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    Wyświetlanie 1-4 z 4
    Tytuł:
    Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response
    Autorzy:
    Paziewska, Agnieszka
    Horbacka, Karolina
    Goryca, Krzysztof
    Mikula, Michal
    Jarosz, Dorota
    Dabrowska, Michalina
    Krokowicz, Piotr
    Karon, Jacek
    Ostrowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1039136.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ulcerative colitis
    familial adenomatous polyposis
    pouch
    gene expression
    immune response
    Opis:
    A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 69-75
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats
    Autorzy:
    Krześniak, Natalia
    Paziewska, Agnieszka
    Rubel, Tymon
    Skrzypczak, Magdalena
    Mikula, Michał
    Dzwonek, Artur
    Goryca, Krzysztof
    Wyrwicz, Lucjan
    Jarosz, Dorota
    Laubitz, Daniel
    Woszczyński, Marek
    Bielecki, Krzysztof
    Ostrowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1039955.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    heparins
    gene expression
    wound healing
    microarrays
    Opis:
    Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 79-87
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Combination of vasostatin and cyclophosphamide in the therapy of murine melanoma tumors
    Autorzy:
    Jazowiecka-Rakus, Joanna
    Jarosz, Magdalena
    Kozłowska, Dorota
    Sochanik, Aleksander
    Szala, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1041124.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    combination therapy
    CTX
    anticancer
    vasostatin
    antiangiogenic
    Opis:
    Growth of tumors is strongly dependent upon supply of nutrients and oxygen by de novo formed blood vessels. Inhibiting angiogenesis suppresses growth of primary tumors as well and affects development of metastases. We demonstrate that recombinant MBP/vasostatin fusion protein inhibits proliferation of endothelial cells in vitro. The therapeutic usefulness of such intratumorally delivered recombinant protein was then assessed by investigating its ability to inhibit growth of experimental murine melanomas. In the model of B16-F10 melanoma the MBP/vasostatin construct significantly delayed tumor growth and prolonged survival of treated mice. A combination therapy involving MBP/vasostatin construct and cyclophosphamide was even more effective and led to further inhibition of the tumor growth and extended survival. We show that such combination might be useful in the clinical setting, especially to treat tumors which have already formed microvessel networks.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 1; 125-133
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Psycho-social problems in patients with 22q11.2 deletion syndrome – according to subjective evaluation by parents
    Autorzy:
    Cywińska-Bernas, Agnieszka
    Paśnik, Jarosław
    Szałowska-Woźniak, Dorota
    Pilarz, Eliza
    Jarosz, Paweł
    Piotrowicz, Małgorzata
    Moll-Maryńczak, Agnieszka
    Machnia, Marcin
    Zeman, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/973092.pdf
    Data publikacji:
    2018
    Wydawca:
    Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
    Tematy:
    22q11 deletion syndrome
    behavior
    psychology
    child
    parents.
    Opis:
    Background. Deletion syndrome 22q11.2 is a frequently occurring genetic disorder effecting not only malfunctions of the structure and function of many organs and systems, but also a number of psycho-social problems in patients of all ages. Objectives. The aim of the study was the evaluation of psycho-social problems experienced by people with confirmed 22q11DS observed by their parents/caregivers. Material and methods. A group of 32 parents’/caregivers’ children with 22q11DS diagnosis (confirmed by FISH or MLPA analysis) were examined. The age of patients at the moment of examination was from 3 months to 23 years. To identify the most frequent problems a questionnaire survey was used with the use of the authors’ questionnaire. Results. On the basis of the acquired data analysis it was stated that the most frequent problems in children reported by the questioned parents/caregivers were problems with speech development, problems with focusing attention, problem in relations with peers, and school difficulties. The questioned parents also emphasized excessive anxiety of the children and frequent behavior disorders. Moreover, many parents are concerned with their children’s adult lives, and emphasize the necessity of professional support (including psychological) in different stages of the sick child’s upbringing. Conclusions. Patients with 22q11DS experience many psychological and social problems and require, with their families, psychological support in different stages of life. The child’s condition, in many parents’ opinion, is a factor significantly influencing functioning in life and determining the occurrence of problems in the future. The task of primary care physicians is not only to identify patients suspected of 22q11DS and to lead them to genetic diagnostics, but also to provide support to the patients and their families in different stages of life in cooperation with many other specialists.
    Źródło:
    Family Medicine & Primary Care Review; 2018, 2; 117-123
    1734-3402
    Pojawia się w:
    Family Medicine & Primary Care Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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