Wszystkie pola: methylation analysis - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: LBP gene methylation involved in mRNA expression and resistance to E. coli F18 in weaned piglets
Autorzy:: Gan, L.N.
Bao, W.B.
Wu, S.L.
Qin, W.Y.
Sun, L.
Zhao, C.X.
Powiązania:: https://bibliotekanauki.pl/articles/2087872.pdf
Data publikacji:: 2017
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: LBP gene
methylation analysis of the LBP region
E.coli F18 strain
weaned piglets
Źródło:: Polish Journal of Veterinary Sciences; 2017, 4; 643-650
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Integrated statistical and rule-mining techniques for dna methylation and gene expression data analysis
Autorzy:: Mallik, S.
Mukhopadhyay, A.
Maulik, U.
Powiązania:: https://bibliotekanauki.pl/articles/1396742.pdf
Data publikacji:: 2013
Wydawca:: Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:: statistical analysis
gene marker
methylation
genetic algorithm
DNA
Opis:: For determination of the relationships among significant gene markers, statistical analysis and association rule mining are considered as very useful protocols. The first protocol identifies the significant differentially expressed/methylated gene markers, whereas the second one produces the interesting relationships among them across different types of samples or conditions. In this article, statistical tests and association rule mining based approaches have been used on gene expression and DNA methylation datasets for the prediction of different classes of samples (viz., Uterine Leiomyoma/class-formersmoker and uterine myometrium/class-neversmoker). A novel rule-based classifier is proposed for this purpose. Depending on sixteen different rule-interestingness measures, we have utilized a Genetic Algorithm based rank aggregation technique on the association rules which are generated from the training set of data by Apriori association rule mining algorithm. After determining the ranks of the rules, we have conducted a majority voting technique on each test point to estimate its class-label through weighted-sum method. We have run this classifier on the combined dataset using 4-fold cross-validations, and thereafter a comparative performance analysis has been made with other popular rulebased classifiers. Finally, the status of some important gene markers has been identified through the frequency analysis in the evolved rules for the two class-labels individually to formulate the interesting associations among them.
Źródło:: Journal of Artificial Intelligence and Soft Computing Research; 2013, 3, 2; 101-115
2083-2567
2449-6499
Pojawia się w:: Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Comparative analysis of CpG islands in two genotypes of African swine fever virus
Autorzy:: Yu, Y.-Y.
X, M.-S.
Liu, Q.
Powiązania:: https://bibliotekanauki.pl/articles/16539329.pdf
Data publikacji:: 2022
Wydawca:: Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:: African Swine Fever Virus (ASFV)
genotype
DNA methylation
CpG island
Opis:: African swine fever (ASF) is an acute, hemorrhagic, and devastating viral infectious disease that causes important economic losses to the swine industry. Currently, there are no effective vaccines or drugs available. Epigenetic mechanisms, especially cytosine methylation of cytosine-phosphate-guanine (CpG) islands, have a significant impact on the life cycle of several viruses. Hence, drugs targeting DNA methylation may potentially be used for the treatment of ASF. Here, we selected the inner core, core shell, inner membrane, capsid, and external envelope membrane, to analyze the characteristics of CpG islands in the ASF virus (ASFV) genomes. Furthermore, we analyzed the promoters and CpG islands in the upstream regions of these genes. Results showed that the CpG islands of seven genes were conserved in the genomes of two genotype of ASFV strains, whereas the CpG islands of other genes were relatively conserved (ASFV strains differed mainly in the quantity of CpG islands). The different distribution of CpG islands in the genomes of different ASFV strains may affect their methylation status, which may in turn affect the regulation of viral gene expression, leading to different clinical outcomes. In addition, the predicted promoter regions based on the upstream sequences of most genes overlapped with CpG island positions. Methylation of the binding sites of the promoter regions inhibits the binding of the transcription factors to the promoters, thus inhibiting the activation of the promoters and limiting the synthesis of viral proteins. The results of this study provide a basis for exploring new antiviral therapeutic strategies from an epigenetic perspective.
Źródło:: Polish Journal of Veterinary Sciences; 2022, 25, 3; 455-462
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Structural enzymology at the legume-microbe interface: S-adenosyl-L-homocysteine hydrolase of rhizobia
Autorzy:: Manszewski, T.
Singh, K.
Imiolczyk, B.
Jaskolski, M.
Powiązania:: https://bibliotekanauki.pl/articles/80810.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: S-adenosyl-L-homocysteine hydrolase
rhizobia
biological methylation
methyl group
enzymatic hydrolysis
enzymatic process
crystal structure
phylogenetic analysis
biochemical analysis
legume plant
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 1
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Sequence determination and analysis of S-adenosyl-L-homocysteine hydrolase from yellow lupine (Lupinus luteus).
Autorzy:: Brzeziński, Krzysztof
Janowski, Robert
Podkowiński, Jan
Jaskólski, Mariusz
Powiązania:: https://bibliotekanauki.pl/articles/1044143.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Southern blot
S-adenosyl-L-homocysteinase
Northern blot
biological methylation
screening of cDNA library
phylogeny
Opis:: The coding sequences of two S-adenosyl-L-homocysteine hydrolases (SAHases) were identified in yellow lupine by screenig of a cDNA library. One of them, corresponding to the complete protein, was sequenced and compared with 52 other SAHase sequences. Phylogenetic analysis of these proteins identified three groups of the enzymes. Group A comprises only bacterial sequences. Group B is subdivided into two subgroups, one of which (B1) is formed by animal sequences. Subgroup B2 consist of two distinct clusters, B2a and B2b. Cluster B2b comprises all known plant sequences, including the yellow lupine enzyme, which are distinguished by a 50-residue insert. Group C is heterogeneous and contains SAHases from Archaea as well as a new class of animal enzymes, distinctly different from those in group B1.
Źródło:: Acta Biochimica Polonica; 2001, 48, 2; 477-483
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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