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    Wyświetlanie 1-5 z 5
    Tytuł:
    Characterization of catechol 2,3-dioxygenase from Planococcus sp. strain S5 induced by high phenol concentration
    Autorzy:
    Hupert-Kocurek, Katarzyna
    Guzik, Urszula
    Wojcieszyńska, Danuta
    Powiązania:
    https://bibliotekanauki.pl/articles/1039708.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Planococcus
    phenol degradation
    catechol 2,3- dioxygenase
    Opis:
    This study aimed at characterization of a new catechol 2,3-dioxygenase isolated from a Gram-positive bacterium able to utilize phenol as the sole carbon and energy source. Planococcus sp. strain S5 grown on 1 or 2 mM phenol showed activity of both a catechol 1,2- and catechol 2,3-dioxygenase while at a higher concentrations of phenol only catechol 2,3-dioxygenase activity was observed. The enzyme was optimally active at 60°C and pH 8.0. Kinetic studies showed that the Km and Vmax of the enzyme were 42.70 µM and 329.96 mU, respectively. The catechol 2,3-dioxygenase showed the following relative meta-cleavage activities for various catechols tested: catechol (100%), 3-methylcatechol (13.67%), 4-methylcatechol (106.33%) and 4-chlorocatechol (203.80%). The high reactivity of this enzyme towards 4-chlorocatechol is different from that observed for other catechol 2,3-dioxygenases. Nucleotide sequencing and homology search revealed that the gene encoding the S5 catechol 2,3-dioxygenase shared the greatest homology with the known genes encoding isoenzymes from Gram-negative Pseudomonas strains.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 3; 345-351
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Altering substrate specificity of catechol 2,3-dioxygenase from Planococcus sp. strain S5 by random mutagenesis
    Autorzy:
    Hupert-Kocurek, Katarzyna
    Wojcieszyńska, Danuta
    Guzik, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/1039199.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Planococcus
    catechol 2,3-dioxygenase
    substrate specificity
    mutagenesis
    Opis:
    c23o gene, encoding catechol 2,3-dioxygenase from Planococcus sp. strain S5 was randomly mutagenized to generate variant forms of the enzyme with higher degradation activity. Additionally, the effect of introduced mutations on the enzyme structure was analyzed based on the putative 3D models the wild-type and mutant enzymes. C23OB58 and C23OB81 mutant proteins with amino acid substitutions in close proximity to the enzyme surface or at the interface and in the vicinity of the enzyme active site respectively showed the lowest activity towards all catecholic substrates. The relative activity of C23OC61 mutant towards para-substituted catechols was 20-30% lower of the wild-type enzyme. In this mutant all changes: F191I, C268R, Y272H, V280A and Y293D were located within the conserved regions of C-terminal domain. From these F191I seems to have significant implications for enzyme activity. The highest activity towards different catechols was found for mutant C23OB65. R296Q mutation improved the activity of C23O especially against 4-chlorocatechol. The relative activity of above-mentioned mutant detected against this substrate was almost 6-fold higher than the wild-type enzyme. These results should facilitate future engineering of the enzyme for bioremediation.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 4; 705-710
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of Hydraulic Retention Time and Filling Time on Simultaneous Biodegradation of Phenol, Resorcinol and Catechol in a Sequencing Batch Reactor
    Autorzy:
    Thakur, C.
    Mall, I. D.
    Srivastava, V. C.
    Powiązania:
    https://bibliotekanauki.pl/articles/205058.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    phenol
    resorcinol
    catechol
    batch reactor
    BR
    hydraulic retention time
    biodegradation
    Opis:
    In the present study, treatment of synthetic wastewater containing phenol, resorcinol and catechol was studied in a sequencing batch reactor (SBR). Parameters such as hydraulic retention time (HRT) and filling time have been optimized to increase the phenol, resorcinol, catechol and chemical oxygen demand (COD) removal efficiencies. More than 99% phenol, 95% resorcinol and 96% catechol and 89% COD removal efficiency was obtained at optimum conditions of HRT = 1.25 d and fill time = 1.5 h. The heating value of the sludge was found to be 12 MJ/kg. The sludge can be combusted to recover its energy value.
    Źródło:
    Archives of Environmental Protection; 2013, 39, 2; 69-80
    2083-4772
    2083-4810
    Pojawia się w:
    Archives of Environmental Protection
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Toxicity of Some Phenolic Derivatives : In Vitro Studies
    Autorzy:
    Zapór, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/89791.pdf
    Data publikacji:
    2004
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    phenol
    catechol
    resorcinol
    hydroquinone
    phloroglucinol
    cytotoxicity
    fenol
    hydrochinon
    badania in vitro
    działanie toksyczne
    substancje toksyczne
    rezorcynol
    zagrożenia chemiczne
    Opis:
    Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) wastested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson’s correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC50 values) and physicochemical parameters of compounds or their toxicity in vivo expressed by LD50 values. The studies showed that physicochemical properties of compounds seemed to have less influence on their cytotoxic potency than structural properties. Cytotoxicity of the compounds probably depends on the number of -OH groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC50 values and LD50 values determined following rabbit skin administration and experimental skin irritation score.
    Źródło:
    International Journal of Occupational Safety and Ergonomics; 2004, 10, 4; 319-331
    1080-3548
    Pojawia się w:
    International Journal of Occupational Safety and Ergonomics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The level of endogenous DNA damage in lymphocytes isolated from blood is associated with the fluctuation of 17β-estradiol concentration in the follicular phase of healthy young women.
    Autorzy:
    Kapiszewska, Maria
    Kalemba, Malgorzata
    Grzesiak, Aneta
    Kocemba, Kinga
    Powiązania:
    https://bibliotekanauki.pl/articles/1041444.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    endogenous DNA damage
    catechol-O-methyltransferase (COMT)
    comet assay
    17β-estradiol
    Opis:
    The aim of this study was to evaluate whether the differences in plasma 17β-estradiol concentration in early and late follicular phases of the menstrual cycle can affect the level of endogenous DNA damage in lymphocytes assessed by comet assay, and whether the extent of this damage in the follicular phase is associated with the genotype of catechol-O-methyltransferase (COMT). The level of DNA damage was positively correlated with 17β-estradiol concentration only in the late follicular phase. Subjects with the COMT L/L homozygous mutated variant revealed more DNA damage as compared to individuals with the COMT wild-type and heterozygous (H/L+HH) genotype.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 535-539
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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