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Tytuł:
Technological and organisational challenges for e-mobility
Autorzy:
Stańczyk, Tomasz Lech
Hyb, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1363315.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz. Przemysłowy Instytut Motoryzacji
Tematy:
electric vehicles
hybrid vehicles
e-mobility
electric drive
Opis:
With the rapid growth of schemes and initiatives to promote e-mobility and numerous measures taken to ensure its quick and effective implementation, there is a wide range of technological and non-technological problems, especially organisational, economic, legal and social in nature, that have to be handled by national and local governments all over the world. This article addresses some of the technological and organisational challenges for electromobility. The key technology-related issues to be coped with are the need for longer ranges of electric vehicles (EVs), shorter charging times and smart power grids (because of a higher demand for electrical energy). Another important problem to be solved urgently is the high battery weight, affecting the vehicle dynamics. Because of the excessive weight of the battery pack, there is a risk of its displacement during a crash, which may jeopardize the safety on the road. The next big concern, also associated with safety, is protection against electrical and fire hazards in the event of a collision. The most important of all the organisational challenges related to EVs is the necessity to create networks of charging stations. Their insufficient number and unsatisfactory distribution are strong barriers hampering the development of e-mobility. The organisational measures also include privileges such as access to bus lanes, already offered in some countries. Finally, there is the need to urgently train a large number of electricians to test and maintain EVs, the need to create a recycling system for used EV batteries, and the need to deal with the organisational aspects of the development of smart power grids.
Źródło:
Archiwum Motoryzacji; 2019, 84, 2; 57-70
1234-754X
2084-476X
Pojawia się w:
Archiwum Motoryzacji
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
OECD Recommendation’s draft concerning access to research data from public funding: a review
Autorzy:
Madeyski, Lech
Lewowski, Tomasz
Kitchenham, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/2173542.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
open data
open access
empirical research
data-driven research
data science
otwarte dane
otwarty dostęp
badanie empiryczne
badania oparte na danych
nauka o danych
Opis:
Sharing research data from public funding is an important topic, especially now, during times of global emergencies like the COVID-19 pandemic, when we need policies that enable rapid sharing of research data. Our aim is to discuss and review the revised Draft of the OECD Recommendation Concerning Access to Research Data from Public Funding. The Recommendation is based on ethical scientific practice, but in order to be able to apply it in real settings, we suggest several enhancements to make it more actionable. In particular, constant maintenance of provided software stipulated by the Recommendation is virtually impossible even for commercial software. Other major concerns are insufficient clarity regarding how to finance data repositories in joint private-public investments, inconsistencies between data security and user-friendliness of access, little focus on the reproducibility of submitted data, risks related to the mining of large data sets, and sensitive (particularly personal) data protection. In addition, we identify several risks and threats that need to be considered when designing and developing data platforms to implement the Recommendation (e.g., not only the descriptions of the data formats but also the data collection methods should be available). Furthermore, the non-even level of readiness of some countries for the practical implementation of the proposed Recommendation poses a risk of its delayed or incomplete implementation.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2021, 69, 1; art. no. e135401
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary driving style classification of the professional drivers
Autorzy:
Szumska, Emilia M.
Stańczyk, Tomasz Lech
Powiązania:
https://bibliotekanauki.pl/articles/2200796.pdf
Data publikacji:
2022
Wydawca:
Sieć Badawcza Łukasiewicz. Przemysłowy Instytut Motoryzacji
Tematy:
driver behaviour
urban bus
acceleration
professional driver
driving style
Opis:
Driving style and driver behaviour are important in evaluating city bus drivers. Buses are one of the means of public transportation in cities, used by millions of people. The purpose of this study was to present a model for preliminary classification of driving style of the professional drivers based on averaged maximum values of lateral and longitudinal acceleration recorded during regular work. First, the recorded acceleration values of 69 city bus drivers were analysed. Then, the correlation between the acceleration values and the age and experience of the city bus drivers was examined. Based on the results of the preliminary classification of drivers, extreme values for both lateral acceleration and longitudinal acceleration (deceleration and acceleration) were obtained by 3 drivers out of the 69 tested. The study also examined the relationship between averaged values of maximum lateral and longitudinal acceleration and driver age and experience. Based on the correlation results, showed that age and the number of years of holding a driver’s license are not significantly related to acceleration. Therefore, the method can be used to analyse drivers regardless of their age and experience.
Źródło:
Archiwum Motoryzacji; 2022, 98, 4; 25--39
1234-754X
2084-476X
Pojawia się w:
Archiwum Motoryzacji
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
OECD Recommendation’s draft concerning access to research data from public funding: a review
Autorzy:
Madeyski, Lech
Lewowski, Tomasz
Kitchenham, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/2090696.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
open data
open access
empirical research
data-driven research
data science
otwarte dane
otwarty dostęp
badanie empiryczne
badania oparte na danych
nauka o danych
Opis:
Sharing research data from public funding is an important topic, especially now, during times of global emergencies like the COVID-19 pandemic, when we need policies that enable rapid sharing of research data. Our aim is to discuss and review the revised Draft of the OECD Recommendation Concerning Access to Research Data from Public Funding. The Recommendation is based on ethical scientific practice, but in order to be able to apply it in real settings, we suggest several enhancements to make it more actionable. In particular, constant maintenance of provided software stipulated by the Recommendation is virtually impossible even for commercial software. Other major concerns are insufficient clarity regarding how to finance data repositories in joint private-public investments, inconsistencies between data security and user-friendliness of access, little focus on the reproducibility of submitted data, risks related to the mining of large data sets, and sensitive (particularly personal) data protection. In addition, we identify several risks and threats that need to be considered when designing and developing data platforms to implement the Recommendation (e.g., not only the descriptions of the data formats but also the data collection methods should be available). Furthermore, the non-even level of readiness of some countries for the practical implementation of the proposed Recommendation poses a risk of its delayed or incomplete implementation.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2021, 69, 1; e135401, 1--5
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of meteorological conditions on the shores of Szczecin Lagoon
Autorzy:
Kasyk, Lech
Pleskacz, Krzysztof
Kapuściński, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/24202521.pdf
Data publikacji:
2022
Wydawca:
Akademia Morska w Szczecinie. Wydawnictwo AMSz
Tematy:
SAR
shipwreck drift modelling
Szczecin Lagoon safety
wind parameters modelling
wind parameters and forecasting
pollution drift modelling
Opis:
The definition of dynamic areas of searching for shipwrecks, and/or the movement of pollution across waters of Szczecin Lagoon first requires the knowledge and specification of hydro-meteorological conditions across the area. This article compares wind parameters from various sources of meteorological stations located close to Szczecin Lagoon. The wind speed and direction were obtained from Ueckermuende, I Brama Torowa (Urząd Morski Szczecin), and Kopice (wind meter of Szczecin Maritime Academy). Wind direction data analysis was based on directional statistics methods and tools.
Źródło:
Zeszyty Naukowe Akademii Morskiej w Szczecinie; 2022, 70 (142); 83--93
1733-8670
2392-0378
Pojawia się w:
Zeszyty Naukowe Akademii Morskiej w Szczecinie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differential distribution of cathepsin b in human umbilical cord tissues
Autorzy:
Gogiel, Tomasz
Galewska, Zofia
Romanowicz, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1039685.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
umbilical cord
pregnancy
cathepsin B
umbilical cord artery
umbilical cord vein
Wharton's jelly
Opis:
The extracellular matrix components are differentially distributed among various structures of the umbilical cord. Wharton's jelly is especially rich in collagens and growth factors. Cathepsin B is a major cysteine protease involved in collagen degradation, as well as in the activation of precursor forms of other collagenolytic enzymes and growth factors. We assessed the activity and expression of cathepsin B in the umbilical cord arteries, veins and Wharton's jelly. Extracts of separated umbilical cord components were subjected to an activity assay with the use of specific fluorogenic substrate. The expression of cathepsin B protein was qualitatively evaluated by Western immunoblotting and quantitatively determined with an immunoenzymatic method. The total cathepsin B activity and content calculated per gram of DNA were higher in Wharton's jelly than in the umbilical cord vessels, and the latter parameter was the lowest in the umbilical cord arteries. Moreover, the expression and the activity of latent cathepsin B (following activation by pepsin digestion) calculated per gram of DNA were the highest in Wharton's jelly and the lowest in the umbilical cord arteries. High expression and activity of latent, pepsin-activatable cathepsin B related to DNA content in Wharton's jelly seem to reflect the stimulation of its cells by high amounts of collagen I and growth factors.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 679-684
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A study on carbonation depth prediction for concrete made with GBFS cement and FA addition
Badanie dotyczące prognozowania głębokości karbonatyzacji betonu wykonanego z cementu GBFS z dodatkiem FA
Autorzy:
Lech, Maciej
Juszczak, Tomasz
Wawrzeńczyk, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/2124786.pdf
Data publikacji:
2022
Wydawca:
Politechnika Świętokrzyska w Kielcach. Wydawnictwo PŚw
Tematy:
concrete carbonation
carbonation model
carbonation accelerated testing
GBFS cement
FA addition
karbonatyzacja betonu
model karbonatyzacji
przyspieszone badania karbonatyzacji
cement GBFS
dodatek FA
Opis:
This paper presents the results of the examination of accelerated carbonation of concrete mixes made with CEM III / A blast furnace slag cement and the addition of fly ash. The test program was developed using an experiment design with two factors: a water-binder ratio and a fly-ash / cement ratio. Carbonation depth measurements were carried out according to FprCEN/TS 12390-12 (CO2 concentration = 4%, T = 20°C, RH = 55%). Associated tests were also carried out, including compressive strength, porosity, depth of absorption, water penetration depth, and capillary suction. Analysis of the test results allowed us to determine the influence of binder composition on concrete carbonization depth under standard test conditions. The results show that the carbonation depth increases along with the increase in the W/B ratio and as a result of the increase in the fly ash content in the binder. A mathematical model was developed to describe the carbonation process over time, which can predict the depth and rate of concrete carbonation. Furthermore, it was found that there is no close relationship between other properties tested (e.g. strength) and the depth of the carbonated concrete.
W pracy przedstawiono wyniki badań przyspieszonej karbonatyzacji mieszanek betonowych wytworzonych cementem żużlowym wielkopiecowym CEM III/A z dodatkiem popiołu lotnego. Program badań został opracowany na podstawie projektu eksperymentu z dwoma czynnikami: stosunkiem wody do spoiwa oraz stosunkiem popiołu lotnego do cementu. Pomiary głębokości karbonatyzacji przeprowadzono zgodnie z FprCEN/TS 12390-12 (stężenie CO2 = 4%, T = 20°C, RH = 55%). Przeprowadzono również powiązane testy, w tym wytrzymałości na ściskanie, porowatości, głębokości absorpcji, głębokości penetracji wody i ssania kapilarnego. Analiza wyników badań pozwoliła na określenie wpływu składu spoiwa na głębokość karbonatyzacji betonu w standardowych warunkach testowych. Wyniki wskazują, że wraz ze wzrostem stosunku W/B oraz zawartością popiołu lotnego w spoiwie wzrasta głębokość karbonatyzacji. Opracowano model matematyczny do opisu procesu karbonatyzacji w czasie, który umożliwia przewidywanie głębokości i szybkości karbonatyzacji betonu. Ponadto stwierdzono, że nie ma ścisłego związku między innymi badanymi właściwościami (np. wytrzymałością) a głębokością betonu karbonatyzowanego.
Źródło:
Structure and Environment; 2022, 14, 1; 1--10
2081-1500
Pojawia się w:
Structure and Environment
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficiency analysis of parallel computing applied to auto-tuning of state feedback speed controller for PMSM drive
Autorzy:
Szczepański, Rafał
Tarczewski, Tomasz
Grzesiak, Lech M.
Powiązania:
https://bibliotekanauki.pl/articles/376463.pdf
Data publikacji:
2019
Wydawca:
Politechnika Poznańska. Wydawnictwo Politechniki Poznańskiej
Tematy:
parallel computing
Artificial Bee Colony
PMSM
state feedback
controller
MATLAB/Simulink
Opis:
Nowadays the simulation is inseparable part of researcher's work. Its computation time may significantly exceed the experiment time. On the other hand, multi-core processors are common in personal computers. These processors can be used to reduce computation time by using parallel computing on multiple cores. The most popular software applied to simulate behavior of the plant is MATLAB/Simulink. A single simulation of Simulink model cannot be computed by multiple cores, but there are many engineering problems, that require a multiple simulation of the same model with different parameters. In these problems, the parallel computing can be employed to decrease the overall simulation time. In this paper the parallel computing is used to speed-up the auto-tuning process of state feedback speed controller for PMSM drive. In order to obtain the optimal coefficients of the controller, an Artificial Bee Colony optimization algorithm is employed.
Źródło:
Poznan University of Technology Academic Journals. Electrical Engineering; 2019, 100; 145-156
1897-0737
Pojawia się w:
Poznan University of Technology Academic Journals. Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Providing the Ability of Working Remotely on Local Company Server via VPN
Autorzy:
Muc, Adam
Muchowski, Tomasz
Murawski, Lech
Szeleziński, Adam
Powiązania:
https://bibliotekanauki.pl/articles/2064905.pdf
Data publikacji:
2020
Wydawca:
STE GROUP
Tematy:
remote work
server services
VPN
OpenVPN
server costs
Opis:
Increasingly popular remote work requires the use of modern network technologies to provide employees in a remote location with access to the company’s IT resources. The answer to the needs of remote access to files and server services can be the use of clouds and VPS. However, this involves high costs and requires entrusting the enterprise’s data to the providers of these services. Both for reasons of data security and too high costs, enterprises sometimes cannot use these technologies. The solution to the problem may be the use of encrypted VPN tunneling, which allows the device to be connected at a remote location to the company’s local network and use its resources as if it was connected to the local network with physical transmission medium.
Źródło:
Multidisciplinary Aspects of Production Engineering; 2020, 3, 1; 195--205
2545-2827
Pojawia się w:
Multidisciplinary Aspects of Production Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adjuvant imatinib after resection of gastrointestinal stromal tumour – systematic review and meta-analysis
Imatynib w terapii adiuwantowej pacjentów po zabiegu usunięcia nowotworów podścieliskowych przewodu pokarmowego (GIST) – przegląd systematyczny badań klinicznych i metaanaliza
Autorzy:
Kawalec, Paweł
Kryst, Joanna
Laczewski, Tomasz
Martyna, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1065969.pdf
Data publikacji:
2013
Wydawca:
Medical Education
Tematy:
GIST
adjuvant therapy
gastrointestinal stromal tumour
imatinib
systematic review
Opis:
Background: Adjuvant therapy is recommended for the population of patients with high risk of recurrence of gastrointestinal stromal tumour after resection. The aim of the study: Evaluation of the clinical efficacy and safety profile of imatinib used in adjuvant therapy in patients after complete resection of a gastrointestinal stromal tumour. Material and methods: A systematic review of the literature published up to 30.03.2012 was performed, and a meta-analysis of identified studies was carried out. Databases were searched: PubMed, EMBASE, The Cochrane Library and others. Results: Two randomised clinical trials regarding comparisons of: imatinib vs. placebo and 12 months of adjuvant imatinib vs. 36 months of adjuvant imatinib as well as 20 non-randomised trials fulfilled the established criteria. Adjuvant imatinib statistically significantly improves recurrence-free survival compared with placebo. Patients with high risk of recurrence benefit most from assigned treatment. Three years of adjuvant imatinib therapy improves recurrence-free state and overall survival compared with 1 year of imatinib in patients after resection of a gastrointestinal stromal tumour. The safety profile of imatinib in the analyzed population is acceptable. Conclusions: For patients with a significant risk of recurrence adjuvant therapy with imatinib should be considered for every patient, due to the clinical benefits it brings.
Wstęp: Zastosowanie terapii adiuwantowej jest zalecane u pacjentów ze znaczącym ryzykiem nawrotu choroby po zabiegu usunięcia nowotworu podścieliskowego przewodu pokarmowego. Cel pracy: Ocena skuteczności klinicznej i profilu bezpieczeństwa imatynibu stosowanego w ramach terapii adiuwantowej u pacjentów po zabiegu całkowitej resekcji nowotworu podścieliskowego przewodu pokarmowego. Materiał i metody: Przeprowadzono systematyczny przegląd literatury opublikowanej do 30 marca 2012 r. oraz metaanalizę zakwalifikowanych do opracowania badań. Przeszukano następujące bazy danych: PubMed, EMBASE, The Cochrane Library oraz inne. Wyniki: Odnaleziono 2 randomizowane badania kliniczne, dotyczące porównania: imatynibu z placebo oraz imatynibu stosowanego przez 12 miesięcy z imatynibem podawanym przez 36 miesięcy, oraz 20 nierandomizowanych badań klinicznych dotyczących stosowania imatynibu w analizowanym wskazaniu. Zastosowanie imatynibu w terapii adiuwantowej prowadzi do istotnego statystycznie wydłużenia przeżycia wolnego od nawrotu choroby względem placebo. Największe korzyści z zastosowanej terapii odnoszą chorzy z wysokim ryzykiem nawrotu choroby. Przedłużenie 12-miesięcznej terapii imatynibem do 36 miesięcy zwiększa prawdopodobieństwo przeżycia wolnego od progresji choroby oraz przeżycia całkowitego pacjentów po zabiegu resekcji nowotworu podścieliskowego przewodu pokarmowego. Profil bezpieczeństwa imatynibu w analizowanej populacji okazał się korzystny. Wnioski: U pacjentów o znaczącym ryzyku nawrotu terapia adiuwantowa imatynibem powinna być rozpatrywana w przypadku każdego pacjenta ze względu na korzyści kliniczne, jakie przynosi.
Źródło:
OncoReview; 2013, 3, 4; 232-342, 343-354
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Artificial Neural Network-Based Gain-Scheduled State Feedback Speed Controller for Synchronous Reluctance Motor
Autorzy:
Tarczewski, Tomasz
Niewiara, Łukasz J.
Grzesiak, Lech M.
Powiązania:
https://bibliotekanauki.pl/articles/1956002.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
synchronous reluctance motor
state feedback controller
gain scheduling
artificial neural network
robustness analysis
Opis:
This paper focuses on designing a gain-scheduled (G-S) state feedback controller (SFC) for synchronous reluctance motor (SynRM) speed control with non-linear inductance characteristics. The augmented model of the drive with additional state variables is introduced to assure precise control of selected state variables (i.e. angular speed and d-axis current). Optimal, non-constant coefficients of the controller are calculated using a linear-quadratic optimisation method. Non-constant coefficients are approximated using an artificial neural network (ANN) to assure superior accuracy and relatively low usage of resources during implementation. To the best of our knowledge, this is the first time when ANN-based gain-scheduled state feedback controller (G-S SFC) is applied for speed control of SynRM. Based on numerous simulation tests, including a comparison with a signum-based SFC, it is shown that the proposed solution assures good dynamical behaviour of SynRM drive and robustness against q-axis inductance, the moment of inertia and viscous friction fluctuations.
Źródło:
Power Electronics and Drives; 2021, 6, 41; 276-288
2451-0262
2543-4292
Pojawia się w:
Power Electronics and Drives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cholelithiasis – always infected?
Autorzy:
Matyjas, Tomasz
Pomorski, Lech
Witas, Henryk
Płoszaj, Tomasz
Matyjas, Katarzyna
Kaczka, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1393554.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
bile
bile deposits
gallstones
biliary infection
bacteria
Opis:
This study aims to present results regarding the presence and identification of bacterial strains found in bile and gallstones located in the gallbladder and bile ducts in patients operated on due to cholelithiasis. Materials and Methods. Bacterial culture was evaluated in 92 patients. There were 54 women (59%) and 38 men (41%) who underwent surgery on account of cholelithiasis and /or gallstones in bile ducts between 2013 and 2014. Bile and gallstone samples were cultured intraoperatively for bacteria; bacterial strains were identified, and their sensitivity to antibiotics was determined. Molecular methods (NGS and Sanger method) were used to separate bacterial strains in one of the gallbladder stones and the results were compared with bacterial strains grown from the bile. Results. Bile cultures were positive in 46 patients that is, 50% of the study group. The following bacteria strains were grown: Enterococcus spp. (44%), Escherichia coli (37%) and Klebsiella spp. (35%). Candidiasis accompanied by bacterial infection was detected in 7 patients (15%). Molecular testing of gallstones revealed DNA of Enterococcus spp., Escherichia spp., Streptococcus spp. and Clostridium spp. In the bile culture of the same patient Enterococcus spp. (avium and faecalis) was detected. Conclusion 1. More than one pathogen was grown on samples obtained from 31 patients (70%) with bile infection. 2. The most common pathogens include Enterococcus spp., Escherichia coli and Klebsiella spp. 3. Bacterial infections are often accompanied by a fungal infection (Candida albicans) 4. Bacterial strains grown from a gallstone sample partially corresponded with strains identified in the bile of the same patient.
Źródło:
Polish Journal of Surgery; 2017, 89, 3; 23-26
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution of cathepsin L in human umbilical cord tissues
Autorzy:
Gogiel, Tomasz
Wolańska, Małgorzata
Galewska, Zofia
Kinalski, Piotr
Sobolewski, Krzysztof
Romanowicz, Lech
Powiązania:
https://bibliotekanauki.pl/articles/1038609.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cathepsin L
cysteine protease inhibitors
umbilical cord
umbilical cord artery
umbilical cord vein
Wharton's jelly
Opis:
The extracellular matrix components show specific distribution patterns within various structures of the umbilical cord, among which Wharton's jelly is especially collagen-rich tissue. Cathepsin L is a potent cysteine protease engaged in degradation of extracellular matrix proteins, including collagens. We evaluated the activity and expression of cathepsin L, and the inhibitory effect of cysteine protease inhibitors in the umbilical cord arteries, vein and Wharton's jelly. Cathepsin L activity and anti-papain inhibitory effect of cysteine protease inhibitors were quantified in extracts of separated umbilical cord tissues using fluorogenic substrates. The results were calculated per DNA content. The enzyme expression was assessed by Western immunoblotting. The active cathepsin L activity (without activation by pepsin digestion), its percentage in the total activity (after pepsin activation), and the expression of the mature single-chain enzyme were the lowest in the umbilical cord arteries and the highest in Wharton's jelly. The effect of cysteine protease inhibitors showed similar distribution as in the case of the active enzyme, being the highest in Wharton's jelly. Distribution of the activity and expression of mature cathepsin L within the umbilical cord probably results from distinctions in the proenzyme activation process. Differences in the action of cysteine protease inhibitors can partly restrict divergences in the enzyme activity that could reflect its expression alone. Differential enzyme action seems to contribute to tissue-specific collagen turnover within the umbilical cord cells, especially those of Wharton's jelly.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 507-512
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carcinoembryonic antigen and matrix metalloproteinase 2 serum and peritoneal washes concentration in staging and prognosis in colorectal cancer patients
Autorzy:
Guzel, Tomasz
Mirowska-Guzel, Dagmara
Lech, Gustaw
Wroński, Marek
Iwanowska, Marzena
Słodkowski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1392892.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
colorectal cancer
CEA
MMP-2
peritoneal washes
Opis:
Purpose: The aim of the study was to determine the significance of carcinoembryonic antigen and matrix metalloproteinase 2 peritoneal washes and serum concentration in patients suffering from colorectal cancer concerning tumor staging and 5-year survival rate in these patients. Methods: 80 patients who underwent curative surgery for colorectal cancer were included in the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. Results: Regarding tumor penetration, CEA-s and CEA-p concentrations were higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentrations were lower in T2 compared to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP-2-s concentration was higher in T3 compared to T2, the highest MMP-2-p concentration was in T4, with no statistical significance. Regarding nodular status, a significant difference of CEA-s was noted between N0 and N1. For CEA-p, significance was found between N0 and N2 as between N1 and N2. MMP-2-s concentration was the highest in N1, MMP-2-p concentration was the highest in T4, with no statistical significance. The 5-year survival rate for all patients was 63.53%. There were significant differences in CEA-s and CEA-p concentrations between patients with negative and positive 5-year survival. Conclusion: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentrations correlate with survival rate in patients suffering from colorectal cancer and can be useful as an additional prognostic factor. The usefulness of MMP-2 measurement still requires further studies.
Źródło:
Polish Journal of Surgery; 2018, 90, 5; 36-43
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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