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Wyświetlanie 1-2 z 2
Tytuł:
Modelling particle deagglomeration in a batch homogenizer using full CFD and mechanistic models
Autorzy:
Krzosa, Radosław
Wojtas, Krzysztof
Golec, Jakub
Makowski, Łukasz
Orciuch, Wojciech
Adamek, Radosław
Powiązania:
https://bibliotekanauki.pl/articles/2034041.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
population balance
titanium dioxide
CFD
breakup
high shear impeller
bilans populacji
dwutlenek tytanu
wirnik o wysokim ścinaniu
Opis:
Modelling of titanium dioxide deagglomeration in the mixing tank equipped with a high shear impeller is presented in this study. A combination of computational fluid dynamics with population balance was applied for prediction of the final particle size. Two approaches are presented to solve population balance equations. In the first one, a complete population balance breakage kinetics were implemented in the CFD code to simulate size changes in every numerical cell in the computational domain. The second approach uses flow field and properties of turbulence to construct a mechanistic model of suspension flow in the system. Such approach can be considered as an attractive alternative to CFD simulations, because it allows to greatly reduce time required to obtain the results, i.e., the final particle size distribution of the product. Based on experiments shattering breakage mechanism was identified. A comparison of the mechanistic model and full CFD does not deviate from each other. Therefore the application of a much faster mechanistic model has comparable accuracy with full CFD. The model of particle deagglomeration does not predict a very fast initial drop of particle size, observed in the experiment, but it can predict, with acceptable accuracy, the final particle size of the product.
Źródło:
Chemical and Process Engineering; 2021, 42, 2; 105-118
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity.
Autorzy:
Pawełczak, Krzysztof
Makowski, Maciej
Kempny, Michał
Dzik, Jolanta
Gołos, Barbara
Rode, Wojciech
Rzeszotarska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1043769.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
thymidylate synthase inhibitors
antifolate analogues
antifolates
p-aminobenzenesulfonic acid
Opis:
Synthesis and biological evaluation are described of seven new analogues (3-9) of two potent thymidylate synthase inhibitors, 10-propargyl-5,8-dideazafolate (1) and its 2-methyl-2-deamino congener ICI 198583 (2). While the new compunds 3 and 4 were analogues of 1 and 2, respectively, containing a p-aminobenzenesulfonyl residue in place of the p-aminobenzoic acid residue, the remaining 5 new compounds were analogues of 4 with the L-glutamic acid residue replaced by glycine (5), L-valine (6), L-alanine (7), L-phenylglycine (8) or L-norvaline (9). The new analogues were tested as inhibitors of thymidylate synthases isolated from tumour (Ehrlich carcinoma), parasite (Hymenolepis diminuta) and normal tissue (regenerating rat liver) and found to be weaker inhibitors than the parent 10-propargyl-5,8-dideazafolic acid. Selected new analogues, tested as inhibitors of growth of mouse leukemia L 5178Y cells, were less potent than the parent 10-propargyl-5,8-dideazafolic acid. Substitution of the glutamyl residue in compound 4 with l-norvaline (9) resulted in only a 5-fold stronger thymidylate synthase inhibitor, but a 40-fold weaker cell growth inhibitor.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 407-420
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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