Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Mazur, Jacek" wg kryterium: Wszystkie pola

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 16
Tytuł:
New Trends in the Works of Supreme Audit Institutions : Inspired by the ECA’s Audit
Autorzy:
Mazur, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2041340.pdf
Data publikacji:
2020-06
Wydawca:
Najwyższa Izba Kontroli
Tematy:
Supreme Audit Institutions
SAIs
SAI work trends
European Court of Auditors
ECA audit
conducting public consultations
Opis:
In his article, the author presents several elements of the practices of Supreme Audit Institutions (SAIs): a multiannual audit strategy, selection of non-routine audit topics, informing the public about planned audits or audits in progress, or giving citizens an opportunity to contribute to audits. These illustrate new trends in the works of some SAIs. The inspiration for the article came from the audit conducted by the European Court of Auditors on the performance of public consultations by the European Commission.
Źródło:
Kontrola Państwowa; 2020, 65, 3 (392); 28-46
0452-5027
Pojawia się w:
Kontrola Państwowa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigations of the UK NAO : A New Type of Audit?
Autorzy:
Mazur, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2042143.pdf
Data publikacji:
2020-12
Wydawca:
Najwyższa Izba Kontroli
Tematy:
investigations
performance audit
UK National Audit Office
NAO
SAI of the United Kingdom
Opis:
Supreme Audit Institutions (SAIs) strive to address important and topical concerns which attract media coverage and are of interest to the Parliament and citizens. Since 2013, the National Audit Office of the United Kingdom (NAO) has been carrying out ‘Investigations’. These are not investigations as defined in criminal law but rapid and responsive ‘engagements’ with data gathered and presented quickly. The topics of such investigations are specific, so that they can be developed fast (usually within three–four months) and described briefly (reports should not exceed 5,000 words). Investigations usually address issues that give rise to social concerns that things might not work properly, so their main addressees are not state bodies, but citizens, too. Unlike in financial and performance audit, investigations are facts only (without evaluations or recommendations), however they are written in a way that allows the readers to draw their own conclusions. In this article, the author discusses changes impacting on the NAO and its work supporting the House of Commons, and presents the concept and practice behind these. The role of such investigations is viewed in the context of other NAO activities, the topics covered and procedures adopted.
Źródło:
Kontrola Państwowa; 2020, 65, 6 (395); 30 - 49
0452-5027
Pojawia się w:
Kontrola Państwowa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reactive and Rapid Auditing : New Forms of SAIs’ Work
Autorzy:
Mazur, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2047038.pdf
Data publikacji:
2021-04
Wydawca:
Najwyższa Izba Kontroli
Tematy:
Supreme Audit Institutions
the concept of audit
audit methodology
types of audit
simplification of audits
Opis:
The operations of contemporary states and societies are more and more related to information flow. New technologies allow for producing infor mation easily, and for circulating it rapidly. What conclusions should Su preme Audit Institutions draw from this? What should they do in order to deal with important and topical issues of high interest to the public?
Źródło:
Kontrola Państwowa; 2021, 66, 2 (397); 49-73
0452-5027
Pojawia się w:
Kontrola Państwowa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Splenunculus. A misdiagnosed pancreatic tumor
Splenunculus. Błędne rozpoznanie guza trzustki
Autorzy:
Grolik-Kachnic, Marzena
Mazur, Jacek
Szlachetka, Bartłomiej
Komorowski, Andrzej L.
Powiązania:
https://bibliotekanauki.pl/articles/1623693.pdf
Data publikacji:
2020
Wydawca:
Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Tematy:
splenunculus
intrapancreatic accessory spleen
pancreatic neuroendocrine tumor
wewnątrztrzustkowa śledziona dodatkowa
guzy neuroendokrynne trzustki
Opis:
An intrapancreatic accessory spleen, often referred to as a splenunculus, can imitate neuroendocrine or lobular pancreatic cancer. 17% of accessory spleens are found within the pancreatic tail. We report the case of a splenunculus found within the tail of the pancreas during a laparoscopy for a suspected pancreatic neuroendocrine tumor.
Wewnątrztrzustkowa śledziona dodatkowa jest wczesną anomalią rozwojową, która może naśladować neuroendokrynne lub zrazikowe nowotwory trzustki. W 17% przypadków występuje w ogonie trzustki i jest często określana jako splenunculus. W pracy zaprezentowano przypadek chorego, u którego podczas operacji laparoskopowej z powodu podejrzenia guza neuroendokrynnego trzustki stwierdzono wewnątrztrzustkową śledzionę dodatkową umiejscowioną w ogonie tego narządu.
Źródło:
Państwo i Społeczeństwo; 2020, 4; 73-76
1643-8299
2451-0858
Pojawia się w:
Państwo i Społeczeństwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of carrot and apple pomace in the production of healthy snack bars
Zastosowanie wytłoków z marchwi i jabłek do produkcji zdrowych batonów
Autorzy:
Łusiak, Patrycja
Mazur, Jacek
Sobczak, Paweł
Zawiślak, Kazimierz
Panasiewicz, Marian
Powiązania:
https://bibliotekanauki.pl/articles/21151187.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Inżynierii Rolniczej
Tematy:
fruit pomace
vegetable pomace
aggregation
texture
bar
wytłoki z owoców
wytłoki z warzyw
agregacja
tekstura
baton
Opis:
In recent years, the increasing popularity of healthy eating brought about a significant increase in the consumption of fruit and vegetables in the form of juices, purees and cocktails. In the process of their production, the byproduct is pomace, which is treated by the food processing industry as waste. Assuming that pomace accounts for only 20% of the raw material used, annually up to 630 000 tonnes of pomace are obtained globally. However, numerous studies have demonstrated that fruit pomace is a valuable source of many nutritious substances. The objective of the study was to develop a compressionbased production technology of apple pomace-based bars, and to assess their quality. Based on the analysis of the structure of produced bars, it can be concluded that their hardness and resistance to cutting does not differ significantly from that of commercial bars made with alternative technology and from different ingredients.
W ostatnich latach, na fali popularności zdrowego odżywiania, znacznie wzrosło spożycie owoców, warzyw, soków, przecierów i wszelkiego rodzaju koktajli (smoothies). Ich produkcja jest bezpośrednio związana z powstawaniem wytłoków. Zakładając, że wytłoki powstałe podczas produkcji soków stanowią jedynie 20% wykorzystywanego surowca, przemysł przetwórczy produkuje aż 630 000 ton wytłoków rocznie. Ponowne wykorzystanie tego surowca stanowi poważny problem dla producentów. Liczne badania dowodzą jednak, że wytłoki owocowe są cennym źródłem wielu substancji odżywczych. Celem pracy było opracowanie technologii produkcji batonów na bazie wytłoków jabłkowych wytwarzanych metodą prasowania oraz ocena ich jakości. Wyniki analizy struktury batonów pozwalają stwierdzić, że pod względem twardości i odporności na krojenie parametry tego produktu nie odbiegają istotnie od parametrów komercyjnych batonów wytworzonych inną technologią i z innych składników.
Źródło:
Agricultural Engineering; 2023, 27, 1; 289--300
2083-1587
Pojawia się w:
Agricultural Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Microscopic Evaluation of Concrete Samples from Manholes Exposed on Hydrogen Sulphide
Autorzy:
Bogusławski, Bartosz
Bering, Sławomira
Mazur, Jacek
Tarnowski, Krzysztof
Rucińska, Teresa
Głowacka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/123945.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
hydrogen sulphide corrosion
biocorrosion
pressure sewage system
hydrogen sulphide
Opis:
The field test of the sewer system in a rural area was made. The results from two different pressure-gravity systems localized in two settlements were compared. The investigated sewer system operates in serial connection; the sewage from one settlement is pumped to the expansion well in the next one. In both systems, the high concentration of hydrogen sulfide, exceeding 200 ppm, and visible concrete wells corrosion effects were recorded. The samples of corroded concrete from the internal walls of the chosen wells were collected. The results of an electron microscope with the EDS attachment (Energy dispersive X-ray Spectroscopy) analysis showed a significant sulfur content in a concrete surface layer from 11.2% to 64.2% for the first system and from 7.53% to 42.9% for the second one. The exposure of concrete to high concentrations of hydrogen sulfide and relatively high content of sulfur on the surface of concrete might be a reason for hydrogen sulfide corrosion of concrete in the investigated systems.
Źródło:
Journal of Ecological Engineering; 2020, 21, 1; 188-194
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in the quality characteristics of raspberry fruit due to mechanical vibrations and storage conditions
Autorzy:
Mazur, Jacek
Panasiewicz, Marian
Zawiślak, Kazimierz
Sobczak, Paweł
Nadulski, Rafał
Łysiak, Grzegorz
Kraśnicka, Kinga
Powiązania:
https://bibliotekanauki.pl/articles/298046.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
raspberry fruits
mechanical impact
juice leakage
Opis:
The paper presents the results of a study investigating a mechanical impact, in the form of vibrations, on the overall quality of raspberry fruits after harvest, in view of the conditions of their transport to the consumer and the processing plant. The degree of compaction of the raspberry fruit layer was determined during a test carried out under laboratory conditions, and the amount of juice leakage, resulting from the vibrations to which the raspberries were subjected, was measured. It was demonstrated that the quantity (mass) of juice leakage was considerably affected by the mechanical impact, in the form of vibrations, exerted on a layer of raspberry fruits. The leakage was smaller in cooled fruits, and significantly greater in fruits that were not subjected to cooling immediately after harvest, and were stored under ambient conditions.
Źródło:
Technical Sciences / University of Warmia and Mazury in Olsztyn; 2019, 22(4); 319-328
1505-4675
2083-4527
Pojawia się w:
Technical Sciences / University of Warmia and Mazury in Olsztyn
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elektrochemioterapia w nowotworach piersi
Electrochemotherapy in breast cancer
Autorzy:
Piechocki, Jacek
Mazur, Sławomir
Nowecki, Zbigniew I.
Powiązania:
https://bibliotekanauki.pl/articles/1030145.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
breast cancer
electrochemotherapy
local recurrence
elektrochemioterapia
rak piersi
wznowa miejscowa
Opis:
Electrochemotherapy is a local therapy method reserved for cases not subject to surgery in advanced surface-localized cancers in the integuments. It may be applied in treating primary skin neoplasms (cancer and melanoma) as well as metastases of other neoplasms to the skin/hypodermis not qualified for another therapy (e.g. local removal or isolated limb perfusion, radiotherapy), regardless of the histological type of the neoplasm. It is a palliative type of treatment, and its objective is to obtain local control over cancerous lesions deteriorating the quality of life of the patients (infections, hemorrhages, limb function limitation). In selected cases, it is possible to obtain a long-term local control (e.g. in advanced, unresectable or qualifying to an extensive procedure on scalp and neck neoplasms and breast cancers with extensive dermis infiltration, reacting poorly to systemic treatment). Especially local breast cancer recurrence, frequently of large area or multiple with tissue infiltration, persisting despite systemic treatment, may be subject to electrochemotherapy. It especially applies to patients with disseminated cancer. In the paper, the authors are summarizing their experience in the application of that method among patients with breast cancer.
Elektrochemioterapia jest metodą terapii miejscowej zarezerwowaną dla przypadków nieoperacyjnych w zaawansowanych nowotworach zlokalizowanych powierzchownie w powłokach ciała. Może być stosowana zarówno w leczeniu pierwotnych nowotworów skóry (raki i czerniaki), jak i przerzutów innych nowotworów do skóry/tkanki podskórnej niekwalifikujących się do innej terapii (np. miejscowego wycięcia lub izolowanej perfuzji kończynowej, radioterapii), niezależnie od typu histologicznego nowotworu. Jest to z założenia leczenie paliatywne, a jego celem jest uzyskanie miejscowej kontroli nad zmianami nowotworowymi pogarszającymi jakość życia chorych (zakażenia, krwawienia, ograniczenie funkcji kończyn). W wybranych przypadkach możliwe jest uzyskanie długotrwałej kontroli miejscowej (np. w zaawansowanych, nieresekcyjnych lub kwalifikujących się do rozległego zabiegu okaleczającego nowotworach skóry głowy i szyi oraz rakach piersi z rozległym naciekiem skóry, słabo reagujących na leczenie systemowe). Zwłaszcza wznowy miejscowe raka piersi, nierzadko o dużej powierzchni lub liczne z naciekiem tkanek, utrzymujące się pomimo leczenia systemowego, mogą być poddane elektrochemioterapii. Dotyczy to szczególnie chorych z rozsianą chorobą nowotworową. W niniejszej pracy autorzy podsumowują własne doświadczenie w zastosowaniu tej metody u chorych na raka piersi.
Źródło:
Current Gynecologic Oncology; 2016, 14, 1; 5-12
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glycosylation of immune system proteins and its role in autoimmune diseases and cancer
Autorzy:
Trzyna, Anna
Tabarkiewicz, Jacek
Mazur, Artur
Powiązania:
https://bibliotekanauki.pl/articles/1597351.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Glycosylation
Immunity
Cellular
Humoral
Autoimmune Diseases
Opis:
Introduction. Structural glycans have great biological significance and are involved in signaling and cell communication of the immune system. They are attached to proteins and lipids in an enzymatic process called glycosylation where glycosyltransferase and glycosidases bind sugar residues and lead to the formation of bioconjugates. Aim. In this paper we describe the importance of glycosylation in the immune system and its changes in diseases. Material and methods. This review was performed according to systematic literature search of major bibliographic databases. Results. Proper glycosylation ensures the functioning of the organism, however, defects in structural glycans of immune system changes their properties and can lead to disorders and further to autoimmune diseases. It has been also proven that glycosylation of autoimmune system is changed during cancer. In this paper we described types of structural glycans, significance of glycosylation of selected components of the immune system and its modifications in disorders. Conclusions. Knowledge about changes in the glycosylation in diseases is the key to understanding the processes of autoimmune diseases and may allow the development of new treatments in the future.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 32-37
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Personality correlates in the tendency to incur debt in patients with and without osteoarthritis
Autorzy:
Łukasiewicz, Jacek
Stencel, Marcin
Raczkowski, Adam
Cwynar, Andrzej
Cwynar, Wiktor
Saran, Tomasz
Mazur, Anna
Powiązania:
https://bibliotekanauki.pl/articles/454971.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
life on credit
osteoarthritis
personality
Opis:
Introduction. Osteoarthritis is the most common disease of the musculoskeletal system. Osteoarthritis progresses slowly, but with time it results in movement disability and chronic pain. Its progression is also significantly associated with personality functioning and the ability to make rational life choices regarding various aspects of human life, including the economic sphere. Aim. The aim of the research was to determine how personality correlates with a tendency towards indebtedness between patients with and without osteoarthritis. Material and methods. The researched sample consisted of two groups - 50 patients diagnosed with osteoarthritis hospitalized in the Department of General and Neuro Rehabilitation in the Institute of Rural Health in Lublin and 50 healthy people. The KOS-B Questionnaire, the IVE Questionnaire, the SES Scale, the SPP-25 Scale, the Delta Questionnaire and the APSZ questionnaire were used in the research. Results. In the group of patients with osteoarthritis, the leading correlates of indebtedness are: assessment of the stress situation related to the current economic situation seen as a threat, and perceiving it as harm or loss. In the healthy group, the leading correlates of incurring financial liabilities are impulsiveness, self-esteem, assessment of the stress situation related to the current economic situation seen as a threat, openness to new experiences and sense of humor, empathy, and the need for social approval. Conclusion. In the group of patients with osteoarthritis, the factor conducive to incurring financial liabilities is the assessment of the stressful situation related to the current economic situation seen as a threat, while perceiving it as harm or loss leads to abandoning reliance on credit. In the healthy group, the factors that favor this type of activity are impulsiveness, self-esteem, the assessment of the stress situation related to the current economic situation seen as a threat and the need for social approval; the factors protecting against indebtedness in healthy persons are openness to new experiences and sense of humor as well as empathy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 26-32
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The algorithm of adaptive determination of amplification of the PD filter estimating object state on the basis of signal measurable on-line
Autorzy:
Kwater, Tadeusz
Hawro, Przemysław
Bartman, Jacek
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/1409165.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
estimation
Kalman filter
adaptive PD filter
filter amplification
Opis:
The article presents the algorithm that enables adaptive determination of the amplification coefficient in the filter equation provided by Kalman. The method makes use of an estimation error, which was defined for this purpose, and its derivative to determine the direction of correction changes of the gain vector. This eliminates the necessity to solve Riccati equation, which causes reduction of the method computational complexity. The experimental studies carried out using the proposed approach relate to the estimation of state coordinates describing river pollution using the BOD (biochemical oxygen demand) and DO (dissolved oxygen) indicators).The acquired results indicate that the suggested method does better estimations than the Kalman filter. Two indicators were used to measure the quality of estimates: the Root Mean Squared Error (RMSE) and the Mean Percentage Error (MPE).
Źródło:
Archives of Control Sciences; 2021, 31, 1; 129-143
1230-2384
Pojawia się w:
Archives of Control Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of Impact Hammer Crusher for Rock Salt Purification®
Zastosowanie udarowej kruszarki m’rotkowej do rozdrabniania i oczyszczania soli kamiennej®
Autorzy:
Feliks, Jacek
Mazur, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/2171923.pdf
Data publikacji:
2022
Wydawca:
Wyższa Szkoła Menedżerska w Warszawie
Tematy:
food salt
crushing
hammer crusher
salt purification
sól spożywcza
kruszenie
kruszarki młotkowe
oczyszczanie soli
Opis:
The article presents the results of research on crushing rock salt. At the Department of Machinery Engineering and Transport, AGH University of Science and Technology in Krakow, an attempt was made to crush salt with a grain size of up to 5 mm. The aim of the research was to obtain a product with a grain size of up to 2 mm with the smallest possible fraction of less than 0.5 mm, which will allow obtaining a product that meets the requirements of customers. The technological system should allow for a minimum efficiency of 20 Mg/h of product. The tests were carried out on two types of crushers: a Vibratory jaw crusher and a hammer crusher with a variable grate size. Based on the analysis of the research results, the use of a hammer crusher was proposed. Using this type of crusher with an adequately selected grate allowed to obtain satisfactory results. It was also proposed to modify the crusher’s functional elements (hammers), which should increase the efficiency of the process.
W artykule przedstawiono wyniki badań, dotyczących kruszenia soli kamiennej. W Katedrze Inżynierii Maszyn i Transportu Akademii Górniczo-Hutniczej w Krakowie podjęto próbę kruszenia soli o uziemieniu do 5 mm. Celem badań było uzyskanie produktu o uziemieniu do 2 mm 2 jak najmniejszym odziałem frakcji poniżej 0,5 mm co pozwoli na uzyskanie produktu spełniającego wymagania odbiorców. Układ technologiczny powinien pozwolić na uzyskanie wydajności wynoszącej minimalnie 20 Mg/h produktu. Badania przeprowadzono na dwóch typach kruszarek: szczękowej kruszarki wibracyjnej i kruszarce młotkowej ze zmiennym rusztem. Na podstawie analizy wyników badań zaproponowano zastosowanie kruszarki młotkowej. Zastosowanie tego typu kruszarki z odpowiednio dobranym rusztem pozwoliło na uzyskanie zadawalających efektów. Zaproponowano również modyfikacje elementów roboczych kruszarki co powinno pozwolić na zwiększenie efektywności procesu.
Źródło:
Postępy Techniki Przetwórstwa Spożywczego; 2022, 2; 11--18
0867-793X
2719-3691
Pojawia się w:
Postępy Techniki Przetwórstwa Spożywczego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of individual predispositions in coping with the sudden loss of mobility caused by a traffic accident
Autorzy:
Mazur, Anna
Sojka, Anna
Stachyra-Sokulska, Anna
Łukasiewicz, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/2106163.pdf
Data publikacji:
2019-07-21
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
optimism
psychological resilience
self-efficacy
emotion-oriented style
avoidant style
task-oriented style
Opis:
The sudden loss of mobility is always an extremely difficult situation, since it entails many consequences. In the process of dealing with it, the individual’s predispositions play a significant role. Three predispositions seem to be crucial for maintaining emotional balance, accepting the existing health situation and coping with challenges: dispositional optimism, a sense of self-efficacy and psychological resilience. The aim of our study was to compare the levels of these individual predispositions and dimensions that affected the ability of the study group to cope with the sudden loss of mobility as a result of a traffic accident, and to determine the relationships between them. The study group consisted of 72 adults (36 women and 36 men), who suffered from full paralysis of the lower limbs due to spinal cord injury caused by a traffic accident. The research tools used were the GSES Scale, the LOT-R Test, the SPP-25 N Scale, the Beck Depression Scale, the AIS Scale and the CISS Questionnaire. The women in our study exhibited lower levels of all three of the selected predispositions. They also present more severe symptoms of depression and a lower acceptance of the loss of mobility. When facing stressful situations, they prefer the emotion-oriented style and, less frequently, the avoidant style, and they reveal a lower tendency to choose the task-oriented response. Dispositional optimism, self-efficacy and resilience positively correlate with acceptance of the disability and the use of a task-oriented style to cope with stress. However, they correlate negatively with the severity of depressive symptoms and a style focused on emotions. Gender is a moderator of relationships between the studied parameters.
Źródło:
Acta Neuropsychologica; 2019, 17(2); 151-165
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma
Autorzy:
Małodobra-Mazur, Małgorzata
Paduch, Agnieszka
Lebioda, Arleta
Konopacka, Maria
Rogoliński, Jacek
Szymczyk, Cezary
Wierzgoń, Janusz
Maciejewski, Adam
Chmielik, Ewa
Jonkisz, Anna
Półtorak, Stanisław
Dobosz, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1039670.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
VDR gene
SNP
oral cavity cancer
Opis:
Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin D3 receptor (VDR) gene might influence both the risk of cancer occurrence and cancer progression. The aim of this study was to search for genetic correlations between individual SNPs in the VDR gene and the risk of oral cavity carcinoma. Two SNPs were selected based on the literature and our previous results. Seventy-three patients with squamous cell carcinoma of the head and neck and one hundred control subjects were investigated. Two SNPs in the VDR gene were genotyped in minisequencing reactions followed by capillary electrophoresis. Hardy-Weinberg equilibrium (HWE), the χ2 test and logistic regression were used for statistical analysis. The SNP rs2238135 in the VDR gene displayed statistical differences in frequency between the tested groups (p=0,0007). Furthermore, the G/C genotype of the rs2238135 in the VDR gene was characterized by a 3.16 fold increased risk of oral cavity carcinoma. The obtained results provide evidence for a genetic association between rs2238135 in the VDR gene and the occurrence and risk of oral cavity cancer.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 627-630
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibody reactivity in patients with IgE-mediated wheat allergy to various subunits and fractions of gluten and non-gluten proteins from omega-gliadin-free wheat genotypes
Autorzy:
Skoczowski, Andrzej
Obtułowicz, Krystyna
Czarnobilska, Ewa
Dyga, Wojciech
Mazur, Marcel
Stawoska, Iwona
Waga, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/989784.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
gliadins
glutenins
immunoblotting
food allergy
wheat
Opis:
Introduction and objective. Gluten proteins (gliadins and glutenins) are polymorphic wheat storage proteins of allergenic properties. Significant differences in chemical composition between both protein groups allow to expect highly specific immunological response of individual subunits and fractions in reactions with IgE sera of people allergic to wheat. The aim of these studies was to identify and characterize the most allergenic gluten proteins (GP) and nongluten proteins (NGP) occurred in two closely related wheat hybrid genotypes. Materials and method. 3xC and 3xN wheat hybrids, which differ strongly in regard of gliadin composition, were analyzed. Seven people manifesting different symptoms of wheat allergy donated sera for the experiment. The technique of immunoblotting after SDS-PAGE was used for identification of allergenic subunits and fractions among GP and NGP. Immunologically active protein bands were visualized by chemiluminescence. Results. Great variation of immunodetection spectra was observed. Results of immunoblotting showed LMW glutenins to be of highest, gliadins of medium, while NGP of lowest allergenicity for selected patients. The 43-kDa and 47-kDa LMW glutenin subunits, 40-kDa and 43-kDa γ-gliadin fractions and 49-kDa NGP can be considered as the most immunoreactive among all protein bands separated by SDS-PAGE. Conclusion. The observed differentiation of immunodetection spectra allows to model highly specific IgE-binding profiles of allergenic wheat proteins attributed to individual patients with symptoms of gluten intolerance. Highly immunoreactive subunits and fractions among GP and NGP were identified. The observed immunoreactivity of 49 kDa NGP is worth to emphasize, as it has never been reported as wheat allergenic protein before.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies