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    Wyświetlanie 1-9 z 9
    Tytuł:
    Functional neuromarkers for neuropsychology
    Autorzy:
    Kropotov, Juri D
    Powiązania:
    https://bibliotekanauki.pl/articles/2137701.pdf
    Data publikacji:
    2018-03-19
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    neuroimaging
    quantitative EEG
    event related de/synchronization
    event-related potentials
    Opis:
    This article is written to commemorate the 40th year of the scientific career of Professor Maria Pąchalska, Head of the Department of Neuropsychology and Neurorehabilitation at Krakow University, President of the Polish Neuropsychological Society, and the Editor-in-chief of Acta Neuropsychologica, with whom I have been collaborating for over ten years. The subject matter of our work includes the introduction of HBI methodology to clinics and the search for neuromarkers in particular disease entities. What is the new methodology we are talking about? In general, we think of a biomarker (or biological marker) as a characteristic that can be objectively measured and evaluated as an index of normal or pathological biological processes. For disorders of the central nervous system, biomarkers can be classified as clinical, neuroimaging, biochemical or genetic, according to the type of information they provide. Expectations for the development of biomarkers are high, since they could lead to a significant improvement in diagnosing and possibly preventing neurological and psychiatric diseases. Neuroimaging is an array of neuroscience methods that include the techniques of magnetic resonance imaging (MRI), functional MRI (fMRI), and PET (positron emission tomography), as well as Electroencephalogram (EEG) and Magnetoencephalogram (MEG) techniques, such as quantitative EEG (QEEG), event related de/synchronization (ERD/ERS) and event-related potentials (ERPs).
    Źródło:
    Acta Neuropsychologica; 2018, 16(1); 1-7
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CURRENT AND TRADITIONAL VIEWS ON THE BRAIN WORKS
    Autorzy:
    Kaczmarek, Bożydar L.J
    Markiewicz, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/2137723.pdf
    Data publikacji:
    2018-07-22
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    ERPs
    neuronal circuits
    neuromarkers
    neuromodulation
    neurofeedback
    Opis:
    The present paper argues that the development of a new methodology in studying the brain has resulted in a change of our views on the way it works, has seen the emergence of new ideas, and a considerable modification of traditionally accepted theories. The most significant are neuroplasticity, negative activity network (NAT), the nature of aphasic disorders, and the approach to the localization of brain functions. New brain imaging techniques have confirmed also the ability to change the neuronal circuits by mental force. Moreover, new techniques have brought about a rise in new methods for both the diagnosis and rehabilitation of individuals with various brain disorders. Most valuable in this respect has proved to be neurofeedback. We have concentrated on the most important contributions of Prof. Pąchalska in the implementation and development of these new ideas on brain functioning. We also emphasize the fact that her theoretical considerations are firmly based upon her extensive (forty years) work with brain damaged patients.
    Źródło:
    Acta Neuropsychologica; 2018, 16(2); 201-212
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FUNCTIONAL NEUROMARKERS OF POST-TRAUMATIC STRESS DISORDER (PTSD) IN A MAJOR ISCHEMIC STROKE SURVIVOR AFTER CAROTID ENDARTERECTOMY (CEA) REVASCULARIZATION
    Autorzy:
    Trystuła, Mariusz
    Góral-Półrola, Jolanta
    Kropotov, Juri D
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137757.pdf
    Data publikacji:
    2018-12-20
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Event-Related Potentials (ERPs)
    cued GO/NOGO task
    information processing
    functional neuromarkers
    Opis:
    The aim of this study was to test the hypothesis of developing Post-Traumatic Stress Disorder (PTSD) in a major right-hemisphere ischemic brain stroke survivor half a year after CEA revascularization, with the use of Event Related Potentials (ERPs). He was in a serious condition and had limited consciousness. Therefore, the doctor informed the patient's wife about the possibility of sudden death. The patient heard this information and remembered it, which was one of the main causes of the development of PTSD. On the basis of previous research amplitudes of P3 ERP, components elicited in the cued GO/NOGO tasks have been chosen as the candidate for PTSD neuromarkers . A 44-year-old patient had a major ischemic brain stroke while sizeable atherosclerotic plaque causing critical stenosis of the internal carotid artery in Angio-CT was dioscovered. The patient was urgently operated on using CEA. After the operation he had the opportunity to see the removed plaque which had been the cause of his stroke. Despite the positive postoperative recovery, half a year later, the patient began to complain of flashbacks, anxiety, trouble in falling and staying asleep, difficulty in concentration, a loss of interest. For the diagnosis of PTSD we used Checklist Specific for a stressor (PCL-S). Additionally we used Checklist according to the Diagnostic Statistical Manual-5 (DSM-5) classification, and the patient met the PTSD criteria. The cognitive profile of the patient was measured with the use of the Wechsler Memory Test – III (WMS-III). Subsequently, the patient participated in the cued GO/NOGO task (Kropotov, 2009) with a recording 19-channel EEG. The P3 GO and NOGO waves in this task were found to be significantly smaller at p
    Źródło:
    Acta Neuropsychologica; 2018, 16(4); 417-429
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FUNCTIONAL NEUROMARKERS IN PARKINSON’S DISEASE (PD)
    Autorzy:
    Góral-Półrola, Jolanta
    Mirski, Andrzej
    Knapik, Henryk
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2138039.pdf
    Data publikacji:
    2021-03-20
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    high rolandic beta
    ERPs
    HBI methodology
    Opis:
    New neurotechnologies which help to study not only the structure but also brain work, especially in milliseconds, allow for a more accurate diagnosis of a given disease entity. The aim of our study was to characterize the functional neuromarkers, including a new neuromarker, that is high rolandic beta, in Parkinson’s disease (PD). A 76-year-old male patient, a university professor, a widower, in an intimate relationship with a beloved partner, was tested in the Reintegration and Training Center of the Polish Society of Neuropsychology. Five years earlier (when he was 71 years old), following long-term stress, he had had a transient ischemic attack (TIA). In the following years he experienced two neurological episodes, and was diagnosed, on the basis of MRI findings and clinical symptoms, with vascular (multi-infarct) Parkinsonism. A sudden deterioration in his functioning, including hand tremors at rest, bradykinesia (motor slowdown), asymmetrical gait difficulties, postural instability, and falls typical for PD, as well as MRI finding (the appearance of ‘a swallow tail ’ on the left side, and the lack on the right of the substantia nigra within the midbrain) was the cause of further differential diagnosis. He was assessed using the HBI methodology (Kropotov 2016; Pąchalska, Kaczmarek, Kropotov 2014). EEG was recorded from 19 scalp sites, in resting state conditions, with eyes open and eyes closed, and during the cued GO/NOGO tasks with animal/plants as GO/NOGO stimuli. The electrodes were applied according to the International 10-20 system. The EEG was recorded referentially to linked ears, allowing for a computational re-referencing of the data (remontaging). Event related potentials (ERPs) were used to assess the functional changes manifested by the patient. To compare our patient with healthy controls we used the normative Human Brain Index (HBI), a database obtained through joint research by Swiss, Norwegian, Polish and Russian neuroscientists (Kropotov 2018). This database included behavioral parameters and ERP measures in 6 different neuropsychological tasks for 1000 healthy subjects. What is striking, no signs of cognitive dysfunction was found; however observed were an asymmetrical frontal lobe alpha (a neuromarker of depression) and excessive Rolandic beta (a neuromarker of Parkinson’s disease). We will discuss the results on the basis of recent subject literature findings, including the personal factors that might influenced the process of the diagnosis and treatment of this patient, ones which should be also taken into account in any differential diagnosis. The obtained results show the importance of using HBI methodology in clinical practice. Physicians involved in the diagnosis and treatment of those with progressive ambulatory impairment and an abnormal white matter (WM) signal on neuroimaging, should when formulating any differential diagnosis consider the use of this approach. ------------------------------------------------------------------------------------------------------------------------------------
    Źródło:
    Acta Neuropsychologica; 2021, 19(2); 147-168
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation - ERP case study
    Autorzy:
    Chrapusta, Anna
    D. Kropotov, Juri
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/986653.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    replantation
    anxiety
    flashback
    Opis:
    Introduction. There is a lack in the worldwide literature of reports on the Neuromarkers of Post-Traumatic Stress Disorder (PTSD) in patients after bilateral hand amputation The aim of this study was to test a hypothesis regarding developing Post-Traumatic Stress Disorder (PTSD) in a patient after bilateral hand amputation with the use of Event Related Potentials (ERPs). On the basis of previous research, the amplitudes of P3 ERP components elicited in the cued GO/NOGO tasks have been chosen as candidates for neuromarkers of PTSD. Case study. A 24-year-old patient had undergone bilateral hand amputation 12 months previously. The patient was repeatedly operated on (he had undergone successful bilateral hand replantation) and despite the severity of the injuries, he recovered. However, the patient complained of flashbacks, anxiety and sleep difficulties. Specialist tests showed the presence of PTSD. The patient participated in the cued GO/NOGO task (Kropotov, 2009) with recording 19-channel EEG. P3 GO and NOGO waves in this task were found to be significantly smaller, in comparison to a group of healthy control subjects of the same age (N=23) taken from the HBI normative database (https://www.hbimed.com/). This observed pattern of ERP waves in the patient corresponds to the pattern found in PTSD patients. Conclusions. ERPs in a GO/NOGO task can be used in the assessment of the functional brain changes induced by chronic PTSD.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma - effect of individually-tailored tDCS and neurofeedback
    Autorzy:
    Mirski, A.
    Pachalska, M.
    Moskala, M.
    Orski, M.
    Orska, M.
    Miaskiewicz, M.
    Zapala, J.
    Kropotov, J.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/51672.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2015, 22, 4
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    FUNCTIONAL NEUROMARKERS OF COGNITIVE IMPAIRMENT IN VASCULAR DEMENTIA: A CASE STUDY
    Autorzy:
    Supińska, Marzena
    Górla-Półrola, Jolanta
    Cielebąk, Ksenia
    Herman-Sucharska, Izabela
    Kropotov, Juri D
    Pąchalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/2137937.pdf
    Data publikacji:
    2020-07-02
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    Cognitive impairment
    Quantitative Electro- Encephalogram (QEEG)
    Event-Related Potentials (ERPs)
    cued GO/NOGO task
    Opis:
    Early diagnosis and monitoring of disease progression in patients with Vascular Dementia (VaD) have become vital in clinical practice, as disease modifying treatments for VaD become available. The goal of our research was to study cognitive impairment in a patient at an early stage of VaD. We evaluated latencies of the P3 GO and NOGO components of event-related potentials (ERPs), elicited in cued GO/NOGO tasks, as potential neuromarkers of cognitive im- pairment, as suggested by previous research. The patient, a right-handed, 53-year-old male with a college edu- cation, suffered a transient ischemic attack (TIA) in 2011. During this attack, which lasted for a few minutes, he was confused and had trouble speaking, trouble seeing in both eyes, difficulty walking, problems with balance and coordination, and strange behavior. Se - ven years later, in 2018, he was assessed using the HBI methodol- ogy, which consisted of recording (1) a 19-channel EEG in resting state (with eyes open and eyes closed), and (2) a cued GO/NOGO task, and then comparing the results with EEG spectra and Event- Related Potentials (ERPs) data from normative and patient data - bases. The patient died in 2019. Post-mortem studies confirmed cortical microhaemorrhages neuropathological criteria for VaD. We did not found deposits of hyperphosphorylated tau (HPτ) and Aβ, which fulfil the neuropathological criteria for AD. The parietal-temporal-occipital EEG power was significantly higher in all conditions in this subject in comparison to healthy controls, indicating idling of the corresponding areas. The amplitude and la- tency of the P3 GO wave were found to be intact in the subject, in- dicating normal posterior cortical functioning in the cognitive task. The latency of the P3 GO wave was found to be significantly higher in the subject, indicating impairment of engagement operations. In a GO/NOGO task, ERPs provide a useful tool for assessment of brain functioning in clinical settings.
    Źródło:
    Acta Neuropsychologica; 2020, 18(3); 313-325
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of ERPs neuromarkers for assessment and treatment of a patient with chronic crossed aphasia after severe TBI and long-term coma - case report
    Autorzy:
    Chantsoulis, Marzena
    Półrola, Paweł
    Góral-Półrola, Jolanta
    Hajdukiewicz, Anna
    Kropotov, Juri D.
    Pachalska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/989909.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    cognitive control
    emotional control
    relative beta training
    rtms
    microgenetic theory
    Opis:
    Objective. The study aimed to evaluate the application of ERPs neuromarkers for the assessment and treatment of a patient with chronic crossed aphasia after severe TBI and a long-term coma. Case report. An ambidextrous female patient, aged 29, suffered from posttraumatic chronic crossed aphasia, severe TBI and a prolonged coma after a car accident. The patient took part in two differentiated rehabilitation programmes of neurotherapy included 20 sessions of relative beta training and 20 sessions of rTMS; both programmes were combined with behavioural training. The patient was tested 3 times: before the experiment, after completion of programme A, and after completion of programme B. Results. In the 1st recording, the neuromarker of aphasia was found – an excess of the P2 wave over the left temporal area. There was a cognitive control deficit – an excess of omission errors and an increase of RT variability – all indexes of sporadic ADHD. In the 2nd recording, slight improvements in cognitive control, and language functions were found. In the 3rd recording, after the rTMS sessions most of her cognitive dysfunctions had been resolved, including language functions. It should be stressed that the activation (especially the increase in the ERP potential of the right side over the frontal lobe) was found. The neuromarker of aphasia did not change, only the location had slightly moved frontally. Conclusions. The application of ERP neuromarkers assists in the diagnosis, treatment, and academic success of an ambidextrous patient with chronic posttraumatic aphasia and sporadic ADHD. ERPs can be used to assess the functional brain changes induced by neurotherapeutical programmes.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 1
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    NEUROMARKERS OF ANXIETY IN A PATIENT WHO HAD EXPERIENCED A TRANSIENT ISCHEMIC ATTACK (TIA) OF THE LEFT BRAIN HEMISPHERE AS A RESULT OF A CRITICAL STENOSIS OF THE INTERNAL CAROTID ARTERY (ICA) PERATED ON BY ENDARTERECTOMY (CEA)
    Autorzy:
    Wilczek-Rużyczka, Ewa
    Mirski, Andrzej
    Korab, Maciej
    Trystuła, Mariusz
    Powiązania:
    https://bibliotekanauki.pl/articles/2137987.pdf
    Data publikacji:
    2021-01-13
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    neuromarker
    postoperative anxiety
    TIA
    endarterectomy
    CEA
    Opis:
    The search for neuromarkers is a very promising way to improve psychiatric and psychological care. They are now considered to be an innovative diagnostic tool in psychiatry and neuropsychology, but more broadly in all human health sciences. The aim of our study was to find the neuromarker of anxiety in a patient who had experienced a Transient IschemicAttack (TIA) of the left brain hemisphere as a result of a critical stenosis of the Internal Carotid Artery (ICA) operated on byendarterectomy (CEA). We will present the case of a 54-year-old man,an architect, who experienced a Transient Ischemic Attack (TIA) of the left brain hemispherecaused by a critical stenosis of theInternal Carotid Artery (ICA) and was treated successfully with surgical endarterectomy (CEA). One year after the surgery itself, the patient developed severe postoperative anxiety, headaches, difficulty in sleepingas well as the inability to continue working in his profession. Strong anxiety was notedon the adapted 100-millimeter Visual Analogue Anxiety Scale (VAAS). The patient was assessed using the Human Brain Index (HBI) methodology (Kropotov 2009; 2016; 2017; Pąchalska, Kaczmarek&Kropotov 2014) which consisted of recording 19-channel EEG in resting state conditions, during the cued GO/NOGO task and comparing the parameters of EEG spectra and Event-Related Potentials (ERPs) with the normative and patient databases of the Human Brain Index(HBI). No signs of cognitive dysfunction was found, however an excessive Rolandic beta was observed. In line with the working hypothesis as to the presence of an anxiety neuromarker, the patient’s studies confirmed an increased P1 time wave in the left hemisphere of the brain in ERP in response to visual stimuli, i.e. an anxiety neuromarker. Following the detection of this neuromarkera specific anodic Transcranial Direct Current Stimulations (tDCS) pro- tocol was proposed (see: Kropotov 2016; Pąchalska, Kaczmarek & Kropotov 2020). Ten tDCS sessions were performed and the postoperativeanxiety was found to be resolved. The patient returned to work. The use of Human Brain Index (HBI) methodologyenabling the isolation of the Event Related Potentials (ERPs) patterns revealed the presence of a distinct anxietyneuromarker. Neurotherapy with the use of tDCS allowed the reduction of anxiety symptoms and the patient’s return to work. The above case study indicates the necessity to use new neurotechnologies in the diagnosis of mental diseases, with particular emphasis on postoperative anxiety. ------------------------------------------------------------------------------------------------------------------------------------
    Źródło:
    Acta Neuropsychologica; 2021, 19(1); 1-9
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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