Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "myeloma" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-12 z 12
    Tytuł:
    Multiple myeloma – cancer among elderly people
    Autorzy:
    Januszewska, Joanna
    Świderska-Kołacz, Grażyna
    Zmorzyński, Szymon
    Powiązania:
    https://bibliotekanauki.pl/articles/472516.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
    Tematy:
    multiple myeloma
    etiology of multiple myeloma
    epidemiology
    prognostic factors
    genetic mutations
    chromosomal abberration
    Źródło:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia; 2016, VI; 52-61
    2083-7267
    2450-3487
    Pojawia się w:
    Annales Universitatis Paedagogicae Cracoviensis. Studia ad Didacticam Biologiae Pertinentia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Plasma cell myeloma as one of the causes of bone pain in family medicine
    Autorzy:
    Kade, Grzegorz
    Michalak, Maciej
    Kade, Bartosz
    Spaleniak, Sebastian
    Podgórska, Agnieszka
    Hałka, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/22676881.pdf
    Data publikacji:
    2023-05-12
    Wydawca:
    Medical Education
    Tematy:
    myeloma
    hypercalcaemia
    treatment
    Opis:
    The article draws attention to the need to maintain oncological vigilance in the daily practice of a family doctor. Diagnosis and effective treatment of hypercalcemia and plasma cell myeloma are presented.
    Źródło:
    OncoReview; 2023, 13, 1; 33-35
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Patient with atypical chest pain and nephrotic range proteinuria finally diagnosed with non-secretory myeloma
    Autorzy:
    Holecki, Michał
    Fryźlewicz-Moska, Agata
    Strzałkowska, Dorota
    Chudek, Jerzy
    Duława, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1039564.pdf
    Data publikacji:
    2010
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    chest pain
    myeloma
    proteinuria
    Opis:
    Multiple myeloma is the second most common neoplastic disease of lymphoid tissue in adults. However, its atypical non secretory form, is quite rare. We present a case of 70 year old male with atypical chest pain and nephrotic range proteinuria fi nally diagnosed as non secretory myeloma who did not present any of characteristic fi ndings when admitted to hospital. Despite the unusual course the diagnosis was established quickly enough to provide a proper treatment. One should remember that occasionally patients do not match typical criteria necessary for diagnosing a disease.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2010, 64, 5-6; 89-91
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    IgM multiple myeloma: diagnostic difficulties and results of bortezomib treatment – case report
    Autorzy:
    Machowicz, Rafał
    Skwierawska, Kamila
    Mądry, Krzysztof
    Górka, Michał
    Żurawska, Jagoda
    Kacprzyk, Piotr
    Waszczuk-Gajda, Anna
    Dwilewicz-Trojaczek, Jadwiga
    Powiązania:
    https://bibliotekanauki.pl/articles/773502.pdf
    Data publikacji:
    2014
    Wydawca:
    Medical Education
    Tematy:
    IgM
    Waldenström’s macroglobulinemia
    bortezomib
    multiple myeloma
    Opis:
    The IgM paraprotein secretion is most frequently associated with Waldenström’s macroglobulinemia. In very rare cases it may also occur in multiple myeloma. The diagnostic and therapeutic process of a 84 year old male suffering from IgM multiple myeloma is described, including difficulties in establishing this diagnosis. Due to infectious complications, after the first cycle of melphalan– prednisone–bortezomib treatment, melphalan was stopped, subsequently, bortezomib and prednisone doses were also reduced. Two treatment interruptions have occurred. Despite reduced treatment intensity, the patient was in very good partial remission, while the toxicity profile was acceptable. IgM multiple myeloma should be included in the differential diagnosis of IgM paraproteinemia, also when osteolytic lesions and translocation 11:14 are not detected. Bortezomib-based therapy can be effective in elderly patients (also in those suffering from cardiac insufficiency), even when dose reduction is required.
    Źródło:
    OncoReview; 2014, 4, 4; A160-A164
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma
    Autorzy:
    Szudy-Szczyrek, A.
    Legiec, W.
    Mańko, J.
    Gmyz, K.
    Szczyrek, M.
    Hus, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2052439.pdf
    Data publikacji:
    2015
    Wydawca:
    Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
    Tematy:
    multiple myeloma
    immunomodulatory drugs
    maintenance therapy
    lenalidomide
    Opis:
    Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.
    Źródło:
    Health Problems of Civilization; 2015, 09, 2; 50-54
    2353-6942
    2354-0265
    Pojawia się w:
    Health Problems of Civilization
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The massive nodular cutaneous and soft tissues lesions of the right shoulder and the arm as the extramedullary manifestation of the advanced stage of multiple myeloma
    Autorzy:
    Drobiecki, Arkadiusz
    Pasiarski, Marcin
    Stelmach-Gołdyś, Agnieszka
    Garus, Bartosz
    Powiązania:
    https://bibliotekanauki.pl/articles/773404.pdf
    Data publikacji:
    2017
    Wydawca:
    Medical Education
    Tematy:
    cutaneous involvement
    multiple myeloma
    Opis:
    Cutaneous and soft tissue involvement is a very rare manifestation of multiple myeloma. We are describing a woman with the huge multiple plasma cells infiltrations of the soft tissues and the skin of the right shoulder and the arm that had occurred 2.5 years after the diagnosis of multiple myeloma. In the case of the described patient there is a distinct correlation between the appearance of the nodular lesions in soft tissues and the underlying osteolytic changes found in the skeleton. We assumed that the fracture of the right humerus in the past was the beginning of the plasma cells dissemination in the adherent tissues. The skin changes in our patient appeared in the advanced stage of multiple myeloma. There was only transient improvement of cutaneous changes after the chemotherapy, despite the complete remission of the underlying disease in the bone marrow. Despite of the intensive treatment (chemotherapy, radiotherapy) the patient died 7 months after the first appearance of the skin changes.
    Źródło:
    OncoReview; 2017, 7, 4; 180-183
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxic effect of nitric oxide on human hematological malignant cells.
    Autorzy:
    Tsumori, Michihiro
    Tanaka, Junko
    Koshimura, Kunio
    Kawaguchi, Mikiko
    Murakami, Yoshio
    Kato, Yuzuru
    Powiązania:
    https://bibliotekanauki.pl/articles/1043819.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    lymphoma
    myeloma
    leukemia
    nitric oxide
    Opis:
    We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 139-144
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peroxidation of proteins and lipids in suspensions of liposomes, in blood serum, and in mouse myeloma cells.
    Autorzy:
    Gebicki, Janusz
    Du, Juan
    Collins, James
    Tweeddale, Helen
    Powiązania:
    https://bibliotekanauki.pl/articles/1044208.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    liposomes
    lipid peroxides
    mouse cells
    serum
    free radicals
    protein peroxides
    Opis:
    There is growing evidence that proteins are early targets of reactive oxygen species, and that the altered proteins can in turn damage other biomolecules. In this study, we measured the effects of proteins on the oxidation of liposome phospholipid membranes, and the formation of protein hydroperoxides in serum and in cultured cells exposed to radiation-generated hydroxyl free radicals. Lysozyme, which did not affect liposome stability, gave 50% protection when present at 0.3 mg/ml, and virtually completely prevented lipid oxidation at 10 mg/ml. When human blood serum was irradiated, lipids were oxidized only after the destruction of ascorbate. In contrast, peroxidation of proteins proceeded immediately. Protein hydroperoxides were also generated without a lag period in hybrid mouse myeloma cells, while at the same time no lipid peroxides formed. These results are consistent with the theory that, under physiological conditions, lipid membranes are likely to be effectively protected from randomly-generated hydroxyl radicals by proteins, and that protein peroxyl radicals and hydroperoxides may constitute an important hazard to biological systems under oxidative stress.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 901-911
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Targeting the hypoxia pathway in malignant plasma cells by using 17-allylamino-17-demethoxygeldanamycin
    Autorzy:
    Kocemba-Pilarczyk, Kinga
    Ostrowska, Barbara
    Trojan, Sonia
    Aslan, Ecce
    Kusior, Dorota
    Lasota, Małgorzata
    Lenouvel, Claire
    Dulińska-Litewka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038530.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Multiple myeloma
    HIF-1
    hypoxia
    17-AAG
    Opis:
    Multiple myeloma (MM) is characterized as a clonal expansion of malignant plasma cells in the bone marrow, which is often associated with pancytopenia and osteolytic bone disease. Interestingly, myeloma-infiltrated bone marrow is considered to be hypoxic, providing selection pressure for a developing tumour. Since HSP90 was shown to participate in stabilization of the subunit of the key transcription factor HIF-1, which controls the hypoxic response, the aim of this study was to investigate the influence of a HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), on MM cells cultured under low oxygenation conditions. We confirmed that 17-AAG inhibits hypoxic induction of the HIF-1 target genes in malignant plasma cells and demonstrate the concentration range of severe hypoxia-specific cytotoxicity. Next, we selected the malignant plasma cells under severe hypoxia/re-oxygenation culture conditions in the presence or absence of 17-AAG and subsequently, the cells which survived were further expanded and analyzed. Interestingly, we have noticed significant changes in the survival and the response to anti-MM drugs between the parental cell lines and those selected in cyclic severe hypoxia in the presence and absence of 17-AAG. Importantly, we also observed that the lack of oxygen itself, irrespectively of HIF-1 inhibition, is the main/pivotal factor driving the selection process in the experiments presented here.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 101-109
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New bone formation in the mandibular corpus after mucosal healing in a patient with medication related osteonecrosis of the jaw after treatment by bisphosphonates for multiple myeloma: a case report and pictorial review
    Autorzy:
    Debiève, Maxime
    Crevecoeur, Hervé
    Powiązania:
    https://bibliotekanauki.pl/articles/6329994.pdf
    Data publikacji:
    2022-10-16
    Wydawca:
    Presses Universitaires de Louvain
    Tematy:
    Medication related osteonecrosis of the jaw
    MRONJ
    antiresorptive drugs
    bisphosphonate
    new bone formation
    Opis:
    Objective: First cases of osteonecrosis of the jaw in patient exposed to bisphosphonates were presented in 2003. Bisphosphonates related osteonecrosis of the jaw (BRONJ) was further extended to medication-related osteonecrosis of the jaw (MRONJ) to include antiresorptive and anti-angiogenic drugs. Some directives were described for the treatment of this disease in function of its gravity. Treatments of high stage of MRONJ are subject to discussion because of their morbidity. Complete healing is difficult to reach and often needs combination of invasive and non-invasive treatment. Case report: We report and illustrate a clinical case of new bone formation after MRONJ on pamidronate and zoledronate treatment for multiple myeloma. The treatment of choice was sequestrectomy and conservative treatment. Discussion: The consensus to reach a complete healing after MRONJ is not already known. More studies are needed.
    Źródło:
    Nemesis. Negative Effects in Medical Sciences Oral and Maxillofacial Surgery; 2022, 27, 1; 1-13
    2593-3604
    Pojawia się w:
    Nemesis. Negative Effects in Medical Sciences Oral and Maxillofacial Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Efficacy of ixazomib-lenalidomidedexamethasone in high-molecular-risk relapsed/refractory multiple myeloma – case series and literature review
    Autorzy:
    Szudy-Szczyrek, A.
    Chocholska, S.
    Bachanek-Mitura, O.
    Czabak, O.
    Mlak, R.
    Szczyrek, M.
    Muzyka-Kasietczuk, J.
    Hus, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/28761872.pdf
    Data publikacji:
    2022
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2022, 29, 1; 103-109
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies