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    Wyświetlanie 1-4 z 4
    Tytuł:
    Biodistribution of doxorubicin-loaded succinoyl chitosan nanoparticles in mice injected via intravenous or intranasal routes
    Autorzy:
    Zubareva, Anastasia
    Shcherbinina, Tatyana
    Varlamov, Valery P.
    Svirshchevskaya, Elena
    Powiązania:
    https://bibliotekanauki.pl/articles/1035197.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biodistribution
    doxorubicin
    succinoyl chitosan nanoparticles
    Opis:
    Chitosan (Chi) is an extremely promising natural biopolymer with remarkable potency for the development of drug and vaccine delivery nanosystems. Various Chi derivatives are used to form nanoparticles (NPs) with unique properties. However, the efficacy of the therapy delivered by Chi NPs depends significantly on NP biodistribution in the body. The aim of this study was the analysis of biodistribution of NPs formed by succinoyl Chi and loaded with doxorubicin (SCNPDOX). We compared the distribution of free DOX and SCNP-DOX after intravenous (i.v.) and intranasal (i.n.) delivery into tumour-bearing mice. Distribution of DOX and SCNP-DOX was comparable after i.v. injection while they differed significantly after i.n. instillation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 145-154
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of mucoadhesive chitosan-based drug delivery system
    Autorzy:
    Konovalova, Mariya
    Shagdarova, Balzhima
    Zubareva, Anastasia
    Generalov, Alexander
    Grechikhina, Maria
    Svirshchevskaya, Elena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034369.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    drug delivery systems
    hexanoylchitosan
    mucoadhesion
    quaternised chitosan
    Opis:
    Chitosan is a highly versatile biopolymer characterised by low toxicity, biocompatibility, and slow but complete biodegradation in the human body, possessing multiple reactive groups. One of the most well-known properties of positively charged chitosan derivatives is their ability to bind mucous membranes. The aim of this work was the analysis of mucoadhesion of unmodified 20 kDa chitosan and its hydrophobic (HC) and hydrophobic quaternised (QHC) derivatives in vitro and ex vivo. Unmodified chitosan formed large aggregates in vitro in keratinocyte and colon cell cultures and ex vivo in murine small intestine and muscle explants. At the same time, HC and especially QHC bound cells in vitro and ex vivo in a fine dotted manner, as evidenced by confocal microscopy. Such a pattern of hydrophobic derivatives distribution provides the possibility to develop mucoadhesive drug delivery systems with increased local drug release and improved chitosan biodegradation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 103-113
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cell binding and penetration of quaternized chitosan derivatives
    Autorzy:
    Zubareva, Anastasia A.
    Shagdarova, Balzhima Ts.
    Varlamov, Valery P.
    Svirshchevskaya, Elena V.
    Powiązania:
    https://bibliotekanauki.pl/articles/1034738.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride
    cell uptake
    chitosan
    cytotoxicity
    quaternized chitosan
    trypan blue
    Opis:
    Chitosan (Ch) is an attractive biopolymer with multiple reactive groups. However it is poorly soluble at neutral pH. Quaternization improves its solubility and permits the development of various positively charged drug delivery systems. The aim of this work was to study the solubility, toxicity, cell binding, and penetration of 20 kDa chitosan with 9, 40, 58 and 98% of quaternary ammonium group substitution (ChQ1 to ChQ4 accordingly). We showed that ChQ with substitution degree >40% was soluble in a wide pH range. Unexpectedly ChQ2 and ChQ3 were more toxic to cells than Ch, ChQ1 and ChQ4. Higher toxicity of ChQ was found against macrophage like cell line RAW264.7 than against epithelial cells MiaPaCa-2. All ChQ, in contrast to unmodified Ch, easily bound and penetrated the cells with the highest uptake by ChQ4. Thus, quaternized chitosan derivatives can be used for biomedical applications.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 217-223
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Protein delivery by nanoparticles formed by chitosan-n-acyl derivatives
    Autorzy:
    Zubareva, Anastasia А.
    Ilyina, Alla.V.
    Levov, Аlexandr N.
    Zueva, Vera S.
    Svirshchevskaya, Еlena V.
    Varlamov, Valery P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1035474.pdf
    Data publikacji:
    2011
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    N-acyl derivatives of chitosan
    chitosan nanoparticles
    ionic gelation
    protein delivery
    Opis:
    Biodegradable nanoparticulated carriers have important potential applications for administration of therapeutic proteins and peptides. Chitosan based nanoparticles have attracted attention due to their biological properties such as biodegrability and biocompatibility. However, chitosan nanoparticles are not stable in colloid form. Therefore, to increase the stability of these particles is an important problem. The aim of this work was to obtain stable nanoparticles formed by N-acyl derivatives of chitosan by ionic gelation and to investigate their ability to interact with acidic, neutral and basic proteins.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 61-70
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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