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    Wyświetlanie 1-5 z 5
    Tytuł:
    Effect of aging and oxidative/genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain
    Autorzy:
    Strosznajder, Robert
    Jesko, Henryk
    Adamczyk, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041342.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    poly(ADP-ribosyl)ation
    brain
    p53 protein
    PARP-1
    genotoxic stress
    oxidative stress
    Opis:
    Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a DNA-bound enzyme, plays a key role in genome stability, but after overactivation can also be responsible for cell death. The aim of the present study was to investigate PARP-1 activity in the hippocampus, brain cortex, striatum and cerebellum in adult (4 months) and aged (24 months) specific pathogen free Wistar rats and to correlate it with PARP-1 protein level and p53 expression. Moreover, the response of PARP-1 in adult and aged hippocampus to oxidative/genotoxic stress was evaluated. Our data indicated a statistically significant enhancement of PARP-1 activity in aged hippocampus and cerebral cortex comparing to adults without statistically significant changes in PARP-1 protein level. The expression of p53 mRNA was elevated in all aged brain parts with the exception of the cerebral cortex. Our data suggest that enhancement of PARP-1 activity and p53 expression in aged brain may indicate higher DNA damage. Our data also indicate that during excessive oxidative/genotoxic stress there is no response of PARP-1 activity in aged hippocampus in contrast to a significant enhancement of PARP-1 activity in adults which may have important consequences for the physiology and pathology of the brain.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 909-914
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relief as an important factor in determining priority landscapes: a case study on Polish landscape parks
    Autorzy:
    Wałdykowski, Piotr
    Adamczyk, Joanna
    Ciszewska, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/947094.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Warszawski. Wydział Geografii i Studiów Regionalnych
    Tematy:
    Relief typology
    landscape conservation
    applied geomorphology
    landscape audit
    Opis:
    The practical problems of implementing the Regulation on Landscape Audits (European Landscape Convention, ELC) in Poland are discussed through the topic of landscape relief, on an example of landscape classification of three of Poland’s landscape parks. In the existing landscape typologies, various criteria are proposed, in which relief is usually considered to be one of the leading components. The study was carried out for the purposes of the Landscape Parks Conservation Plans, based on a comparison of the method under the Principles of Landscape Audits and the authors’ method. The results indicate that the landscape types set out in the regulation insufficiently take relief into account, leading to omitting the local specific nature of the terrain. The essential attributes of the terrain in the analysed parks are the morphometry of relief and its genesis. Relief helps to determine the landscape types that are more related to the terrain.
    Źródło:
    Miscellanea Geographica. Regional Studies on Development; 2020, 24, 1; 42-50
    0867-6046
    2084-6118
    Pojawia się w:
    Miscellanea Geographica. Regional Studies on Development
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nasal glial heterotopia – Clinical manifestation in 2.5 month-old boy
    Autorzy:
    Kałużna-Młynarczyk, Agata
    Pucher, Beata
    Sroczyński, Jakub
    Kotowski, Michał
    Adamczyk, Paulina
    Szydłowski, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/1399445.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    congenital defec
    midline nasal tumor
    nasal glial heterotopia
    nasal glioma
    rhinology
    Opis:
    Nasal glial heterotopia is a rare congenital defect that is formed during embryonic development. This lesion is a part of a larger group of diseases, congenital midline nasal tumors, that occur with a frequency of one per 20,000-40,000 live births. Histologically, nasal glial heterotopia is a concentration of glial tissue which exhibits no malignant potential. We can differentiate three basic types of the disease based on the location of the lesion: 60% of nasal gliomas are extra nasal, 30% are intranasal and only 10% combine extra- and intranasal components. Because of its rare occurrence, correct diagnosis is quite difficult. We present a case of a 2.5-month-old male who was admitted to the Department of Pediatric Otolaryngology for the diagnosis and treatment of a tumor deforming the bridge of his nose. Initial differential diagnosis included encephalocele, glial heterotopia (nasal glioma), angioma, nasal dorsal cyst, rhabdomyosarcoma, lacrimal duct cysts. We performed endoscopic examination, radiological imaging (CT, MRI) and histological assessment of the lesion. The patient was diagnosed with nasal glial heterotopia (extra-and intranasal) based on diagnostic studies and clinical manifestation. The resection of the lesion was performed by means of dual access, external and endoscopic. The results of surgical treatment are satisfactory, control endoscopy showed no presence of residual tumor.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2019, 8, 2; 43-48
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prevalence of allergy in children with adenoid hypertrophy and otitis media with effusion admitted to the Department of Pediatric Otolaryngology in Poznan
    Autorzy:
    Adamczyk, Paulina
    Pucher, Beata
    Prauzińska, Magdalena
    Kałuzna-Młynarczyk, Agata
    Kotowski, Michał
    Szydłowski, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/552782.pdf
    Data publikacji:
    2018
    Wydawca:
    Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
    Tematy:
    hypersensitivity, adenoids, otitis media with effusion.
    Źródło:
    Family Medicine & Primary Care Review; 2018, 3; 205-209
    1734-3402
    Pojawia się w:
    Family Medicine & Primary Care Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Acute mastoiditis, a severe complication of acute otitis media in children – prevalence, diagnosis and treatment
    Autorzy:
    Kałużna-Młynarczyk, Agata
    Pucher, Beata
    Nurczyk, Nel
    Adamczyk, Paulina
    Prauzińska, Magdalena
    Kotowski, Michał
    Szydłowski, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/551997.pdf
    Data publikacji:
    2018
    Wydawca:
    Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
    Tematy:
    mastoiditis
    otitis media
    child
    ear diseases.
    Źródło:
    Family Medicine & Primary Care Review; 2018, 3; 227-231
    1734-3402
    Pojawia się w:
    Family Medicine & Primary Care Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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