Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Marczak, Lukasz" wg kryterium: Autor

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-5 z 5
    Tytuł:
    Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma
    Autorzy:
    Jelonek, Karol
    Wojakowska, Anna
    Marczak, Lukasz
    Muer, Annika
    Tinhofer-Keilholz, Ingeborg
    Lysek-Gladysinska, Malgorzata
    Widlak, Piotr
    Pietrowska, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1039103.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    exosomes
    head and neck cancer
    ionizing radiation
    proteome
    radiobiology
    Opis:
    Exosomes are membrane vesicles of endocytic origin that participate in inter-cellular communication. Environmental and physiological conditions affect composition of secreted exosomes, their abundance and potential influence on recipient cells. Here, we analyzed protein component of exosomes released in vitro from cells exposed to ionizing radiation (2Gy dose) and compared their content with composition of exosomes released from control not irradiated cells. Exosomes secreted from FaDu cells originating from human squamous head and neck cell carcinoma were analyzed using LC-MS/MS approach. We have found that exposure to ionizing radiation resulted in gross changes in exosomal cargo. There were 217 proteins identified in exosomes from control cells and 384 proteins identified in exosomes from irradiated cells, including 148 "common" proteins, 236 proteins detected specifically after irradiation and 69 proteins not detected after irradiation. Among proteins specifically overrepresented in exosomes from irradiated cells were those involved in transcription, translation, protein turnover, cell division and cell signaling. This indicated that exosomal cargo reflected radiation-induced changes in cellular processes like transient suppression of transcription and translation or stress-induced signaling.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 2; 265-272
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Panel of serum metabolites discriminates cancer patients and healthy participants of lung cancer screening - a pilot study
    Autorzy:
    Roś-Mazurczyk, Małgorzata
    Wojakowska, Anna
    Marczak, Łukasz
    Polański, Krzysztof
    Pietrowska, Monika
    Polanska, Joanna
    Dziadziuszko, Rafał
    Jassem, Jacek
    Rzyman, Witold
    Widlak, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1038611.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    early detection
    lung cancer screening
    metabolomics
    serum biomarkers
    Opis:
    Introduction. Blood biomarkers may support early diagnosis of lung cancer by enabling pre-selection of candidates for computed tomography screening or discrimination between benign and malignant screening-detected nodules. We aimed to identify features of serum metabolome distinguishing individuals with early-detected lung cancer from healthy participants of the lung cancer screening program. Methods. Blood samples were collected in the course of a low-dose computed tomography screening program performed in the Gdansk district (Northern Poland). The analysis included 31 patients with screening-detected lung cancer and the pair-matched group of 92 healthy controls. The gas chromatography coupled to mass spectrometry (GC/MS) approach was used to identify and quantify small metabolites present in serum. Results. There were several metabolites detected in the sera whose abundances discriminated patients with lung cancer from controls. Majority of the differentiating components were downregulated in cancer samples, including amino acids, carboxylic acids and tocopherols, whereas benzaldehyde was the only compound significantly upregulated. A classifier including nine serum metabolites allowed separation of cancer and control samples with 100% sensitivity and 95% specificity. Conclusions. Signature of serum metabolites discriminating between cancer patients and healthy participants of the early lung cancer screening program was identified using a GC/MS metabolomics approach. This signature, though not validated in an independent dataset, deserves further investigation in a larger cohort study.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 513-518
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy
    Autorzy:
    Roś-Mazurczyk, Małgorzata
    Wojakowska, Anna
    Marczak, Łukasz
    Polański, Krzysztof
    Pietrowska, Monika
    Jelonek, Karol
    Domińczyk, Iwona
    Hajduk, Agata
    Rutkowski, Tomasz
    Składowski, Krzysztof
    Widłak, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1038706.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    head and neck cancer
    mass spectrometry
    metabolomics
    radiation response
    serum metabolome
    Opis:
    Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 189-193
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research on an Innovative FLEX Bicycle Frame with a Softtail Vibration Damping System
    Autorzy:
    Kuczek, Łukasz
    Marczak, Paweł
    Muzykiewicz, Wacław
    Mroczkowski, Marcin
    Paćko, Paweł
    Drop, Dawid
    Powiązania:
    https://bibliotekanauki.pl/articles/2201887.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    elastomer
    bike frame
    FLEX bike frame
    damping system
    strength analysis
    fatigue analysis
    impact test
    softtail damping system
    Opis:
    Bicycles are gaining more and more popularity, especially in crowded cities where there is a problem with traffic jams and a limited number of parking spaces. The bicycles are also often used by mountain bikers during riding on off-road trails. In both cases, the important parameters are the stiffness of the bicycle frame, the weight of the bicycle, but also driving comfort. To improve comfort and reduce vibrations in the bicycle frame both front and rear shock absorbers are used. The use of traditional shock absorbers increase the weight of the bike and its price. The work characterizes a modern damping system, Softtail type, designed by AG Motors. In this case, the damping element (elastomer) was placed directly in the rear fork. Analyses of polyurethanes of various hardness were carried out in terms of the possibility of using them as a vibration damper. A numerical and experimental analysis of the bicycle frame was performed, adapted to the a new shock-absorber system. Strength, fatigue and impact tests were carried out in accordance with the relevant bicycle standards. Research has shown that the frame bicycle with the Softtail system, meets the requirements of the standards.
    Źródło:
    Advances in Science and Technology. Research Journal; 2023, 17, 1; 290--303
    2299-8624
    Pojawia się w:
    Advances in Science and Technology. Research Journal
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glove failure in elective thyroid surgery: A prospective randomized study
    Autorzy:
    Timler, Dariusz
    Kusiński, Michał
    Iltchev, Petre
    Szarpak, Łukasz
    Śliwczyński, Andrzej
    Kuzdak, Krzysztof
    Marczak, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/2177242.pdf
    Data publikacji:
    2015-04-02
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    thyroidectomy
    surgical gloves
    surgeon
    glove failure
    elective surgery
    thyroid surgery
    Opis:
    Objectives To analyze perforation rate in sterile gloves used by surgeons in the operating theatre of the Department of Endocrinological and General Surgery of Medical University of Lodz. Material and Methods Randomized and controlled trial. This study analyses the incidents of tears in sterile surgical gloves used by surgeons during operations on 3 types of thyroid diseases according to the 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) codes. Nine hundred seventy-two pairs (sets) of gloves were collected from 321 surgical procedures. All gloves were tested immediately following surgery using the water leak test (EN455-1) to detect leakage. Results Glove perforation was detected in 89 of 972 glove sets (9.2%). Statistically relevant more often glove tears occurred in operator than the 1st assistant (p < 0.001). The sites of perforation were localized mostly on the middle finger of the non-dominant hand (22.5%), and the non-dominant ring finger (17.9%). Conclusions This study has proved that the role performed by the surgeon during the procedure (operator, 1st assistant) has significant influence on the risk of glove perforations. Nearly 90% of glove perforations are unnoticed during surgery.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 3; 499-505
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies