Autor: Bugno, M. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Comparison between thr G-banded karyotype of the aoudad [Ammotragus lervia] and sheep [Ovis aries]
Autorzy:: Slota, E
Kozubska-Sobocinska, A.
Bugno, M.
Giemza-Marek, A.
Kulig, B.
Powiązania:: https://bibliotekanauki.pl/articles/2041924.pdf
Data publikacji:: 2001
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: Ovis aries
animal production
sheep
Ammotragus lervia
comparative cytogenetics
karyotype
aoudad
Źródło:: Journal of Applied Genetics; 2001, 42, 1; 59-64
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Relevance of molecular changes in the ND4 gene in German Shepherd dog tumours
Autorzy:: Slaska, B.
Grzybowska-Szatkowska, L.
Bugno-Poniewierska, M.
Gurgul, A.
Smiech, A.
Rozanska, D.
Dudka, J.
Powiązania:: https://bibliotekanauki.pl/articles/31142.pdf
Data publikacji:: 2016
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:: The aim of the study was to identify polymorphisms and mutations in the mitochondrial ND4 gene and to analyse the associations between the occurrence of molecular changes in mtDNA and phenotypic traits in tumours in German Shepherd dogs. Fifty samples obtained from blood and tumour tissues of German Shepherd dogs with diagnosed tumours were analysed. DNA extraction, amplification, and sequencing of the mtDNA ND4 gene, and bioinformatics, statistical, and in silico protein coding SNP analyses were performed. ND4 mutations and/or polymorphisms were noted in eleven nucleotide positions in nearly half of the examined dogs. All the changes were substitution mutations. A majority of the changes identified were homoplasmic. In one dog with osteosarcoma, blood heteroplasmy was detected. In two positions of the ND4 gene, presence of non-synonymous mutations leading to amino acid changes in the ND4 protein was reported. Analyses carried out to determine the deleterious effect of mutations indicated an almost 97 and 62% probability that a single amino acid substitution (p.G239V and p.I401T, respectively) in the protein has a negative impact on its function. The results of statistical analyses indicate a significant association between the occurrence of mutations in three loci of the ND4 gene and the location of tumours. The mutations identified may be a result of cell adaptation to the changes in the environment occurring during carcinogenesis. The high frequency of mutations in the tumours may indicate genetic instability of mtDNA, which may also play a role in carcinogenesis.
Źródło:: Polish Journal of Veterinary Sciences; 2016, 19, 3
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Characterisation of genome-wide structural aberrations in canine mammary tumours using single nucleotide polymorphism (SNP) genotyping assay
Autorzy:: Surdyka, M.
Gurgul, A.
Slaska, B.
Pawlina, K.
Szmatola, T.
Bugno-Poniewierska, M.
Smiech, A.
Kasperek, K.
Powiązania:: https://bibliotekanauki.pl/articles/2087566.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: dog
cancer
mammary tumour
structural aberration
CNV
LOH
Źródło:: Polish Journal of Veterinary Sciences; 2019, 1; 133-141
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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