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    Wyświetlanie 1-5 z 5
    Tytuł:
    Glioblastoma - actual knowledge and future perspectives
    Glejak - aktualna wiedza oraz perspektywy
    Autorzy:
    Bilicki, Dominik
    Zbrożek, Mikołaj
    Fudalej, Marta
    Deptała, Andrzej
    Badowska-Kozakiewicz, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/2159008.pdf
    Data publikacji:
    2022-06-30
    Wydawca:
    Medical Education
    Tematy:
    glioblastoma multiforme
    oncology
    miRna
    pathogenesis
    siRNA
    glejak wielopostaciowy
    onkologia
    miRNA
    patogeneza
    Opis:
    Glioblastoma is the most severe IV-class glioma and therefore the prognosis for patients remains poor despite some improvement in the treatment area. The neurological or psychiatric symptoms especially fast-developing ones should be fully investigated. This article aims to summarize actual knowledge of glioblastoma and present future perspectives. The underlying causes are usually associated with mutations of EGFR, PTEN, IDH1, p53 genes. The MRI scan, MGMT promoter methylation status, GFAP immunohistochemical detection and Karnofsky performance status are valuable diagnostic tools and some other potential biomarkers with high specificity are proposed. The standard of care is surgery and Stupp protocol which is the combination of radiotherapy and chemotherapy with temozolomide. Nevertheless, after remission the treatment possibilities are limited. Many efforts have been devoted to elaborate novel therapeutic strategies using e.g. CAR-T cells, nanoparticles, monoclonal antibodies, miRNA, siRNA or proteasome inhibitors.
    Glejak wielopostaciowy klasyfikowany jest do grupy najbardziej złośliwych glejaków o IV stopniu złośliwości ze szczególnie niekorzystnymi prognozami związanymi z jego leczeniem. Pojawienie się u pacjenta szybko postępujących objawów zarówno psychiatrycznych, jak i neurologicznych powinno być zawsze dokładnie zbadane. Artykuł ma na celu zebranie oraz podsumowanie aktualnej wiedzy na temat glejaka oraz zaprezentowanie możliwych perspektyw rozwoju metod diagnostyczno-leczniczych. Rozwój glejaka ma zazwyczaj związek z mutacjami w genach EGFR, PTEN, IDH1 lub p53. Do użytecznych narzędzi diagnostycznych należą m.in. badanie MRI, analiza metylacji promotora genu MGMT oraz immunohistochemiczne oznacznie GFAP. W leczeniu glejaków wielopostaciowych najczęściej stosowanym schematem jest protokół Stuppa bazujący na połączeniu radioterapii z chemioterapią temozolomidem. Niemniej jednak, dalsze możliwości leczenia są limitowane. Zintegrowane wysiłki naukowców są ukierunkowane na poszukiwanie nowych strategii leczenia przy użyciu m.in. teraapii CAR-T, nanocząteczek, przeciwciał monoklonalnych, miRNA, siRNA oraz inhibitorów proteasomów
    Źródło:
    OncoReview; 2022, 12, 2; 35-44
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cancer pain as a meaningful aspect of the oncological treatment
    Autorzy:
    Marzec, Izabela
    Grabska, Kinga
    Fudalej, Marta M.
    Badowska-Kozakiewicz, Anna M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2033688.pdf
    Data publikacji:
    2021-01-08
    Wydawca:
    Medical Education
    Tematy:
    pain
    scales
    cancer
    analgesic treatment
    palliative care
    Opis:
    Introduction and objective: Pain is the most common and universal symptom among all patients with the oncological disease. Pain significantly reduces the quality of life, hinders decent functioning, and plays a significant role in the deterioration of the mental health of the patient and his close relatives. The study aimed to discuss the mainstreaming of effective pain treatment and to review various assessments and scales (including Brief Pain Inventory, Illness Perception Questionnaire and Numeric Rating Scale) concerning the psychological aspect of pain in selected neoplastic diseases.State of knowledge: We can distinguish various treatments for pain that can be divided into pharmacological and non-pharmacological methods. Latest studies revealed that pain treatment appears to be more and more meaningful. Various factors might influence pain perception and response to the applied treatment. Among all malignancies, special attention is paid to the pain issue in following cancers: colon cancer, gastric cancer, pancreatic cancer, ovarian cancer, breast cancer and lung cancer, that were described in this paper. Conclusions: Effective pain relief presents a positive effect, both on the physical and mental state of the patient. It also helps to maintain calm mental health among relatives. Nowadays, integration of the best methods for pain relief that are characterized as humanitarian, easily accessible and effective, seems to be one of the biggest challenges for both oncological and palliative health workers.
    Źródło:
    OncoReview; 2020, 10, 4; 145-152
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies
    Autorzy:
    Domańska, Julia
    Poboży, Kamil
    Domański, Paweł
    Fudalej, Marta
    Deptała, Andrzej
    Badowska-Kozakiewicz, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/22792539.pdf
    Data publikacji:
    2023-07
    Wydawca:
    Medical Education
    Tematy:
    E2F2
    E2F
    cancer
    transcription factor
    oncology
    p53
    p21
    Opis:
    Introduction and objective. E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. State of knowledge. Numerous studies have demonstrated a role for E2F2 in various signaling pathways. Certain components of these pathways may serve as potential targets for oncological therapy. E2F2 has been shown to be associated with neoplasms of various locations and histological types (breast, colon, gastric, laryngeal, liver, lung, ovarian, pancreatic, and prostate cancers). Conclusions. Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments.
    Źródło:
    OncoReview; 2023, 13, 2; 58-66
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ELF3 as an important factor in carcinogenesis – a brief review of the recent studies
    Autorzy:
    Domańska, Julia
    Poboży, Kamil
    Kuryłek, Michał
    Fudalej, Marta M.
    Sobiborowicz, Aleksandra
    Deptała, Andrzej
    Badowska-Kozakiewicz, Anna M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1035652.pdf
    Data publikacji:
    2020
    Wydawca:
    Medical Education
    Tematy:
    ELF3
    carcinogenesis
    molecular biology
    Opis:
    Introduction and objective: E74-like transcription factor 3 (ELF3) is mainly expressed in epithelial tissue, being responsible for differentiation and regeneration. Furthermore, it plays a role in inflammation, remodeling, allergy regulation and apoptosis. Various studies on ELF3 conducted since 1997 have also proved its connection with carcinogenesis and metastasis. This review summarizes recent advances in understanding the role of ELF3 in the following cancers: ampullary, bladder, breast, gastric, hepatocellular, nasopharyngeal, thyroid, lung and ovarian ones. State of knowledge: There are still many unresolved and undiscovered issues regarding ELF3 mutations, however, based on research since 2016, a link to many signaling pathways important for carcinogenesis has been shown. There is no simple correlation between a specific ELF3 mutation and effect on cancer cells. In various types of cancers, ELF3 is associated with other pathways, and modifications exerted by silencing or amplifying its or associated genes, cause different effects in patient prediction. An example of the effect of ELF3 on tumor progression is achieved by negatively regulating the ZEB1 transcription factor responsible for metastasis. WNT, RAS, Akt, mTOR, HER2, Cyclin D, IRF6 are other ELF3-related factors that affects pathways crucial for tumorigenesis. Conclusions: Further research and attempts to use ELF3 in the treatment and prognosis of cancer appear to be beneficial.
    Źródło:
    OncoReview; 2020, 10, 2; 77-81
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identifying the portrayal of 50+ consumers in Polish print advertising
    Autorzy:
    Badowska, Sylwia
    Rogala, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/943125.pdf
    Data publikacji:
    2016-12-20
    Wydawca:
    Uniwersytet Ekonomiczny w Poznaniu
    Tematy:
    consumer 50+
    elderly
    older consumer
    consumer portrayal
    print advertising
    Opis:
    This article raises an issue of consumers at the age of 50+. The role of this market segment is constantly growing in Poland, but despite of this, it is still hard to identify this wide consumer group. Therefore, the aim of the paper is to identify the portrayal of older people (50+) in Polish print advertising. Amongst over-fifty consumers, the press media are still the key communication channel for spreading marketing recommendations to this consumer group. Content analysis was employed to define the characteristics of these consumers. The research demonstrates that firstly, the older generation is depicted mostly marginally, secondly, women are over-represented, and thirdly, only a few product categories portray the older models at all. Two schemes 'brand ambassador' or/and 'representative of a consumer target group' were used to reflect the portrayals of this market group. In spite of the common opinion, that the market segment of people of 50+ is uniform, the findings suggest that older consumers are not homogeneous. A new age segmentation for the elderly has been proposed. The older market segment is sharply divided into two groups ('mature' and 'elderly'). The age of 60 is a strong demarcation line here. The portrayal of 'mature' consumers at the age of 50-59 covers 50% of all the engaged older consumers in print adverts. Over 10 different portrayal models have been found in the market communications analyzed. The contemporary 'mature' ones differ substantially from stereotypical models reserved for elderly consumers. Over 7 different models, mostly still 'young bodies and souls', are adapted to express the portrayal of this target group. However, for both the elderly 'young' and 'mature' (60+) sub-group the models are much more predictable and traditional. The segment of 80+ does not exist at all in print adverts. Generally, the portrayal of 50+ is more complicated and diverse than it is commonly believed in practice.
    Źródło:
    Economics and Business Review; 2016, 2(16), 4; 77-91
    2392-1641
    Pojawia się w:
    Economics and Business Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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