Autor: Litwiniuk, Maria - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: New directions in molecular diagnostics and therapy of vestibular schwannomas
Autorzy:: Litwiniuk, Malgorzata
Makuszewska, Maria
Bartoszewicz, Robert
Niemczyk, Kazimierz
Powiązania:: https://bibliotekanauki.pl/articles/1399284.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: acoustic neuroma
bevacizumab
biological treatment
microRNAs
prognostic markers
vestibular schwannoma
Opis:: The molecular basis for the formation and growth of vestibular schwannomas (VS) has been elucidated in the recent years. The main genetic and epigenetic aberrations, changes in gene expression and specific signaling pathways involved in pathogenesis of sporadic VS and neurofibromatosis type II (NF2) have been defined. These findings facilitated the search for prognostic markers in VS and potential targets for biological therapy. This publication summarizes the main directions of research in the field of molecular diagnostics and pharmacotherapy of VS based on biological agents.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2020, 9, 4; 55-59
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations
Autorzy:: Makuszewska, Maria
Litwiniuk-Kosmala, Małgorzata
Bartoszewicz, Robert
Niemczyk, Kazimierz
Powiązania:: https://bibliotekanauki.pl/articles/1399235.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: gene expression
merlin
microRNA
molecular biology
neuroblastoma
Opis:: Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.
Źródło:: Polski Przegląd Otorynolaryngologiczny; 2020, 9, 3; 23-29
2084-5308
2300-7338
Pojawia się w:: Polski Przegląd Otorynolaryngologiczny
Dostawca treści:: Biblioteka Nauki

Artykuł

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