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    Wyświetlanie 1-14 z 14
    Tytuł:
    Fluorescence Spectroscopy in Camptothecins Studies
    Autorzy:
    Kruszewski, S.
    Kruszewska, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/1537476.pdf
    Data publikacji:
    2010-07
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kv
    87.15.kp
    Opis:
    The application of fluorescence spectroscopy methods to determining the properties of analogues of camptothecin, promising anticancer agents, are described in this paper. The fluorescence anisotropy measurements provide useful information about the binding of camptothecin and its analogues to cell membranes and human serum albumin (HSA) that is important for potential clinical applications of these agents, and permit the selection from many camptothecin analogues those ones exhibiting desirable biomedical properties. Fluorescence anisotropy measurements prove that 3 new camptothecin analogues: 7-tert-butyldimethylsilyl-10-hydroxy-campthothecin, 7-trimethyl-silylethyl-10-hydroxy-camptothecin and 7-trimethyl-silyl-ethyl-10-amino-camptothecin exhibit high affinity of their lactone forms to membranes and low affinity of their carboxylate forms to HSA. Such properties should ensure high stability of these agents in physiological fluids, including blood.
    Źródło:
    Acta Physica Polonica A; 2010, 118, 1; 99-102
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Activation of Silver Colloids for Enhancement of Raman Scattering
    Autorzy:
    Kruszewski, S.
    Cyrankiewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1504412.pdf
    Data publikacji:
    2011-06
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.20.Fb
    33.20.Kf
    62.23.St
    82.70.Dd
    Opis:
    Obtaining of systems that provide ever-increasing enhancement of the Raman scattered light is a big challenge. The silver colloids obtained by reduction of silver nitrate by trisodium citrate are the most promising enhancement systems. Nanoparticles of silver forming fresh colloid obtained by this way exhibit in extinction spectrum the absorption band proving of the surface plasmons excitation, but do not enhance the Raman scattered light, are not surface enhanced Raman scattering active. Adding of KCl or $HNO_3$ causes the surface enhanced Raman scattering activation, i.e. causes that the conditions for aggregation of nanoparticles and for adsorption on their surface of molecules providing Raman scattering are created. Increasing amount of added KCl or $HNO_3$ leads to significant changes in the extinction spectrum and to significant increase in intensity of surface enhanced Raman scattering. The observed changes in extinction spectrum are mainly due to progressive aggregations of nanoparticles. In junctions between nanoparticles existing inside aggregates the condition for single molecule surface enhanced Raman scattering are fulfilled and therefore aggregation leads to increase in average surface enhanced Raman scattering intensity. Silver colloid activated by using KCl provides about 10-fold higher surface enhanced Raman scattering than that treated with $HNO_3$.
    Źródło:
    Acta Physica Polonica A; 2011, 119, 6A; 1018-1022
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rhodamine 6G as a Mediator of Silver Nanoparticles Aggregation
    Autorzy:
    Kruszewski, S.
    Cyrankiewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1400066.pdf
    Data publikacji:
    2013-06
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.20.Fb
    33.20.Kf
    61.46.Df
    78.67.Bf
    87.83.+a
    Opis:
    Surface-enhanced Raman scattering is the phenomenon where a huge increase of Raman scattering intensity from molecules situated close to the metal nanoobjects is observed. Our study is focused on the method of SERS-activation of silver nanoparticles and, in the future, the application of thus obtained SERS substrates for biomedical purposes. As expected, the intensity of Raman scattering from rhodamine 6G used here as a SERS probe strongly increase during the early stages of aggregation of silver sol. Moreover, the evolution of extinction spectra and changes in the degree of the colloid aggregation observed in DLS measurements point out that molecules of the dye do not participate passively in the aggregation process but greatly affect its course.
    Źródło:
    Acta Physica Polonica A; 2013, 123, 6; 965-969
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Optical Spectroscopy Study of the Interaction Between Quercetin and Human Serum Albumin
    Autorzy:
    Wybranowski, T.
    Kruszewski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1197523.pdf
    Data publikacji:
    2014-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.K-
    87.64.kv
    87.15.kp
    Opis:
    Optical methods are very useful for the study on behavior of molecules in albumin-containing solutions. The interaction between quercetin (QUE) and human serum albumin (HSA) under physiological conditions was investigated by the methods of UV-Vis absorption and fluorescence spectroscopy. Fluorescence data show that enhancing of quercetin fluorescence in the presence of HSA is the result of formation of the HSA-QUE complex. On the basis of fluorescence data, the binding affinity constant of quercetin to HSA is determined. In this paper we have attempted to perform a kinetic study of the oxidation of quercetin in presence of human serum albumin by absorption spectroscopy. It has been shown that quercetin easily oxidizes at pH 7.4. The addition of HSA to quercetin solution induces changes in the absorption spectrum. In the human serum albumin solution, the time of quercetin oxidation is longer than in the case of quercetin diluted in phosphate buffered saline. Human albumin also contributes to stabilization of quercetin. These results suggest that HSA prevents degradation of quercetin in blood.
    Źródło:
    Acta Physica Polonica A; 2014, 125, 4A; A-57-A-60
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aggregated Silver Sols as SERS Substrates
    Autorzy:
    Kruszewski, S.
    Cyrankiewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1490450.pdf
    Data publikacji:
    2012-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.20.Fb
    33.20.Kf
    33.50.-j
    Opis:
    The unique plasmonic properties of the noble metal colloidal nanoparticles make them promising enhancement substrates for surface-enhanced Raman scattering. Obtaining of systems that provide ever-increasing enhancement of the Raman scattered light is a big challenge. Silver colloids studied here are prepared by Lee-Meisel's method. Rhodamine 6G and rhodamine B are used as probe adsorbates. The "raw" colloids obtained in this way exhibit a characteristic extinction band proving surface plasmons excitation, but do not enhance the Raman signal. Theoretical calculations indicate that the extremely large electromagnetic field is induced in the junctions between metallic nanostructures so some degree of their aggregation is necessary to achieve a sufficient gain value. The addition of aggregating agents (KCl or HCl) leads to significant changes in the extinction spectrum and to significant increase in the intensity of surface-enhanced Raman scattering. The experiments show that chloride can not only promote the aggregation process but also effectively affect chemical mechanisms contributing to surface-enhanced Raman scattering.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 1A; A-068-A-074
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Silver Nanoparticles as Enhancing Substrates for Raman and Fluorescence Spectroscopy
    Autorzy:
    Cyrankiewicz, M.
    Wybranowski, T.
    Kruszewski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1196708.pdf
    Data publikacji:
    2014-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.20.Fb
    33.20.Kf
    32.50.+d
    61.46.Df
    73.20.Mf
    78.67.Bf
    87.83.+a
    Opis:
    The enhancing properties of silver nanoparticles in surface-enhanced Raman scattering (SERS) and metal-enhanced fluorescence (MEF) are studied in this work. The obtained results confirm that the partial aggregation of nanoparticles leads to a great increase of Raman scattering cross-section but there are significant differences in SERS-activity of colloidal silver treated with various aggregating compounds. The differences are interpreted through the analysis of both experimental and computational results. The same silver colloid covered with silica shell preventing the fluorescence quenching makes possible a several-fold increase in fluorescence emission. The effect strongly depends on thickness of the outer layer of nanoparticles. Geometrical parameters of nanoparticles (radius or radius and thickness of the adsorption layer in core-shell systems) are determined on the basis of the dynamic light scattering (DLS) data and extinction spectra analysis.
    Źródło:
    Acta Physica Polonica A; 2014, 125, 4A; A-11-A-15
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of displacement compounds on the binding of ochratoxin A to human serum albumin examined with fluorescence anisotropy methods
    Autorzy:
    Wybranowski, T
    Ziomkowska, B.
    Cwynar, A
    Kruszewski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/173353.pdf
    Data publikacji:
    2014
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    ochratoxin A
    binding of drug to albumin
    flurbiprofen
    ibuprofen
    warfarin
    Opis:
    The subject of the research is the application of the methods of fluorescence anisotropy measurements to study the interaction between human serum albumin (HSA) and toxins and selected medicines (ibuprofen, warfarin, flurbiprofen). Optical spectroscopic methods are useful tools for the study of biologically active compounds. Determining binding intensity of ochratoxin A (OTA) to albumin may be helpful in explaining the effects of toxic influence of OTA. The main factor influencing the distribution of OTA is its affinity for plasma proteins. It was shown that ochratoxin binds strongly to albumin. By the use of the method of fluorescence anisotropy it was proved that the unbound fraction of OTA is higher due to competing interactions with drugs. As a result of separating ochratoxin from protein by competitive compounds, a decrease in the fluorescence anisotropy of the HSA-OTA complex was observed. The largest increase in free fraction of OTA is caused by flurbiprofen, then ibuprofen and warfarin. It will accelerate OTA transport to target organs and shortening its half-life period, leading consequently to a decrease in chronic toxic effects.
    Źródło:
    Optica Applicata; 2014, 44, 3; 357-364
    0078-5466
    1899-7015
    Pojawia się w:
    Optica Applicata
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Selective Resonance Raman Scattering of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ Dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ Salts
    Autorzy:
    Kruszewski, S.
    Feltre, L.
    Bozio, R.
    Bellitto, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/1929169.pdf
    Data publikacji:
    1993-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    34.70.+e
    78.30.-j
    Opis:
    Raman investigation of Peierls-Hubbard (TTF$\text{}^{+}$)$\text{}_{2}$ dimers in (TTF)$\text{}_{2}$Mo$\text{}_{6}$O$\text{}_{19}$ and (TTF)$\text{}_{2}$W$\text{}_{6}$O$\text{}_{19}$ salts have been performed. It was found that the resonance enhancement of Raman intensity of intramolecular vibration modes exists only when the frequency of excitation light fits to the localised electron transition, however, the resonance enhancement of intermolecular modes occurs when the frequency of excitation light corresponds to the charge transfer transition.
    Źródło:
    Acta Physica Polonica A; 1993, 83, 4; 431-440
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of the Protein-Binding Properties of Camptothecins by Means of Optical Spectroscopy Methods
    Autorzy:
    Ziomkowska, B.
    Cyrankiewicz, M.
    Wybranowski, T.
    Kruszewski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/1197530.pdf
    Data publikacji:
    2014-04
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.K-
    87.64.kv
    87.15.kp
    02.50.Sk
    Opis:
    Optical spectroscopy methods are widely used in studies of drugs. The affinity of camptothecins - anticancer agents - to human serum albumin (HSA) was determined in this work. Camptothecins (CPTs) exist in two forms: active lactone and open ring inactive carboxylate. In blood, the hydrolysis process of lactone form occurs which leads to deactivation of CPTs. Research is being done on biophysical properties of synthesized CPT compounds, in particular on binding to albumin. The affinity to plasma proteins is an important determinant of stability of CPTs in blood. The following analogues of CPT were tested in this paper: irinotecan, SN-38, topotecan, and 9-amino camptothecin. Using the method of fluorescence anisotropy measurement, the association constants of the studied compounds to HSA were determined. The authors attempted to determine the deactivation rate of topotecan in HSA solution using Principal Component Analysis and Factor Analysis of absorption spectra recorded during hydrolysis process of lactone form.
    Źródło:
    Acta Physica Polonica A; 2014, 125, 4A; A-61-A-65
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enhancement of FITC Fluorescence by Silver Colloids and Silver Island Films
    Autorzy:
    Kruszewski, S.
    Wybranowski, T.
    Cyrankiewicz, M.
    Ziomkowska, B.
    Pawlaczyk, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1812349.pdf
    Data publikacji:
    2008-06
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    33.20.Fb
    33.20.Kf
    33.50.-j
    Opis:
    Silver colloids and silver island films as fluorescence enhancement systems are the subject of this paper. Enhancement of fluorescence of molecules placed near metallic nanoparticles is a result of resonance interaction of exciting and emitted lights with surface plasmons. Two models explaining this phenomenon are presented. Processes of silver colloids and silver island films forming are described. Results of extinction, absorption and scattering studies of fluorescence enhancement systems are presented. The influence of these systems, i.e. silver colloids and silver island films on the fluorescence of fluorescein-5-isothiocyanate was studied. 7-fold increase in fluorescence intensity of fluorescein-5-isothiocyanate molecules placed near silver nanoparticles was observed.
    Źródło:
    Acta Physica Polonica A; 2008, 113, 6; 1599-1608
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Slimhole well casing design for high-temperature geothermal exploration and reservoir assessment
    Autorzy:
    Kruszewski, M.
    Thorhallsson, S.
    Assadi, M.
    Śliwa, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/298892.pdf
    Data publikacji:
    2017
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    geothermal exploration wells
    slimhole casing
    Opis:
    It is anticipated that utilization of geothermal resources for renewable energy production will continue to grow globally. Since cost of drilling and well construction constitutes a considerable share of the total cost of the geothermal installations, development and evaluation of low-cost alternatives is crucial for expansion of this industry. This paper describes slimhole casing design for geothermal exploration wells, as an alternative for reduced cost and improved environmental performance. The main goal of the paper is to contribute to cost effective casing design program that satisfies severe reservoir conditions of geothermal wells. A case study is presented for casing design for a 2000 m deep vertical well with water level at 200 m, where the New Zealand Code of Practice has been applied. The “worst case scenario”, i.e. when temperature and pressure follow the boiling point depth curve (BPD), has been considered as base case for the casing design, when drilling in a high-temperature geothermal area. Alternative methods are also presented for determining the minimum casing setting depths and the results are compared. Pressure and temperature conditions inside the well were established using X-steam program, an Excel add-in, and the final results, establishing loading criteria that the casing has to withstand i.e.: burst, collapse and tension/compression are presented.
    Źródło:
    AGH Drilling, Oil, Gas; 2017, 34, 2; 465-493
    2299-4157
    2300-7052
    Pojawia się w:
    AGH Drilling, Oil, Gas
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The rapid interphase chromosome assay (RICA) implementation : comparison with other PCC methods
    Autorzy:
    Sommer, S.
    Buraczewska, I.
    Sikorska, K.
    Bartłomiejczyk, T.
    Szumiel, I.
    Kruszewski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/147263.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    biodosimetry
    ionizing radiation
    premature chromosome condensation (PCC)
    human lymphocytes
    Opis:
    A report is presented on the advantages of the rapid interphase chromosome assay (RICA) and the difficulties that may be met while implementing this method for application in biological dosimetry. The RICA test can be applied on unstimulated human lymphocytes; this is an advantage in comparison with the dicentric chromosomes or micronucleus tests. In the former two tests, stimulated lymphocytes are examined and hence, 48 h more are needed to obtain cells traversing the cell cycle. Due to the use of unstimulated nondividing cells, higher numbers of cells are available for RICA analysis than for dicentric chromosomes or micronuclei tests. Moreover, the method can be applied after exposure to ionizing radiation doses in excess of 5 Gy. Such doses cause a signifi cant cell cycle delay or result in the loss of G2 phase and mitotic cells because of apoptosis. Therefore, the traditional biodosimetry based on the evaluation of the incidence of damage to chromosomes is very difficult to carry out. This is due to the lack of an adequate number of mitotic cells for analysis. RICA is free of this disadvantage. An automatic microscope can be used to retrieve cell images; automatic image analysis can also be used.
    Źródło:
    Nukleonika; 2015, 60, No. 4, part 2; 933-941
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nuclear Factor kappa B activation by Ag, Au nanoparticles, CdTe quantum dots or their binary mixtures in HepG2 cells
    Autorzy:
    Kapka-Skrzypczak, L.
    Męczyńska-Wielgosz, S.
    Matysiak-Kucharek, M.
    Czajka, M.
    Sawicki, K.
    Kruszewski, M.
    Brzóska, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085648.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    nanomaterials
    NF-κB
    dual-luciferase reporter system
    nanoparticles binary mixtures
    Opis:
    Introduction and Objective. Nuclear factor kappa B (NF-κB) signalling pathway plays a central role in the regulation of cellular response to stress. The aim of the study was to investigate the ability of silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), CdTe quantum dots (CdTeQDs) or their binary mixtures to stimulate NF-κB binding in HepG2 cells. A dual luciferase reporter system was used to investigate NF-κB binding. Materials and method. Cells were transiently transfected with a firefly luciferase reporter system and Renilla luciferase expression plasmid as a transfection efficiency control. Twenty- four hours after transfection, the cells were treated with nanoparticles (10 µg/cm3 AgNPs, 10 µg/cm3 AuNPs, 3 µg/cm3 CdTeQDs) or with 10 ng/cm3 TNFα as a positive control. Six hours later, the cells were lysed and the activities of the luminescence of firefly and Renilla luciferases were measured using the Dual-Luciferase Reporter Assay System. Results. AuNPs and CdTeQDs alone significantly inhibited NF-κB binding activity. Co-treatment with AgNPs and CdTeQDs resulted in an additive effect, whereas the presence of AgNPs diminished the inhibitory effect of AuNPs. Interestingly, significant antagonism was observed between AuNPs and CdTeQDs, suggesting a similar mode of action. Conclusions. Comparison of the NF-κB binding activity induced by the mixtures of NPs suggests that in some cases NF-κB binding activity might differ from that observed for the NPs alone.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 231-234
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Heavy Ion Beams for Radiobiology: Dosimetry and Nanodosimetry at HIL
    Autorzy:
    Kaźmierczak, U.
    Bantsar, A.
    Banaś, D.
    Braziewicz, J.
    Czub, J.
    Jaskóła, M.
    Korman, A.
    Kruszewski, M.
    Lankoff, A.
    Lisowska, H.
    Pietrzak, M.
    Pszona, S.
    Stępkowski, T.
    Szefliński, Z.
    Wojewódzka, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1402627.pdf
    Data publikacji:
    2015-05
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.53.Bn
    87.53.-j
    Opis:
    Ionizing radiation induces a variety of DNA lesions, including single and double strand breaks. Large energy deposition precisely localized along the ion track that occurs in the case of heavy ion irradiation can lead to complex types of DNA double strand breaks in exposed biological material. The formation of nuclear double strand breaks triggers phosphorylation of histone H2AX, which can be microscopically visualized as foci in the γ-H2AX assay. Studies with a carbon ion beam are being carried out at the Heavy Ion Laboratory of the University of Warsaw. The γ-H2AX assay as a method of measuring the biological response of cells irradiated with $\text{}^{12}C$ ions as well as the frequency cluster size distributions obtained in the nanodosimetry experiment at HIL will be presented.
    Źródło:
    Acta Physica Polonica A; 2015, 127, 5; 1516-1519
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-14 z 14

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