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Wyszukujesz frazę "Oliver, Peter" wg kryterium: Wszystkie pola


Wyświetlanie 1-2 z 2
Tytuł:
SNARE proteins and schizophrenia: linking synaptic and neurodevelopmental hypotheses
Autorzy:
Johnson, Reuben
Oliver, Peter
Davies, Kay
Powiązania:
https://bibliotekanauki.pl/articles/1040660.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
schizophrenia
syntaxin
Snap25
SNARE
synaptobrevin
genetics
mouse mutants
Opis:
Much of the focus of neurobiological research into schizophrenia is based on the concept that disrupted synaptic connectivity underlies the pathology of the disorder. Disruption of synaptic connectivity is proposed to be a consequence of both disrupted synaptic transmission in adulthood and abnormalities in the processes controlling synaptic connectivity during development of the central nervous system. This synaptic hypothesis fits with neurodevelopmental models of schizophrenia and our understanding of the mechanisms of antipsychotic medication. This conceptual model has fostered efforts to define the exact synaptic pathology further. Synaptic proteins are obvious candidates for such studies, and the integral role of the SNARE complex, and SNARE-associated proteins, in synaptic transmission will ensure that it is the focus of much of this research. Significant new insights into the role of this complex are arising from new mouse models of human disease. Here the evidence from both animal and human clinical studies showing that the SNARE complex has a key role to play in the aetiology and pathogenesis of schizophrenia is discussed.
Źródło:
Acta Biochimica Polonica; 2008, 55, 4; 619-628
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy.
Autorzy:
Borowski, Peter
Mueller, Oliver
Niebuhr, Andreas
Kalitzky, Matthias
Hwang, Lih-Hwa
Schmitz, Herbert
Siwecka, Maria
Kulikowski, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1044428.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ribavirin-5'-triphosphate
enzyme inhibition
HCV NTPase/helicase
Opis:
To enhance the inhibitory potential of 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) vs hepatitis C virus (HCV) NTPase/helicase, ribavirin-5'-triphosphate (ribavirin-TP) was synthesized and investigated. Ribavirin-TP was prepared with the use of modified Yoshikawa-Ludwig-Mishra-Broom procedure (cf. Mishra & Broom, 1991, J. Chem. Soc., Chem. Commun, 1276-1277) involving phosphorylation of unprotected nucleoside. Kinetic analysis revealed enhanced inhibitory potential of ribavirin-TP (IC50=40 μM) as compared to ribavirin (IC50 > 500 μM). Analysis of the inhibition type by means of graphical methods showed a competitive type of inhibition with respect to ATP. In view of the relatively low specificity towards nucleoside-5'-triphosphates (NTP) of the viral NTPase/helicases, it could not be ruled out that the investigated enzyme hydrolyzed the ribavirin-TP to less potent products. Investigations on non- hydrolysable analogs of ribavirin-TP or ribavirin-5'-diphosphate (ribavirin-DP) are currently under way.
Źródło:
Acta Biochimica Polonica; 2000, 47, 1; 173-180
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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