Wszystkie pola: Nowak, Irena. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Content of carotenoids in roots of seventeen cultivars of Daucus carota L.
Autorzy:: Mech-Nowak, Aleksandra
Świderski, Adam
Kruczek, Michał
Łuczak, Irena
Kostecka-Gugała, Anna
Powiązania:: https://bibliotekanauki.pl/articles/1039802.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: carotenoid
carrot
antioxidant activity
Opis:: The aim of this study was to compare the content of carotenoids in seventeen cultivars of carrots grown in Poland. Conventional orange cultivars with rarely grown were compared: white, yellow and purple with yellow core cultivars. To determine the content of carotenoids, extracts from lyophilized carrot roots were prepared and analyzed by spectrophotometric as well as HPLC methods with DAD detector. The highest content of carotenoids was found in cultivars: 'Korund F1' (48 mg/100g of fresh weight) and 'Salsa F1' (36 mg/100g of fresh weight). The antioxidant properties of selected cultivars were compared using the DPPH method.
Źródło:: Acta Biochimica Polonica; 2012, 59, 1; 139-141
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes
Autorzy:: Nowak, Robert
Baranowska-Bosiacka, Irena
Stefańska, Barbara
Machaliński, Bogusław
Hłyńczak, Alina
Tarasiuk, Jolanta
Powiązania:: https://bibliotekanauki.pl/articles/1041354.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: non-cross resistant antitumour benzoperimidines and anthrapyridones
ATP-dependent efflux
erythrocytes
multidrug resistance
energy state
Opis:: Multidrug resistance (MDR) of tumour cells is related to the overexpression of ATP-dependent pumps responsible for the active efflux of antitumour agents out of resistant cells. Benzoperimidine and anthrapyridone compounds exhibit comparable cytotoxic activity against sensitive and MDR tumour cells. They diffuse extremely rapidly across the plasma membrane and render the ATP-dependent efflux inefficient. Such uptake could disturb an energy metabolism of normal cells possessing an elevated level of ATP-dependent proteins, especially erythrocytes having a high level of the MRP1, MRP4 and MRP5 proteins. In this study the effect of five antitumour agents: benzoperimidine (BP1), anthrapyridones (CO1, CO7) and reference drugs used in the clinic: doxorubicin (DOX) and pirarubicin (PIRA), on the energetic state in human erythrocytes has been examined. These compounds have various types of structure and kinetics of cellular uptake (slow - DOX, CO7, moderate - PIRA, fast - BP1, CO1) resulting in their different ability to saturate ATP-dependent transporters. The energetic state of erythrocytes was examined by determination of purine nucleotide contents (ATP, ADP, AMP), NAD+ and values of adenylate energy charge (AEC) using an HPLC method. It was found that the level of nucleotides as well as the AEC value of erythrocytes were not changed during 24 h of incubation with these agents independently of their structure and ability to saturate ATP-dependent pumps. This is a very promising result in view of their potential use in the clinic as antitumour drugs against multidrug resistant cancers.
Źródło:: Acta Biochimica Polonica; 2005, 52, 4; 953-957
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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