Wszystkie pola: IL -6 - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Ezetimibe prevents myocardial remodeling in an obese rat model by inhibiting inflammation
Autorzy:: Li, Xiao-Xing
Zhao, Lang
Chang, Ying
Liu, Bao-Shan
Xu, Feng
Zhang, Cheng
Ji, Xiao-Ping
Chen, Yu-Guo
Li, Chuan-Bao
Powiązania:: https://bibliotekanauki.pl/articles/1038380.pdf
Data publikacji:: 2018
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: obese
inflammation
remodeling
ezetimibe
IL-6
Opis:: Inflammation plays an important role in the development of many obesity-related diseases. This study aimed to investigate the effect of ezetimibe on inflammation and myocardial remodeling in obese rats. A rat model of obesity was established, and myocardial damage was examined by transmission electron microscopy and Masson staining. Twenty obese rats were divided into two groups (n=10): obese group and ezetimibe group. Ten SD rats were used as controls. Western blot was performed to monitor the expression of P-p38MAPK and interleukin (IL)-6. Immunohistochemical staining was used to monitor the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. In the obese rats group, we observed increased inflammatory factors and myocardial hypertrophy. In contrast, the ezetimibe group exhibited decreased expression of inflammatory factors and an improvement in myocardial remodeling compared to the obese group. Mechanistically, we found that ezetimibe decreased P-p38MAPK, IL-6, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 levels in the hearts of the obese rats. Taken together, these results indicate that ezetimibe may improve myocardial remodeling in obese rats by inhibiting inflammation.
Źródło:: Acta Biochimica Polonica; 2018, 65, 3; 465-470
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The level of proinflammatory and antiinflammatory cytokines in sperm plasma of fertile and infertile men
Autorzy:: Maksymyuk, H.
Vorobets, Z.
Maksymyuk, V.
Powiązania:: https://bibliotekanauki.pl/articles/2052361.pdf
Data publikacji:: 2015
Wydawca:: Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:: sperm
IL-6
IL-8
IL-10
Opis:: The present study was carried out with the aim to evaluate the relation of the content of proinflammatory and antiinflammatory cytokines with the sperm quality indicators. The study involved 45 patients with a pathological spermogram and 15 practically healthy men. A positive correlation (r = 0.45) between the content of IL-6 and the sperm concentration in the ejaculate and a negative correlation (r = -0.42) of this cytokine with the number of live sperm were revealed. The concentration of IL-8 was positively correlated with sperm density (r = 0.52) and it was negatively correlated with the number of live sperm (r = -0.55). A positive correlation between the content of IL-10 and the sperm concentration as well as the number of active forms was observed (r = 0.45 and 0.5, respectively), and a negative correlation (r = -0.7) was observed between the ejaculate volume and the concentration of IL-10. In the obtained ejaculates, a close positive correlation between the content of IL-8 and IL-6 (r = 0.74) and between the concentration of IL-10 and IL-6 (r = 0.72) was observed. Based on the completed study, a conclusion was made that the increased level of IL-6 and IL-8 may result in the reduction of the sperm quality, and, possibly, infertility, and that IL-10 plays an important role in improving sperm parameters.
Źródło:: Health Problems of Civilization; 2015, 09, 4; 21-25
2353-6942
2354-0265
Pojawia się w:: Health Problems of Civilization
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Mutual relations between the amygdala and pro-inflammatory cytokines: IL-1β and IL-6
Autorzy:: Czerwiec, Katarzyna
Ruciński, Jan
Piwko, Grzegorz
Myślińska, Dorota
Kosiński, Adam
Powiązania:: https://bibliotekanauki.pl/articles/2203182.pdf
Data publikacji:: 2022-05-31
Wydawca:: Gdański Uniwersytet Medyczny
Tematy:: inflammation
IL-6
amygdala
IL-1β
Opis:: Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multfunctonal pro-infammatory cytokines involved in the regulaton of the immune response, hematopoiesis, and infammaton. Both peripheral and intraventricular administraton of these cytokines causes acute phase symptoms, e.g. fever, actvaton of the hypothalamic-pituitary-adrenal axis and psychological depression. The amygdala belongs to the structures of the limbic system involved in the regulaton of the immune response. Increased actvity of immune system may lead to changes in the role of amygdala, medial prefrontal cortex, anterior cingulate cortex or insula. The aim of the study was to present the mutual interactons between the amygdala and pro-infammatory cytokines such as interleukin-1β (IL-1 beta) and interleukin 6 (IL-6). Most of the data included in this review comes from animal studies.
Źródło:: European Journal of Translational and Clinical Medicine; 2022, 5, 1; 40-46
2657-3148
2657-3156
Pojawia się w:: European Journal of Translational and Clinical Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Vitamin D status in patients with rheumatoid arthritis: a correlation analysis with disease activity and progression, as well as serum IL-6 levels
Autorzy:: Polasik, Kinga
Piotrowska, Ewa
Lipińska, Barbara
Witkowski, Jacek
Bryl, Ewa
Tukaj, Stefan
Powiązania:: https://bibliotekanauki.pl/articles/1038556.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: rheumatoid arthritis
vitamin D deficiency
25(OH)D
IL-6
Opis:: Objectives. Recent epidemiological studies suggested an association between a poor vitamin D [25(OH)D] status, inflammatory mediators, and rheumatoid arthritis (RA). We have recently proposed that pro-inflammatory interleukin 6 (IL-6) may represent a good marker for disease activity of RA. The aim of this study was to investigate the relationship between serum 25(OH)D levels and disease activity, joint damage, as well as serum IL-6 levels in a Polish RA population. Materials and Methods. Serum 25(OH)D levels were measured in 35 female RA patients and 38 age- and gender-matched healthy controls. Statistical correlations between 25(OH)D levels and the disease activity score 28 (DAS 28), joint damage based on the Steinbrocker criteria, as well as serum IL-6 levels were performed. Results. There was no statistically significant difference between levels of 25(OH)D in RA (16.89±8.57 ng/ml) and healthy controls (14.12±7.51 ng/ml), and the vitamin D deficiency (<20 ng/ml) was found in 71.43% of RA patients and 73.68 % of healthy controls. While vitamin D status did not correlate with DAS 28 (r=0.265, p=0.149) and joint damage based on the Steinbrocker criteria (r=0.367, p=0.065), a positive correlation between 25(OH)D and IL-6 (r=0.537, p=0.002) was observed in RA. Conclusion. Although further studies on a larger group of patients will be needed to confirm the data presented here, it seems that hypovitaminosis D is common in the RA patients and middle-aged non-RA healthy women in the Polish population. 25(OH)D levels were similar in the RA patients and age- and gender-matched healthy controls, and were not associated with joint damage and disease activity in patients.
Źródło:: Acta Biochimica Polonica; 2017, 64, 4; 667-670
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Proinflammatory cytokines (IL-6, IL-18) and apoptotic factors (HP 53, survivin) in patients with alcoholic liver cirrhosis
Autorzy:: Prystupa, Andrzej
Kiciński, Paweł
Sak, Jarosław
Grzybowski, Andrzej
Boguszewska-Czubara, Anna
Toruń-Jurkowska, Anna
Niedziałek, Jarosław
Załuska, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/972717.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: survivin
alcoholic liver cirrhosis
proinflammatory cytokines
apoptosis
human protein p53
Opis:: Background. Apoptosis is involved in the pathogenesis of alcoholic liver cirrhosis. Its development can be triggered by an inflammatory process. In the present study, levels of apoptotic factors – survivin human protein p53 (HP 53) and IL-6, IL-18 were determined according to the stage of liver cirrhosis. Material and methods. Seventy patients with alcoholic liver cirrhosis, treated in various hospitals of the Lublin region, Poland were included in the study. Serum levels of IL-6, IL-18, HP53 and survivin were determined by the enzyme-linked immunosorbent assay (ELISA) technique. Results. The serum level of survivin in patients with alcoholic liver cirrhosis was not statistically different from that found in the control group. The level of HP53 was significantly higher in the group of patients with alcoholic liver cirrhosis compared to the control group (16.53±22.69 vs. 0.39±1.31 U/ml; p<0.001). Likewise, the level of IL-6 was significantly higher in the group of patients with alcoholic liver cirrhosis compared to the control group (33.83±41.78 vs. 0.88 ± 0.56 pg/ml; p<0.001). Moreover, the level of IL-18 was significantly higher in the group of patients with liver cirrhosis compared to the control group (23.96±31.07 vs. 5.3±8.6 pg/ml; p<0.001). Conclusion. In conclusion, increased serum levels of IL-6 and IL-18 were demonstrated in patients with alcoholic liver cirrhosis. Moreover, the liver cirrhosis patients had elevated levels of HP53, which is a marker of apoptosis. Our results did not demonstrate the correlation between the levels of apoptosis markers (survivin, HP53) and the levels of cytokines (IL-6, IL-18) in the blood serum.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 1-5
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: The relation between glutathione S-Transferase M1 null-genotype and cardiac problems in beta-thalassemia
Autorzy:: Abo-Shanab, Asem
El-Desouky, Mohamed
Kholoussi, Naglaa
El-Kamah, Ghada
Helwa, Iman
Powiązania:: https://bibliotekanauki.pl/articles/1038809.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: GSTM1
β-thalathemia
Cardiac complications
hs-CRP
IL-6
Opis:: This work was carried out to investigate the role of Glutathione S-Transferase M1 (GSTM1) null genotype frequency in prognosis of β-thalassemia, and to detect the correlation between GSTM1 null genotype and appearance of cardiac complications in β-thalassemia. Materials and Methods. The studied groups in the present work were divided to three groups (group I: 20 healthy subjects, group II: 56 β-thalassemic patients and group III: 16 β-thalassemic patients with cardiac complications were taken from group II). The measurement of human high sensitive C-reactive protein (hs-CRP) was performed using nephelometry. GSTM1 genotype was detected by Polymerase Chain Reaction (PCR) and cardiac complications were determined by using Echocardiography. Results. A statistically significant increase in hs-CRP and interleukin-6 (IL-6) levels was found in β-thalassemic patients with cardiac complications compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency neither with β-thalassemia nor with cardiac complications appearance, where the interaction between GSTM1 null genotype in β-thalassemic patients with cardiac complications and healthy subjects were insignificant compared to subjects with GSTM1 non-null genotype. Conclusions. GSTM1 null genotype frequency has no role in β-thalassemia or cardiac complications appearance.
Źródło:: Acta Biochimica Polonica; 2016, 63, 2; 267-271
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Origin of circulating acute phase cytokines: modified proteins may trigger il-6 production by macrophages. Preliminary report
Autorzy:: Koj, A
Guzdek, A.
Potempa, J.
Korzus, E.
Travis, J.
Powiązania:: https://bibliotekanauki.pl/articles/68989.pdf
Data publikacji:: 1994
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: interleukin 6
macrophage
acute phase cytokine
cytokine
modified protein
glycated albumin
fibrinogen degradation product
modified serpin
Źródło:: Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells
Autorzy:: Tukaj, Stefan
Trzonkowski, Piotr
Tukaj, Cecylia
Powiązania:: https://bibliotekanauki.pl/articles/1039718.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: IκB-α
TNF-α
calcitriol
HSP70
NF-κB
IL-6
vitamin D
VSMC
Opis:: Inflammatory response has been recognized as a central feature in the development and progression of atherosclerosis, and VSMCs (Vascular Smooth Muscle Cells) - the main cellular component of media, play an important role in this process. Many reports indicate that the biologically active vitamin D metabolite - 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 = calcitriol), besides its well established role in calcium homeostasis, plays an essential role in the regulation of the inflammation process. The aim of this study was to determine the regulatory effects of calcitriol, applied at two supra-physiological doses (10 nM and 100 nM), in VSMC culture. Secretion of the pro-inflammatory cytokines, IL-6 and TNF-α, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-β was generally unchanged. Since in advanced atherosclerosis lesions several cell types, including VSMCs, overproduce the HSP70 chaperone protein, we also checked the effects of calcitriol on its synthesis. The presence of 1,25(OH)2D3 did not affect HSP70 synthesis under physiological conditions but the synthesis of HSP70 in VSMCs exposed to heat shock was significantly inhibited by calcitriol (=100 nM). We observed that 1,25(OH)2D3 induced SOD 1 activity, stimulated the expression of IκB-α, and did not influence the level of NF-κB-p65 in VSMCs. The results of our study suggest that 1,25(OH)2D3 may serve as a natural anti-inflammatory agent and may therefore play a beneficial role in the physiology of VSMC in some contexts of atherosclerosis.
Źródło:: Acta Biochimica Polonica; 2012, 59, 3; 395-400
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Central single and chronic administration of morphine stimulates corticosterone and interleukin 9(IL)-6 in adjuvant-induced arthritis
Autorzy:: Zubelewicz, B.
Muc-Wierzgon, M.
Harbuz, M.S.
Brodziak, A.
Powiązania:: https://bibliotekanauki.pl/articles/69429.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: interleukin 6
arthritis
cytokine
corticosterone
morphine
central nervous system
neuroendocrine change
rat
hypothalamic-pituitary-adrenal axis
immune response
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Detection of IL-1β, IL-6 and TNF-αin Sprague-Dawely rats’ atrophic thymus induced by lipopolysaccharide
Autorzy:: Zhong, Y.B.
Zhang, X.L.
Lv, M.Y.
Hu, X.F.
Li, Y.
Powiązania:: https://bibliotekanauki.pl/articles/2087664.pdf
Data publikacji:: 2018
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: lipopolysaccharide
pro-inflammatory cytokines
thymus atrophy
rat
Źródło:: Polish Journal of Veterinary Sciences; 2018, 21, 3; 589-597
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Nutritional status, IL-6 serum concentration and prediction of cardiovascular complications in haemodialised patients with end-stage chronic renal disease
Autorzy:: Jeznach-Steinhagen, A.
Ostrowska, J.
Boniecka, I.
Czerwonogrodzka-Senczyna, A.
Powiązania:: https://bibliotekanauki.pl/articles/13588.pdf
Data publikacji:: 2019
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Źródło:: Journal of Elementology; 2019, 24, 3
1644-2296
Pojawia się w:: Journal of Elementology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Associations between interleukin-8 receptor (CXCR1) and interleukin-6 (IL6) polymorphism and immunity to mastitis in the Black-and-White variety of Polish Holstein-Friesian cows
Poszukiwanie asocjacji pomiędzy polimorfizmem genu receptora interleukiny-8 (CXCR1) oraz interleukiny-6 (IL6) a odpornością na mastitis wśród krów rasy polskiej holsztynsko-fryzyjskiej odmiany czarno-białej
Autorzy:: Stanisławczyk, A.
Wojdak-Maksymiec, K.
Powiązania:: https://bibliotekanauki.pl/articles/2606370.pdf
Data publikacji:: 2018
Wydawca:: Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:: interleukin 8
interleukin 6
polymorphism
immunity
Black-and-White breed
Polish Holstein-Friesian breed
animal breeding
dairy cattle
milk production
milk production trait
mastitis
Źródło:: Acta Scientiarum Polonorum. Zootechnica; 2018, 17, 3; 23-30
1644-0714
Pojawia się w:: Acta Scientiarum Polonorum. Zootechnica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Ochratoxin A and Aflatoxin B1 as Factors of Bone Damage and Neurodegeneration Through the Influence on the Immunomodulation Processes of TNF-α and IL-6 Concentrations
Autorzy:: Radzka-Pogoda, Agnieszka
Radzki, Radosław Piotr
Bieńko, Marek
Szponar, Jarosław
Sokołowska, Barbara
Kulik, Anna
Lewicka, Małgorzata
Borzęcki, Andrzej
Powiązania:: https://bibliotekanauki.pl/articles/32874334.pdf
Data publikacji:: 2022
Wydawca:: Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:: bone metabolism
bone development
bone remodelling
mycotoxin
aflatoxin B1
ochratoxin A
neurodegeneration
Opis:: The wide distribution of mycotoxins, including aflatoxin B1 and ochratoxin A, in the environment and their influence on living organisms make them an interesting research problem. Numerous complications of intoxication with these substances are known, however, particular attention is paid to the effects on the skeletal and nervous systems. The inflammatory effect, presented by the increase in the concentration of cytokines - IL-6 and TNF-α may influence the immune dysregulation present in bone metabolism disorders, as well as in neurodegeneration. Mycotoxins also contribute to osteodegeneration by modifying vitamin D metabolism. Interestingly, and still unexplored, is the mechanism of intrauterine influence on bone metabolism and neurodegeneration processes. Understanding the above mechanisms may help in monitoring the toxic effects of intoxication with these toxins. It can also help develop methods of therapy for poisoning with this compound, in animals and humans.
Źródło:: Polish Hyperbaric Research; 2022, 3(80); 61-72
1734-7009
2084-0535
Pojawia się w:: Polish Hyperbaric Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Association between depression, parameters of adiposity and genetic polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β, IL-2 and IL-6 in subjects over 55 years old
Autorzy:: Adler, Grażyna
Skonieczna-Żydecka, Karolina
Madlani, Agnieszka
Ogonowski, Jarosław
Grochans, Elżbieta
Pierzak-Sominka, Joanna
Brodowski, Jacek
Karakiewicz, Beata
Powiązania:: https://bibliotekanauki.pl/articles/1038807.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: cross sectional study
genetic variants of cytokines
obesity
depression
Opis:: Background. During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. Aim. We sought to assess the prevalence of -889C>T IL-1α, -31T>C and -511C>T IL-1β, -330T>G IL-2 and -174G>C IL-6 genes and their association with adiposity and depression in Polish subjects. Methods. A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. Results. A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R=0.135 and p=0.02, R=0.114 and p<0.05, respectively) was found. No association between studied polymorphisms and depression was observed. Conclusion. Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
Źródło:: Acta Biochimica Polonica; 2016, 63, 2; 253-259
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Effect of T6 Heat Treatment on the Scratch Wear Behavior of Extruded Al-12wt.%Si Alloy
Autorzy:: Kang, Yeon-Ji
Kim, Jong-Ho
Hwang, Jong-Il
Lee, Kee-Ahn
Powiązania:: https://bibliotekanauki.pl/articles/356776.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: Al-12wt.%Si alloy
scratch test
wear-resistance
T6 heat treatment
Opis:: This study investigated the effect of T6 heat treatment on the microstructure and scratch wear behavior of hypoeutectic Al-12wt.%Si alloy manufactured by extrusion. Microstructural observation identified spherical eutectic Si phases before and after the heat treatment of alloys (F, T6). Phase analysis confirmed Al matrix and Si phase as well as Al₂Cu and Al₃Ni, Mg₂Si in both alloys. In particular, Al₂Cu was finer and more evenly distributed in T6 alloy. This resulted in Vickers hardness of T6 alloy that was 2.3 times greater compared to F alloy. The scratch wear test was conducted using constant load scratch test (CLST) mode and multi-pass scratch test (MPST) mode. The scratch coefficient and worn out volume obtained by such were used to evaluate wear properties before and after heat treatment. In the case of T6 alloy, its scratch coefficient was lower than F alloy in all load ranges. After 15 repeated tests to measure worn out volume, F alloy and T6 alloy measured 1.2×10^-1 mm³ and 7.8×10^-2 mm³, respectively. In other words, the wear resistance of T6 alloy were confirmed to be better than those of F alloy. In addition, this study attempted to identify the microstructural factors that contribute to the better scratch wear resistance of T6 alloy and wear mechanism from surface and cross-section observations after the wear tests.
Źródło:: Archives of Metallurgy and Materials; 2019, 64, 2; 617-622
1733-3490
Pojawia się w:: Archives of Metallurgy and Materials
Dostawca treści:: Biblioteka Nauki

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