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Wyszukujesz frazę "Mazurek, Mariusz" wg kryterium: Autor


Wyświetlanie 1-6 z 6
Tytuł:
The Problem of Existence of Virtual Objects from the Philosophical Perspective
Autorzy:
Mazurek, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/31234163.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Instytut Filozofii i Socjologii PAN
Tematy:
ontology
virtual existence
virtual objects
artefacts
fictions
Opis:
I consider the problem of existence of virtual objects, mainly their mode of existence, while omitting the issue of the criteria of their existence. I present and analyze the concepts of modes (forms, kinds) of existence of virtual objects proposed in the literature of the subject, and then I demonstrate my own position on the issue. My position on the existence of virtual objects has certain points coinciding with the already postulated views, but at the same time it differs from them in some basic aspects. In my view virtual objects are “born” in human individual consciousness as the objects of specific creative states of the mind. So initially they are private objects belonging to the individual subjective sphere. However, their final and ready forms emerge in complex processes of objectifying and autonomizing the respective private conscious states and their objects. In these processes the private objects are transformed into objects intersubjectively accessible and existing in the collective cultural sphere. In both their forms, initial and final, virtual objects are non-material entities: first subjective, then objective. The ontic status of virtual objects is very similar to the status of intangible ideas and all the non-material objects created by the human mind. The main difference consists in that virtual objects are expressed by the use computers programmes, while other non-material objects created by human beings are expressed by use of words, pictures, literature and art works, etc.
Źródło:
Filozofia i Nauka; 2022, 10, zeszyt specjalny; 137-156
2300-4711
2545-1936
Pojawia się w:
Filozofia i Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of finite difference method for measurement simulation in ultrasound transmission tomography
Autorzy:
Kania, Konrad
Mazurek, Mariusz
Rymarczyk, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/2097434.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
forward problem
ultrasound transmission tomography
sensors
machine learning
finite difference
Opis:
In this work, we present a computer simulation model that generates the propagation of sound waves to solve a forward problem in ultrasound transmission tomography. The simulator can be used to create data sets used in the supervised learning process. A solution to the "free-space" boundary problem was proposed, and the memory consumption was significantly optimized from O(n2) to O(n). The given method of simulating wave scattering enables the control of the noise extinction time within the tomographic probe and the permeability of the sound wave. The presented version of the script simulates the classic variant of a circular probe with evenly distributed sensors around the circumference.
Źródło:
Applied Computer Science; 2022, 18, 2; 101--109
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monitoring of loads in arch support with wire strain gauge
Autorzy:
Woszczyński, Mariusz
Tokarczyk, Jarosław
Mazurek, Krzysztof
Pytlik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/111324.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
transducers with vibrating wire strain gauge
strain measurements
geometry of arch support
testing
FEM analysis
Opis:
A concept of measuring the load and geometry of a roadway support with the use of vibrating wire strain gauges and draw-wire sensors is presented. Laboratory and in-situ tests of complete frames of arch supports under load were carried out within the INESI project. The deformations recorded by the vibrating wire strain gauges are similar to those recorded by the strain gauges. FEM strength calculations (which were similar to the results from the stand tests) were also presented.
Źródło:
Mining – Informatics, Automation and Electrical Engineering; 2019, 57, 1; 48-58
2450-7326
2449-6421
Pojawia się w:
Mining – Informatics, Automation and Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in expression of genes related to caspases and BCL-2 family in RPTEC treated with amphotericin B and its modified forms
Zmiany w ekspresji genów kodujących białka związane z aktywnością kaspaz oraz białka z rodziny BCL-2 w komórkach RPTEC traktowanych amfoterycyną B i jej modyfikowanymi formami
Autorzy:
Gola, Joanna M.
Simka, Klaudia
Strzałka-Mrozik, Barbara
Kruszniewska-Rajs, Celina
Gagoś, Mariusz
Mazurek, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/1035842.pdf
Data publikacji:
2018
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
caspases
bcl-2
amphotericin b
copper complexes
oligonucleotide microarrays
kaspazy
amfoterycyna b
kompleksy miedzi
mikromacierze oligonukleotydowe
Opis:
INTRODUCTION: The main limitation of the use of amphotericin B (AmB) – effective in the treatment of systemic fungal infections – is its high toxicity to human cells. The mechanism of AmB toxicity is not clear. Caspase-related and BCL-2 proteins participate in the regulation of apoptosis. Thus, they may be involved in drug toxicity. In this study we evaluated the influence of AmB on the transcriptional activity of genes related to caspases and the BCL-2 family. We also tested the influence of modified forms of AmB: AmB-Cu2+ (the complex with copper(II) ions) and the AmB-ox (oxidized form). MATERIAL AND METHODS: Human RPTECs (Renal Proximal Tubule Epithelial Cells) were treated with AmB, AmB-Cu2+ and AmB-ox. Total RNA was extracted using the phenol-chloroform method. The expression profiles of genes related to caspase activity and BCL-2 were determined using oligonucleotide microarrays (HG-U133A 2.0, Affymetrix). Analysis included 67 ID related to caspases and 32 ID associated with BCL-2, according to the Affymetrix database. RESULTS: The analysis revealed upregulation of the BCL-2 and BCL2L1genes in the cells treated with AmB-Cu2+, in comparison to the control. In both the AmB and AmB-Cu2+ -treated cells, differentiating genes were associated with inflammation and mitophagy activated by intrinsic signals. In the cells treated with AmB-ox, the BCL-2 genes were downregulated. CONCLUSIONS: The results suggest that AmB and AmB-Cu2+ activate genes involved in the regulation of inflam-mation and autophagy induced by intrinsic signals, but overexpression of BCL-2 and BCL2L1 may protect AmB-Cu2+--treated cells from death. In the cells treated with AmB-ox extrinsic signals prevail, indicating the distinct molecular mechanism of its cytotoxicity.
WSTĘP: Głównym ograniczeniem stosowania amfoterycyny B (AmB) – skutecznej w leczeniu grzybic układowych – jest jej wysoka toksyczność wobec komórek ludzkich. Mechanizm cytotoksyczności nie został wyjaśniony. Białka związane z aktywnością kaspaz oraz białka należące do rodziny BCL-2 uczestniczą w regulacji apoptozy, mogą być zatem zaangażowane w procesy odpowiedzialne za toksyczność leku. W pracy oceniono wpływ AmB na aktywność transkrypcyjną genów kodujących białka związane z aktywnością kaspaz oraz białka z rodziny BCL-2. Zbadano również wpływ modyfikowanych form AmB: AmB-Cu2+ (kompleks z jonami miedzi (II)) i AmB-ox (formy utlenione). MATERIAŁ I METODY: Ludzkie komórki RPTECs (Human Renal Proximal Tubule Epithelial Cells) inkubowano z AmB, AmB-Cu2+ i AmB-ox. Całkowity RNA wyekstrahowano metodą fenolowo-chloroformową. Profil ekspresji genów wyznaczono techniką mikromacierzy oligonukleotydowych (HG-U133A 2.0, Affymetrix). Analiza obejmowała 67 ID genów związanych z aktywnością kaspaz i 32 ID geny kodujące białka z rodziny BCL-2, zaproponowane przez bazę Affymetrix. WYNIKI: Analiza wykazała nadekspresję genów BCL-2 i BCL2L1 w komórkach traktowanych AmB-Cu2+, w porównaniu z kontrolą. Zarówno w komórkach traktowanych AmB, jak i AmB-Cu2+ geny różnicujące związane były z za-paleniem i mitofagią aktywowanymi w odpowiedzi na sygnały wewnątrzkomórkowe. W komórkach traktowanych AmB-ox geny z rodziny BCL-2 były wyciszone. WNIOSKI: Wyniki sugerują, że AmB i AmB-Cu2+ aktywują geny zaangażowane w regulację zapalenia i mitofagii aktywowanych sygnałami wewnątrzkomórkowymi, jednak nadekspresja genów BCL-2 i BCL2L1 może chronić komórki traktowane AmB-Cu2+ przed śmiercią. W komórkach traktowanych AmB-ox przeważa sygnał zewnątrzkomórkowy, co wskazuje na odrębny mechanizm cytotoksyczności tej formy antybiotyku.
Źródło:
Annales Academiae Medicae Silesiensis; 2018, 72; 62-68
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of energy consumption in the acceleration process of a passenger car
Autorzy:
Mamala, Jarosław
Graba, Mariusz
Bieniek, Andrzej
Prażnowski, Krzysztof
Hennek, Krystian
Kołodziej, Szymon
Mazurek, Bartosz
Sproch, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/2097656.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Naukowe Silników Spalinowych
Tematy:
acceleration
energy consumption
vehicle dynamic
dynamic index
przyspieszenie
zużycie energii
dynamika pojazdu
wskaźnik dynamiki
Opis:
The analysis of the vehicle acceleration process is a current topic based on the aspects related to the general characteristics of the car, its parameters, design, drive unit performance, and the influence of external factors. However, the ability to accelerate is essential from the point of view of the active safety of the car. Often the dynamic parameters are determined on the basis of the car acceleration test carried out on a level road with good surface in terms of the acceleration time is not reliable and the credibility of such results depends on many factors. Therefore in the article, the authors assessed the dynamic and energy parameters of the car motion, in which the intensity of acceleration of the car with different intensities was examined. The acceleration intensity test was carried out from the set initial speed of the car of 45 km/h to the final speed of 120 km/h at a constant gear ratio, and the set intensity of the acceleration process resulted from the constant throttle with a constant deflection of the accelerator pedal. Acceleration was carried out in two variants, the first for a normal internal combustion engine and the second for the same engine but additionally equipped with a short-term boost system. In this way, it influences the increase in power and energy in the car drive system, changing its acceleration intensity. Variable car acceleration intensity was obtained in the range from 0.12 to 1.37 m/s2, and energy consumption at the level of 0.4 to 1.2 MJ in the distance of 1/4 mile. The article proposes a combination of energy parameters and engine power in order to assess the acceleration dynamics, for this purpose, the specific energy consumption of the car was determined, ranging from 0.35 to 2.0 J/(kg∙m), which was related to the engine power, denoting it with the dynamics index. The study focuses on the assessment of the relationship between the specific energy consumption and acceleration of passenger cars in the available powertrain system using a new dynamics index. The proposed dynamics index combines the energy and dynamic parameters of the car to be able to objectively quantify the acceleration process.
Źródło:
Combustion Engines; 2022, 61, 3; 35--44
2300-9896
2658-1442
Pojawia się w:
Combustion Engines
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
National comparison of methods for determination of radon in water
Autorzy:
Mazur, Jadwiga
Kozak, Krzysztof
Grządziel, Dominik
Guguła, Szymon
Mroczek, Mariusz
Kozłowska, Beata
Walencik-Łata, Agata
Podgórska, Zuzanna
Wołoszczuk, Katarzyna
Przylibski, Tadeusz A.
Kowalska, Agata
Domin, Elżbieta
Wysocka, Małgorzata
Chałupnik, Stanisław
Chmielewska, Izabela
Długosz-Lisiecka, Magdalena
Szajerski, Piotr
Chau, Nguyen Dinh
Krakowska, Paulina
Pliszczyński, Tomasz
Ośko, Jakub
Dymecka, Małgorzata
Mazurek, Daria
Powiązania:
https://bibliotekanauki.pl/articles/148272.pdf
Data publikacji:
2020
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
AlphaGUARD monitor
interlaboratory comparison
LSC method
radon in water
Z-score value
Opis:
The article describes three interlaboratory experiments concerning 222Rn determination in water samples. The first two experiments were carried out with the use of artificial radon waters prepared by the Laboratory of Radiometric Expertise (LER), Institute of Nuclear Physics, Polish Academy of Sciences in Kraków in 2014 and 2018. The third experiment was performed using natural environment waters collected in the vicinity of the former uranium mine in Kowary in 2016. Most of the institutions performing radon in water measurements in Poland were gathered in the Polish Radon Centre Network, and they participated in the experiments. The goal of these exercises was to evaluate different measurement techniques used routinely in Polish laboratories and the laboratories’ proficiency of radon in water measurements. In the experiment performed in 2018, the reference values of 222Rn concentration in water were calculated based on the method developed at LER. The participants’ results appeared to be worse for low radon concentration than for high radon concentrations. The conclusions drawn on that base indicated the weaknesses of the used methods and probably the sampling. The interlaboratory experiments, in term, can help to improve the participants’ skills and reliability of their results.
Źródło:
Nukleonika; 2020, 65, 2; 77-81
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-6 z 6

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