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    Wyświetlanie 1-10 z 10
    Tytuł:
    Supporting knowledge workers : case management model and notation (CMMN)
    Autorzy:
    Grudzińska-Kuna, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/95125.pdf
    Data publikacji:
    2013
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    knowledge workers
    case management
    model
    notation
    pracownik wiedzy
    zarządzanie
    Opis:
    Since the intensive computer automation of operational and administrative processes there has been increase in demand for knowledge intensive work. Knowledge workers have significant impact on companies they work in but the processes they use in their work are not well supported by technology. Case management with its data centric and artefact based approach to business process management is emerging as a way to provide knowledge workers with flexibility they need in planning and executing their tasks. In January 2013 Object Management Group released specification of Case Management Model and Notation (CMMN). Aim of this paper is to present CMMN basic concepts and provide some insights in ways how CMMN can be used to support knowledge workers and their effectiveness and efficiency.
    Źródło:
    Information Systems in Management; 2013, 2, 1; 3-11
    2084-5537
    2544-1728
    Pojawia się w:
    Information Systems in Management
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ICT advancement index for enterprise evaluation
    Autorzy:
    Bolek, C.
    Grudzińska-Kuna, A.
    Papińska-Kacperek, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/95155.pdf
    Data publikacji:
    2012
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    ICT advancement measures
    composite indicators
    information and communication technologies
    technologie informacyjne i komunikacyjne (ICT)
    syntetyczne wskaźniki
    Opis:
    The article aims the conceptualization and operationalization of the sophistication of ICT use at firm level focusing on selection of indicators and measurement methods. Due to complexity of ICT implementation and adoption process, for constructive and detailed assessment, it is necessary to get many indicators analysed. However multi-indicator approach can be unintelligible for non-professionals. Therefore, authors have decided to employ composite indicator that can be synthetic form of enterprise ICT advancement measure as well as evaluation and comparison tool.
    Źródło:
    Information Systems in Management; 2012, 1, 2; 87-99
    2084-5537
    2544-1728
    Pojawia się w:
    Information Systems in Management
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnosis and differentiation of infarction of the gastrocolic omentum and epiploic appendagitis – case description
    Autorzy:
    Grudzinska-Raczek, A.
    Dziurzynska-Bialek, E.
    Solinska, A.
    Guz, W.
    Krupski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/3535.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2012, 06, 2
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Etiology, clinical manifestation and radiological findings in cerebral venous and sinus thrombosis
    Autorzy:
    Solinska, A.
    Dziurzynska-Bialek, E.
    Grudzinska-Raczek, A.
    Guz, W.
    Kurys-Denis, E.
    Krupski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/3618.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2012, 06, 2
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CT and MRI examination in diagnosis of cerebral venous and sinus thrombosis
    Autorzy:
    Dziurzynska-Bialek, E.
    Solinska, A.
    Grudzinska-Raczek, A.
    Kurys-Denis, E.
    Krupski, W.
    Guz, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/3524.pdf
    Data publikacji:
    2012
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2012, 06, 2
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relative sea level changes and development of the Hiiumaa Island during the Holocene
    Autorzy:
    Vassiljev, J.
    Saarse, L.
    Grudzinska, I.
    Heinsalu, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2059662.pdf
    Data publikacji:
    2015
    Wydawca:
    Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
    Tematy:
    Litorina Sea
    Limnea Sea
    lithology
    diatoms
    AMS 14C dates
    Estonia
    Opis:
    Three sediment cores (Loopsoo, Tihu, Prassi) from Hiiumaa Island (Estonia) were investigated using diatoms, lithological proxies, magnetic susceptibility, geochronological dates and incorporated with the previously studied Kõivasoo site, aiming to reconstruct the development of the island and shoreline changes during the Litorina Sea and the Limnea Sea. The highest level of the Litorina Sea shoreline near Kõivasoo is at 27.6 m a.s.l., and it occurred during the Initial Litorina Sea. Within the Litorina Sea transgression, 7800 cal yr BP, relative sea level reached 24.9 m a.s.l. at Kõivasoo, 24.1 m a.s.l. at Loopsoo, 23.6 m a.s.l. at Tihu, and 21.5 m a.s.l. at Prassi. Kõivasoo became isolated from the sea about 8500 cal yr BP, Loopsoo between 7100 and 6800 cal yr BP, Tihu around 4800 cal yr BP, and Prassi about 2500 cal yr BP. Presently gained data from Hiiumaa Island confirm that the Litorina Sea regressed consistently during the last 8000 years due to progressively declining isostatic rebound. The present study is also illustrated by 3-dimensional palaeogeographic maps of the Hiiumaa Island development.
    Źródło:
    Geological Quarterly; 2015, 59, 3; 517--530
    1641-7291
    Pojawia się w:
    Geological Quarterly
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinicopathological significance of Epo, EpoR, Ki-67 and Bax expression in colorectal cancer
    Autorzy:
    Lopmerta, K.
    Grudzinska, M.
    Jakubowska, K.
    Samocik, P.
    Kozlowski, L.
    Fudala, A.
    Wincewicz, A
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918787.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colon cancer
    erythropoietin
    erythropoietin receptor
    Opis:
    Introduction: Expression of Epo, a glycoprotein secreted by the fetal liver and the adult kidney in response to cellular hypoxia and its receptor have been described in human solid tumors, such as colon and breast cancer. Purpose: Since activation of Epo-EpoR signaling pathway in erythroid progenitor and precursor cells leads to promotion of proliferation and differentiation or prevention of programmed cell death through Bcl-xl and Bcl-2 it was of interest to investigate expression of Epo, EpoR, apoptosis regulator – Bax and marker of proliferating cells - Ki-67 and assess correlation between them, with regard to clinicopathological variables of colorectal cancer. Materials and methods: The correlations between expression of Epo, EpoR, Bax and Ki-67 in colorectal cancer were analyzed in regard to patient age, sex, primary localization, histopathological type, grading, staging and lymph node invasion. Statistical analyses were performed by using the Spearman rank correlation test applying a significance level of p<0,05. Results: Correlation between Bax and EpoR is positive and statistically significant at all groups of patients except group pT1+pT2. Positive correlation between Bax and Epo is statistically significant at following groups of patients: all patients, age 60, age >60, male, female , primary localization in rectum, primary localization in colon, adenocarcinoma, G2, G3. Statistical analysis revealed no significant correlations between expression of neither Ki-67 with Epo nor Ki-67 with EpoR in all groups of patients. Conclusions: Epo seems to be a pleiotropic cytokine, which can exert its biological effect on several cell types, including neoplastic cells. The effect of Epo-EpoR signaling can differ in various cells and conditions.
    Źródło:
    Progress in Health Sciences; 2018, 8(2); 112-117
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Monte Carlo simulations for the Cherenkov Telescope Array Observatory using PL-Grid e-infrastructure
    Autorzy:
    Barnacka, A.
    Bogacz, L.
    Grudzińska, M.
    Janiak, M.
    Komin, N.
    Lamanna, G.
    Moderski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/305301.pdf
    Data publikacji:
    2012
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
    Tematy:
    very high energy astrophysics
    Monte Carlo simulations
    extensive air showers
    telescope design
    Cherenkov Telescope Array
    Opis:
    The paper presents Monte Carlo simulations carried out during the preparatory phase of the Cherenkov Telescope Array project. The aim of the project is to build the next generation observatory of very high energy gamma rays. During the preparatory phase there is a need to optimize and verify design concepts for various elements of the array. In this paper we describe the main components of the software being used for that purpose, their functions and requirements. Preliminary results of the optimization of the small telescope – one of the several kinds intended for the array, are presented.
    Źródło:
    Computer Science; 2012, 13 (2); 113-122
    1508-2806
    2300-7036
    Pojawia się w:
    Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The oncoprotein HBXIP – its functions and roles in oncogenesis
    Autorzy:
    Grudzinska, M.
    Lomperta, K.
    Jakubowska, K.
    Samocik, P.
    Jarząbek, K.
    Kanczuga-Koda, L.
    Wincewicz, A.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918747.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    HBXIP
    survivin
    oncoprotein
    transcription factor
    Opis:
    Nowadays, Hepatitis B X interacting protein (HBXIP) is an object of scientists’ interest worldwide. It is a protein with significant involvement in the development of malignant tumors like breast or ovarian cancer. One of the most important functions of HBXIP is the regulation of cell proliferation, which is related to the progression of a cell cycle. Many studies provide the growing number of evidence that HBXIP plays various important roles, including the regulation of a cell cycle through complexes with survivin, belonging to the inhibitors of apoptosis and interactions with transcriptional factors like STAT4, SP1, TFIID or E2F1. It also has the influence on the promotion of tumor angiogenesis thanks to the association with VEGF and FGF8. Another important role of HBXIP is a reprogramming of glucose metabolism to conditions favorable to growing cancerous cells due to regulating the activation of SCO2 and PDHA1. Furthermore, it impacts on the complement-dependent cytotoxicity, also, HBXIP affects on lipid metabolism through disturbing of metabolic pathways of FAS. According to recent studies, HBXIP can be used as a prognostic biomarker in many tumors, including cervical cancer, ovarian cancer, and esophageal squamous cell carcinoma thanks to the high expression of this protein noted exclusively in these tumor tissues. What is even more interesting, it significantly correlates with clinical attributes like metastasis to lymph nodes or grading and in some cases can potentially be used as the indicator of prognosis of treatment effectiveness. The paper is review through main functions of HBXIP and its possible applications.
    Źródło:
    Progress in Health Sciences; 2018, 8(2); 215-222
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
    Autorzy:
    Grudzińska, M.
    Jakubowska, K.
    Kańczuga-Koda, L.
    Kisielewski, W.
    Famulski, W.
    Smereczański, N.M.
    Lomperta, K.
    Płoński, M.A.
    Rogoz-Jezierska, N.
    Koda, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918914.pdf
    Data publikacji:
    2020-06-10
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Colorectal cancer
    inflammatory cells
    fibrosis
    Opis:
    Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
    Źródło:
    Progress in Health Sciences; 2020, 10(1); 69-76
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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