Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "liver" wg kryterium: Wszystkie pola


Tytuł:
History of liver transplantation in Poland
Autorzy:
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1392651.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
liver transplantations
history of liver transplantation
liver transplant centers in Poland
liver transplantation technique
Opis:
Experimental research on liver transplantation was introduced in Poland by Waldemar Olszewski and his team in 1972. Not until 15 years later, in 1987, did Stanisław Zieliński in Szczecin and Marian Pardela in Katowice make an attempt of transplanting liver in humans. In 1989 another attempt was made by Jacek Pawlak and Marek Krawczyk in Warsaw. The first successful liver transplantation in Poland was performed in 1990 by Piotr Kaliciński at the Children’s Memorial Health Institute, Warsaw. Also, in early 1990s the attempts were made by Jerzy Polański in Warsaw and Piotr Szyber in Wrocław. In the next years, liver transplantations were connected with three centers in Szczecin and were associated with the following persons: Roman Kostryka, Maciej Wójcicki and Samir Zeaira. In Warsaw, 1994, Jacek Pawlak, Bogdan Michałowicz and Krzysztof Zieniewicz performed another successful liver transplantation. The program started to develop rapidly and is still up and running. In 2000, Wojciech Rowiński and Marek 
Pacholczyk created another liver transplant center in Warsaw, while in 2005 Lech Cierpka and Robert Król did the same in Katowice. In the following years, liver transplantation was initiated by Maciej Słupski in Bydgoszcz (2017) and Zbigniew Śledziński in Gdańsk (2018). In the developing liver transplant centers, an exceptional contribution was made by Paweł Nyckowski, Jacek Pawlak, Krzysztof Zieniewicz, Waldemar Patkowski, Tadeusz Wróblewski, Rafał Paluszkiewicz, Marek Pacholczyk, Andrzej Chmura, Maciej Kosieradzki and Marek Krawczyk – all employed by the Medical University of Warsaw. In Wrocław, Dariusz Patrzałek and Paweł Chudoba were very active in the field of liver transplantations. In 1996, the Organizing-Coordinating Center for Transplantation POLTRANSPLANT was brought to life and at first was directed by Janusz Wałaszewski, then by Roman Danielewicz and Artur Kamiński. In 1999, Piotr Kaliciński and Marek Krawczyk started the program for liver fragment harvesting and transplantation from living donors. Until the end of 2016, 4186 liver transplantations including 314 liver transplants from living donors were performed in Poland. Currently there are three active centres in Warsaw, namely Pediatric Surgery and Transplantation Surgery, Children’s Memorial Health Institute; Department of General, Transplant and Liver Surgery, Medical University of Warsaw; 
Department of General and Transplant Surgery, Medical University of Warsaw. Other active centres in Poland are Department of General and Transplant Surgery, Provincial Hospital in Szczecin, Department of General, Vascular and Transplant Surgery, Medical University of Silesia, Katowice, Department of Vascular, General and Transplant Surgery in Wrocław. Liver transplant programs have also been initiated at the Department of Liver and General Surgery, Bydgoszcz, and Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk.
Źródło:
Polish Journal of Surgery; 2018, 90, 3; 60-68
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Early results of liver resection using laparoscopic technique
Autorzy:
Stranek, Maciej
Pędziwiatr, Michał
Radkowiak, Dorota
Zychowicz, Anna
Budzyński, Piotr
Major, Piotr
Budzyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1394071.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
laparoscopy
liver resection
liver metastases
Opis:
The aim of the study was to present early outcomes of liver resection using laparoscopic technique. Material and methods. Retrospective analysis of patients who underwent liver resection using laparoscopic method was conducted. The analyzed group included 23 patients (11 women and 12 men). An average patient age was 61.3 years (37 – 83 years). Metastases of the colorectal cancer to the liver were the cause for qualification to the procedure of 15 patients, metastasis of breast cancer in 1 patient and primary liver malignancy in 5 patients. The other 2 patients were qualified to the liver resection to widen the surgical margins due to gall-bladder cancer diagnosed in the pathological assessment of the specimen resected during laparoscopic cholecystectomy, initially performed for other than oncology indications. Results. Hemihepatectomy was performed in 11 patients (9 right and 2 left), while the other 12 patients underwent minor resection procedures (5 metastasectomies, 4 nonanatomical liver resections, 1 bisegmentectomy, 2 resections of the gall-bladder fossa). An average duration of the surgical procedure was 275 minutes 65 – 600). An average size of the resected tumors was 28 mm (7 – 55 mm). In three cases conversion to laparotomy occurred, caused by excessive bleeding from the liver parenchyma. Postoperative complications were found in 4 patients (17.4%). Median hospitalization duration was 6 days (2 – 130 days). One patient (4.3%) was rehospitalized due to subhepatic abscess and required reoperation. Histopathology assessment confirmed radical resection (R0) in all patients in our group. Conclusion. Laparoscopic liver resections seem to be an interesting alternative in the treatment of focal lesions in the liver.
Źródło:
Polish Journal of Surgery; 2016, 88, 1; 20-25
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the zearalenone on the activity of chosen liver enzymes in a rat
Autorzy:
Stadnik, A
Borzecki, A.
Powiązania:
https://bibliotekanauki.pl/articles/51110.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
rat
liver
enzyme
enzyme activity
zearalenone
mycotoxin
Fusarium
liver cell
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 1; 31-35
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cartilaginous compression of the liver – clinical and ultrasonographic aspects
Autorzy:
Smereczyński, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1033246.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
costal cartilages
liver
muscles
pseudolesions
ultrasonography
Opis:
Introduction: The musculocartilaginous complex is a structure composed of cartilaginous, osseous and muscular elements, which is located at the thoracoabdominal junction, at the level of the right costal arch. Aim: To determine the ultrasonographic characteristics of this complex under normal conditions as well as to demonstrate its effects on the liver depending on the constitutional body built, respiratory phase and patient’s body position. Materials and methods: All abdominal ultrasound scans were performed between 2006 and 2015. A total of 1000 patients (566 females and 434 males aged between 35 and 82 years, mean age 52 years), who had no significant upper abdominal pathologies identified based on clinical and imaging data, were enrolled for the analysis. In addition to standard internal organ assessment, we also attempted to identify the symptoms of hepatic compression by the musculocartilaginous complex. We used 3–6 MHz convex and 7–12 MHz linear transducers. The degree of musculocartilaginous compression of the liver was assessed during breathing in supine and sitting position, as well as with trunk inclined forward. Results: The study showed that musculocartilaginous compression of the liver mostly affects females (96%) with leptosomatic body build. The complex compressing the liver shows a heterogeneous echostructure. Increased hepatic compression was observed during exhalation, in a sitting position and with trunk inclined forward. Conclusions: Cartilaginous compression of the liver depends on body built and patient’s body position. The musculocartilaginous complex may cause focal or segmental compression of the hepatic parenchyma, causing pain in the right upper abdomen in some patients.
Wprowadzenie: Kompleks chrząstkowo-mięśniowy to struktura składająca się z elementów chrzęstnych, kostnych i mięśniowych, zlokalizowana na pograniczu piersiowo-brzusznym, na poziomie prawego łuku żebrowego. Cel: Określenie ultrasonograficznych cech tego kompleksu w warunkach prawidłowych oraz wykazanie jego wpływu na wątrobę w zależności od budowy konstytucjonalnej, fazy oddechowej oraz pozycji przyjmowanej przez pacjenta. Materiał i metoda: Wszystkie badania ultrasonograficzne jamy brzusznej przeprowadzono w okresie od 2006 do 2015. Do analizy zakwalifikowano 1000 osób (566 kobiet i 434 mężczyzn, w przedziale wiekowym 35–82 lata, średnio 52 lata), u których na podstawie danych klinicznych i obrazowych nie stwierdzono istotnych zmian w narządach nadbrzusza. W badaniach ultrasonograficznych jamy brzusznej, oprócz standardowo ocenianych narządów wewnętrznych, skupiono się na poszukiwaniu objawów ucisku wątroby przez kompleks chrząstkowo-mięśniowy. Do badań wykorzystywano głowice konweksowe o częstotliwości 3–6 MHz oraz liniowe o częstotliwości 7–12 MHz. Stopień ucisku wątroby przez kompleks chrząstkowo-mięśniowy oceniano w trakcie oddychania, w ułożeniu pacjenta na plecach, w pozycji siedzącej i w przodopochyleniu tułowia. Wyniki: Wykazano, że ucisk chrząstkowopochodny wątroby dotyczy głównie kobiet (96%) o budowie leptosomicznej. Uciskający wątrobę kompleks najczęściej wykazuje heterogeniczną echostrukturę. Większy stopień ucisku wątroby występował w trakcie wydechu, w pozycji siedzącej i w przodopochyleniu tułowia. Wnioski: Ucisk chrząstkowopochodny wątroby jest uzależniony od budowy ciała oraz przyjmowanej przez pacjenta pozycji. Kompleks chrząstkowo-mięśniowy może wywierać ucisk ogniskowy lub odcinkowy na miąższ wątroby, powodując u części osób ból w prawym nadbrzuszu. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-18-no-72
Źródło:
Journal of Ultrasonography; 2018, 18, 72; 9-15
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin
Autorzy:
Panoutsopoulos, Georgios
Beedham, Christine
Powiązania:
https://bibliotekanauki.pl/articles/1041506.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
xanthine oxidase
phthalazine
aldehyde oxidase
liver slices
disulfiram
isovanillin
allopurinol
Opis:
The enzymes aldehyde oxidase and xanthine oxidase catalyze the oxidation of a wide range of N-heterocycles and aldehydes. These enzymes are widely known for their role in the metabolism of N-heterocyclic xenobiotics where they provide a protective barrier by aiding in the detoxification of ingested nitrogen-containing heterocycles. Isovanillin has been shown to inhibit the metabolism of aromatic aldehydes by aldehyde oxidase, but its inhibition towards the heterocyclic compounds has not been studied. The present investigation examines the oxidation of phthalazine in the absence and in the presence of the inhibitor isovanillin by partially purified aldehyde oxidase from guinea pig liver. In addition, the interaction of phthalazine with freshly prepared guinea pig liver slices, both in the absence and presence of specific inhibitors of several liver oxidizing enzymes, was investigated. Aldehyde oxidase rapidly converted phthalazine into 1-phthalazinone, which was completely inhibited in the presence of isovanillin (a specific inhibitor of aldehyde oxidase). In freshly prepared liver slices, phthalazine was also rapidly converted to 1-phthalazinone. The formation of 1-phthalazinone was completely inhibited by isovanillin, whereas disulfiram (a specific inhibitor of aldehyde dehydrogenase) only inhibited 1-phthalazinone formation by 24% and allopurinol (a specific inhibitor of xanthine oxidase) had little effect. Therefore, isovanillin has been proved as an inhibitor of the metabolism of heterocyclic substrates, such as phthalazine, by guinea pig liver aldehyde oxidase, since it had not been tested before. Thus it would appear from the inhibitor results that aldehyde oxidase is the predominant enzyme in the oxidation of phthalazine to 1-phthalazinone in freshly prepared guinea pig liver slices, whereas xanthine oxidase only contributes to a small extent and aldehyde dehydrogenase does not take any part.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 943-951
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection
Autorzy:
Hołówko, Wacław
Grąt, Michał
Wronka, Karolina Maria
Stypułkowski, Jan
Roszkowski, Rafał
Studnicki, Paweł
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1395543.pdf
Data publikacji:
2015-02-01
Wydawca:
Index Copernicus International
Tematy:
colorectal liver metastases
liver resection
total tumor volume
Opis:
Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease. The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy. Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve. Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively. Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatment
Źródło:
Polish Journal of Surgery; 2015, 87, 2; 53-58
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arginase isoenzymes in human cirrhotic liver
Autorzy:
Chrzanowska, Alicja
Gajewska, Beata
Barańczyk-Kuźma, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040542.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
arginase activity
liver cirrhosis
isoenzyme expression
Opis:
Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on arginase isoenzymes and their possible role in liver cirrhosis. The study was performed on tissues obtained during liver transplantation from 60 patients with liver cirrhosis, and on samples of histologically normal liver (control) from 40 patients with benign or colorectal cancer liver metastases removed during surgery, 6-7 cm from the tumor border. Arginase isoenzymes AI (so-called liver-type arginase) and AII (called extrahepatic arginase) were identified by Western blotting and isolated by ion-exchange chromatography. Their expression on mRNA level was studied by RT-PCR. A significant decrease in arginase activity, dependent of the liver clinical stage, was observed in cirrhotic tissue. Arginase AI activity and its mRNA level were significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII were concurrently raised, as compared to normal liver. Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 465-469
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contrast-enhanced ultrasonography (CEUS) in canine liver examination
Autorzy:
Wdowiak, M.
Rychlik, A.
Nieradka, R.
Nowicki, M.
Powiązania:
https://bibliotekanauki.pl/articles/31671.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
contrast-enhanced ultrasonography
canine liver
examination
liver
dog
ultrasonography
cancer
diagnostics
imaging technique
Opis:
Ultrasonography is a noninvasive diagnostic tool used to image size, shape, parenchyma and vascularization of various body organs. Unfortunately, the ultrasonographic image is characterized by a low contrast due to similar acoustic properties of the soft tissue. The Doppler mode provides information about blood flow, but is incapable of imaging small vessels and capillaries because of their low blood flow velocity (1 mm/s). However, a possibility to increase the effectiveness of ultrasonographic diagnostics exists, thanks to intravenous ultrasound contrast agents (UCAs) consisted of gas microbubbles. The purpose of this review paper is to characterize specific imaging techniques necessary to conduct a contrast-enhanced liver examination and indications for CEUS as an alternative diagnostic method.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis
Autorzy:
Maretskyi, V.
Lobanets, N.
Powiązania:
https://bibliotekanauki.pl/articles/2052423.pdf
Data publikacji:
2015
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
hepatic encephalopathy
liver cirrhosis
psychometric test
Opis:
The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patients and thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.
Źródło:
Health Problems of Civilization; 2015, 09, 2; 31-34
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver
Autorzy:
Tharwat, M.
Powiązania:
https://bibliotekanauki.pl/articles/30512.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ultrasonography
diagnostics
prognosis
cattle
buffalo
fatty infiltration
liver
fatty liver
hepatic lipidosis
lipid metabolism
dairy cow
Opis:
The aim of the present study was to determine whether ultrasonographic evaluation of the hepatic parenchyma could be used as a diagnostic and prognostic approach in cows and buffaloes with hepatic lipidosis. For this purpose, cows (n=16) and buffaloes (n=10) with fatty infiltration of the liver were examined by ultrasonography. Treated cows and buffaloes were monitored for hepatic changes ultrasonographically, biochemically and histologically. Clinical findings were non-specific and included anorexia, recumbency, muzzle necrosis, and icteric mucosal membranes. Laboratory data revealed neutrophilia, hyper γ-globulinemia, elevated activities of aspartate aminotransferase, γ-glutamyl transpeptidase, creatine kinase and lactate dehydrogenase, and high concentrations of insulin, total bilirubin, non-esterified fatty acids and β-hydroxyl butyric acid. Laboratory results 7, and 21 days after treatment showed progressive improvement in the chemistry profile. On admission, ultrasonographic examination of the hepatic parenchyma in cows and buffaloes revealed either increased or decreased hepatic echogenicity; histologic examination revealed marked fatty infiltration of the hepatocytes. One week after treatment, the hepatic parenchyma was visualized easily, liver boundaries were clearly imaged, and histologic examination of hepatic specimen showed a moderate degree of fatty infiltration. Three weeks after treatment, the hepatic parenchyma was almost similar to normal, the hepatic and portal blood vessels could be easily imaged, and the histologic picture had greatly improved where the liver resembled the normal organ. Six cows and seven buffaloes made a full recovery while the remaining ten cows and three buffaloes were slaughtered and thoroughly examined postmortem. Ultrasonography showed a good correlation with histologic and laboratory findings.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Post-transplant Metabolic Syndrome (PTMS) after Liver Transplantation – Review of the Literature
Autorzy:
Kotarska, Katarzyna
Raszeja-Wyszomirska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1054740.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
liver transplantation
metabolic syndrome
Opis:
Liver transplant provides a definitive therapeutic measure for patients with chronic and acute liver diseases. Apart from the improvement of overall health, an organ transplant entails several metabolic complications. They are multi-agent and depend, among others, on the function of organ being transplanted, adverse effects of immunosuppression being applied, organ complications induced by failure of the organ being transplanted, current treatment, concomitant diseases and consequences of the acute and chronic rejection processes. Improvements in surgical techniques, peritransplant intensive care, and immunosuppressive regimens have resulted in significant improvements in short-term survival. Focus has now shifted to address long-term outcomes of liver transplantation. Therefore, this paper presents the current review of literature referring to specificity of the prevalence of metabolic syndrome and its complications in patients after liver transplantation.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2015, 11, 3; 29-37
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fatty liver disease in dairy cattle – risk factors, symptoms and prevention
Autorzy:
Bombik, E.
Sokol, J.
Pietrzkiewicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/2119575.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Zootechniczne
Tematy:
dairy cattle
metabolic disease
fatty liver
Opis:
Fat cow syndrome (fatty liver disease) is a common metabolic problem in dairy cow production during the transition period, from the dry period to lactation. This syndrome occurs when due to liver uptake of non-esterified fatty acids (NEFAs), they are stored in excess as triacylglycerols (TAGs) in the liver. Currently, diagnosis of this disorder must be confirmed by a liver biopsy to determine the fat content of liver cells, as well as blood tests for increased levels of liver enzymes (GGT, SDH, AST, and bilirubin). Fat cow syndrome is associated with the occurrence of clinical diseases, decreased immunity, and problems with reproduction. It is a major problem in the herd health due to the high cost of veterinary services, a longer calving interval, and reduced longevity of cows, causing enormous economic losses. The best means of prevention is good nutrition and routine blood tests in the herd.
Źródło:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego; 2020, 16, 4; 51-58
1733-7305
Pojawia się w:
Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prevalence of non-alcoholic fatty liver disease and hypercholesterolemia in patients with gallstone disease undergoing laparoscopic cholecystectomy
Autorzy:
Singh, Kaptan
Dahiya, Divya
Kaman, Lileswar
Das, Ashim
Powiązania:
https://bibliotekanauki.pl/articles/1391850.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
dyslipidemia
gallstone disease
liver biopsy
non-alcoholic fatty liver disease (NAFLD)
Opis:
Background: Gallstone disease (GSD) and nonalcoholic fatty liver disease (NAFLD) are connected with a high prevalence in the general population and they share common risk factors for their occurrence. Limited literature with inconsistent results is available, suggesting a potential association between these lifestyle-induced diseases. Liver biopsy is the gold standard for diagnosing NAFLD. The aim of this study was (1) to identify the prevalence of asymptomatic NAFLD or NASH in liver biopsy; (2) to identify the association of hypercholesterolemia with NAFLD in patients undergoing laparoscopic cholecystectomy (LC). Methods: This is a prospective observational study conducted on patients who underwent LC for symptomatic gallstones in the Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, from 1st July 2013 to 31st December 2014. All included patients had ultrasonography (USG) and the following parameters tested: serum triglycerides (TG), cholesterol, low density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). A wedge liver biopsy was obtained from free edge of the right liver lobe during LC and all biopsy specimens were analyzed by a single pathologist. Results: Among 101 patients included in the study, dyslipidemia was present in 49.50%. There was no association between NAFLD and serum cholesterol, TG or LDL-C (P, 0.428, 0.848, 0.371 respectively). NAFLD was confirmed in liver biopsy in 21.8% of patients but none had fibrosis or cirrhosis on biopsy. No complications were observed following liver biopsy. Conclusions: Liver biopsy during LC gives an opportunity to diagnose the disease at an early and reversible stage. It is feasible, safe and cost effective.
Źródło:
Polish Journal of Surgery; 2020, 92, 1; 18-22
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Perspectives of pharmacological intervention promoting liver regeneration
Perspektywy farmakologicznej interwencji w promowaniu regeneracji wątroby
Autorzy:
Danilova, Irina
Kalota, Hanna
Abidov, Musa
Powiązania:
https://bibliotekanauki.pl/articles/2097693.pdf
Data publikacji:
2018-06-22
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
terapia komórek macierzystych
przeprogramowanie makrofagów
farmakoterapia chorób wątroby
regeneracja wątroby
liver regeneration
stem cells therapy
macrophage reprogramming
pharmacotherapy of liver diseases
Opis:
Effective drug therapy promoting liver regeneration is a challenging goal in pharmacotherapy of liver diseases. Several plant phytochemicals recommended in traditional medicine from over hundred plants have been investigated for its use in various liver disorders. Regeneration of injured liver depend on a proliferative potential of mature hepatocytes as well as different subsets of intrahepatic and extrahepatic stem/progenitor cells. In clinical trials a stem cell therapy resulted in a limited improvement of liver functions. Animal studies have demonstrated the involvement of bone marrow-derived stem/progenitor cells in liver regeneration. For this reason, the pharmacological activation of endogenous stem cells and pharmacological control of macrophage phenotypic polarization could be an effective method of mobilizing progenitor cells to injured liver.
Wyzwaniem dla współczesnej farmakoterapii są skuteczne leki wspomagające regenerację wątroby. Wiele substancji z ponad stu roślin zalecanych w tradycyjnej medycynie przebadano w celu ich zastosowania w chorobach wątroby. W procesie regeneracji wątroby biorą udział subpopulacje wewnątrz-wątrobowych i poza-wątrobowych komórek macierzystych/progenitorowych oraz dochodzi do proliferacji dojrzałych hepatocytów. Dane kliniczne wskazują na ograniczoną skuteczność terapii komórek macierzystych w polepszeniu funkcji wątroby. W badaniach modeli zwierzęcych regeneracji wątroby wykazano udział komórek macierzystych/ progenitorowych, pochodzących ze szpiku kostnego. Z tego powodu, rozważa się możliwość wprowadzenia farmakologicznej aktywacji endogennych komórek macierzystych oraz farmakologiczną kontrolę fenotypowej polaryzacji makrofagów, jako skutecznej metody mobilizacji komórek progenitoworych dla uszkodzonej wątroby.
Źródło:
Health Promotion & Physical Activity; 2018, 2, 1; 1-4
2544-9117
Pojawia się w:
Health Promotion & Physical Activity
Dostawca treści:
Biblioteka Nauki
Artykuł

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies