- Tytuł:
- Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations
- Autorzy:
-
Makuszewska, Maria
Litwiniuk-Kosmala, Małgorzata
Bartoszewicz, Robert
Niemczyk, Kazimierz - Powiązania:
- https://bibliotekanauki.pl/articles/1399235.pdf
- Data publikacji:
- 2020
- Wydawca:
- Index Copernicus International
- Tematy:
-
gene expression
merlin
microRNA
molecular biology
neuroblastoma - Opis:
- Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
- Źródło:
-
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 3; 23-29
2084-5308
2300-7338 - Pojawia się w:
- Polski Przegląd Otorynolaryngologiczny
- Dostawca treści:
- Biblioteka Nauki
Artykuł