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    Wyświetlanie 1-8 z 8
    Tytuł:
    Nuclear magnetic resonance spectroscopy reveals metabolic changes in living cardiomyocytes after low doses of ionizing radiation
    Autorzy:
    Gramatyka, Michalina
    Skorupa, Agnieszka
    Sokół, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1038408.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ionizing radiation
    metabolomics
    HR MAS NMR
    cardiotoxicity
    Opis:
    Several lines of evidence indicate that exposure of heart to ionizing radiation increases the risk of cardiotoxicity manifested by heart dysfunction and cardiovascular diseases. It was initially believed that the heart is an organ relatively resistant to radiation. Currently, however, it is suspected that even low doses of radiation (< 2 Gy) may have a negative impact on the cardiovascular system. Cardiotoxicity of ionizing radiation is associated with metabolic changes observed in cardiac cells injured by radiation. In this study, we used human cardiomyocytes as a model system, and studied their metabolic response to radiation using high-resolution magic angle spinning nuclear magnetic resonance techniques (HR-MAS NMR). Human cardiomyocytes cultured in vitro were exposed to ionizing radiation and their survival was assessed by clonogenic assay. Changes in apoptosis intensity and cell cycle distribution after the irradiation were measured as well. NMR spectra of cardiomyocytes were acquired using Bruker Avance 400 MHz spectrometer at a spinning rate of 3200 Hz. Survival of cardiomyocytes after NMR experiments was assessed by the Trypan blue exclusion assay. Exposure of cardiomyocytes to small doses of ionizing radiation had no effect on cell proliferation potential and intensity of cell death. However, analysis of metabolic profiles revealed changes in lipids, threonine, glycine, glycerophosphocholine, choline, valine, isoleucine, glutamate, reduced glutathione and taurine metabolism. The results of this study showed that ionizing radiation affects metabolic profiles of cardiomyocytes even at low doses, which potentially have no effect on cell viability.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 2; 309-318
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mannitol vs. methacholine in the evaluation of airway responsiveness in bakers’ asthma
    Autorzy:
    Nowakowska-Świrta, Ewa
    Wiszniewska, Marta
    Lipińska-Ojrzanowska, Agnieszka
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2116654.pdf
    Data publikacji:
    2020-03-13
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    mannitol
    methacholine
    nonspecific bronchial hyper-responsiveness
    occupational asthma
    specific inhalation challenge test
    bakery workers
    Opis:
    ObjectivesVarious indirect or direct airway challenge tests are used to measure nonspecific bronchial hyper-responsiveness (NSBHR). The evaluation of NSBHR in diagnosing occupational asthma (OA) is performed, e.g., to monitor the specific inhalation challenge test (SICT). The aim of this study was to preliminarily compare the results of methacholine and mannitol inhalation challenge tests in SICT monitoring in bakers with work-related airway symptoms.Material and MethodsFour bakery workers with a suspicion of OA underwent single-blind placebo-controlled SICTs involving workplace allergens, accompanied by the evaluation of NSBHR with mannitol and methacholine, both before and after SICTs. Clinical examinations, spirometry tests, skin prick tests (SPTs) to common aeroallergens and occupational allergens, as well as tests to determine serum specific IgE antibodies to occupational aeroallergens were also performed.ResultsPositive SPTs results to occupational aeroallergens were found in all bakery workers, and specific IgE antibodies to flour were detected in 2 subjects. Three patients displayed positive SICT reactions. In all of these 3 patients, airway responsiveness to methacholine increased significantly. In 2 patients, airway reaction to mannitol was significant, whereas in 1 subject there was no increase in NSBHR after mannitol inhalation. The patient with a negative SICT result did not reveal any changes in NSBHR before and after the test, either to methacholine or mannitol.ConclusionsThe data obtained by the authors show that there is no clear correlation between the methacholine and mannitol inhalation challenge tests in SICT monitoring. Preliminary results indicate the need for further investigations to evaluate the usefulness of the mannitol challenge test in the diagnostics of OA.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2020, 33, 2; 235-239
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Work-related symptoms among workers exposed to black tea dust
    Objawy związane z pracą u pracowników eksponowanych na pył czarnej herbaty
    Autorzy:
    Lipińska-Ojrzanowska, Agnieszka
    Wiszniewska, Marta
    Tymoszuk, Diana
    Pałczyński, Cezary
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2165413.pdf
    Data publikacji:
    2014-12-19
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    alergia zawodowa
    pył czarnej herbaty
    uczulenie na pleśnie
    mikrobiologiczne zanieczyszczenie herbaty
    objawy związane z pracą
    occupational allergy
    black tea dust
    sensitization to moulds
    microbial contamination of tea
    work-related symptoms
    Opis:
    Background: Tea may be classified as unfermented green, semi-fermented oolong and fermented black. All of these types are derived from Camellia sinensis, the Tea Plant, which contains the low molecular weight (LMW) agent Epigallocatechin gallate (EGCg), probably responsible for allergic reactions. The aim of our study was to asses the work-related allergic symptoms and IgE-mediated sensitivity among black tea packers. Material and Methods: Study groups comprised 26 black tea packers (group 1) and 20 office workers (group 2). A questionnaire, skin prick tests (SPTs) to common allergens and black tea, evaluation of specific IgE (asIgE) to Camellia sinensis and moulds, pre- and post-work-shift spirometry were performed. Results: At least 1 symptom suggesting allergic disease was reported by 85% of the tea packers and 60% of the office workers. The most frequent positive results of SPTs were obtained with moulds (8%). A small decline in FEV1 (forced expiratory volume in 1 s) after the work shift was observed among tea packers sensitized to moulds. Conclusions: Although specific sensitization to black tea was not observed in our study groups, cough and skin symptoms were significantly more frequently among the tea packers than in office workers. The irritant impact on the airways and the skin of tea dust and/or sensitization to moulds contaminating tea leaves are being suspected. Med Pr 2015;66(1):11–15
    Wstęp: Herbatę można sklasyfikować jako niesfermentowaną zieloną, częściowo sfermentowaną oolong i w pełni sfermentowaną czarną. Wszystkie wymienione typy herbaty otrzymuje się z rośliny Camellia sinensis, która zawiera czynnik o małej masie cząsteczkowej – galusan epigalokatechiny (Epigallocatechin gallate – EGCg) o potencjale alergizującym. Celem badania było scharakteryzowanie związanych z pracą objawów sugerujących schorzenia alergiczne oraz ocena statusu immunologicznego pakowaczy czarnej herbaty. Materiał i metody: Zbadano 26 pakowaczy czarnej herbaty (grupa 1) oraz 20 pracowników biurowych (grupa 2). U wszystkich badanych przeprowadzono badanie ankietowe dotyczące objawów oraz punktowe testy skórne (skin prick tests – SPTs) z alergenami pospolitymi i czarną herbatą, oznaczono poziom swoistych przeciwciał w klasie IgE dla rośliny Camellia sinensis i pleśni oraz wykonano badanie spirometryczne przed zakończeniem i po zakończeniu zmiany roboczej. Wyniki: Występowanie co najmniej 1 objawu sugerującego alergię zgłosiło 85% pakowaczy herbaty i 60% pracowników biurowych. Najczęściej obserwowanym uczuleniem w wynikach punktowych testów skórnych wśród pakowaczy herbaty było uczulenie na pleśnie (8%). U tych pracowników obserwowano także spadek natężonej 1-sekundowej objętości wydechowej (FEV1 – forced expiratory volume in 1 s) po zakończeniu zmiany roboczej w stosunku do wartości wyjściowych. Wnioski: Kaszel i objawy skórne zdecydowanie częściej występowały u pakowaczy herbaty niż u pracowników biurowych, chociaż w żadnej z badanych grup nie wykazano uczulenia na alergeny czarnej herbaty. Nie można jednak wykluczyć drażniącego działania pyłu herbacianego na drogi oddechowe i skórę oraz uczulenia na grzyby pleśniowe zanieczyszczające liście herbaty. Med. Pr. 2015;66(1):11–15
    Źródło:
    Medycyna Pracy; 2015, 66, 1; 11-15
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Recognition COVID-19 as an occupational disease in Poland – definition, criteria and recommendation
    Autorzy:
    Wiszniewska, Marta
    Rybacki, Marcin
    Lipińska-Ojrzanowska, Agnieszka
    Szkiela, Marta
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/22651746.pdf
    Data publikacji:
    2023-12-15
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    occupational exposure
    occupational disease
    employees
    infectious disease
    SARS-CoV-2 virus
    COVID-19 pandemic
    Opis:
    A major challenge over the pandemic period was to establish the criteria for recognizing COVID-19 as an occupational disease. The European Center for Disease Prevention and Control has attempted to estimate the incidence of COVID-19 in individual occupational groups and economy sectors in the European Union and the United Kingdom, and to identify possible factors increasing the transmission of the virus at workplaces. Legal regulations of various countries in the world allow COVID-19 to be recognized as an accident at work and/or an occupational disease. In Poland, an occupational disease is defined as a disease caused by harmful factors occurring in the work environment or connected with performing a given job, included in the official list of occupational diseases. When assessing occupational exposure in the healthcare sector, it should be considered that healthcare workers include all persons in contact with patients or their biological material, as well as employees who are not medical professionals but who share a common space with patients due to the nature of their work. The latter group includes administrative and technical employees, control and rescue service workers, people supporting medical staff, and employees of nursing homes. In the case of non-medical occupations, the decision to recognize COVID-19 as an occupational disease should be made on an individual basis, after confirming a significant risk of contracting a SARS-CoV-2 virus infection at the workplace and in the absence of evidence of a non-occupational source of infection. An assessment of occupational exposure should always include evaluating the possibility of SARS-CoV-2 transmission.
    Źródło:
    Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 5; 435-442
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy. Workers’ Health and Safety
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spirometric and hygienic criteria in recognition of occupational COPD in Poland – A retrospective analysis of medical records
    Autorzy:
    Kleniewska, Aneta
    Walusiak-Skorupa, Jolanta
    Lipińska-Ojrzanowska, Agnieszka
    Szcześniak, Kamila
    Wiszniewska, Marta
    Powiązania:
    https://bibliotekanauki.pl/articles/2161758.pdf
    Data publikacji:
    2017-11-03
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    compensation
    acknowledgement of occupational disease
    VGDF
    occupational
    COPD
    chronic obstructive pulmonary disease
    Opis:
    Objectives: Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low prevalence of work-related COPD in the context of the existing criteria as well as to analyze which part of the assessment – clinical or hygienic one – is responsible for such a low rate of occupational COPD recognitions. Material and Methods: The study group included 150 patients hospitalized with a suspicion of occupational COPD. Each patient underwent a clinical examination, spirometry and reversibility test using bronchodilator. Moreover, hygienic evaluation of work conditions was performed in all the considered cases. Results: In the case of the patients who fulfilled the criteria for COPD diagnosis in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) occupational origins of the disease, the disease was not recognized because 24.1% of the individuals did not meet spirometric criteria included in a definition of COPD in the Polish list of occupational diseases, while 27.8% of the individuals did not fulfill the criterion of a documented exposure to dusts and irritant gases. None of these criteria was fulfilled by 42.6% of the patients. Conclusions: In our country, both clinical and hygienic criteria result in limitations in recognition of occupational COPD. There is the need to establish new guidelines for the recognition of COPD as a compensable disease in Poland. Int J Occup Med Environ Health 2018;31(2):139–150
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 2; 139-150
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of occupational health services in cancer prevention – which factors determine the implementation of preventive measures?
    Autorzy:
    Wiszniewska, Marta
    Marcinkiewicz, Andrzej
    Lipińska-Ojrzanowska, Agnieszka
    Kalska-Sochacka, Katarzyna
    Walusiak Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2093890.pdf
    Data publikacji:
    2021-12-13
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    mammography
    occupational health services
    cancer prevention
    cytology
    surveillance
    screening program
    Opis:
    ObjectivesEpidemiological data on cancer diseases are alarming. The workplace has become an increasingly important site for disseminating health information and implementing health promotion activities. Occupational medicine physicians (OMPs) have the opportunity to carry out primary and secondary preventive activities focused on civilization diseases, especially cancer. The aim of this study was to evaluate the potential of OMPs in cancer prevention, including the analysis of factors determining the implementation of preventive measures, as part of standard healthcare for employees.Material and MethodsThe study was conducted among 362 OMPs. The interviews were carried out by the computer assisted telephone interview (CATI) method.ResultsOver 60% of the surveyed OMPs are ready to implement cancer preventive activities among employees. The doctors with the longest seniority in occupational health services are more likely to declare unwillingness to implement cancer preventive activities. Patient’s consent, informing women about the program and adjusting the time of the medical visit are the most important conditions for introducing cancer prevention programs by OMPs. Neither seniority nor the number of examinations performed by a physician influenced the currently implemented cancer preventive activities as part of occupational health services (including the evaluation of cancer risk factors occurrence among employees).ConclusionsIn Poland, OMPs are willing to implement cancer preventive activities among employees, but their current activity in this area is limited and needs development. The most specific actions should be addressed to doctors with the longest seniority in occupational health services, who are frequently unwilling to implement cancer preventive activities. Strengthening the preventive potential of Polish occupational health services requires a systemic approach to the scope and way of action of healthcare professionals.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 6; 723-736
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of selected risk factors for cardiovascular diseases and diabetes as a background for the prevention program in occupational healthcare
    Autorzy:
    Lipińska-Ojrzanowska, Agnieszka
    Walusiak-Skorupa, Jolanta
    Ojrzanowski, Marcin
    Marcinkiewicz, Andrzej
    Plewka, Michał
    Wiszniewska, Marta
    Powiązania:
    https://bibliotekanauki.pl/articles/2085782.pdf
    Data publikacji:
    2021-06-28
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    occupational medicine
    health promotion at the workplace
    occupational health system
    risk factors of civilization diseases
    Systemic Coronary Risk Evaluation
    health of the working-age population
    Opis:
    ObjectivesCardiovascular and metabolic disorders constitute major health problems in the working populations in Europe. The aim of this project was to evaluate the health condition of workers employed in a Polish research and medical institution, and then to establish the necessary preventive actions by creating a modern model of occupational healthcare integrated with civilization disease (CivD) prevention.Material and MethodsOverall, 100 workers voluntarily participated in a health program for CivD prevention during mandatory prophylactic examinations. Data from these examinations was collected in a system of electronic documentation to enable the analysis of the workers’ health condition and risk factors of CivDs.ResultsWomen accounted for 72% of the employees who voluntarily participated in the prevention program, and 80% of the subjects had university education. As regards the health condition, 27% of the patients had elevated systolic, and 23% diastolic, blood pressure, and 21% had an abnormal fasting glucose level. Stressful job was an important factor correlated with an excessive body mass index, diastolic blood pressure, as well as total and low-density lipoprotein cholesterol levels. Smoking, sedentary work and a lack of physical activity were significant factors for abdominal obesity. Generally, 94% of the program participants required some further interventions in lifestyle, diagnostics or treatment.ConclusionsCivilization disease prevention should focus on increasing physical activity both in leisure time and at the workplace as far as practicable. There is a need for implementing projects leading to occupational stress reduction and smoking cessation. Men as well as workers with vocational and elementary education need to be recruited for prevention programs dedicated to employees.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2021, 34, 3; 403-413
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Work-related respiratory symptoms among health centres cleaners: A cross-sectional study
    Autorzy:
    Lipińska-Ojrzanowska, Agnieszka
    Wiszniewska, Marta
    Świerczyńska-Machura, Dominika
    Wittczak, Tomasz
    Nowakowska-Świrta, Ewa
    Pałczyński, Cezary
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2178854.pdf
    Data publikacji:
    2014-06-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    cleaners
    occupational allergy
    work-related respiratory symptoms
    work-related asthma
    WRA
    Opis:
    Objectives: Several studies, mostly based on questionnaire-derived data, have shown an increased risk of allergic diseases, especially asthma, among cleaners. The risk factors and etiological mechanisms are still being investigated. Occupational exposure to various chemical and biological agents may induce specific sensitization and/or irritant effects. The aim of our study was to estimate the prevalence of work-related symptoms suggesting the presence of allergic disease reported by cleaners, and to relate them to the results of commercially available and standardized objective tests used for screening detection of occupational sensitization and chronic respiratory disorders. Material and Methods: A cross-sectional study was performed among 142 Polish workers of cleaning service in their workplaces. A detailed questionnaire, skin prick tests to common allergens and chemicals used by these workers for cleaning purposes (chloramine T, chlorhexidine, formaldehyde, glutaraldehyde, benzalconium chloride), total and specific serum IgE antibodies to disinfectants and rest spirometry were performed in all the subjects. Results: Fifty nine percent of all the subjects declared occurrence of at least 1 symptom suggesting allergic ailment during cleaning activities at work. Skin prick tests and specific serum IgE antibodies to disinfectants were negative in all the subjects. In 8 cases wheezing was detected during auscultation, but only in 5 of them obstructive pattern in rest spirometry was found. Conclusions: Occupational allergic causation of symptoms among cleaners could be less likely than work-related symptoms associated with exacerbations of new-onset or pre-existing respiratory diseases. Therefore, in this group of workers, mainly the non-specific irritant impact of chemicals on airways should be taken into consideration.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 3; 460-466
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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