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    Wyświetlanie 1-9 z 9
    Tytuł:
    Sorption of oil products on the synthetic zeolite granules
    Autorzy:
    Król, Magdalena
    Rożek, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/127613.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Mineralogiczne
    Tematy:
    sorbent
    adsorption
    oil pollution
    zeolite Na-P1
    expanded glass
    Opis:
    In this work, lightweight granules of zeolite Na-P1 based on expanded glass aggregates were synthesized for the application in oil products’ sorption. The sorption of gasoline, diesel and silicone oil tests were also conducted for raw expanded glass, zeolite A, clinoptilolite and mineral sorbent available at a fuel station. All sorbents were also characterized in terms of the phase composition (X-ray diffraction) and structure (infrared spectroscopy). The zeolite Na-P1 granules achieved the highest values of sorption capacities (1.8, 2.1 and 2.6 g/g, respectively), which makes them promising materials for oils’ removal.
    Źródło:
    Mineralogia; 2020, 51, 1; 1-7
    1899-8291
    1899-8526
    Pojawia się w:
    Mineralogia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Knowledge of young women concerning the impact of natural feeding on the growth and state of health of a baby
    Autorzy:
    Trojanowska, Alina
    Brodowicz-Król, Magdalena
    Trojanowska, Paulina
    Powiązania:
    https://bibliotekanauki.pl/articles/990868.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    natural feeding
    young women
    knowledge
    Opis:
    Introduction. Proper nutrition in childhood has a huge significance for the optimal physical and psychical growth and good state of health of a baby. Natural feeding is admittedly the healthiest method of feeding infants. In spite of increased knowledge about the short and long-term benefits of feeding babies with human milk, the percentage of infants nourished only by breastfeeding is still too low. Knowledge about the health benefits of breast milk should be spread among young women. Objective. The aim of the study was to attempt to discover how much knowledge young women have about the impact of natural feeding on the growth and state of health of a baby, as well as estimating the need for education in this area. Materials and method. Questionnaire study conducted in 2013 among 155 young women (average age 25.43±5.98 years) in Poland and in Belgium. Results. Own studies show that natural feeding still needs promotion and support. Knowledge about this among respondents varied and was incomplete. Often, they did not know all the benefits of natural feeding. The majority of respondents were aware that breastfeeding influenced the growth and health of the baby, but they did not have full knowledge about it. The respondents also did not have sufficient knowledge about the advantages of natural feeding in subsequent adult life. Only a small percentage of respondents (15%) had good knowledge about the benefits of breastfeeding. A higher level of knowledge occurred among women living in Poland who were older, better educated, lived in cities, and had breastfed earlier. Conclusions. A quite varied and not too high level of knowledge among young women about the benefits of natural feeding was observed, which points to the necessity of intensification of educational activities among them in this area.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Is threat recognition special? Resistance of threat recognition to perceptual noise
    Autorzy:
    Król, Ewa Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/2129201.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    threat superiority
    object recognition
    signal detection
    fear module
    misperceptions
    Opis:
    Perception takes into account the costs and benefits of possible interpretations of incoming sensory data. This should be especially pertinent for threat recognition, where minimising the costs associated with missing a real threat is of primary importance. We tested whether recognition of threats has special characteristics that adapt this process to the task it fulfils. Participants were presented with images of threats and visually matched neutral stimuli, distorted by varying levels of noise. We found threat superiority effect and liberal response bias. Moreover, increasing the level of noise degraded the recognition of the neutral images to higher extent than the threatening images. To summarise, recognising threats is special, in that it is more resistant to noise and decline in stimulus quality, suggesting that threat recognition is a fast ‘all or nothing’ process, in which threat presence is either confirmed or negated.
    Źródło:
    Polish Psychological Bulletin; 2018, 49, 4; 489-495
    0079-2993
    Pojawia się w:
    Polish Psychological Bulletin
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Developmental toxicity of N-methylaniline following prenatal oral administration in rats
    Autorzy:
    Sitarek, Krystyna
    Gromadzińska, Jolanta
    Stetkiewicz, Jan
    Lutz, Piotr
    Król, Magdalena
    Domeradzka-Gajda, Katarzyna
    Wąsowicz, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2177441.pdf
    Data publikacji:
    2016-02-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    rat
    N-methylaniline
    NMA
    developmental toxicity
    metHb
    toxicity
    Opis:
    Objectives The objective of the study was to assess prenatal toxicity of N-methylaniline (NMA) administered by gavage to pregnant female rats. Material and Methods Pregnant female rats were administered N-methylaniline in corn oil by gavage at daily doses of 0.8 mg/kg of body weight (b.w.), 4 mg/kg b.w., 20 mg/kg b.w. and 100 mg/kg b.w. from implantation (the 5th day post mating) to the day prior to the scheduled caesarean section (the 20th day of pregnancy). General behavior, body weight, food and water consumption, hematological, biochemical analyses and pathomorphological changes of the dams were recorded. Results All the females survived until the end of the study. The test substance was toxic to pregnant females, even at the lowest of the used doses, i.e., 0.8 mg/kg b.w./day. Lower weight gain during pregnancy and significantly higher NMA-dose-dependent absolute weight of the organs were noted in the exposed females. The females from the groups exposed at doses of 20 mg/kg b.w./day and 100 mg/kg b.w./day developed anemia and showed higher concentrations of free thyroxine (FT3) and free triiodothyronine (FT4) thyroid hormones. Total protein concentration exhibited an increase in all the exposed groups of females. In the prenatal toxicity study, administration of N-methylaniline throughout the embryonic and fetal periods produced embryotoxic effects at doses ranging 4–100 mg/kg b.w./day. Conclusions Considering the data obtained in this study, it is reasonable to assume that N-methylaniline administered orally to pregnant rats is toxic for mothers even at a low dose of 0.8 mg/kg b.w./day. However, this dose was not associated with any significant effects to their offspring. This prenatal exposure level may be considered as no-observed-adverse-effect level (NOAEL) for the progeny and a dose of 4 mg/kg b.w./day as the lowest-observed-adverse-effect level (LOAEL) for the progeny.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2016, 29, 3; 479-492
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The ESR1 and GPX1 gene expression level in human malignant and non-malignant breast tissues
    Autorzy:
    Król, Magdalena
    Galicki, Michał
    Grešner, Peter
    Wieczorek, Edyta
    Jabłońska, Ewa
    Reszka, Edyta
    Morawiec, Zbigniew
    Wąsowicz, Wojciech
    Gromadzińska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038523.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    estrogen receptor
    antioxidant enzymes
    gene expression
    breast cancer tissue
    Opis:
    Background: The aim of this study was to establish whether the gene expression of estrogen receptor alpha (encoded by ESR1) correlates with the expression of glutathione peroxidase 1 (encoded by GPX1) in the tumor and adjacent tumor-free breast tissue, and whether this correlation is affected by breast cancer. Such relationships may give further insights into breast cancer pathology with respect to the status of estrogen receptor. Methods: We used the quantitative real-time PCR technique to analyze differences in the expression levels of the ESR1 and GPX1 genes in paired malignant and non-malignant tissues from breast cancer patients. Results: ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. Down-regulation of these genes was independent of the tumor histopathology classification and clinicopathological factors, while the ESR1 mRNA level was reduced with increasing tumor grade (G1: 103% vs. G2: 85.8% vs. G3: 84.5%; p<0.05). In the non-malignant and malignant breast tissues, the expression levels of ESR1 and GPX1 were significantly correlated with each other (Rs=0.450 and Rs=0.360; respectively). Conclusion: Our data suggest that down-regulation of ESR1 and GPX1 was independent of clinicopathological factors. Down-regulation of ESR1 gene expression was enhanced by the development of the disease. Moreover, GPX1 and ESR1 gene expression was interdependent in the malignant breast tissue and further work is needed to determine the mechanism underlying this relationship.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 51-57
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prognostic value of lymphocyte-related systemic inflammatory biomarkers in triple negative breast cancer
    Wartość prognostyczna biomarkerów stanu zapalnego powiązanych z limfocytami w potrójnie ujemnym raku piersi
    Autorzy:
    Oraczewski, Rafał Karol
    Czerniawska-Meler, Małgorzata
    Korzeniewicz, Martyna
    Kade, Grzegorz
    Kozielec, Zygmunt
    Michalak, Maciej
    Król, Magdalena
    Zdaniukiewicz, Adam
    Bodnar, Lubomir
    Powiązania:
    https://bibliotekanauki.pl/articles/2159007.pdf
    Data publikacji:
    2022-06-29
    Wydawca:
    Medical Education
    Tematy:
    triple negative breast cancer
    neutrophil-to-lymphocyte ratio
    platelet-to-lymphocyte ratio
    the systemic immune inflammation index
    prognostic factor
    potrójnie ujemny rak piersi
    czynnik prognostyczny
    stosunek neutrofilów do limfocytów
    stosunek płytek do limfocytów
    wskaźnik ogólnoustrojowej reakcji immunologiczno-zapalnej
    Opis:
    The aim was to evaluate inflammatory biomarkers as prognostic factors in patients with triple negativbreast cancer. We have collected data from 143 patients and evaluated using Chi-Squared test, Wilcoxon–Mann–Whitney test and Cox regression. We found a relationship between high neutrophil- to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index and local advancement features: tumor (T3/T4) (P = 0.0001, P = 0.0198, P = 0.0001), positive regional lymph nodes (P = 0.0014, P = 0.0075, P = 0.0206). In the multivariate analysis metastatic disease, worse performance status and high NLR (Hazard ratio: 4.48 [2.05–9.80], P=0.0002; 2.23 [1.24–4.03], P=0.0010; 2.23 [1.24–4.03], P=0.0075) were adverse prognostic factors. High neutrophil-to-lymphocyte ratio with worse performance status turned out an adverse independent prognostic factors.
    Celem pracy było określenie wartości prognostycznej markerów stanu zapalnego u pacjentów z potrójnie ujemnym rakiem piersi. Zebrano dane dotyczące 143 chorych i oceniono używając testu chi-kwadrat, testu Wilcoxon–Mann–Whitney oraz regresji Coxa. Stwierdzono związek między wysokim poziomem stosunku neutrofilów do limfocytów, płytek do limfocytów, wskaźnikiem ogólnoustrojowej reakcji immunologiczno-zapalnej a miejscowym stopniem zaawansowania: guz (T3/T4) (P=0.0001, P=0.0198, P=0.0001), dodatnie regionalne węzły chłonne (P=0.0014, P=0.0075, P=0.0206). Wielowymiarowa analiza wykazała, że choroba rozsiana, gorszy stan sprawności oraz wysoki stosunek neutrofilów do limfocytów (Hazard ratio: 4.48 [2.05-9.80], P=0.0002; 2.23 [1.24-4.03], P=0.0010; 2.23 [1.24-4.03], P=0.0075) stanowią negatywne czynniki prognostyczne. Wysoki stosunek neutrofilów do limfocytów oraz gorszy stan sprawności stanowią niezależne negatywne czynniki prognostyczne.
    Źródło:
    OncoReview; 2022, 12, 2; 25-34
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of sugar substitutes on selected characteristics of shortcrust pastry
    Autorzy:
    Król, Katarzyna
    Ponder, Alicja
    Gantner, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/105648.pdf
    Data publikacji:
    2019
    Wydawca:
    Centrum Badań i Innowacji Pro-Akademia
    Tematy:
    xylitol
    stevia
    dried banana
    coconut sugar
    crust pastry
    ksylitol
    stewia
    suszony banan
    cukier kokosowy
    Opis:
    The aim of this study was to evaluate the possibility of substituting sugar in crust pastry with natural substitutes, such as stevia, xylitol, coconut sugar as well as dried banana. Furthermore, a comparison of physicochemical properties was carried out. The crust pastry obtained was analyzed in terms of color by CIEL*a*b*, textures, water activity, bake loss, semi-consumer assessments and the nutritional value was calculated. There was a clear impact caused by the sugar substitute on the physicochemical properties and their sensory assessment. The cakes with xylitol had the closest color, smell and taste to the control sample (with sucrose). The cakes with dried banana had a significantly reduced hardness compared to the control sample. The lowest bake loss was observed in the case of pastry with dried banana, while the highest was in the case of xylitol. In sensory analysis, the “Just-about-right” method was used, and pastries with a sweeter taste were more desirable (xylitol) and pastry with the stevia substitute showed the lowest desirability. The lowest energy value per 100 g was obtained for stevia (392 kcal/ 100g), while for xylitol energy, the value was reduced by 6%.
    Źródło:
    Acta Innovations; 2019, 31; 57-63
    2300-5599
    Pojawia się w:
    Acta Innovations
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of selected chemokines and their receptors in the pathogenesis and destabilisation of atheromatous plaques in the carotid arteries
    Rola wybranych chemokin i ich receptorów w patogenezie rozwoju i destabilizacji blaszki miażdżycowej w tętnicy szyjnej
    Autorzy:
    Konarska-Król, Maria
    Kacperska, Magdalena Justyna
    Walenczak, Jakub
    Tomasik, Bartłomiej
    Szpakowski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1030415.pdf
    Data publikacji:
    2015
    Wydawca:
    Medical Communications
    Tematy:
    atheromatous plaque
    blaszka miażdżycowa
    chemokine receptors
    chemokines
    chemokiny
    mediators of inflammation
    mediatory zapalenia
    receptory chemokinowe
    Opis:
    Chemokines are cytokines that act selectively on cells and are capable of inducing selective migration of cells in vitro and in vivo. The term was first coined at the 3rd International Symposium on Chemotactic Cytokines in 1992. The name “chemokine” is a contraction of “chemotactic cytokine,” meaning that these molecules combine features of both cytokines and chemotactic factors. They are a family of low-molecular-mass proteins acting on specific membrane receptors. A cell’s overall sensitivity to chemotaxis depends on the expression profile of chemokine receptors. Atherosclerosis is essentially an excessive inflammatory and proliferative response to the damage of arterial walls. It takes place within the wall and leads to the formation of unstable atherosclerotic plaques. Many chemokines have been studied in terms of their role in the pathogenesis of an atheromatous plaque in the carotid arteries, both in animal models and with the use of human tissue. It seems that molecules that are the most involved in the formation of atheromas in the carotid arteries include: CCL2, CCL3, CCL4 and CCL5. However, reports are sometimes contradictory, and more research is needed. Finding a marker that could help predict the destabilisation of an atheromatous plaque would be a valuable addition to the standard diagnostic panel of tests used in both the diagnosis and monitoring of vascular pathologies.
    Chemokiny są cytokinami, które działają na wybrane komórki i mają zdolność stymulowania migracji komórek in vitro i in vivo. Nazwa „chemokina” została utworzona na Trzecim Międzynarodowym Sympozjum Cytokin Chemotaktycznych w 1992 roku. Chemokiny są chemotaktycznymi cytokinami, czyli łączą w sobie cechy charakterystyczne dla czynników chemotaktycznych oraz cytokin. Są rodziną małocząsteczkowych białek, które działają poprzez pobudzanie swoistych dla nich receptorów błonowych. Profil ekspresji tych receptorów decyduje o wrażliwości komórek na bodziec chemotaktyczny. Miażdżyca zaliczana jest do procesu chorobowego, w którym mamy do czynienia z nadmierną, zapalno-proliferacyjną odpowiedzią na uszkodzenie ściany tętnicy. Proces zapalny toczący się w obrębie ściany naczynia wiąże się z rozwojem niestabilnych zmian miażdżycowych. Dotychczas przebadano wiele chemokin pod kątem ich udziału w rozwoju blaszki miażdżycowej w tętnicach szyjnych, zarówno na modelach zwierzęcych, jak i w badaniach na materiale ludzkim. Wydaje się, że największą rolę w rozwoju miażdżycy w tętnicach szyjnych odgrywają chemokiny CCL2, CCL3, CCL4 oraz CCL5. Jednakże doniesienia na ten temat są często niejednoznaczne i wymagają prowadzenia dalszych badań. Znalezienie markerów zapalnego podłoża destabilizacji blaszek miażdżycowych może stanowić istotne uzupełnienie badań diagnostycznych stosowanych w rozpoznawaniu i monitorowaniu leczenia niektórych chorób. Co ważne, szczegółowe poznanie roli wybranych chemokin i ich receptorów w rozwoju miażdżycy może przyczynić się do dokładniejszego zrozumienia mechanizmu powstawania niestabilnej blaszki miażdżycowej.
    Źródło:
    Aktualności Neurologiczne; 2015, 15, 1; 41-46
    1641-9227
    2451-0696
    Pojawia się w:
    Aktualności Neurologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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