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    Wyświetlanie 1-3 z 3
    Tytuł:
    Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro.
    Autorzy:
    Szurko, Agnieszka
    Krämer-Marek, Gabriela
    Wideł, Maria
    Ratuszna, Alicja
    Habdas, Jan
    Kuś, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1043409.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    malignant melanoma
    tumour megacolonies in vitro
    necrosis
    photodynamic therapy
    synthetic porphyrins
    apoptosis
    Opis:
    Two water soluble porphyrins: meso-tetra-4-N-methylpyridyl-porphyrin iodide (P1) and 5,10-di-(4-acetamidophenyl)-15,20-di-(4-N-methylpyridyl) porphyrin (P2) were synthesised and evaluated in respect to their photochemical and photophysical properties as well as biological activity. Cytotoxic and phototoxic effects were evaluated in human malignant melanoma Me45 line using clonogenic assay, cytological study of micronuclei, apoptosis and necrosis frequency and inhibition of growth of megacolonies. Both porphyrins were characterised by high UV and low visible light absorptions. Dark toxicity measured on the basis of the clonogenic assay and inhibition of megacolony growth area indicated that P1 was non-toxic at concentrations up to 50 μg/ml (42.14 μM) and P2 at concentrations up to 20 μg/ml (16.86 μM). The photodynamic effect induced by red light above 630 nm indicated that both porphyrins were able to inhibit growth of melanoma megacolonies at non-toxic concentrations. Cytologic examination showed that the predominant mode of cell death was necrosis.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 4; 1165-1174
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of olanzapine and aripiprazole on spatial memory of female rats exposed to stress in the perinatal period
    Autorzy:
    Kus, Krzysztof
    Ratajczak, Piotr
    Zaprutko, Tomasz
    Kopciuch, Dorota
    Paczkowska, Anna
    Nowakowska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/895623.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    olanzapine
    aripiprazole
    Prenatal stress
    female rats
    variation in sexes
    Opis:
    Cognitive functions, such as learning and memory, are instrumental in improving the patient’s quality of life. Commonly used antipsychotic drugs are also useful in depression treatment, and have a positive effect on spatial memory dysfunction caused by schizophrenia. Olanzapine (OLA) and aripiprazole (ARI) are known to have substantially different pharmacokinetics depending on sex, thus their therapeutic efficacy and dose of treatment may be different for males and females. The aim of the study was to assess whether dysfunction of spatial memory (Morris Water Maze - MWM) and locomotor activity (LA) improve in prenatally stressed rats (animal model of schizophrenia (AMS)) by OLA and ARI. OLA (0.5 mg/kg ip) and ARI (1.5 mg/kg ip) were administered to female Wistar rats (non-stressed control group (NSCG) and PSG). Single administration of ARI and OLA in the NSCG yielded no differences in spatial memory compared to the control group (C-NSCG), while OLA improved memory after 7 days of treatment compared to the C-NSCG. In the prenatally stressed group (PSG), an impairment of spatial memory by the drug was observed (vs. C-NSCG) after long-term treatment. Only chronic administration of ARI and OLA (PSG) improved spatial memory in female rats. Conclusion: Stress causes memory dysfunction in female rats. Chronic administration of ARI and OLA reverses this effect which can probably be associated with the mechanism of action of the drugs used (ARI/OLA). ARI acts as an agonist or antagonist mainly on D2 and 5-HT2A receptors, while OLA induces antagonist effects for these receptors.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 885-893
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE PRESCRIPTION TO OVER-THE-COUNTER SWITCHES AND DOUBLE REGISTRATION OF MEDICINES - THE PERSPECTIVE OF PHARMACISTS FROM THE GREATER POLAND.
    Autorzy:
    Zaprutko, Tomasz
    Kopciuch, Dorota
    Ratajczak, Piotr
    Paczkowska, Anna
    Adamczak, Olga
    Kus, Krzysztof
    Nowakowska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/895258.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    pharmaceutical market
    pharmacies
    Rx-to-OTC switches
    double registration
    Opis:
    The prescription to over-the-counter switch is a global occurrence. However, the switch phenomenon might be considered controversial. Nevertheless, the further development of switches seems to be inevitable, thus we collected pharmacists’ opinions about Rx-to-OTC switches including double registration of medicines. The study was conducted in pharmacies from the Greater Poland, using an anonymous questionnaire, which was delivered by direct contact. Finally, answers from 232 pharmacies were included in the study. Moreover, we analyzed data from 5500 Polish pharmacies, concerning the turnover of selected and doubly registered medicines. Rx-to-OTC switches were negatively evaluated by the majority (81.5%) of respondents. “Furaginum” was the most frequently chosen (60.8%) substance, which according to obtained answers should be available only on prescription. Study participants claimed that the most important drawback (chosen by 44.4% participants) of the double registration of medicines is the development of uncontrolled self-medication. Data obtained from a market research company revealed that the Rx-to-OTC switch may lead to the market share growth of OTC class (e.g. “furaginum”), but it is not the rule (e.g. “omeprazole/pantoprazole”). Although Rx-to-OTC switches are considered somewhat controversial, the switch, as well as double registration phenomenon, seems to be a subject of further development. However, in pharmacists opinion substances like “furaginum” should be available as an Rx-only brand instead of double registered medicine. In the case of Rx-to-OTC switches, additional information about possible side effects and/or interactions should be provided to the patients who might inappropriately use medicines.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 907-912
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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