympathectomy with 6-hydroxydopamine (50 mg/kg for three consecutive days) inhibited cardiovascular changes evoked by JNJ 5207852 and decreased to 0% the survival rate at 2 h in rats treated with JNJ 5207852 (5 mg/kg). CONCLUSIONS: Histamine H3 receptor antagonist JNJ 5207852 induces the resuscitating effect in haemorrhage-shocked rats, and the mechanism responsible is associated with the activity of postganglionic sympathetic neurons.
WSTĘP: Receptory histaminowe H3 występują w ośrodkowym i obwodowym układzie nerwowym, w tym na zakończeniach pozazwojowych układu współczulnego. Działają głównie jako presynaptyczne auto- i heteroreceptory, są odpowiedzialne za regulację syntezy oraz wydzielania histaminy i innych neurotransmiterów/neuromodulatorów. Celem pracy było zbadanie wpływu zablokowania receptorów H3 na czynność układu krążenia podczas fazy hamowania aktywności układu współczulnego w modelu wstrząsu krwotocznego u szczurów. MATERIAŁ I METODY: Badania przeprowadzono u szczurów samców szczepu Wistar, w znieczuleniu ogólnym przy użyciu ketaminy i ksylazyny (100 mg/kg + 10 mg/kg dootrzewnowo), u których wywołano nieodwracalny wstrząs krwotoczny ze średnim ciśnieniem tętniczym (MAP) 20-25 mmHg (wskaźnik przeżycia 2 h: 0%). W 5 min krytycznej hipotensji zwierzętom podawano dożylnie antagonistę receptorów H3 JNJ 5207852 bądź 0,9% roztwór NaCl. WYNIKI: Krwotok prowadził do obniżenia ciśnienia tętna (PP) i częstości rytmu serca (HR). JNJ 5207852 (1 i 5 mg/kg) wywoływał długotrwałe wzrosty MAP, PP i HR, a także zwiększenie do 100% wskaźnika przeżycia 2 h (5 mg/kg). Chemiczna sympatektomia wykonana przy użyciu 6-hydroksydopaminy (50 mg/kg przez trzy kolejne dni) hamowała zmiany MAP, PP i HR wywoływane przez JNJ 5207852 (5 mg/kg) i zmniejszała do 0% wskaźnik przeżycia 2 h. WNIOSKI: Antagonista receptorów histaminowych H3 JNJ 5207852 wywołuje efekt resuscytacyjny u szczurów we wstrząsie krwotocznym, a jego mechanizm działania związany jest z aktywnością pozazwojowych neuronów układu współczulnego.
Źródło:
Annales Academiae Medicae Silesiensis; 2016, 70; 89-94
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modern drive systems of rail vehicles
Autorzy:
Andrzejewski, Maciej
Pielecha, Ireneusz
Merkisz, Jerzy
Świechowicz, Robert
Nowak, Mateusz
Powiązania:
https://bibliotekanauki.pl/articles/133660.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Naukowe Silników Spalinowych
Tematy:
rail vehicles
combustion engines
hybrid drive system
pojazdy szynowe
silniki spalinowe
hybrydowy układ napędowy
Opis:
Rail vehicles are one of the sources of environmental pollution in the transport sector. Therefore, it is necessary to equip these vehicles with modern drive systems. This article concerns the issues of contemporary and future-oriented solutions of drive systems used in rail vehicles. The article analyzes energy storage possibilities including: electrochemical, mechanical and hydraulic accumulators. The conducted analyzes have taken into account the importance of how frequently they charge up, which dictates their possible applications. Characteristics of hybrid drive systems were presented, with particular emphasis on parallel systems of: hydrostatic, flywheels and electrochemical batteries. The analysis of energy flow control strategies in hybrid drive systems of railway vehicles has been made. In the summary, a solution was chosen that resulted in high conversion efficiency of the energy extracted from the vehicle's wheels.
Źródło:
Combustion Engines; 2019, 58, 3; 76-81
2300-9896
2658-1442
Pojawia się w:
Combustion Engines
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An analysis of the use of cruise control in a passenger car
Autorzy:
Andrzejewski, Maciej
Merkisz, Jerzy
Nowak, Mateusz
Ziółkowski, Andrzej
Daszkiewicz, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/263054.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz. Przemysłowy Instytut Motoryzacji
Tematy:
fuel consumption
cruise control
speed driving strategy
Opis:
Most vehicles are powered by internal combustion engines. Due to the nature of their operation they emit, among others, carbon dioxide which contributes to the greenhouse effect. CO2 production is strictly correlated with fuel consumption. The article presents the results of road tests of a passenger car with a spark-ignition engine meeting the Euro 6 emission norm. The test vehicle was equipped with a classic exhaust gas aftertreatment system – a three-way catalytic converter. The aim of the study was to verify the impact of the cruise control use on the vehicle fuel consumption. The measurements were based on Portable Emission Measurement System type mobile equipment for exhaust emission tests. The tests were carried out in real driving conditions travelling on an express way. Test drives took place on a route with variable topographic profile. Three test drives with different speeds were carried out, but the aim was to obtain an average speed of 130 km/h.
Źródło:
Archiwum Motoryzacji; 2020, 89, 3; 37-49
1234-754X
2084-476X
Pojawia się w:
Archiwum Motoryzacji
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bombesin-like peptides are able to affect central histamine-induced resuscitating effect in haemorrhage-shocked rats
Peptydy bombezynopodobne mogą wpływać na efekt resuscytacyjny ośrodkowo działającej histaminy we wstrząsie krwotocznym u szczurów
Autorzy:
Jasikowska, Karolina
Rybus-Kalinowska, Barbara
Klose, Aleksandra
Nowak, Damian
Jochem, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1035475.pdf
Data publikacji:
2020
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
bombesin receptors
histaminergic system
rats
haemorrhagic shock
receptory bombezynowe
szczury
wstrząs krwotoczny
układ histaminergiczny
Opis:
INTRODUCTION: Activation of the central histaminergic system induces a resuscitating effect in haemorrhage-shocked rats. Since peripherally administered bombesin evokes a similar action, and bombesin receptors are present in the central nervous system regions responsible for cardiovascular regulation, the aim of the study was to examine the effects of bombesin receptor blockage on histamine-induced cardiovascular effects in haemorrhagic shock. MATERIAL AND METHODS: Studies were carried out in male Wistar rats anaesthetized with ketamine/xylazine (100 mg/kg + 10 mg/kg, intraperitoneally) and then subjected to reversible haemorrhagic shock with a mean arterial pressure (MAP) of 30–35 mmHg. Immediately after terminating bleeding, the animals were pre-treated intracerebroventricularly (icv) with bombesin receptor antagonists/0.9% NaCl solution, and 5 min later – treated via the same route with histamine (50 nmol) or 0.9% NaCl solution. RESULTS: Haemorrhage led to decreases in the pulse pressure (PP), heart rate (HR) and mesenteric blood flow (MBF). Histamine induced a pressor effect, with a significant increase in PP and MBF. The effect was inhibited by both [D-Phe12,Leu14]-bombesin and BIM 23042, non-selective and selective bombesin 1 (BB1) receptor antagonists, respectively. In the control groups the antagonists had no effect. CONCLUSIONS: Endogenous bombesin-like peptides, acting via BB1 receptors, are able to affect a histamine-induced pressor effect in haemorrhage-shocked rats.
WSTĘP: Pobudzenie ośrodkowego układu histaminergicznego wywołuje działanie resuscytacyjne u szczurów we wstrząsie krwotocznym. Skoro podawana dożylnie bombezyna wykazuje podobne działanie, a receptory bombezynowe są obecne w strukturach ośrodkowego układu nerwowego, odpowiedzialnych za regulację czynności układu krążenia, celem pracy było zbadanie wpływu zablokowania receptorów bombezynowych na efekty krążeniowe wynikające z podania do komory bocznej mózgu (icv) histaminy we wstrząsie krwotocznym u szczurów. MATERIAŁ I METODY: Badania przeprowadzono u szczurów, samców szczepu Wistar w znieczuleniu ogólnym (ketamina 100 mg/kg + ksylazyna 10 mg/kg, dootrzewnowo). Zastosowano model odwracalnego wstrząsu krwotocznego ze średnim ciśnieniem tętniczym (MAP) 30–35 mmHg. Niezwłocznie po zakończeniu krwawienia podawano icv antagonistów receptorów bombezynowych/0,9% roztwór NaCl, a 5 min później tą samą drogą histaminę (50 nmol) bądź 0,9% roztwór NaCl. WYNIKI: Utrata krwi prowadziła do obniżenia ciśnienia tętna (PP), częstości rytmu serca (HR) i przepływu krezkowego krwi (MBF). Histamina wywoływała działanie presyjne ze wzrostem PP i MBF. Efekty działania histaminy były częściowo hamowane przez [D-Phe12,Leu14]-bombezynę i BIM 23042, odpowiednio nieselektywnego antagonistę receptorów bombezynowych oraz selektywnego blokera receptorów bombezynowych typu 1 (BB1). W grupach kontrolnych nie stwierdzono wpływu antagonistów receptorów bombezynowych na mierzone parametry układu krążenia. WNIOSKI: Endogenne peptydy bombezynopodobne, działając poprzez receptory BB1, mogą wpływać na wywoływane przez ośrodkowo działającą histaminę działanie resuscytacyjne we wstrząsie krwotocznym u szczurów.
Źródło:
Annales Academiae Medicae Silesiensis; 2020, 74; 40-45
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Predicted real solubility (– log x$\text{}_{2}$) and the level of hydrophilic-lipophilic balance (HLB$\text{}_{Requ.}$) of phytochemicals contained in extracts isolated from linden inflorescence (Tiliae flos) with solvents of diversified polarity (ε$\text{}_{M}$)
Autorzy:
Marczyński, Zbigniew
Zgoda, Marian Mikołaj
Stańczak, Andrzej
Nowak, Sławomira
Jambor, Jerzy
Skibska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/2048772.pdf
Data publikacji:
2019
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
real solubility
phytochemicals
Tiliae flos
level of hydrophilic-lipophilic balance (HLBRequ.)
rozpuszczalność rzeczywista
fitozwiązki
poziom równowagi hydrofilo-lipofilowej (HLBRequ.)
Opis:
Introduction: The broad spectrum of pharmacological properties of linden inflorescence extracts results from polarity and the level of hydrophilic-lipophilic balance of solvents (medium) used to separate compatible phytochemical structures with the expected pharmacotherapeutic profile. Objective: The use of the general Hildebrand-Scatchard-Fedors theory of solubility to calculate the predicted solubility of classes of phytochemicals contained in linden inflorescences (Tiliae flos) and the indication of those structures which, due to their high solubility in the medium, are responsible for the profile of pharmacological activity. Material and methods: The Hildebrand, Scatchard equation, supported with computational technique proposed by Fedors, allows calculation of the solubility parameters of the extraction medium. Despite application reservations, it is a fundamental tool for estimating the predictable solubility of phytochemicals in real solution. Results: The structure of phytochemicals isolated from linden inflorescences (Tiliae flos) owing to the use of solvents of significantly diversified polarity (– dielectric constant – ε$\text{}_{M}$) was the basis for calculating the molar evaporation energy – ΣΔE$\text{}_{i}$ (cal/mol) and molar volume – ΣΔV$\text{}_{i}$ (cm$\text{}^{3}$/mol) by Fedors method, which are fundamental quantities necessary to estimate the solubility parameter– δ$\text{}^{1}\text{}^{/}\text{}^{2}$ and required solubility level of hydrophilic-lipophilic balance – HLB$\text{}_{Requ.}$. Conclusions: Results of the presented research indicate that basing on the parameters characterizing the structure of phytochemicals and the calculated ideal (–logx$\text{}_{2}^{i}$) and predicted real (–logx$\text{}_{2}$) solubility, it is possible – using the general Hildebrand-Scatchard-Fedors theory of solubility – to choose selectively the cascade of extraction media in order to distinguish in the plant material chemical and structural individuals of different polarity.
Źródło:
Herba Polonica; 2019, 65, 3; 39-50
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of fecal pyruvate kinase isoform M2 and calprotectin in assessment of pediatric inflammatory bowel disease severity and activity
Autorzy:
Czub, Elzbieta
Nowak, Jan
Szaflarska-Poplawska, Anna
Grzybowska-Chlebowczyk, Urszula
Landowski, Piotr
Moczko, Jerzy
Adamczak, Daria
Mankowski, Przemyslaw
Banasiewicz, Tomasz
Plawski, Andrzej
Walkowiak, Jaroslaw
Powiązania:
https://bibliotekanauki.pl/articles/1039342.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
: pyruvate kinase
calprotectin
inflammatory bowel diseases
ulcerative colitis
Crohn's disease
pediatrics
Opis:
Aims: Accurate assessment of inflammatory bowel disease (IBD) activity is the cornerstone of effective therapy. Fecal M2 isoform of pyruvate kinase (M2-PK) and fecal calprotectin (FC) are noninvasive markers of mucosal inflammation in IBD. The aim of this study was to compare performance of M2-PK and FC in assessment of pediatric ulcerative colitis (UC) and Crohn's disease (CD) severity and activity. Materials and methods: 121 patients with IBD, including 75 with UC and 46 with CD were recruited. Control group consisted of 35 healthy children (HS). Patients were assigned to groups depending on disease severity and activity. M2-PK and calprotectin concentration were determined in stool samples using ELISA. Areas under receiver operating characteristic curves (AUC) for FC and M2-PK with cut-off level at which M2-PK specificity was matching FC specificity were calculated and compared. Results: Performance of M2-PK at identifying patients with IBD, UC and CD among HS was inferior to FC. The differences in AUC were respectively: -0.10 (95% confidence interval [CI] [-0.13-(-0.06)], p<0.0001), -0.14 (95% CI [-0.19-(-0.09)], p<0.0001) and -0.03 (95% CI [-0.05-(-0.001)], p<0.02). M2-PK was inferior to FC in discriminating patients with mild UC from those with HS (AUC difference -0.23, 95% CI [-0.31-(-0.15)], p<0.0001). Conclusions: FC reflects pediatric IBD severity and activity better than M2-PK. This difference is particularly pronounced when identifying patients with mild UC and UC in remission.
Źródło:
Acta Biochimica Polonica; 2014, 61, 1; 99-102
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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