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    Tytuł:
    Investigation of interactions between dermorphin analogs and µ-opioid receptor
    Autorzy:
    Karczyńska, A.
    Zaborowski, B.
    Ślusarz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1935820.pdf
    Data publikacji:
    2014
    Wydawca:
    Politechnika Gdańska
    Tematy:
    molecular modeling
    opioid receptors
    defmorphin
    molecular docking
    drug design
    modelowanie molekularne
    receptory opioidowe
    dokująca molekularna
    projektowanie leków
    dermorfina
    Opis:
    Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic is morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin was discovered as another potent analgesic [Mont ecucchi P C et al. 1981 Int. J. Pept. Protein Res. 17 275]. Unfortunately, this peptide is not resistant to enzymatic metabolism [Kisara K et al. 1986 Br. J. Pharmacol. 87 183; Sasaki Y et al. 1985 Neuropeptides 5 391]. The objective of this study is to search for new opioid analgesics by investigation of interactions between dermorphin analogs and the μ -opioid receptor using molecular modeling methods. MOPR ( μ -Opioid Peptide Receptor) complexes with several ligands (with known biological activity) were modeled to explain how the structure of the complex was related to the biological activity. The investigated dermorphin analogs containing [ DMT1, D -Arg 2 ] (especially tetrapeptides) may become a good alternative for the currently used an algesics.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2014, 18, 4; 331--336
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of the frequency of childhood hospitalization due to thermal injuries in the Provincial Polyclinical Hospital in Torun, Poland, 2007–2011
    Autorzy:
    Barczykowska, E.
    Cyran, M.
    Zreda-Pikies, A.
    Kowalczyk, M.
    Ślusarz, R.
    Kurylak, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081550.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    burns
    children
    hospitalization
    Opis:
    Introduction. Burns constitute the most common and severe injuries suffered in childhood. Objective. The study was aimed at providing a retrospective analysis of the etiology, location, extent and depth of burns, as well as treatment methods and length of hospital stay. Materials and method. A retrospective analysis of 508 cases of children treated due to a thermal injury between 1 January 2007 31 December 2011 was conducted at the Department of Paediatrics, Urology and Paediatric Surgery, Children’s Hospital, L. Rydygier Provincial Hospital in Toruń, Poland. Results. The sample group included more boys (58.9%) than girls (41.1%). The most numerous group comprised children aged 1–2 years (44.5%). Burns were largely suffered at home (91.9%). Injuries were largely caused by thermal burns (99.2%). Half of the children sustained injury to one body area (51.4%), while every third sufferer (37.9%) was affected by burns to body parts prone to trigger shock. Burns up to 5% of the Total Body Surface Area (TBSA) were suffered by half (51.2%) of the children. Most of the patients underwent conservative treatment (89.4%). Conclusions. Burns were mostly suffered by children at 1–2 years of age, with boys prevailing over girls. Injuries were largely suffered at the child’s family home, in the afternoon or evening, while the child was in the care of the parents. Scalds, caused by hot liquid, constituted the most frequent type of injury. The most numerous group of affected children comprised burns to limb areas, and thorax with limbs, with the TBSA of up to 5%. The great majority of the patients underwent conservative treatment, with a hospitalization period of up to 3 days.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 26-30
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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