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    Wyświetlanie 1-4 z 4
    Tytuł:
    Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
    Autorzy:
    Li, Xiao-Xing
    Zhao, Lang
    Chang, Ying
    Liu, Bao-Shan
    Xu, Feng
    Zhang, Cheng
    Ji, Xiao-Ping
    Chen, Yu-Guo
    Li, Chuan-Bao
    Powiązania:
    https://bibliotekanauki.pl/articles/1038380.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    obese
    inflammation
    remodeling
    ezetimibe
    IL-6
    Opis:
    Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 465-470
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association between sleep duration and sleep quality, and metabolic syndrome in Taiwanese police officers
    Autorzy:
    Chang, Jen-Hung
    Huang, Pai-Tsang
    Lin, Yen-Kuang
    Lin, Ching-En
    Lin, Chien-Min
    Shieh, Ying-Hua
    Lin, Ying-Chin
    Powiązania:
    https://bibliotekanauki.pl/articles/2177099.pdf
    Data publikacji:
    2015-08-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    metabolic syndrome
    sleep duration
    sleep quality
    police officer
    Opis:
    Objectives This study’s objective was to examine association between sleep duration and sleep quality, and metabolic syndrome (MetS) and its components in Taiwanese male police officers. Material and Methods Male police officers who underwent annual health examinations were invited to join the study and eventually a total of 796 subjects was included in it. The study subjects were divided into 5 groups according to the length (duration) of sleep: < 5, 5–5.9, 6–6.9, 7–7.9 and ≥ 8 h per day, and the global Pittsburgh Sleep Quality Index was used to categorize their sleep quality as good or poor. To analyze the association between sleep problems and MetS, adjusted odds ratio and respective 95% confidence intervals (CI) were computed. Results The prevalence of MetS in Taiwanese male police officers was 24.5%. Abdominal obesity had the highest proportion (36.2%) among 5 components of MetS. More than 1/2 of the police officers (52.3%) had poor sleep quality. Police officers with higher scores of sleep disturbances had a higher prevalence of MetS (p = 0.029) and abdominal obesity (p = 0.009). After adjusting for age, low-density lipoprotein cholesterol, smoking status, alcohol drinking habit, physical habitual exercise, snoring and type of shift work, the police officers who slept less than 5 h were 88% more likely to suffer from abdominal obesity than those who slept 7–7.9 h (95% CI: 1.01–3.5). Sleep quality was not associated with MetS and its components. Conclusions The police officers who slept less than 5 h were more likely to experience abdominal obesity in Taiwan, and those with higher scores of sleep disturbances had a higher prevalence of MetS and abdominal obesity. It is recommended that police officers with short sleep duration or sleep disturbances be screened for MetS and waist circumference in order to prevent cardiovascular diseases.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 1011-1023
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cooperative adaptive driving for platooning autonomous self driving based on edge computing
    Autorzy:
    Chang, Ben-Jye
    Hwang, Ren-Hung
    Tsai, Yueh-Lin
    Yu, Bo-Han
    Liang, Ying-Hsin
    Powiązania:
    https://bibliotekanauki.pl/articles/330778.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    mobile edge computing
    active safe driving
    cooperative platoon driving
    cooperative adaptive cruise control
    przetwarzanie mobilne
    bezpieczna jazda
    tempomat adaptacyjny
    Opis:
    Cooperative adaptive cruise control (CACC) for human and autonomous self-driving aims to achieve active safe driving that avoids vehicle accidents or traffic jam by exchanging the road traffic information (e.g., traffic flow, traffic density, velocity variation, etc.) among neighbor vehicles. However, in CACC, the butterfly effect is encountered while exhibiting asynchronous brakes that easily lead to backward shock-waves and are difficult to remove. Several critical issues should be addressed in CACC, including (i) difficulties with adaptive steering of the inter-vehicle distances among neighbor vehicles and the vehicle speed, (ii) the butterfly effect, (iii) unstable vehicle traffic flow, etc. To address the above issues in CACC, this paper proposes the mobile edge computing-based vehicular cloud of the cooperative adaptive driving (CAD) approach to avoid shock-waves efficiently in platoon driving. Numerical results demonstrate that the CAD approach outperforms the compared techniques in the number of shock-waves, average vehicle velocity, average travel time and time to collision (TTC). Additionally, the adaptive platoon length is determined according to the traffic information gathered from the global and local clouds.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2019, 29, 2; 213-225
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sequence analysis of human cytomegalovirus US28 gene in low-passage clinical isolates from children and AIDS patients
    Autorzy:
    He, Rong
    Xia, Chang
    Ruan, Qiang
    Qi, Ying
    Ma, Yan-Ping
    Ji, Yao-Hua
    Guo, Jin-Jin
    Powiązania:
    https://bibliotekanauki.pl/articles/1039923.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    chemokine receptors
    cytomegalovirus
    genetic polymorphism
    US28
    Opis:
    Human cytomegalovirus (HCMV) is often a dangerous opportunistic pathogen that causes significant morbidity and mortality in newborn children and immunocompromised patients. The different symptoms and tissue tropisms of HCMV infection may result from genetic polymorphism. This study investigated the sequence variability of the HCMV US28 ORF, which shows sequence homology to the G protein-coupled receptor. HCMV isolated from suspected pediatric cases and isolates from AIDS patients were compared in order to examine the possible associations between polymorphisms and pathogenesis. Seventy children with suspected congenital HCMV infection, who suffered from jaundice (47), megacolon (10), and microcephaly (13), and 17 AIDS patients, were studied. Mutation was prevalent among the sequences of US28, with a focus on the two ends of US28. The important functional groups of US28 are highly conserved. An unrooted tree showed that all sequences from suspected congenitally infected infants and AIDS patients were divided into three groups. Comparison showed that most of the sequences (12/17) from pediatric patients were included in the first group (G1), whereas most of the sequences (11/17) from AIDS patients were included in the third group (G3). The specific high mutation sites in US28 from children were located at the C terminus of the protein, whereas those from AIDS patients were located at the N terminus. We demonstrated the existence of polymorphisms among the US28 genes of clinical isolates of HCMV from infants with suspected congenital infection. Comparison of US28 sequences from AIDS patients with those from children showed that both sequences have their own specific high mutation points.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 2; 231-236
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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