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    Wyświetlanie 1-3 z 3
    Tytuł:
    Pancreatic cysts or pancreatic cystic neoplasms? An analysis of 145 cases
    Autorzy:
    Wlaźlak, Michał
    Oleśna, Aleksandra
    Danilewicz, Marian
    Strzelczyk, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1392895.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    pancreas
    cyst
    neoplasm
    surgery
    cancer
    Opis:
    Introduction: Detection of the frequency of pancreatic cystic lesions has increased in the recent years. The majority are pseudocysts, the remaining cysts are mainly neoplasms. Proven risk of malignancy affects intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN). The aim of this study was to analyze clinical data of patients with pancreatic cysts or pancreatic cystic neoplasms on operate at Department of General and Transplant Surgery in the Barlicki Hospital in Lodz. Material and methods: In 2007-2016, there were 145 patients operated on at the Department of General and Transplant Surgery in Barlicki Hospital in Lodz, due to pancreatic cystic lesion. The type of operation, histopathological diagnosis and basic demographic data were analyzed. Results: Non-neoplastic cyst (mainly pseudocysts) was found in 66.9% of patients, neoplasms were detected in 33.1%. The mean age was significantly higher in patients with neoplasm than without neoplasm (57.06 years vs. 50.88 years, p=0.009). Neoplastic cyst occurred more frequently in women (68.75% of women, 31.25% of men, p=0.001). Malignant tumor was found in 14.58% of neoplasms cases and in 4.83% of all pancreatic cystic lesions. Conclusions: According to the analyzed material, there is a significant risk of malignancy in patients with pancreatic cyst. Neoplastic cysts are more common in women. Discussion: Pancreatic cystic tumors are treated mainly by resections of pancreas. In case of benign lesions with low risk of malignancy, there are less extensive operations performed, such as enucleations of lesions. There are no guidelines that could be used satisfactorily in follow up of patients with pancreatic cysts.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 5; 22-26
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Clinical manifestation of malignant lymphomas of the head and neck region
    Autorzy:
    Bojanowska-Poźniak, Katarzyna
    Nurkowska, Monika
    Danilewicz, Marian
    Pietruszewska, Wioletta
    Powiązania:
    https://bibliotekanauki.pl/articles/1398500.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    malignant lymphoma
    head and neck neoplasm
    extranodal lymphoma
    Opis:
    Introduction: Malignant lymphoma (ML) is a neoplasm caused by clonal expansion of undifferentiated B, T and NK-lymphoid cells. WHO classification divides lymphomas into two main types, i.e. Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL), with numerous subtypes. The majority of MLs are localized in lymph nodes, but extranodal locations are also possible. MLs represent approximately 3-5% of all malignant neoplasms in Poland, but their incidence has been increasing in recent years, especially in young patients. The objective of the study was to evaluate clinical manifestations and diagnostic process in patients with malignant lymphomas of the head and neck region as diagnosed in the Department of Otorhinolaryngology of the Medical University of Lodz in years 2013-2017. Material and method: 30 patients diagnosed with malignant lymphomas of the head and neck region at the Departbadament of Otorhinolaryngology of the Medical University of Lodz in 2013-2017. Results: The study group consisted of 8 cases of nodal lymphomas and 22 cases of extranodal lymphomas. In 29 cases B-cell lymphomas were diagnosed. The most common symptoms included lymphadenopathy or neck tumor. Other symptoms were associated with the location of tumors in particular body organs. The diagnosis was based on histopathological examination of biopsy (needle or surgical) samples. Conclusion: Malignant lymphomas should be taken into account during differential diagnosis of the tumor or lymphadenopathy of the neck. The diagnosis is difficult because of the nonspecificity of symptoms and the need for interdisciplinary cooperation of many specialists.
    Źródło:
    Polish Journal of Otolaryngology; 2017, 71, 6; 14-21
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Distinct inhibitory efficiency of siRNAs and DNAzymes to β1 integrin subunit in blocking tumor growth
    Autorzy:
    Wiktorska, Magdalena
    Sacewicz-Hofman, Izabela
    Stasikowska-Kanicka, Olga
    Danilewicz, Marian
    Niewiarowska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1039612.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    adhesion
    β1 integrins
    invasiveness
    tumor angiogenesis
    tumor growth
    Opis:
    Receptors of the β1 integrin family are involved in many tumor-promoting activities. There are several approaches currently used to control integrin activity, and thus to potentially restrain tumor metastasis and angiogenesis. In this study, we compared inhibitory efficiencies of siRNA and DNAzymes against the β1 integrin subunit (DEβ1), in a mouse xenograft model. Both inhibitors were used under their most favorable conditions, in terms of concentrations, incubation time and lack of cytotoxic effects. Transfection of siRNAβ1 or DEβ1 remarkably inhibited the growth of both PC3 and HT29 colon cancer cells in vitro, and decreased their capability of initiating tumor formation in the mouse xenograft model. siRNAβ1 appeared to be slightly more efficient than DEβ1 when tested in vitro, however it was comparably less proficient in blocking the tumor growth in vivo. We conclude the DNAzyme, due to its greater resistance to degradation in extra- and intracellular compartments, to be a superior inhibitor of tumor growth in long lasting experiments in vivo when compared to siRNA, while the latter seems to be more efficient in blocking β1 expression during in vitro experiments using cell cultures.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 1; 77-82
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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