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    Wyświetlanie 1-3 z 3
    Tytuł:
    Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer
    Autorzy:
    Linkowska, Katarzyna
    Jawień, Arkadiusz
    Marszałek, Andrzej
    Skonieczna, Katarzyna
    Grzybowski, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039019.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    POLG gene
    CAG repeat
    colorectal cancer
    somatic mutations
    Opis:
    Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 625-627
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    An unusual case of a tuberculous granuloma of the liver presenting thirteen years after intravesical BCG – therapy for bladder cancer
    Autorzy:
    Szczęsny, Wojciech
    Szylberg, Łukasz
    Słupski, Maciej
    Marszałek, Andrzej
    Szmytkowski, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1391514.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    BCG therapy
    bladder carcinoma
    liver
    tuberculous granuloma
    Opis:
    The authors present the case of a female patient with a tumor of segment VII of the liver, which was postoperatively identified as a tuberculous granuloma. The patient was admitted for elective surgery for a liver tumor, which had been diagnosed a few months before. Computed tomography and nuclear magnetic resonance were performed, based on which focal nodular hyperplasia was suspected. Thirteen years prior to admission the patient had undergone a transurethral resection of superficial bladder carcinoma, followed by adjuvant intravesical Bacillus Calmette-Guérin (BCG-therapy). Upon surgery, segment VII of the liver was resected; postoperative course was uneventful. After the identification of granuloma, the patient was referred to a phthysiatric clinic for further diagnostics and treatment. The authors have deemed this case worthy of reporting primarily due to the exceptionally long period between the completion of BCG therapy and the onset of hepatic tumor.
    Źródło:
    Polish Journal of Surgery; 2021, 93, 5; 1-5
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of muscle activity during hand rim and lever wheelchair propulsion over flat terrain
    Autorzy:
    Błażkiewicz, Michalina
    Wiszomirska, Ida
    Fiok, Krzysztof
    Mróz, Anna
    Kosmol, Andrzej
    Mikicin, Mirosław
    Molik, Bartosz
    Marszałek, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/306401.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    biomechanika
    aktywność mięśni
    EMG
    wózek inwalidzki
    biomechanics
    assistive technology
    muscle activity
    wheelchair
    lever
    Opis:
    The aim of this study was to compare the activity of upper limb muscles during hand rim wheelchair propulsion and lever wheelchair propulsion at two different velocity levels. Methods: Twenty male volunteers with physical impairments participated in this study. Their task was to push a lever wheelchair and a hand rim wheelchair on a mechanical wheelchair treadmill for 4 minutes at a speed of 3.5 km/h and 4.5 km/h in a flat race setting (conditions of moving over flat terrain). During these trials, activity of eight muscles of upper limbs were examined using surface electromyography. Results: The range of motion in the elbow joint was significantly higher in lever wheelchair propulsion (59.8 ± 2.43°) than in hand rim wheelchair propulsion (43.9 ± 0.26°). Such values of kinematics resulted in a different activity of muscles. All the muscles were more active during lever wheelchair propulsion at both velocity levels. The only exceptions were extensor and flexor carpi muscles which were more active during hand rim wheelchair propulsion due to the specificity of a grip. In turn, the examined change in the velocity (by 1 km/h) while moving over flat terrain also caused a different EMG timing of muscle activation depending on the type of propulsion. Conclusions: Lever wheelchair propulsion seems to be a good alternative to hand rim wheelchair propulsion owing to a different movement technique and a different EMG timing of muscle activity. Therefore, we believe that lever wheelchair propulsion should serve as supplement to traditional propulsion.
    Źródło:
    Acta of Bioengineering and Biomechanics; 2019, 21, 3; 67-74
    1509-409X
    2450-6303
    Pojawia się w:
    Acta of Bioengineering and Biomechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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